Leonard B Bacharier

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. doi request reprint Step-down therapy in asthma: a focus on treatment options for patients receiving inhaled corticosteroids and long-acting beta-agonist combination therapy
    Leonard B Bacharier
    Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Allergy Asthma Proc 33:13-8. 2012
  2. doi request reprint Diagnosis and management of early asthma in preschool-aged children
    Leonard B Bacharier
    Division of Pediatric Allergy, Immunology, and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    J Allergy Clin Immunol 130:287-96; quiz 297-8. 2012
  3. doi request reprint Management of asthma in preschool children with inhaled corticosteroids and leukotriene receptor antagonists
    Leonard B Bacharier
    Department of Pediatrics, Division of Allergy and Pulmonary Medicine, Washington University School of Medicine and St Louis Children s Hospital, One Children s Place, St Louis, MO 63110, USA
    Curr Opin Allergy Clin Immunol 8:158-62. 2008
  4. ncbi request reprint Long-term effect of budesonide on hypothalamic-pituitary-adrenal axis function in children with mild to moderate asthma
    Leonard B Bacharier
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Pediatrics 113:1693-9. 2004
  5. ncbi request reprint Classifying asthma severity in children: mismatch between symptoms, medication use, and lung function
    Leonard B Bacharier
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, One Children s Place, St Louis, MO 63110, USA
    Am J Respir Crit Care Med 170:426-32. 2004
  6. doi request reprint Viral-induced wheezing episodes in preschool children: approaches to therapy
    Leonard B Bacharier
    Department of Pediatrics, Division of Allergy, Immunology, and Pulmonary Medicine, Washington University School of Medicine, St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Curr Opin Pulm Med 16:31-5. 2010
  7. pmc Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing
    Leonard B Bacharier
    Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, MO 63110, USA
    J Allergy Clin Immunol 122:1127-1135.e8. 2008
  8. ncbi request reprint Pets and childhood asthma--how should the pediatrician respond to new information that pets may prevent asthma?
    Leonard B Bacharier
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
    Pediatrics 112:974-6. 2003
  9. ncbi request reprint Hospitalization for asthma: atopic, pulmonary function, and psychological correlates among participants in the Childhood Asthma Management Program
    Leonard B Bacharier
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Pediatrics 112:e85-92. 2003
  10. ncbi request reprint Severe intermittent wheezing in preschool children: a distinct phenotype
    Leonard B Bacharier
    Department of Pediatrics, Washington University, St Louis Children s Hospital, St Louis, MOO 63110, USA
    J Allergy Clin Immunol 119:604-10. 2007

Detail Information

Publications45

  1. doi request reprint Step-down therapy in asthma: a focus on treatment options for patients receiving inhaled corticosteroids and long-acting beta-agonist combination therapy
    Leonard B Bacharier
    Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Allergy Asthma Proc 33:13-8. 2012
    ..Therefore, clinicians will need to balance the benefits and risks associated with these therapies on an individual patient basis as they consider which patients should undergo step-down and which approach would be most appropriate...
  2. doi request reprint Diagnosis and management of early asthma in preschool-aged children
    Leonard B Bacharier
    Division of Pediatric Allergy, Immunology, and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    J Allergy Clin Immunol 130:287-96; quiz 297-8. 2012
    ..Finally, regular monitoring of symptom control and medication side effects is important along with titrating controllers to the minimally effective dose...
  3. doi request reprint Management of asthma in preschool children with inhaled corticosteroids and leukotriene receptor antagonists
    Leonard B Bacharier
    Department of Pediatrics, Division of Allergy and Pulmonary Medicine, Washington University School of Medicine and St Louis Children s Hospital, One Children s Place, St Louis, MO 63110, USA
    Curr Opin Allergy Clin Immunol 8:158-62. 2008
    ..The aim of this article is to review the recently published studies addressing various treatment approaches for asthma in preschool children...
