Research Topics
Genomes and GenesSpecies | Deanna M BarchSummaryAffiliation: Washington University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Context-processing deficits in schizotypal personality disorderDeanna M Barch
Department of Psychology, Washington University, Campus Box 1125, One Brookings Drive, St Louis, MO 63130, USA
J Abnorm Psychol 113:556-68. 2004..Context processing was strongly associated with working memory and selective attention performance in the SPD individuals...
Prefrontal cortex function in nonpsychotic siblings of individuals with schizophreniaZainab Delawalla
Department of Psychology, Washington University, St Louis, Missouri 63130, USA
Biol Psychiatry 63:490-7. 2008..In individuals with schizophrenia, deficits in context processing have been associated with functional impairments of the dorsolateral prefrontal cortex (DLPFC)...
Functional developmental similarities and differences in the neural correlates of verbal and nonverbal working memory tasksShefali B Brahmbhatt
Washington University in St Louis, St Louis, MO 63130, United States
Neuropsychologia 46:1020-31. 2008..Our results provide further evidence for continued functional development through adolescence and into adulthood...
The default mode network and self-referential processes in depressionYvette I Sheline
Department of Psychiatry, Washington University, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 106:1942-7. 2009..These findings provide a brain network framework within which to consider the pathophysiology of depression...
Specificity of prefrontal dysfunction and context processing deficits to schizophrenia in never-medicated patients with first-episode psychosisAngus W MacDonald
Department of Psychology, University of Minnesota, N219 Elliott Hall, 75 E River Rd, Minneapolis, MN 55455, USA
Am J Psychiatry 162:475-84. 2005....
Antidepressant treatment normalizes hypoactivity in dorsolateral prefrontal cortex during emotional interference processing in major depressionChristina L Fales
Department of Psychology, Washington University in St Louis, St Louis, Missouri 63110, United States
J Affect Disord 112:206-11. 2009..The purpose of this study was to examine the effects of antidepressant treatment on anomalous neural activity in cognitive-control and emotion-processing circuitry...
Cognitive improvement following treatment in late-life depression: relationship to vascular risk and age of onsetDeanna M Barch
Department of Psychology, Washington University School of Medicine, St Louis, MO, USA
Am J Geriatr Psychiatry 20:682-90. 2012..To test the hypothesis that the degree of vascular burden and/or age of onset may influence the degree to which cognition can improve during the course of treatment in late-life depression...
Imaging genetic liability to schizophrenia: systematic review of FMRI studies of patients' nonpsychotic relativesAngus W MacDonald
Department of Psychology, University of Minnesota, N218 Elliott Hall, 75 East River Road, Minneapolis, MN 55455, USA
Schizophr Bull 35:1142-62. 2009....
Familial aggregation of clinical and neurocognitive features in sibling pairs with and without schizophreniaLi Shiun Chen
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Schizophr Res 111:159-66. 2009....
Altered emotional interference processing in affective and cognitive-control brain circuitry in major depressionChristina L Fales
Department of Psychology, Washington University in St Louis, St Louis, Missouri 63110, USA
Biol Psychiatry 63:377-84. 2008....
Negative and nonemotional interference with visual working memory in schizophreniaAlan Anticevic
Department of Psychology, Washington University, St Louis, Missouri, USA
Biol Psychiatry 70:1159-68. 2011..We tested the hypothesis that SCZ is associated with a general inability to filter distraction versus a specific deficit in the ability to filter aversive emotional distraction...
Functional connectivity of the amygdala in early-childhood-onset depressionKatherine R Luking
Department of Psychology, Washington University in St Louis, MO 63110, USA
J Am Acad Child Adolesc Psychiatry 50:1027-41.e3. 2011..However, it is unclear whether such connectivity alterations are also present in early-childhood-onset MDD...
