JIANXIN J BAO

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Prophylactic and therapeutic functions of drug combinations against noise-induced hearing loss
    Jianxin Bao
    Department of Otolaryngology, Center for Aging, Washington University School of Medicine, 4560 Clayton Avenue, St Louis, MO 63110, USA Electronic address
    Hear Res 304:33-40. 2013
  2. pmc Age-related synaptic loss of the medial olivocochlear efferent innervation
    Benjamin Fu
    Department of Otolaryngology, Washington University, St, Louis, MO, 63110, USA
    Mol Neurodegener 5:53. 2010
  3. pmc No dramatic age-related loss of hair cells and spiral ganglion neurons in Bcl-2 over-expression mice or Bax null mice
    Haiyan Shen
    Department of Otolaryngology, Washington University School of Medicine, St, Louis, MO, 63110, USA
    Mol Neurodegener 5:28. 2010
  4. pmc Neuroprotective effects of blockers for T-type calcium channels
    Norelle C Wildburger
    Department of Otolaryngology, Center for Aging, Washington University, 4560 Clayton Avenue, St Louis, MO 63110, USA
    Mol Neurodegener 4:44. 2009
  5. pmc Age-related loss of spiral ganglion neurons
    Jianxin Bao
    Fay and Carl Simmons Center for the Biology of Hearing and Deafness, Department of Otolaryngology, Washington University Medical School, 660 S Euclid, St Louis, MO 63110, USA
    Hear Res 264:93-7. 2010
  6. ncbi request reprint Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos
    Jianxin Bao
    Department of Otolaryngology, Washington University, St Louis, Missouri 63110, USA
    Nat Neurosci 7:1250-8. 2004
  7. pmc Requirement of nicotinic acetylcholine receptor subunit beta2 in the maintenance of spiral ganglion neurons during aging
    Jianxin Bao
    Department of Otolaryngology, Center for Aging, Washington University, St Louis, Missouri 63110, USA
    J Neurosci 25:3041-5. 2005
  8. ncbi request reprint Temporal and genetic influences on protection against noise-induced hearing loss by hypoxic preconditioning in mice
    Patricia M Gagnon
    Washington University Medical School, Department of Otolaryngology, 660 S Euclid, St Louis, MO 63110, USA
    Hear Res 226:79-91. 2007
  9. pmc The role of glucocorticoids for spiral ganglion neuron survival
    David Xu Jin
    Department of Otolaryngology, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain Res 1277:3-11. 2009
  10. pmc Prophylactic and therapeutic functions of T-type calcium blockers against noise-induced hearing loss
    Haiyan Shen
    Department of Otolaryngology, Center for Aging, Washington University, 4560 Clayton Avenue, St Louis, MO 63110, USA
    Hear Res 226:52-60. 2007