  4. ncbi request reprint Long-term effect of budesonide on hypothalamic-pituitary-adrenal axis function in children with mild to moderate asthma
    Leonard B Bacharier
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Pediatrics 113:1693-9. 2004
    ..To determine the safety of long-term (36 months) administration of an inhaled corticosteroid (budesonide) on hypothalamic-pituitary-adrenal (HPA) axis function in children with mild to moderate asthma...
  5. ncbi request reprint Classifying asthma severity in children: mismatch between symptoms, medication use, and lung function
    Leonard B Bacharier
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, One Children s Place, St Louis, MO 63110, USA
    Am J Respir Crit Care Med 170:426-32. 2004
    ..FEV(1) is generally normal, even in severe persistent childhood asthma, whereas FEV(1)/FVC declines as asthma severity increases...
  6. doi request reprint Viral-induced wheezing episodes in preschool children: approaches to therapy
    Leonard B Bacharier
    Department of Pediatrics, Division of Allergy, Immunology, and Pulmonary Medicine, Washington University School of Medicine, St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Curr Opin Pulm Med 16:31-5. 2010
    ..The high prevalence of wheezing illnesses in the preschool age group and the heterogeneity of wheezing phenotypes early in life combine to present significant challenges in the clinical management of this problem...
  7. pmc Episodic use of an inhaled corticosteroid or leukotriene receptor antagonist in preschool children with moderate-to-severe intermittent wheezing
    Leonard B Bacharier
    Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, MO 63110, USA
    J Allergy Clin Immunol 122:1127-1135.e8. 2008
    ..Acute wheezing illnesses in preschoolers require better management strategies to reduce morbidity...
  8. ncbi request reprint Pets and childhood asthma--how should the pediatrician respond to new information that pets may prevent asthma?
    Leonard B Bacharier
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
    Pediatrics 112:974-6. 2003
  9. ncbi request reprint Hospitalization for asthma: atopic, pulmonary function, and psychological correlates among participants in the Childhood Asthma Management Program
    Leonard B Bacharier
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Pediatrics 112:e85-92. 2003
    ..Sensitization and exposure to inhalant allergens have been identified as risk factors for asthma hospitalization...
  10. ncbi request reprint Severe intermittent wheezing in preschool children: a distinct phenotype
    Leonard B Bacharier
    Department of Pediatrics, Washington University, St Louis Children s Hospital, St Louis, MOO 63110, USA
    J Allergy Clin Immunol 119:604-10. 2007
    ....
  11. pmc Patient characteristics associated with improved outcomes with use of an inhaled corticosteroid in preschool children at risk for asthma
    Leonard B Bacharier
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63017, USA
    J Allergy Clin Immunol 123:1077-82, 1082.e1-5. 2009
    ..However, determination of baseline features associated with ICS responsiveness may identify children most likely to benefit from ICS treatment...
  12. ncbi request reprint Characterization of within-subject responses to fluticasone and montelukast in childhood asthma
    Stanley J Szefler
    Department of Pediatrics, National Jewish Medical and Research Medical Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
    J Allergy Clin Immunol 115:233-42. 2005
    ..Responses to inhaled corticosteroids (ICSs) and leukotriene receptor antagonists (LTRAs) vary among asthmatic patients...
  13. pmc Azithromycin or montelukast as inhaled corticosteroid-sparing agents in moderate-to-severe childhood asthma study
    Robert C Strunk
    Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, MO 63110, USA
    J Allergy Clin Immunol 122:1138-1144.e4. 2008
    ..Clinical trials in children with moderate-to-severe persistent asthma are limited...
  14. pmc Signs and symptoms that precede wheezing in children with a pattern of moderate-to-severe intermittent wheezing
    Katherine Rivera-Spoljaric
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110 1077, USA
    J Pediatr 154:877-81.e4. 2009
    ..To examine parent-reported signs and symptoms as antecedents of wheezing in preschool children with previous moderate to severe wheezing episodes, and to determine the predictive capacity of these symptom patterns for wheezing events...