Levels-of-processing effects in first-degree relatives of individuals with schizophreniaAaron Bonner-Jackson
Washington University, Department of Psychology, St Louis, Missouri 63130, USA
Biol Psychiatry 61:1141-7. 2007..The current study used a similar paradigm to determine whether siblings of individuals with schizophrenia (SIBs) also show increases in brain activity when presented with beneficial encoding strategies...
Medial temporal lobe structure and cognition in individuals with schizophrenia and in their non-psychotic siblingsMeghana S Karnik-Henry
Department of Psychology, Skidmore College, Saratoga Springs, NY, USA
Schizophr Res 138:128-35. 2012....
Abnormal parietal cortex activation during working memory in schizophrenia: verbal phonological coding disturbances versus domain-general executive dysfunctionDeanna M Barch
Department of Psychology, Washington University, St Louis, MO 63130, USA
Am J Psychiatry 164:1090-8. 2007..e., ventral prefrontal and parietal cortices) or 2) domain-general executive processes engaged by verbal and nonverbal tasks (i.e., dorsal prefrontal and parietal cortices)...
Amphetamine improves cognitive function in medicated individuals with schizophrenia and in healthy volunteersDeanna M Barch
Department of Psychology, Washington University, St Louis, MO 63130, United States
Schizophr Res 77:43-58. 2005....
Transient BOLD responses at block transitionsMichael D Fox
Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Neuroimage 28:956-66. 2005..Relevance of the current findings to studies of exogenous attention, task shifting, and the BOLD overshoot is discussed...
Intrinsic motivation in schizophrenia: relationships to cognitive function, depression, anxiety, and personalityDeanna M Barch
Department of Psychology, Washington University, One Brookings Drive, St Louis, MO 63130, USA
J Abnorm Psychol 117:776-87. 2008..However, they do suggest that the normal relationship between self-reports of intrinsic motivation and cognitive function is disrupted in schizophrenia...
Structural abnormalities in gyri of the prefrontal cortex in individuals with schizophrenia and their unaffected siblingsMichael P Harms
Department of Psychiatry Box 8134, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
Br J Psychiatry 196:150-7. 2010..The relatives of individuals with schizophrenia exhibit deficits of overall frontal lobe volume, consistent with a genetic contribution to these deficits...
Factors influencing Stroop performance in schizophreniaDeanna M Barch
Washington University, St Louis, MO 63130, USA
Neuropsychology 18:477-84. 2004....
Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trialYvette I Sheline
Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Box 8134, St Louis, MO 63110, USA
Arch Gen Psychiatry 67:277-85. 2010..Research on vascular depression has used 2 approaches to subtype late-life depression, based on executive dysfunction or white matter hyperintensity severity...
Effects of environmental support and strategy training on older adults' use of contextJessica L Paxton
Department of Psychology, Washington University, St Louis, MO 63139, USA
Psychol Aging 21:499-509. 2006..These results suggest that age-related differences in context processing can be ameliorated by directed strategy training or extended practice...
The maturing architecture of the brain's default networkDamien A Fair
Department of Neurology, Washington University, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 105:4028-32. 2008..We found that the default regions are only sparsely functionally connected at early school age (7-9 years old); over development, these regions integrate into a cohesive, interconnected network...
BOLD correlates of trial-by-trial reaction time variability in gray and white matter: a multi-study fMRI analysisTal Yarkoni
Department of Psychology, Washington University, Saint Louis, Missouri, United States of America
PLoS ONE 4:e4257. 2009..Using a multi-study approach, we investigated whether there are brain regions that show a general relationship between trial-by-trial RT variability and activation across a range of cognitive tasks...
Resisting emotional interference: brain regions facilitating working memory performance during negative distractionAlan Anticevic
Washington University, St Louis, Missouri 63130, USA
Cogn Affect Behav Neurosci 10:159-73. 2010..Supplemental materials associated with this article may be downloaded from http://cabn.psychonomic-journals.org/content/supplemental...
