JOHN PATTERSON ATKINSON

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Bypassing complement: evolutionary lessons and future implications
    John P Atkinson
    Department of Medicine, Division of Rheumatology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 116:1215-8. 2006
  2. pmc Complement factor H and the hemolytic uremic syndrome
    John P Atkinson
    Division of Rheumatology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 204:1245-8. 2007
  3. pmc C5a and Fcgamma receptors: a mutual admiration society
    John P Atkinson
    Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    J Clin Invest 116:304-6. 2006
  4. pmc Complement system on the attack in autoimmunity
    John P Atkinson
    Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    J Clin Invest 112:1639-41. 2003
  5. ncbi request reprint Hemolytic uremic syndrome: an example of insufficient complement regulation on self-tissue
    John P Atkinson
    Washington University School of Medicine, Department of Medicine Rheumatology Division, 660 South Euclid Avenue, Campus Box 8045, St Louis, MO 63110, USA
    Ann N Y Acad Sci 1056:144-52. 2005
  6. ncbi request reprint Decay-accelerating factor (DAF), complement receptor 1 (CR1), and factor H dissociate the complement AP C3 convertase (C3bBb) via sites on the type A domain of Bb
    Dennis E Hourcade
    Washington University School of Medicine, Department of Medicine, Division of Rheumatology, St Louis, Missouri 63110, USA
    J Biol Chem 277:1107-12. 2002
  7. ncbi request reprint Inherited complement regulatory protein deficiency predisposes to human disease in acute injury and chronic inflammatory statesthe examples of vascular damage in atypical hemolytic uremic syndrome and debris accumulation in age-related macular degeneratio
    Anna Richards
    Washington University School of Medicine, St Louis, Missouri, USA
    Adv Immunol 96:141-77. 2007
  8. pmc Membrane protein Crry maintains homeostasis of the complement system
    Xiaobo Wu
    Department of Medicine, Division of Rheumatology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 181:2732-40. 2008
  9. pmc Modeling how CD46 deficiency predisposes to atypical hemolytic uremic syndrome
    M Kathryn Liszewski
    Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8045, St Louis, MO 63110, USA
    Mol Immunol 44:1559-68. 2007
  10. pmc Inhibiting complement activation on cells at the step of C3 cleavage
    M Kathryn Liszewski
    Washington University School of Medicine, Department of Internal Medicine, Division of Rheumatology, 660 S Euclid, Box 8045, St Louis, MO 63110, USA
    Vaccine 26:I22-7. 2008