  15. ncbi request reprint Response profiles to fluticasone and montelukast in mild-to-moderate persistent childhood asthma
    Robert S Zeiger
    Department of Pediatrics, University of California San Diego, San Diego, CA 92111, USA
    J Allergy Clin Immunol 117:45-52. 2006
    ..Outcome data are needed to base recommendations for controller asthma medication use in school-aged children...
  16. pmc Determinants of asthma after severe respiratory syncytial virus bronchiolitis
    Leonard B Bacharier
    Division of Pediatric Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    J Allergy Clin Immunol 130:91-100.e3. 2012
    ..The development of asthma after respiratory syncytial virus (RSV) bronchiolitis has been demonstrated in case-control studies, although the determinants of post-RSV asthma remain undefined...
  17. pmc Urinary leukotriene E4/exhaled nitric oxide ratio and montelukast response in childhood asthma
    Nathan Rabinovitch
    Department of Pediatrics, National Jewish Health and the University of Colorado Denver School of Medicine, Denver, Colo 80206, USA
    J Allergy Clin Immunol 126:545-51.e1-4. 2010
    ..A subset of children with asthma respond better to leukotriene receptor antagonists than to inhaled corticosteroids. Information is needed to identify children with these preferential responses...
  18. pmc Most nocturnal asthma symptoms occur outside of exacerbations and associate with morbidity
    Caroline C Horner
    Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63110, USA
    J Allergy Clin Immunol 128:977-82.e1-2. 2011
    ..Although nocturnal awakenings help categorize asthma severity and control, their clinical significance has not been thoroughly studied...
  19. doi request reprint Impulse oscillometry versus spirometry in a long-term study of controller therapy for pediatric asthma
    Gary L Larsen
    Department of Pediatrics, National Jewish Health, Denver, CO 80206, USA
    J Allergy Clin Immunol 123:861-7.e1. 2009
    ..Determination of the benefits and limitations of specific physiologic tests has not been well studied in long-term clinical pediatric trials...
  20. pmc Growth of preschool children at high risk for asthma 2 years after discontinuation of fluticasone
    Theresa W Guilbert
    Department of Pediatrics, University of Wisconsin Madison, Wis 53716, USA
    J Allergy Clin Immunol 128:956-63.e1-7. 2011
    ..The effect on linear growth of daily long-term inhaled corticosteroid therapy in preschool-aged children with recurrent wheezing is controversial...
  21. pmc Do oral corticosteroids reduce the severity of acute lower respiratory tract illnesses in preschool children with recurrent wheezing?
    Avraham Beigelman
    Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, MO 63110, USA
    J Allergy Clin Immunol 131:1518-25. 2013
    ..Oral corticosteroids (OCSs) are recommended for severe wheezing episodes in children. However, limited evidence supports this intervention in preschool children with outpatient wheezing illnesses...
  22. pmc Cytokine response after severe respiratory syncytial virus bronchiolitis in early life
    Mario Castro
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    J Allergy Clin Immunol 122:726-733.e3. 2008
    ..Immune response after viral infection usually involves T(H)1-mediated response; however, severe respiratory syncytial virus (RSV) infection appears to be associated with the development of asthma, a T(H)2-predominant phenotype...
  23. pmc Lower levels of plasmacytoid dendritic cells in peripheral blood are associated with a diagnosis of asthma 6 yr after severe respiratory syncytial virus bronchiolitis
    Eli Silver
    Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Pediatr Allergy Immunol 20:471-6. 2009
    ..Children who are diagnosed with asthma after severe RSV bronchiolitis appear to have a relative deficiency of plasmacytoid DC in peripheral blood...
  24. pmc Effect of elevated exhaled nitric oxide levels on the risk of respiratory tract illness in preschool-aged children with moderate-to-severe intermittent wheezing
    Avraham Beigelman
    Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Ann Allergy Asthma Immunol 103:108-13. 2009
    ..The fractional concentration of exhaled nitric oxide (FeNO) is a noninvasive marker for airway inflammation but requires further study in preschool-aged children to determine its clinical relevance...