Neuropsychological abnormalities in schizophrenia and major mood disorders: similarities and differencesDeanna M Barch
Department of Psychology, Washington University in St Louis, Box 1125, One Brookings Drive, St Louis, MO 63130, USA
Curr Psychiatry Rep 11:313-9. 2009..This article provides a brief overview of work comparing cognitive function across the nonaffective and affective psychoses and highlights areas of similarity and dissimilarity in the role cognition plays in these disorders...
Optimization of a goal maintenance task for use in clinical applicationsDori Henderson
Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
Schizophr Bull 38:104-13. 2012..These adjustments were designed to decrease administration time and/or improve reliability of the data...
The cognitive neuroscience of schizophreniaDeanna M Barch
Department of Psychology, Washington University, St Louis, Missouri 63130, USA
Annu Rev Clin Psychol 1:321-53. 2005....
Prediction of individual brain maturity using fMRINico U F Dosenbach
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
Science 329:1358-61. 2010..The greatest relative contribution to predicting individual brain maturity was made by the weakening of short-range functional connections between the adult brain's major functional networks...
Cognitive control, goal maintenance, and prefrontal function in healthy agingJessica L Paxton
Department of Psychology, Washington University, Campus Box 1125, One Brookings Drive, Washington University, St Louis, MO 63139, USA
Cereb Cortex 18:1010-28. 2008..These results are consistent with the hypothesis that age-related impairments in goal maintenance abilities cause a compensatory shift in older adults from a proactive (seen in young adults) to a reactive cognitive control strategy...
Thalamic shape abnormalities in individuals with schizophrenia and their nonpsychotic siblingsMichael P Harms
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 27:13835-42. 2007..Inward deformation of the anterior and posterior regions of the thalamus represents a potential neuroanatomical endophenotype of schizophrenia...
Neural correlates of verbal and nonverbal working memory deficits in individuals with schizophrenia and their high-risk siblingsShefali B Brahmbhatt
Washington University, Department of Psychology, One Brookings Drive, Box 1125, St Louis, MO 63130, USA
Schizophr Res 87:191-204. 2006....
Episodic memory for emotional and non-emotional words in individuals with anhedoniaJennifer R Mathews
Department of Psychology, Washington University, St Louis, MO 63130, USA
Psychiatry Res 143:121-33. 2006....
Regional white matter hyperintensity burden in automated segmentation distinguishes late-life depressed subjects from comparison subjects matched for vascular risk factorsYvette I Sheline
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Am J Psychiatry 165:524-32. 2008..Correlations between neuropsychological performance and whole brain-segmented white matter hyperintensities and white and gray matter volumes were also examined...
The BOLD onset transient: identification of novel functional differences in schizophreniaMichael D Fox
Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
Neuroimage 25:771-82. 2005..Relevance of these findings to both an interpretation of the onset transient and the pathology of schizophrenia are discussed...
The effect of context processing on different aspects of social cognition in schizophreniaYu Sun Chung
Department of Psychology, Washington University in St Louis, St Louis, MO 63130, USA
Schizophr Bull 37:1048-56. 2011..1999;25:309-319). Thus, the purpose of the current study was to investigate the relationship between context processing and different aspects of social cognition in schizophrenia...
Amygdala recruitment in schizophrenia in response to aversive emotional material: a meta-analysis of neuroimaging studiesAlan Anticevic
Department of Psychology, Washington University in St Louis, St Louis, MO 63130, USA
Schizophr Bull 38:608-21. 2012....
Cognition in schizophrenia: core psychological and neural mechanismsDeanna M Barch
Department of Psychology, Washington University in St Louis, Box 1125, One Brookings Drive, St Louis, MO 63130, USA
Trends Cogn Sci 16:27-34. 2012....
The clinical translation of a measure of gain control: the contrast-contrast effect taskDeanna M Barch
Department of Psychology, Washington University, Box 1125, One Brookings Drive, St Louis, MO 63130, USA
Schizophr Bull 38:135-43. 2012..Additional analyses suggested that the length of the task could be shortened without losing power to detect surround effects in healthy individuals...
