Deanna Barch

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi Altered emotional interference processing in affective and cognitive-control brain circuitry in major depression
    Christina L Fales
    Department of Psychology, Washington University in St Louis, St Louis, Missouri 63110, USA
    Biol Psychiatry 63:377-84. 2008
  2. ncbi Pharmacological strategies for enhancing cognition in schizophrenia
    Deanna M Barch
    Washington University, St Louis, One Brookings Drive, Box 1125, St Louis, MO 63130, USA
    Curr Top Behav Neurosci 4:43-96. 2010
  3. ncbi Functional brain activation to emotionally valenced faces in school-aged children with a history of preschool-onset major depression
    Deanna M Barch
    Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA
    Biol Psychiatry 72:1035-42. 2012
  4. ncbi Cognition in schizophrenia: core psychological and neural mechanisms
    Deanna M Barch
    Department of Psychology, Washington University in St Louis, Box 1125, One Brookings Drive, St Louis, MO 63130, USA
    Trends Cogn Sci 16:27-34. 2012
  5. ncbi The cognitive neuroscience of working memory: relevance to CNTRICS and schizophrenia
    Deanna M Barch
    Department of Psychology, Washington University, St Louis, MO 63130, USA
    Biol Psychiatry 64:11-7. 2008
  6. ncbi Goal representations and motivational drive in schizophrenia: the role of prefrontal-striatal interactions
    Deanna M Barch
    Department of Psychology, Washington University, Box 1125, One Brookings Drive, St Louis, MO, USA
    Schizophr Bull 36:919-34. 2010
  7. ncbi Amphetamine improves cognitive function in medicated individuals with schizophrenia and in healthy volunteers
    Deanna M Barch
    Department of Psychology, Washington University, St Louis, MO 63130, United States
    Schizophr Res 77:43-58. 2005
  8. ncbi The relationships among cognition, motivation, and emotion in schizophrenia: how much and how little we know
    Deanna M Barch
    Psychology Department, Washington University, St Louis, MO 63130, USA
    Schizophr Bull 31:875-81. 2005
  9. ncbi What can research on schizophrenia tell us about the cognitive neuroscience of working memory?
    D M Barch
    Psychology, Washington University, Box 1125, One Brookings Drive, St Louis, MO 63130, USA
    Neuroscience 139:73-84. 2006
  10. ncbi Neuropsychological abnormalities in schizophrenia and major mood disorders: similarities and differences
    Deanna M Barch
    Department of Psychology, Washington University in St Louis, Box 1125, One Brookings Drive, St Louis, MO 63130, USA
    Curr Psychiatry Rep 11:313-9. 2009

Research Grants

  1. 1/5-Cognitive Neuroscience Task Reliability & Clinical Applications Consortium
    Deanna M Barch; Fiscal Year: 2010
  2. 1/5-Cognitive Neuroscience Task Reliability & Clinical Applications Consortium
    Deanna M Barch; Fiscal Year: 2010
  3. Schizophrenia, Prefrontal Cortex, and Emotion Regulation
    Deanna M Barch; Fiscal Year: 2010
  4. 1/5-Cognitive Neuroscience Task Reliability & Clinical Applications Consortium
    Deanna Barch; Fiscal Year: 2009
  5. Schizopherenia, Prefrontal Cortex & Emotion Regulation
    Deanna Barch; Fiscal Year: 2007
  6. Schizophrenia, Prefrontal Cortex, and Emotion Regulation
    Deanna M Barch; Fiscal Year: 2011

Collaborators

Detail Information

Publications100

  1. ncbi Altered emotional interference processing in affective and cognitive-control brain circuitry in major depression
    Christina L Fales
    Department of Psychology, Washington University in St Louis, St Louis, Missouri 63110, USA
    Biol Psychiatry 63:377-84. 2008
    ....
  2. ncbi Pharmacological strategies for enhancing cognition in schizophrenia
    Deanna M Barch
    Washington University, St Louis, One Brookings Drive, Box 1125, St Louis, MO 63130, USA
    Curr Top Behav Neurosci 4:43-96. 2010
    ....
  3. ncbi Functional brain activation to emotionally valenced faces in school-aged children with a history of preschool-onset major depression
    Deanna M Barch
    Department of Psychiatry, Washington University School of Medicine, Saint Louis, MO, USA
    Biol Psychiatry 72:1035-42. 2012
    ..Recent research has demonstrated that clinical depression can emerge as early as the preschool period. Here, we examine brain function in children with a history of preschool-onset depression (PO-MDD) in comparison with healthy children...
  4. ncbi Cognition in schizophrenia: core psychological and neural mechanisms
    Deanna M Barch
    Department of Psychology, Washington University in St Louis, Box 1125, One Brookings Drive, St Louis, MO 63130, USA
    Trends Cogn Sci 16:27-34. 2012
    ....
  5. ncbi The cognitive neuroscience of working memory: relevance to CNTRICS and schizophrenia
    Deanna M Barch
    Department of Psychology, Washington University, St Louis, MO 63130, USA
    Biol Psychiatry 64:11-7. 2008
    ....