  25. ncbi request reprint Severity of respiratory syncytial virus bronchiolitis is affected by cigarette smoke exposure and atopy
    Joseph P Bradley
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Pediatrics 115:e7-14. 2005
    ..Little is known about what determines the severity of RSV bronchiolitis, which may be helpful in the initial assessment of these children...
  26. pmc Clinical and laboratory factors associated with negative oral food challenges
    Avraham Beigelman
    Division of Pediatric Allergy, Immunology, and Pulmonary Medicine, Washington University School of Medicine and St Louis Children s Hospital, St Louis, MO 63110, USA
    Allergy Asthma Proc 33:467-73. 2012
    ..Once validated in a different population, these factors might be used for selection of patients who are most likely to show negative OFCs...
  27. ncbi request reprint Pediatric asthma admissions: chronic severity and acute exacerbations
    Arnon Elizur
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
    J Asthma 44:285-9. 2007
    ..Children with different chronic asthma severities had comparable severities of acute exacerbation. In conclusion, acute asthma exacerbations dissociate in severity from chronic asthma and are under-treated with systemic corticosteroids...
  28. doi request reprint Diagnosis and management of asthma in preschool and school-age children: focus on the 2007 NAEPP Guidelines
    Caroline C Horner
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Curr Opin Pulm Med 15:52-6. 2009
    ..This review examines the changes in the revised National Asthma Education and Prevention Program (NAEPP) Guidelines for the diagnosis and management of asthma pertaining to children and highlights areas that may benefit from further study...
  29. ncbi request reprint Nocturnal awakening caused by asthma in children with mild-to-moderate asthma in the childhood asthma management program
    Robert C Strunk
    Department of Pediatrics, Washington University School of Medicine, Division of Allergy and Pulmonary Medicine, St Louis Children s Hospital, MO 63110, USA
    J Allergy Clin Immunol 110:395-403. 2002
    ..Nocturnal symptoms of asthma are a cause of significant morbidity and are included as a central feature in the categorization of asthma severity...
  30. pmc Heterogeneity of severe asthma in childhood: confirmation by cluster analysis of children in the National Institutes of Health/National Heart, Lung, and Blood Institute Severe Asthma Research Program
    Anne M Fitzpatrick
    Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, USA
    J Allergy Clin Immunol 127:382-389.e1-13. 2011
    ..Although unsupervised cluster analysis is a useful tool for identifying phenotypes, it has not been applied to school-age children with persistent asthma across a wide range of severities...
  31. ncbi request reprint Socioeconomic status, stress, and immune markers in adolescents with asthma
    Edith Chen
    Washington University, St Louis Children s Hospital, St Louis, MO, USA
    Psychosom Med 65:984-92. 2003
    ..The second objective was to test whether psychological stress and control beliefs could explain these differences...
  32. pmc The role of early life viral bronchiolitis in the inception of asthma
    Avraham Beigelman
    Department of Pediatrics, Washington University and St Louis Children s Hospital, St Louis, Missouri, USA
    Curr Opin Allergy Clin Immunol 13:211-6. 2013
    ..The purpose of this review is to present the recent findings and current perspectives regarding the interplay between bronchiolitis and long-term respiratory outcomes...
  33. ncbi request reprint The atopic march: the pattern of allergic disease development in childhood
    Eugenia L Hahn
    Division of Allergy and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, 1 Children s Place, St Louis, MO 63110, USA
    Immunol Allergy Clin North Am 25:231-46, v. 2005
    ..This article discusses the populations at risk for the development of atopic conditions and the interventions that have been explored in attempts to modify the progression of allergic disease...
  34. ncbi request reprint Management approaches to intermittent wheezing in young children
    Caroline C Horner
    Department of Pediatrics, Division of Allergy and Pulmonary Medicine, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Curr Opin Allergy Clin Immunol 7:180-4. 2007
    ..To review the recently published studies addressing various treatment approaches for episodic wheezing in young children...