The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validityKeith H Nuechterlein
Department of Psychology, UCLA Semel Institute for Neuroscience and Human Behavior, 300 Medical Plaza, Rm 2251, Los Angeles, CA 90095 6968, USA
Am J Psychiatry 165:203-13. 2008....
CNTRICS final task selection: executive controlDeanna M Barch
Department of Psychology, Washington University, St Louis, MO 63130, USA
Schizophr Bull 35:115-35. 2009..This article describes the ways in which each of these tasks met the criteria used by the breakout group to recommend tasks for further development...
The influence of encoding strategy on episodic memory and cortical activity in schizophreniaAaron Bonner-Jackson
Department of Psychology, Washington University, St Louis, Missouri 63130, USA
Biol Psychiatry 58:47-55. 2005..We tested the hypothesis that providing effective encoding strategies to schizophrenia patients enhances encoding-related brain activity and recognition performance...
Measurement issues in the use of cognitive neuroscience tasks in drug development for impaired cognition in schizophrenia: a report of the second consensus building conference of the CNTRICS initiativeDeanna M Barch
Washington University, St Louis, MO, USA
Schizophr Bull 34:613-8. 2008....
Context processing and context maintenance in healthy aging and early stage dementia of the Alzheimer's typeTodd S Braver
Department of Psychology, Washington University, St Louis, MO 63130, USA
Psychol Aging 20:33-46. 2005..The results suggest that context processing may be composed of functionally dissociable components and point to the utility of this construct in understanding the timecourse of cognitive decline in healthy and pathological aging...
Goal representations and motivational drive in schizophrenia: the role of prefrontal-striatal interactionsDeanna M Barch
Department of Psychology, Washington University, Box 1125, One Brookings Drive, St Louis, MO, USA
Schizophr Bull 36:919-34. 2010....
The cognitive neuroscience of working memory: relevance to CNTRICS and schizophreniaDeanna M Barch
Department of Psychology, Washington University, St Louis, MO 63130, USA
Biol Psychiatry 64:11-7. 2008....
Abnormalities of thalamic activation and cognition in schizophreniaJessica Andrews
Department of Anatomy and Neurobiology, Washington University, St. Louis, MO 63130, USA
Am J Psychiatry 163:463-9. 2006....
Factors mediating cognitive deficits and psychopathology among siblings of individuals with schizophreniaZainab Delawalla
Department of Psychology, Washington University, USA
Schizophr Bull 32:525-37. 2006..Results suggest that there is a complex relationship between cognitive and clinical factors in this high-risk population...
The effect of emotional context on facial emotion ratings in schizophreniaYu Sun Chung
Washington University in St Louis, Psychology, Campus Box 1125, One Brookings Drive, St Louis, MO 63130, USA
Schizophr Res 131:235-41. 2011..These results suggest in schizophrenia, similar mechanisms may influence the processing of context for both social and non-social information...
The effect of age on rule-based category learningCaroline A Racine
Washington University, Department of Psychology, St Louis, Missouri, USA
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 13:411-34. 2006..These results are discussed in reference to the growing body of literature regarding age-related change in executive abilities and frontal lobe function...
Emotion responsivity, social cognition, and functional outcome in schizophreniaJennifer R Mathews
Department of Psychology, Washington University in St Louis, St Louis, MO 63110, USA
J Abnorm Psychol 119:50-9. 2010..This finding suggests that emotion responsivity is an important factor in understanding functional outcome in schizophrenia...
Maternal support in early childhood predicts larger hippocampal volumes at school ageJoan L Luby
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 109:2854-9. 2012..These findings provide prospective evidence in humans of the positive effect of early supportive parenting on healthy hippocampal development, a brain region key to memory and stress modulation...