  6. ncbi Goal representations and motivational drive in schizophrenia: the role of prefrontal-striatal interactions
    Deanna M Barch
    Department of Psychology, Washington University, Box 1125, One Brookings Drive, St Louis, MO, USA
    Schizophr Bull 36:919-34. 2010
    ....
  7. ncbi Amphetamine improves cognitive function in medicated individuals with schizophrenia and in healthy volunteers
    Deanna M Barch
    Department of Psychology, Washington University, St Louis, MO 63130, United States
    Schizophr Res 77:43-58. 2005
    ....
  8. ncbi The relationships among cognition, motivation, and emotion in schizophrenia: how much and how little we know
    Deanna M Barch
    Psychology Department, Washington University, St Louis, MO 63130, USA
    Schizophr Bull 31:875-81. 2005
    ....
  9. ncbi What can research on schizophrenia tell us about the cognitive neuroscience of working memory?
    D M Barch
    Psychology, Washington University, Box 1125, One Brookings Drive, St Louis, MO 63130, USA
    Neuroscience 139:73-84. 2006
    ....
  10. ncbi Neuropsychological abnormalities in schizophrenia and major mood disorders: similarities and differences
    Deanna M Barch
    Department of Psychology, Washington University in St Louis, Box 1125, One Brookings Drive, St Louis, MO 63130, USA
    Curr Psychiatry Rep 11:313-9. 2009
    ..This article provides a brief overview of work comparing cognitive function across the nonaffective and affective psychoses and highlights areas of similarity and dissimilarity in the role cognition plays in these disorders...
  11. ncbi Intrinsic motivation in schizophrenia: relationships to cognitive function, depression, anxiety, and personality
    Deanna M Barch
    Department of Psychology, Washington University, One Brookings Drive, St Louis, MO 63130, USA
    J Abnorm Psychol 117:776-87. 2008
    ..However, they do suggest that the normal relationship between self-reports of intrinsic motivation and cognitive function is disrupted in schizophrenia...
  12. ncbi Selecting paradigms from cognitive neuroscience for translation into use in clinical trials: proceedings of the third CNTRICS meeting
    Deanna M Barch
    Washington University, St Louis, MO, USA
    Schizophr Bull 35:109-14. 2009
    ....
  13. ncbi CNTRICS final task selection: executive control
    Deanna M Barch
    Department of Psychology, Washington University, St Louis, MO 63130, USA
    Schizophr Bull 35:115-35. 2009
    ..This article describes the ways in which each of these tasks met the criteria used by the breakout group to recommend tasks for further development...
  14. ncbi CNTRICS final task selection: working memory
    Deanna M Barch
    Department of Psychology, Washington University, St Louis, MO 63130, USA
    Schizophr Bull 35:136-52. 2009
    ..This article describes the ways in which each of these tasks met the criteria used by the breakout group to recommend tasks for further development...
  15. ncbi Abnormal parietal cortex activation during working memory in schizophrenia: verbal phonological coding disturbances versus domain-general executive dysfunction
    Deanna M Barch
    Department of Psychology, Washington University, St Louis, MO 63130, USA
    Am J Psychiatry 164:1090-8. 2007
    ..e., ventral prefrontal and parietal cortices) or 2) domain-general executive processes engaged by verbal and nonverbal tasks (i.e., dorsal prefrontal and parietal cortices)...
  16. ncbi The cognitive neuroscience of schizophrenia
    Deanna M Barch
    Department of Psychology, Washington University, St Louis, Missouri 63130, USA
    Annu Rev Clin Psychol 1:321-53. 2005
    ....
  17. ncbi Using brain imaging measures in studies of procognitive pharmacologic agents in schizophrenia: psychometric and quality assurance considerations
    Deanna M Barch
    Department of Psychology, Washington University, St Louis, Missouri 63130, USA
    Biol Psychiatry 70:13-8. 2011
    ..and are relevant to both pharmacologic and psychological intervention approaches...
  18. ncbi Factors influencing Stroop performance in schizophrenia
    Deanna M Barch
    Washington University, St Louis, MO 63130, USA
    Neuropsychology 18:477-84. 2004
    ....
  19. ncbi Anterior cingulate cortex and response conflict: effects of response modality and processing domain
    D M Barch
    Department of Psychology, Washington University, One Brookings Drive, St Louis, MO 63130, USA
    Cereb Cortex 11:837-48. 2001
    ..Thus, our results suggest that the same regions of ACC are responsive to conflict arising with both manual and vocal output and with both spatial and verbal processing...
  20. ncbi Working and long-term memory deficits in schizophrenia: is there a common prefrontal mechanism?
    Deanna M Barch
    Department of Psychology, Washington University, St Louis, Missouri 63130, USA
    J Abnorm Psychol 111:478-94. 2002
    ..Some evidence was found for more severe cognitive and functional deficits with verbal than nonverbal stimuli, although these results were mixed...