  35. ncbi request reprint Infectious triggers of asthma
    Ana L MacDowell
    Department of Pediatrics, Division of Allergy and Pulmonary Medicine, Washington University School of Medicine and St Louis Children s Hospital, One Children s Place, St Louis, MO 63110, USA
    Immunol Allergy Clin North Am 25:45-66. 2005
    ..This article examines the evidence for interaction between specific infectious agents and exacerbations of asthma, including the immunopathology of infection-triggered asthma, and the current therapeutic options for management...
  36. doi request reprint The relationships between environmental bacterial exposure, airway bacterial colonization, and asthma
    Avraham Beigelman
    aDepartment of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital bThe Genome Institute, Washington University School of Medicine, St Louis, Missouri, USA
    Curr Opin Allergy Clin Immunol 14:137-42. 2014
    ..The purpose of this review is to present the current perspectives regarding the role of microbial exposure and airway bacterial colonization on the development and the activity of asthma...
  37. pmc Severe asthma in childhood: recent advances in phenotyping and pathogenesis
    Anne M Fitzpatrick
    Emory University Department of Pediatrics, Atlanta, Georgia, USA
    Curr Opin Allergy Clin Immunol 12:193-201. 2012
    ..This review will discuss phenotypic and pathogenic aspects of severe asthma in childhood, as well as remaining knowledge gaps...
  38. ncbi request reprint Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma
    Theresa W Guilbert
    Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
    J Allergy Clin Immunol 114:1282-7. 2004
    ....
  39. ncbi request reprint The Prevention of Early Asthma in Kids study: design, rationale and methods for the Childhood Asthma Research and Education network
    Theresa W Guilbert
    Division of Pediatric Pulmonary Medicine, Arizona Respiratory Center, University of Arizona, 1501 N Campbell Avenue, PO Box 245073, Tucson, AZ 85724, USA
    Control Clin Trials 25:286-310. 2004
    ..These measures were chosen to reflect the progression of the disease from intermittent wheezing to persistent asthma and measurement of the extent of airflow limitation and airway reactivity...
  40. ncbi request reprint Long-term inhaled corticosteroids in preschool children at high risk for asthma
    Theresa W Guilbert
    Division of Pediatric Pulmonary Medicine, Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
    N Engl J Med 354:1985-97. 2006
    ..It is unknown whether inhaled corticosteroids can modify the subsequent development of asthma in preschool children at high risk for asthma...
  41. ncbi request reprint "Step-down" therapy for asthma: why, when, and how?
    Leonard B Bacharier
    J Allergy Clin Immunol 109:916-9. 2002
  42. ncbi request reprint Are the results of oral food challenges predictable?
    Leonard B Bacharier
    Ann Allergy Asthma Immunol 92:195-7. 2004
  43. ncbi request reprint C4b-binding protein (C4BP) activates B cells through the CD40 receptor
    Scott R Brodeur
    Division of Immunology, Children s Hospital and Department of Pediatrics, Harvard Medical School, Boston, MA, USA
    Immunity 18:837-48. 2003
    ..Furthermore, C4BP colocalized with B cells in the germinal centers of human tonsils. These observations suggest that C4BP is an activating ligand for CD40 and establish a novel interface between complement and B cell activation...
  44. ncbi request reprint Does exhaled nitric oxide measurement help distinguish between wheezing phenotypes in preschool children?
    Leonard B Bacharier
    J Allergy Clin Immunol 121:710-1. 2008
  45. ncbi request reprint Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller Trial
    Christine A Sorkness
    Clinical Science Center, University of Wisconsin, Madison, WI 53792, USA
    J Allergy Clin Immunol 119:64-72. 2007
    ..More evidence is needed on which to base recommendations for treatment of mild-moderate persistent asthma in school-aged children...