Automated landmark identification for human cortical surface-based registrationAlan Anticevic
Department of Psychology, Washington University in St Louis, USA
Neuroimage 59:2539-47. 2012..ALI largely circumvents human error and bias and enables high throughput analysis of large neuroimaging datasets for inter-subject registration to an atlas...
Subgenual cingulate connectivity in children with a history of preschool-depressionMichael S Gaffrey
Departments of Psychiatry, Washington University, St Louis, Missouri, USA
Neuroreport 21:1182-8. 2010..These findings demonstrate that atypical sgACC functional connections are evident as early as school age in children with a history of PO-MDD and suggest an association with a very early episode of depression...
Subcortical alignment precision in patients with schizophreniaAlan Anticevic
Department of Psychology, Washington University in St Louis, MO 63130, USA
Schizophr Res 120:76-83. 2010....
CNTRICS final task selection: working memoryDeanna M Barch
Department of Psychology, Washington University, St Louis, MO 63130, USA
Schizophr Bull 35:136-52. 2009..This article describes the ways in which each of these tasks met the criteria used by the breakout group to recommend tasks for further development...
Episodic memory in schizophrenia: the influence of strategy use on behavior and brain activationAaron Bonner-Jackson
Departments of Psychology and Psychiatry, Washington University, St Louis, MO 63130, USA
Psychiatry Res 164:1-15. 2008..However, we found that Incidental encoding did not improve free recall in schizophrenia participants and abnormal brain activity in some regions was observed, despite improvements in recognition memory...
Anhedonia and emotional experience in schizophrenia: neural and behavioral indicatorsErin C Dowd
Department of Neuroscience Program, Washington University, St Louis, Missouri 631320, USA
Biol Psychiatry 67:902-11. 2010..Investigation of neural activity during emotional experience may help clarify whether symptoms of anhedonia more likely reflect alterations of in-the-moment hedonic experience or impairments in other aspects of goal-directed behavior...
Cognitive function in late life depression: relationships to depression severity, cerebrovascular risk factors and processing speedYvette I Sheline
Department of Psychiatry, Washington University, St Louis, Missouri, USA
Biol Psychiatry 60:58-65. 2006....
Selecting paradigms from cognitive neuroscience for translation into use in clinical trials: proceedings of the third CNTRICS meetingDeanna M Barch
Washington University, St Louis, MO, USA
Schizophr Bull 35:109-14. 2009....
BDNF polymorphism rs6265 and hippocampal structure and memory performance in healthy control subjectsMeghana S Karnik
Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
Psychiatry Res 178:425-9. 2010..We concluded that in a large cohort of healthy human subjects, the Met allele of rs6265 is not associated with hippocampal structure or memory performance...
When less is more: TPJ and default network deactivation during encoding predicts working memory performanceAlan Anticevic
Department of Psychology, Campus Box 1125, Washington University, Saint Louis, MO 63130, USA
Neuroimage 49:2638-48. 2010..In addition, the functional connectivity results suggest that TPJ, while not part of the DMN during the resting state, may flexibly "couple" with this network depending on task demands...
Pharmacological strategies for enhancing cognition in schizophreniaDeanna M Barch
Washington University, St Louis, One Brookings Drive, Box 1125, St Louis, MO 63130, USA
Curr Top Behav Neurosci 4:43-96. 2010....
Anhedonia and the experience of emotion in individuals with schizophreniaJennifer A Burbridge
Department of Psychology, Washington University, USA
J Abnorm Psychol 116:30-42. 2007..Disturbances in working memory moderated the relationship between physical anhedonia and participants' emotional experience of positive stimuli...
Comparing surface-based and volume-based analyses of functional neuroimaging data in patients with schizophreniaAlan Anticevic
Department of Psychology, Washington University in St Louis, MO 63130, USA
Neuroimage 41:835-48. 2008..These results indicate that SBR provides significant advantages over affine VBR when analyzing cortical fMRI activations. Furthermore, these improvements can be even greater in disorders that have associated structural abnormalities...