  21. ncbi Measurement issues in the use of cognitive neuroscience tasks in drug development for impaired cognition in schizophrenia: a report of the second consensus building conference of the CNTRICS initiative
    Deanna M Barch
    Washington University, St Louis, MO, USA
    Schizophr Bull 34:613-8. 2008
    ....
  22. ncbi Selective deficits in prefrontal cortex function in medication-naive patients with schizophrenia
    D M Barch
    Department of Psychology, Campus Box 1125, 1 Brookings Dr, Washington University, St Louis, MO 63130, USA
    Arch Gen Psychiatry 58:280-8. 2001
    ..We use functional magnetic resonance imaging to examine PFC activation in medication-naive, first-episode patients with schizophrenia during a WM, task-isolating context processing...
  23. ncbi Anterior cingulate and the monitoriing of response conflict: evidence from an fMRI study of overt verb generation
    D M Barch
    Department of Psychology, Washington University, St Louis, MO 63130, USA
    J Cogn Neurosci 12:298-309. 2000
    ..We discuss the implication of these results for understanding the role that the ACC plays in human cognition...
  24. ncbi Context-processing deficits in schizophrenia: diagnostic specificity, 4-week course, and relationships to clinical symptoms
    Deanna M Barch
    Department of Psychology, St Louis, Missouri 63130 4899, USA
    J Abnorm Psychol 112:132-43. 2003
    ..However, context-processing deficits improved in the psychotic comparison group at 4 weeks but did not improve in patients with schizophrenia...
  25. ncbi The clinical translation of a measure of gain control: the contrast-contrast effect task
    Deanna M Barch
    Department of Psychology, Washington University, Box 1125, One Brookings Drive, St Louis, MO 63130, USA
    Schizophr Bull 38:135-43. 2012
    ..Additional analyses suggested that the length of the task could be shortened without losing power to detect surround effects in healthy individuals...
  26. ncbi Hemodynamic responses in visual, motor, and somatosensory cortices in schizophrenia
    Deanna M Barch
    Department of Psychology, Washington University, St Louis, MO 63130, USA
    Neuroimage 20:1884-93. 2003
    ..These results begin to validate the interpretation of functional neuroimaging studies of schizophrenia in terms of neuronal as opposed to vascular mechanisms...
  27. ncbi Increased stroop facilitation effects in schizophrenia are not due to increased automatic spreading activation
    D M Barch
    Department of Psychiatry, University of Pittsburgh Medical School, PA 15213, USA
    Schizophr Res 39:51-64. 1999
    ..These results are inconsistent with the spreading activation hypothesis. Alternative hypotheses regarding the source of Stroop task performance deficits in schizophrenia are discussed...
  28. ncbi CNTRICS imaging biomarkers selection: Working memory
    Deanna M Barch
    Department of Psychology, Washington University, St Louis, MO 63130, USA
    Schizophr Bull 38:43-52. 2012
    ..The group suggested a promising imaging biomarker measure for capacity, a version of the change detection task that measures delay activity over posterior parietal and occipital cortex...
  29. ncbi Basal ganglia shape abnormalities in the unaffected siblings of schizophrenia patients
    Daniel Mamah
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Biol Psychiatry 64:111-20. 2008
    ..Our aim was to test the hypothesis that abnormalities of basal ganglia structure are intrinsic features of schizophrenia by assessing basal ganglia volume and shape in the unaffected siblings of schizophrenia subjects...
  30. ncbi Imaging genetic liability to schizophrenia: systematic review of FMRI studies of patients' nonpsychotic relatives
    Angus W MacDonald
    Department of Psychology, University of Minnesota, N218 Elliott Hall, 75 East River Road, Minneapolis, MN 55455, USA
    Schizophr Bull 35:1142-62. 2009
    ....
  31. ncbi Specificity of prefrontal dysfunction and context processing deficits to schizophrenia in never-medicated patients with first-episode psychosis
    Angus W MacDonald
    Department of Psychology, University of Minnesota, N219 Elliott Hall, 75 E River Rd, Minneapolis, MN 55455, USA
    Am J Psychiatry 162:475-84. 2005
    ....
  32. ncbi Working memory and prefrontal cortex dysfunction: specificity to schizophrenia compared with major depression
    Deanna M Barch
    Department of Psychology, Washington University, St. Louis, Missouri, USA
    Biol Psychiatry 53:376-84. 2003
    ....
  33. ncbi Antidepressant treatment normalizes hypoactivity in dorsolateral prefrontal cortex during emotional interference processing in major depression
    Christina L Fales
    Department of Psychology, Washington University in St Louis, St Louis, Missouri 63110, United States
    J Affect Disord 112:206-11. 2009
    ..The purpose of this study was to examine the effects of antidepressant treatment on anomalous neural activity in cognitive-control and emotion-processing circuitry...
  34. ncbi Influence of emotional processing on working memory in schizophrenia
    Karla Becerril
    Neuroscience Program, Washington University, St Louis, MO, USA
    Schizophr Bull 37:1027-38. 2011
    ..Our findings suggest that disturbances in emotional processing in schizophrenia relate to alterations in emotion-cognition interactions rather than to the perception and subjective experience of emotion per se...