Research Grants

Collaborators

Detail Information

Publications11

  1. pmc Prophylactic and therapeutic functions of drug combinations against noise-induced hearing loss
    Jianxin Bao
    Department of Otolaryngology, Center for Aging, Washington University School of Medicine, 4560 Clayton Avenue, St Louis, MO 63110, USA Electronic address
    Hear Res 304:33-40. 2013
    ..Our study shows the feasibility of developing pharmacological intervention in multiple pathways, and discovering drug combinations with optimal synergistic effects in preventing permanent NIHL. ..
  2. pmc Age-related synaptic loss of the medial olivocochlear efferent innervation
    Benjamin Fu
    Department of Otolaryngology, Washington University, St, Louis, MO, 63110, USA
    Mol Neurodegener 5:53. 2010
    ..These data demonstrate for the first time that age-related loss of efferent synapses may contribute to the functional decline of the MOC efferent system and that this synaptic loss is not necessary for age-related loss of OHCs...
  3. pmc No dramatic age-related loss of hair cells and spiral ganglion neurons in Bcl-2 over-expression mice or Bax null mice
    Haiyan Shen
    Department of Otolaryngology, Washington University School of Medicine, St, Louis, MO, 63110, USA
    Mol Neurodegener 5:28. 2010
    ..We also found no delay of age-related hearing loss in mice lacking Bax gene. These findings suggest that age-related hearing loss is not through an apoptotic pathway involving key members of Bcl-2 family...
  4. pmc Neuroprotective effects of blockers for T-type calcium channels
    Norelle C Wildburger
    Department of Otolaryngology, Center for Aging, Washington University, 4560 Clayton Avenue, St Louis, MO 63110, USA
    Mol Neurodegener 4:44. 2009
    ..Thus, our findings have important implications in the development of new treatment for age-related neurodegenerative disorders...
  5. pmc Age-related loss of spiral ganglion neurons
    Jianxin Bao
    Fay and Carl Simmons Center for the Biology of Hearing and Deafness, Department of Otolaryngology, Washington University Medical School, 660 S Euclid, St Louis, MO 63110, USA
    Hear Res 264:93-7. 2010
    ..With the advancement of recent genetic and pharmacologic tools, we should not only understand how SGNs die during aging, but also find ways to delay this loss...
  6. ncbi request reprint Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos
    Jianxin Bao
    Department of Otolaryngology, Washington University, St Louis, Missouri 63110, USA
    Nat Neurosci 7:1250-8. 2004
    ..This upregulation of PSD-95 expression by the Nrg-ICD-Eos complex provides a molecular basis for activity-dependent synaptic plasticity...
  7. pmc Requirement of nicotinic acetylcholine receptor subunit beta2 in the maintenance of spiral ganglion neurons during aging
    Jianxin Bao
    Department of Otolaryngology, Center for Aging, Washington University, St Louis, Missouri 63110, USA
    J Neurosci 25:3041-5. 2005
    ..Our findings clearly established a requirement for beta2 nAChR subunit in the maintenance of SGNs during aging...
  8. ncbi request reprint Temporal and genetic influences on protection against noise-induced hearing loss by hypoxic preconditioning in mice
    Patricia M Gagnon
    Washington University Medical School, Department of Otolaryngology, 660 S Euclid, St Louis, MO 63110, USA
    Hear Res 226:79-91. 2007
    ..Elucidation of the events that underlie HPC, and how these are impacted by genetics, may lead to pharmacologic approaches to mimic HPC, and may help identify individuals with elevated risk of NIHL...
  9. pmc The role of glucocorticoids for spiral ganglion neuron survival
    David Xu Jin
    Department of Otolaryngology, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain Res 1277:3-11. 2009
    ..With the advancement of recent pharmacologic and genetic tools, the role of these pathways in the survival of spiral ganglion neurons after noise exposure and during aging should be revealed...
  10. pmc Prophylactic and therapeutic functions of T-type calcium blockers against noise-induced hearing loss
    Haiyan Shen
    Department of Otolaryngology, Center for Aging, Washington University, 4560 Clayton Avenue, St Louis, MO 63110, USA
    Hear Res 226:52-60. 2007
    ..Our findings provide a basis for clinical studies testing T-type calcium blockers both to prevent and treat NIHL...
  11. ncbi request reprint Stem cell therapy for hearing loss: Math1 overexpression in VOT-E36 cells
    Jan Jan Liu
    Department of Otolaryngology, Center for Aging, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Otol Neurotol 27:414-21. 2006
    ..VOT-E36 cells acquire mechanosensitivity after mammalian atonal homolog 1 (Math1) overexpression...

Research Grants8

  1. Molecular Mechanisms Underlying Age-Related Hearing Loss
    Jianxin Bao; Fiscal Year: 2004
    ..The ultimate goal of this research is to develop methods for prevention and treatment of age-related loss of SGNs, based on identifying molecular candidates involved in this aging process. ..
  2. Roles of Neuregulin in Age Related Hearing Loss
    Jianxin Bao; Fiscal Year: 2005
    ..The goal of this award is to elucidate the role of NRG-CD in age-related loss of SGNs as well as to provide the candidate with the continuity of support necessary to develop into an independent investigator. ..
  3. Roles of Neuregulin-1 in Age Related Neuronal Changes
    Jianxin Bao; Fiscal Year: 2009
    ..The ultimate goal of our research is to develop methods for prevention and treatment of age related functional decline of nervous system based on identifying molecular candidates involved in the aging process ..