Easier tasks can have better discriminating power: the case of verbal fluencyMeredith R D Melinder
Department of Psychology, Washington University, St. Louis, MO 63130, USA
J Abnorm Psychol 114:385-91. 2005..In this article, the authors present data from 2 studies using phonologic and category fluency tasks to demonstrate that the critical factor for task selection and matching is discriminating power, not task difficulty...
Sustained neural activity associated with cognitive control during temporally extended decision makingTal Yarkoni
Department of Psychology, Washington University, Campus Box 1125, St. Louis, MO 63130, USA
Brain Res Cogn Brain Res 23:71-84. 2005..These results demonstrate the contribution of cognitive control mechanisms to temporally extended decision-making paradigms and highlight the benefits of decomposing activation responses into sustained and transient components...
Decreased hippocampal 5-HT(2A) receptor binding in older depressed patients using [18F]altanserin positron emission tomographyYvette I Sheline
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Neuropsychopharmacology 29:2235-41. 2004..04) than previously treated subjects (n = 10). It may be that prior medication treatment provides a compensatory upregulation of the 5-HT(2A) receptor...
Development of distinct control networks through segregation and integrationDamien A Fair
Departments of Neurology, Washington University, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 104:13507-12. 2007..Delay/disruption in the developmental processes of segregation and integration may play a role in disorders of control, such as autism, attention deficit hyperactivity disorder, and Tourette's syndrome...
The relationships among cognition, motivation, and emotion in schizophrenia: how much and how little we knowDeanna M Barch
Psychology Department, Washington University, St Louis, MO 63130, USA
Schizophr Bull 31:875-81. 2005....
Hemodynamic responses in visual, motor, and somatosensory cortices in schizophreniaDeanna M Barch
Department of Psychology, Washington University, St Louis, MO 63130, USA
Neuroimage 20:1884-93. 2003..These results begin to validate the interpretation of functional neuroimaging studies of schizophrenia in terms of neuronal as opposed to vascular mechanisms...
Context-processing deficits in schizophrenia: diagnostic specificity, 4-week course, and relationships to clinical symptomsDeanna M Barch
Department of Psychology, St Louis, Missouri 63130 4899, USA
J Abnorm Psychol 112:132-43. 2003..However, context-processing deficits improved in the psychotic comparison group at 4 weeks but did not improve in patients with schizophrenia...
Cognitive-pharmacologic functional magnetic resonance imaging in tourette syndrome: a pilot studyTamara Hershey
Department of Psychiatry, Washington University, St. Louis, Missouri, USA
Biol Psychiatry 55:916-25. 2004..05). CONCLUSIONS: These results are consistent with a dopamine-influenced functional abnormality of brain response in TS and suggest testable hypotheses about the mechanism by which dopamine antagonists and agonists alleviate tics...
A theory of cognitive control, aging cognition, and neuromodulationTodd S Braver
Department of Psychology, Washington University, Campus Box 1125, One Brookings Drive, St Louis, MO 63130, USA
Neurosci Biobehav Rev 26:809-17. 2002..These findings highlight the utility of a computational approach to cognitive aging. Current directions for further refinement and validation of the model are outlined...
Sex influences on material-sensitive functional lateralization in working and episodic memory: men and women are not all that differentKristen M Haut
Department of Psychology, Washington University, St Louis, MO 63150, USA
Neuroimage 32:411-22. 2006..In conclusion, our data suggest that males and females show a similar pattern of lateralized activation to material type during working memory and recognition tasks...
The influence of a working memory load manipulation on language production in schizophreniaMeredith R D Melinder
Department of Psychology, Washington University, St, Louis, Missouri 63130, USA
Schizophr Bull 29:473-85. 2003....
Working memory and prefrontal cortex dysfunction: specificity to schizophrenia compared with major depressionDeanna M Barch
Department of Psychology, Washington University, St. Louis, Missouri, USA
Biol Psychiatry 53:376-84. 2003....