  35. ncbi Factors mediating cognitive deficits and psychopathology among siblings of individuals with schizophrenia
    Zainab Delawalla
    Department of Psychology, Washington University, USA
    Schizophr Bull 32:525-37. 2006
    ..Results suggest that there is a complex relationship between cognitive and clinical factors in this high-risk population...
  36. ncbi Identifying cognitive mechanisms targeted for treatment development in schizophrenia: an overview of the first meeting of the Cognitive Neuroscience Treatment Research to Improve Cognition in Schizophrenia Initiative
    Cameron S Carter
    Department of Psychiatry, University of California, Davis, CA 95817, USA
    Biol Psychiatry 64:4-10. 2008
    ..The articles in this special section report on the results of the first conference, which used a criterion-based consensus-building process to develop a set of cognitive constructs to be targeted for translation efforts...
  37. ncbi Structural analysis of the basal ganglia in schizophrenia
    Daniel Mamah
    Department of Psychiatry, Washington University Medical School, St Louis, MO 63110, USA
    Schizophr Res 89:59-71. 2007
    ..In conclusion, basal ganglia volumes relative to total brain volume were larger in schizophrenia subjects than healthy comparison subjects. Specific patterns of shape change accompanied these volume differences...
  38. ncbi Variable global dysconnectivity and individual differences in schizophrenia
    Michael W Cole
    Department of Psychology, Washington University, St Louis, Missouri 63130, USA
    Biol Psychiatry 70:43-50. 2011
    ..We hypothesized that such heterogeneity might arise in part from consistently widespread yet variably patterned alterations in the connectivity of focal brain regions...
  39. ncbi Language comprehension and working memory language comprehension and working memory deficits in patients with schizophrenia
    Daniel M Bagner
    Department of Psychology, Washington University, Box 1125, One Brookings Drive, 63130, St. Louis, MO, USA
    Schizophr Res 60:299-309. 2003
    ..Contrary to our predictions, language comprehension and working memory deficits were not associated with either formal thought disorder or hallucinations...
  40. ncbi The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validity
    Keith H Nuechterlein
    Department of Psychology, UCLA Semel Institute for Neuroscience and Human Behavior, 300 Medical Plaza, Rm 2251, Los Angeles, CA 90095 6968, USA
    Am J Psychiatry 165:203-13. 2008
    ....
  41. ncbi Abnormalities of thalamic activation and cognition in schizophrenia
    Jessica Andrews
    Department of Anatomy and Neurobiology, Washington University, St. Louis, MO 63130, USA
    Am J Psychiatry 163:463-9. 2006
    ....
  42. ncbi The effect of age on rule-based category learning
    Caroline A Racine
    Washington University, Department of Psychology, St Louis, Missouri, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 13:411-34. 2006
    ..These results are discussed in reference to the growing body of literature regarding age-related change in executive abilities and frontal lobe function...
  43. ncbi Cingulate gyrus neuroanatomy in schizophrenia subjects and their non-psychotic siblings
    Daniel R Calabrese
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, United States
    Schizophr Res 104:61-70. 2008
    ....
  44. ncbi Cognitive control, goal maintenance, and prefrontal function in healthy aging
    Jessica L Paxton
    Department of Psychology, Washington University, Campus Box 1125, One Brookings Drive, Washington University, St Louis, MO 63139, USA
    Cereb Cortex 18:1010-28. 2008
    ..These results are consistent with the hypothesis that age-related impairments in goal maintenance abilities cause a compensatory shift in older adults from a proactive (seen in young adults) to a reactive cognitive control strategy...
  45. ncbi Opiate addicts lack error-dependent activation of rostral anterior cingulate
    Steven D Forman
    Department of Psychology (TSB, DMB, Washington University, St. Louis, Missouri, USA
    Biol Psychiatry 55:531-7. 2004
    ..CONCLUSIONS: The attenuation of this error signal in anterior cingulate cortex may play a role in loss of control in addiction and other forms of impulsive behavior...
  46. ncbi Context-processing deficits in schizotypal personality disorder
    Deanna M Barch
    Department of Psychology, Washington University, Campus Box 1125, One Brookings Drive, St Louis, MO 63130, USA
    J Abnorm Psychol 113:556-68. 2004
    ..Context processing was strongly associated with working memory and selective attention performance in the SPD individuals...
  47. ncbi Prediction of individual brain maturity using fMRI
    Nico U F Dosenbach
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 329:1358-61. 2010
    ..The greatest relative contribution to predicting individual brain maturity was made by the weakening of short-range functional connections between the adult brain's major functional networks...
  48. ncbi Episodic memory in schizophrenia: the influence of strategy use on behavior and brain activation
    Aaron Bonner-Jackson
    Departments of Psychology and Psychiatry, Washington University, St Louis, MO 63130, USA
    Psychiatry Res 164:1-15. 2008
    ..However, we found that Incidental encoding did not improve free recall in schizophrenia participants and abnormal brain activity in some regions was observed, despite improvements in recognition memory...