Opiate addicts lack error-dependent activation of rostral anterior cingulateSteven D Forman
Department of Psychology (TSB, DMB, Washington University, St. Louis, Missouri, USA
Biol Psychiatry 55:531-7. 2004..CONCLUSIONS: The attenuation of this error signal in anterior cingulate cortex may play a role in loss of control in addiction and other forms of impulsive behavior...
Language comprehension and working memory language comprehension and working memory deficits in patients with schizophreniaDaniel M Bagner
Department of Psychology, Washington University, Box 1125, One Brookings Drive, 63130, St. Louis, MO, USA
Schizophr Res 60:299-309. 2003..Contrary to our predictions, language comprehension and working memory deficits were not associated with either formal thought disorder or hallucinations...
The effects of guanfacine on context processing abnormalities in schizotypal personality disorderMargaret M McClure
VA VISN3 Mental Illness Research, Education, and Clinical Center, Bronx, New York 10468, USA
Biol Psychiatry 61:1157-60. 2007..This study examined the potential of guanfacine for improving context processing, a feature of working memory, in SPD...
Identification of separable cognitive factors in schizophreniaKeith H Nuechterlein
Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, USA
Schizophr Res 72:29-39. 2004..These separable cognitive dimensions also have broader relevance to future research aimed at understanding the nature and structure of core cognitive deficits in schizophrenia...
Context processing in schizotypal personality disorder: evidence of specificity of impairment to the schizophrenia spectrumMargaret M McClure
VA VISN 3 Mental Illness Research, Education and Clinical Center, Bronx, New York 10468, USA
J Abnorm Psychol 117:342-54. 2008..These findings, which are quite similar to those previously reported in patients with schizophrenia, suggest that context processing deficits are specific to the schizophrenia spectrum and are not a reflection of overall psychopathology...
Accounting for cognitive aging: context processing, inhibition or processing speed?Beth K Rush
Mayo Clinic College of Medicine, USA
Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 13:588-610. 2006..The sensitivity of the AX-CPT to cognitive aging is discussed in the context of existing theories of cognitive aging. The authors suggest that deficits in context processing and utilization may underlie cognitive aging phenomena...
Identifying cognitive mechanisms targeted for treatment development in schizophrenia: an overview of the first meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia InitiativeCameron S Carter
Department of Psychiatry, University of California, Davis, CA 95817, USA
Biol Psychiatry 64:4-10. 2008..The articles in this special section report on the results of the first conference, which used a criterion-based consensus-building process to develop a set of cognitive constructs to be targeted for translation efforts...
Executive functioning component mechanisms and schizophreniaJohn G Kerns
Department of Psychological Sciences, University of Missouri, Columbia, Missouri 65211, USA
Biol Psychiatry 64:26-33. 2008..Although there is general consensus about what cognitive tasks involve executive functioning, there is disagreement about the specific cognitive mechanisms that comprise executive functioning...
Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteriaMichael F Green
Neuropsychiatric Institute, Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
Biol Psychiatry 56:301-7. 2004..The results from this meeting constitute the initial steps for reaching a consensus cognitive battery for clinical trials in schizophrenia...
Prefrontal functioning during context processing in schizophrenia and major depression: an event-related fMRI studyAvram J Holmes
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Schizophr Res 76:199-206. 2005..The imaging data replicate previous results in showing abnormal activity in the right middle frontal gyrus (BA9) in schizophrenia patients related to context processing...
Subclinical expression of schizophrenia-like symptoms in non-psychotic siblings of individuals with schizophreniaMatthew J Smith
Schizophr Res 103:324-5. 2008
Cognitive neuroscience-based approaches to measuring and improving treatment effects on cognition in schizophrenia: the CNTRICS initiativeCameron S Carter
University of California at Davis, USA
Schizophr Bull 33:1131-7. 2007....