  49. ncbi Resisting emotional interference: brain regions facilitating working memory performance during negative distraction
    Alan Anticevic
    Washington University, St Louis, Missouri 63130, USA
    Cogn Affect Behav Neurosci 10:159-73. 2010
    ..Supplemental materials associated with this article may be downloaded from http://cabn.psychonomic-journals.org/content/supplemental...
  50. ncbi Support for the vascular depression hypothesis in late-life depression: results of a 2-site, prospective, antidepressant treatment trial
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Box 8134, St Louis, MO 63110, USA
    Arch Gen Psychiatry 67:277-85. 2010
    ..Research on vascular depression has used 2 approaches to subtype late-life depression, based on executive dysfunction or white matter hyperintensity severity...
  51. ncbi Emotion responsivity, social cognition, and functional outcome in schizophrenia
    Jennifer R Mathews
    Department of Psychology, Washington University in St Louis, St Louis, MO 63110, USA
    J Abnorm Psychol 119:50-9. 2010
    ..This finding suggests that emotion responsivity is an important factor in understanding functional outcome in schizophrenia...
  52. ncbi Structural abnormalities in gyri of the prefrontal cortex in individuals with schizophrenia and their unaffected siblings
    Michael P Harms
    Department of Psychiatry Box 8134, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Br J Psychiatry 196:150-7. 2010
    ..The relatives of individuals with schizophrenia exhibit deficits of overall frontal lobe volume, consistent with a genetic contribution to these deficits...
  53. ncbi Anhedonia and emotional experience in schizophrenia: neural and behavioral indicators
    Erin C Dowd
    Department of Neuroscience Program, Washington University, St Louis, Missouri 631320, USA
    Biol Psychiatry 67:902-11. 2010
    ..Investigation of neural activity during emotional experience may help clarify whether symptoms of anhedonia more likely reflect alterations of in-the-moment hedonic experience or impairments in other aspects of goal-directed behavior...
  54. ncbi Familial aggregation of clinical and neurocognitive features in sibling pairs with and without schizophrenia
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Schizophr Res 111:159-66. 2009
    ....
  55. ncbi Flexible neural mechanisms of cognitive control within human prefrontal cortex
    Todd S Braver
    Department of Psychology, Washington University, St Louis, MO 63130, USA
    Proc Natl Acad Sci U S A 106:7351-6. 2009
    ....
  56. ncbi The default mode network and self-referential processes in depression
    Yvette I Sheline
    Department of Psychiatry, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:1942-7. 2009
    ..These findings provide a brain network framework within which to consider the pathophysiology of depression...
  57. ncbi BOLD correlates of trial-by-trial reaction time variability in gray and white matter: a multi-study fMRI analysis
    Tal Yarkoni
    Department of Psychology, Washington University, Saint Louis, Missouri, United States of America
    PLoS ONE 4:e4257. 2009
    ..Using a multi-study approach, we investigated whether there are brain regions that show a general relationship between trial-by-trial RT variability and activation across a range of cognitive tasks...
  58. ncbi When less is more: TPJ and default network deactivation during encoding predicts working memory performance
    Alan Anticevic
    Department of Psychology, Campus Box 1125, Washington University, Saint Louis, MO 63130, USA
    Neuroimage 49:2638-48. 2010
    ..In addition, the functional connectivity results suggest that TPJ, while not part of the DMN during the resting state, may flexibly "couple" with this network depending on task demands...
  59. ncbi Subgenual cingulate connectivity in children with a history of preschool-depression
    Michael S Gaffrey
    Departments of Psychiatry, Washington University, St Louis, Missouri, USA
    Neuroreport 21:1182-8. 2010
    ..These findings demonstrate that atypical sgACC functional connections are evident as early as school age in children with a history of PO-MDD and suggest an association with a very early episode of depression...
  60. ncbi Regional white matter hyperintensity burden in automated segmentation distinguishes late-life depressed subjects from comparison subjects matched for vascular risk factors
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Psychiatry 165:524-32. 2008
    ..Correlations between neuropsychological performance and whole brain-segmented white matter hyperintensities and white and gray matter volumes were also examined...
  61. ncbi The influence of encoding strategy on episodic memory and cortical activity in schizophrenia
    Aaron Bonner-Jackson
    Department of Psychology, Washington University, St Louis, Missouri 63130, USA
    Biol Psychiatry 58:47-55. 2005
    ..We tested the hypothesis that providing effective encoding strategies to schizophrenia patients enhances encoding-related brain activity and recognition performance...
  62. ncbi Prefrontal functioning during context processing in schizophrenia and major depression: an event-related fMRI study
    Avram J Holmes
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Schizophr Res 76:199-206. 2005
    ..The imaging data replicate previous results in showing abnormal activity in the right middle frontal gyrus (BA9) in schizophrenia patients related to context processing...
  63. ncbi Extracting core components of cognitive control
    Todd S Braver
    Department of Psychology, Washington University, St Louis, MO 63130, USA
    Trends Cogn Sci 10:529-32. 2006
    ..A recent neuroimaging study by Dosenbach et al. offers a set of novel methodological tools to examine this issue and uncovers new candidate brain regions for a core system that might implement task sets...
  64. ncbi Performance on an episodic encoding task yields further insight into functional brain development
    Tara McAuley
    Department of Psychology, Campus Box 1125, Washington University, St Louis, MO 63130, USA
    Neuroimage 34:815-26. 2007
    ....
  65. ncbi The BOLD onset transient: identification of novel functional differences in schizophrenia
    Michael D Fox
    Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
    Neuroimage 25:771-82. 2005
    ..Relevance of these findings to both an interpretation of the onset transient and the pathology of schizophrenia are discussed...
  66. ncbi Sustained neural activity associated with cognitive control during temporally extended decision making
    Tal Yarkoni
    Department of Psychology, Washington University, Campus Box 1125, St. Louis, MO 63130, USA
    Brain Res Cogn Brain Res 23:71-84. 2005
    ..These results demonstrate the contribution of cognitive control mechanisms to temporally extended decision-making paradigms and highlight the benefits of decomposing activation responses into sustained and transient components...
  67. ncbi Abnormalities of cingulate gyrus neuroanatomy in schizophrenia
    Lei Wang
    Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 S Euclid Ave, St Louis, MO 63110, United States
    Schizophr Res 93:66-78. 2007
    ....
  68. ncbi Context processing and context maintenance in healthy aging and early stage dementia of the Alzheimer's type
    Todd S Braver
    Department of Psychology, Washington University, St Louis, MO 63130, USA
    Psychol Aging 20:33-46. 2005
    ..The results suggest that context processing may be composed of functionally dissociable components and point to the utility of this construct in understanding the timecourse of cognitive decline in healthy and pathological aging...
  69. ncbi Prefrontal cortex function in nonpsychotic siblings of individuals with schizophrenia
    Zainab Delawalla
    Department of Psychology, Washington University, St Louis, Missouri 63130, USA
    Biol Psychiatry 63:490-7. 2008
    ..In individuals with schizophrenia, deficits in context processing have been associated with functional impairments of the dorsolateral prefrontal cortex (DLPFC)...
  70. ncbi Decreased hippocampal 5-HT(2A) receptor binding in older depressed patients using [18F]altanserin positron emission tomography
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuropsychopharmacology 29:2235-41. 2004
    ..04) than previously treated subjects (n = 10). It may be that prior medication treatment provides a compensatory upregulation of the 5-HT(2A) receptor...
  71. ncbi Development of distinct control networks through segregation and integration
    Damien A Fair
    Departments of Neurology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:13507-12. 2007
    ..Delay/disruption in the developmental processes of segregation and integration may play a role in disorders of control, such as autism, attention deficit hyperactivity disorder, and Tourette's syndrome...
  72. ncbi Episodic memory for emotional and non-emotional words in individuals with anhedonia
    Jennifer R Mathews
    Department of Psychology, Washington University, St Louis, MO 63130, USA
    Psychiatry Res 143:121-33. 2006
    ....
  73. ncbi Thalamic shape abnormalities in individuals with schizophrenia and their nonpsychotic siblings
    Michael P Harms
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 27:13835-42. 2007
    ..Inward deformation of the anterior and posterior regions of the thalamus represents a potential neuroanatomical endophenotype of schizophrenia...
  74. ncbi The influence of a working memory load manipulation on language production in schizophrenia
    Meredith R D Melinder
    Department of Psychology, Washington University, St, Louis, Missouri 63130, USA
    Schizophr Bull 29:473-85. 2003
    ....
  75. ncbi Emotional valence and reference disturbance in schizophrenia
    Jennifer A Burbridge
    Department of Psychology, Washington University, St Louis, Missouri 63130 4899, USA
    J Abnorm Psychol 111:186-91. 2002
    ..Both the severity of disorganization symptoms and selective attention deficits predicted increased reference errors in response to emotional questions...
  76. ncbi Functional developmental similarities and differences in the neural correlates of verbal and nonverbal working memory tasks
    Shefali B Brahmbhatt
    Washington University in St Louis, St Louis, MO 63130, United States
    Neuropsychologia 46:1020-31. 2008
    ..Our results provide further evidence for continued functional development through adolescence and into adulthood...
  77. ncbi Association between depression severity and amygdala reactivity during sad face viewing in depressed preschoolers: an fMRI study
    Michael S Gaffrey
    Washington University School of Medicine, Department of Psychiatry, Saint Louis, MO 63110, United States
    J Affect Disord 129:364-70. 2011
    ..Previous research has indicated that symptom severity and amygdala reactivity during the viewing of facial expressions of emotion are related in depression. However, it remains unclear how early in development this can be detected...
  78. ncbi Hippocampal shape and volume changes with antipsychotics in early stage psychotic illness
    Daniel Mamah
    Department of Psychiatry, Washington University St Louis, MO, USA
    Front Psychiatry 3:96. 2012
    ..Our results suggest that OLZ is associated with less longitudinal hippocampal surface deformation than HAL, however the hippocampal regions affected appear to be variable across patients...
  79. ncbi Neural correlates of verbal and nonverbal working memory deficits in individuals with schizophrenia and their high-risk siblings
    Shefali B Brahmbhatt
    Washington University, Department of Psychology, One Brookings Drive, Box 1125, St Louis, MO 63130, USA
    Schizophr Res 87:191-204. 2006
    ....
  80. ncbi Subclinical expression of schizophrenia-like symptoms in non-psychotic siblings of individuals with schizophrenia
    Matthew J Smith
    Schizophr Res 103:324-5. 2008
  81. ncbi Identification of separable cognitive factors in schizophrenia
    Keith H Nuechterlein
    Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at UCLA, USA
    Schizophr Res 72:29-39. 2004
    ..These separable cognitive dimensions also have broader relevance to future research aimed at understanding the nature and structure of core cognitive deficits in schizophrenia...
  82. ncbi Executive functioning component mechanisms and schizophrenia
    John G Kerns
    Department of Psychological Sciences, University of Missouri, Columbia, Missouri 65211, USA
    Biol Psychiatry 64:26-33. 2008
    ..Although there is general consensus about what cognitive tasks involve executive functioning, there is disagreement about the specific cognitive mechanisms that comprise executive functioning...
  83. ncbi Approaching a consensus cognitive battery for clinical trials in schizophrenia: the NIMH-MATRICS conference to select cognitive domains and test criteria
    Michael F Green
    Neuropsychiatric Institute, Geffen School of Medicine, University of California at Los Angeles, Los Angeles, California, USA
    Biol Psychiatry 56:301-7. 2004
    ..The results from this meeting constitute the initial steps for reaching a consensus cognitive battery for clinical trials in schizophrenia...
  84. ncbi Context processing in schizotypal personality disorder: evidence of specificity of impairment to the schizophrenia spectrum
    Margaret M McClure
    VA VISN 3 Mental Illness Research, Education and Clinical Center, Bronx, New York 10468, USA
    J Abnorm Psychol 117:342-54. 2008
    ..These findings, which are quite similar to those previously reported in patients with schizophrenia, suggest that context processing deficits are specific to the schizophrenia spectrum and are not a reflection of overall psychopathology...
  85. ncbi Cognitive-pharmacologic functional magnetic resonance imaging in tourette syndrome: a pilot study
    Tamara Hershey
    Department of Psychiatry, Washington University, St. Louis, Missouri, USA
    Biol Psychiatry 55:916-25. 2004
    ..05). CONCLUSIONS: These results are consistent with a dopamine-influenced functional abnormality of brain response in TS and suggest testable hypotheses about the mechanism by which dopamine antagonists and agonists alleviate tics...
  86. ncbi Comparing surface-based and volume-based analyses of functional neuroimaging data in patients with schizophrenia
    Alan Anticevic
    Department of Psychology, Washington University in St Louis, MO 63130, USA
    Neuroimage 41:835-48. 2008
    ..These results indicate that SBR provides significant advantages over affine VBR when analyzing cortical fMRI activations. Furthermore, these improvements can be even greater in disorders that have associated structural abnormalities...
  87. ncbi A theory of cognitive control, aging cognition, and neuromodulation
    Todd S Braver
    Department of Psychology, Washington University, Campus Box 1125, One Brookings Drive, St Louis, MO 63130, USA
    Neurosci Biobehav Rev 26:809-17. 2002
    ..These findings highlight the utility of a computational approach to cognitive aging. Current directions for further refinement and validation of the model are outlined...
  88. ncbi Keeping the "cognitive" in cognitive neuroscience, the "affective" in affective neuroscience, and the "behavioral" in behavioral neuroscience: the CABN mission for the next five years
    Deanna M Barch
    Cogn Affect Behav Neurosci 8:1-2. 2008
  89. ncbi Cognitive neuroscience-based approaches to measuring and improving treatment effects on cognition in schizophrenia: the CNTRICS initiative
    Cameron S Carter
    University of California at Davis, USA
    Schizophr Bull 33:1131-7. 2007
    ....
  90. ncbi Anhedonia and the experience of emotion in individuals with schizophrenia
    Jennifer A Burbridge
    Department of Psychology, Washington University, USA
    J Abnorm Psychol 116:30-42. 2007
    ..Disturbances in working memory moderated the relationship between physical anhedonia and participants' emotional experience of positive stimuli...
  91. ncbi Accounting for cognitive aging: context processing, inhibition or processing speed?
    Beth K Rush
    Mayo Clinic College of Medicine, USA
    Neuropsychol Dev Cogn B Aging Neuropsychol Cogn 13:588-610. 2006
    ..The sensitivity of the AX-CPT to cognitive aging is discussed in the context of existing theories of cognitive aging. The authors suggest that deficits in context processing and utilization may underlie cognitive aging phenomena...
  92. ncbi Sex influences on material-sensitive functional lateralization in working and episodic memory: men and women are not all that different
    Kristen M Haut
    Department of Psychology, Washington University, St Louis, MO 63150, USA
    Neuroimage 32:411-22. 2006
    ..In conclusion, our data suggest that males and females show a similar pattern of lateralized activation to material type during working memory and recognition tasks...
  93. ncbi Cognitive function in late life depression: relationships to depression severity, cerebrovascular risk factors and processing speed
    Yvette I Sheline
    Department of Psychiatry, Washington University, St Louis, Missouri, USA
    Biol Psychiatry 60:58-65. 2006
    ....
  94. ncbi Easier tasks can have better discriminating power: the case of verbal fluency
    Meredith R D Melinder
    Department of Psychology, Washington University, St. Louis, MO 63130, USA
    J Abnorm Psychol 114:385-91. 2005
    ..In this article, the authors present data from 2 studies using phonologic and category fluency tasks to demonstrate that the critical factor for task selection and matching is discriminating power, not task difficulty...
  95. ncbi Transient BOLD responses at block transitions
    Michael D Fox
    Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 28:956-66. 2005
    ..Relevance of the current findings to studies of exogenous attention, task shifting, and the BOLD overshoot is discussed...
  96. ncbi The effects of guanfacine on context processing abnormalities in schizotypal personality disorder
    Margaret M McClure
    VA VISN3 Mental Illness Research, Education, and Clinical Center, Bronx, New York 10468, USA
    Biol Psychiatry 61:1157-60. 2007
    ..This study examined the potential of guanfacine for improving context processing, a feature of working memory, in SPD...
  97. ncbi Effects of environmental support and strategy training on older adults' use of context
    Jessica L Paxton
    Department of Psychology, Washington University, St Louis, MO 63139, USA
    Psychol Aging 21:499-509. 2006
    ..These results suggest that age-related differences in context processing can be ameliorated by directed strategy training or extended practice...
  98. ncbi Levels-of-processing effects in first-degree relatives of individuals with schizophrenia
    Aaron Bonner-Jackson
    Washington University, Department of Psychology, St Louis, Missouri 63130, USA
    Biol Psychiatry 61:1141-7. 2007
    ..The current study used a similar paradigm to determine whether siblings of individuals with schizophrenia (SIBs) also show increases in brain activity when presented with beneficial encoding strategies...
  99. ncbi Dopaminergic modulation of response inhibition: an fMRI study
    Tamara Hershey
    Psychiatry Department, Washington University School of Medicine, USA
    Brain Res Cogn Brain Res 20:438-48. 2004
    ..In summary, right parietal and cerebellar regions important in mediating specific aspects of the GNG task were modulated by levodopa, suggesting a region-specific role for dopamine in response inhibition...
  100. ncbi Affective reactivity in language: the role of psychophysiological arousal
    Jennifer A Burbridge
    Department of Psychology, Washington University, St. Louis, MO 63130, USA
    Emotion 5:145-53. 2005
    ..Participants displayed greater amounts of reference errors, higher heart rates, and a higher frequency of nonspecific skin conductance responses when discussing affectively negative as compared to positive or neutral topics...

Research Grants11

  1. 1/5-Cognitive Neuroscience Task Reliability & Clinical Applications Consortium
    Deanna M Barch; Fiscal Year: 2010
    ..Thus, we need to improve our methods for detecting and enhancing cognitive function in schizophrenia in order to help individuals with this illness lead more productive and fulfilling lives. ..
  2. 1/5-Cognitive Neuroscience Task Reliability & Clinical Applications Consortium
    Deanna M Barch; Fiscal Year: 2010
    ..Thus, we need to improve our methods for detecting and enhancing cognitive function in schizophrenia in order to help individuals with this illness lead more productive and fulfilling lives. ..
  3. Schizophrenia, Prefrontal Cortex, and Emotion Regulation
    Deanna M Barch; Fiscal Year: 2010
    ..This information can help us to design interventions that may help to improve social and occupational function and quality of life among individuals with schizophrenia. ..
  4. 1/5-Cognitive Neuroscience Task Reliability & Clinical Applications Consortium
    Deanna Barch; Fiscal Year: 2009
    ..Thus, we need to improve our methods for detecting and enhancing cognitive function in schizophrenia in order to help individuals with this illness lead more productive and fulfilling lives. ..
  5. Schizopherenia, Prefrontal Cortex & Emotion Regulation
    Deanna Barch; Fiscal Year: 2007
    ..Such deficits are core aspects of schizophrenia that lead to functional disability, and thus a better understanding of their nature and causes is central to our attempts to better prevent and treat this illness. ..
  6. Schizophrenia, Prefrontal Cortex, and Emotion Regulation
    Deanna M Barch; Fiscal Year: 2011
    ..This information can help us to design interventions that may help to improve social and occupational function and quality of life among individuals with schizophrenia. ..