Research Grants

  1. ZAP70 IN T CELL DEVELOPMENT
    John Atkinson; Fiscal Year: 2002

Collaborators

Detail Information

Publications32

  1. pmc Bypassing complement: evolutionary lessons and future implications
    John P Atkinson
    Department of Medicine, Division of Rheumatology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 116:1215-8. 2006
    ..These types of functional assays will eventually replace the more laborious, less physiologic, and less informative approaches currently in use to monitor complement activation...
  2. pmc Complement factor H and the hemolytic uremic syndrome
    John P Atkinson
    Division of Rheumatology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 204:1245-8. 2007
    ..A mouse model of HUS designed to mirror human mutations in FH has now been developed, providing new understanding of the molecular pathogenesis of complement-related endothelial disorders...
  3. pmc C5a and Fcgamma receptors: a mutual admiration society
    John P Atkinson
    Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    J Clin Invest 116:304-6. 2006
    ..Thus, this work establishes a feedback loop whereby FcgammaR expression and function are enhanced, a very desirable event in concert with an infection but potentially deleterious in autoimmunity...
  4. pmc Complement system on the attack in autoimmunity
    John P Atkinson
    Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    J Clin Invest 112:1639-41. 2003
    ..Specifically, interaction of complement component 5a (C5a) with its receptor is necessary for thrombosis of placental vasculature. Inhibition of complement activation may have a therapeutic role in this disease...
  5. ncbi request reprint Hemolytic uremic syndrome: an example of insufficient complement regulation on self-tissue
    John P Atkinson
    Washington University School of Medicine, Department of Medicine Rheumatology Division, 660 South Euclid Avenue, Campus Box 8045, St Louis, MO 63110, USA
    Ann N Y Acad Sci 1056:144-52. 2005
    ..By contrast, MCP deficiency can be corrected in part by a renal allograft. However, caution in the use of live-related donations is needed because of the high rates of incomplete penetrance of the described mutations...
  6. ncbi request reprint Decay-accelerating factor (DAF), complement receptor 1 (CR1), and factor H dissociate the complement AP C3 convertase (C3bBb) via sites on the type A domain of Bb
    Dennis E Hourcade
    Washington University School of Medicine, Department of Medicine, Division of Rheumatology, St Louis, Missouri 63110, USA
    J Biol Chem 277:1107-12. 2002
    ..Mutations at the C3b.Bb interface interfere with the normal dissociation of C3b from Bb, whether it is spontaneous or promoted by DAF, CR1, or factor H...
  7. ncbi request reprint Inherited complement regulatory protein deficiency predisposes to human disease in acute injury and chronic inflammatory statesthe examples of vascular damage in atypical hemolytic uremic syndrome and debris accumulation in age-related macular degeneratio
    Anna Richards
    Washington University School of Medicine, St Louis, Missouri, USA
    Adv Immunol 96:141-77. 2007
    ..A response to acute injury or chronic debris accumulation must be appropriately balanced. In either case, too much activation or too little regulation promotes undesirable tissue damage and human disease...
  8. pmc Membrane protein Crry maintains homeostasis of the complement system
    Xiaobo Wu
    Department of Medicine, Division of Rheumatology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 181:2732-40. 2008
    ..They imply that there is constant turnover on cells of the AP pathway which functions as an immune surveillance system for pathogens and altered self...
  9. pmc Modeling how CD46 deficiency predisposes to atypical hemolytic uremic syndrome
    M Kathryn Liszewski
    Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8045, St Louis, MO 63110, USA
    Mol Immunol 44:1559-68. 2007
    ..Our results add new information relative to the necessity for appropriate expression levels of MCP and further implicate the alternative pathway in disease processes such as aHUS...
  10. pmc Inhibiting complement activation on cells at the step of C3 cleavage
    M Kathryn Liszewski
    Washington University School of Medicine, Department of Internal Medicine, Division of Rheumatology, 660 S Euclid, Box 8045, St Louis, MO 63110, USA
    Vaccine 26:I22-7. 2008
    ..This review describes lessons learned and the application of this model for functionally characterizing mutations in regulators associated with atypical hemolytic uremic syndrome...
  11. pmc Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome
    Celia J Fang
    Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Blood 111:624-32. 2008
    ..Both the R69W and A304V MCP mutations were deficient in their ability to control the alternative pathway of complement activation on a cell surface, illustrating the importance of modeling transmembrane proteins in situ...
  12. pmc Smallpox inhibitor of complement enzymes (SPICE): regulation of complement activation on cells and mechanism of its cellular attachment
    M Kathryn Liszewski
    Department of Medicine Division of Rheumatology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 181:4199-207. 2008
    ..These results provide insights related to the complement inhibitory activities of poxviral inhibitors of complement and describe a mAb with therapeutic potential...
  13. ncbi request reprint Screening for complement system abnormalities in patients with atypical hemolytic uremic syndrome
    David Kavanagh
    Division of Rheumatology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin J Am Soc Nephrol 2:591-6. 2007
  14. ncbi request reprint Properdin can initiate complement activation by binding specific target surfaces and providing a platform for de novo convertase assembly
    Dirk Spitzer
    Division of Rheumatology, Department of Medicine, School of Medicine, Washington University, St Louis, MO 63110, USA
    J Immunol 179:2600-8. 2007
    ..The properdin-directed model is consistent with a proposal made by Pillemer and his colleagues >50 years ago...
  15. ncbi request reprint Characterization of mutations in complement factor I (CFI) associated with hemolytic uremic syndrome
    David Kavanagh
    Division of Rheumatology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Immunol 45:95-105. 2008
    ..The excessive complement activation for a given degree of damage may result in generation of a procoagulant state and aHUS...
  16. doi request reprint Advances in understanding of pathogenesis of aHUS and HELLP
    Celia J Fang
    Department of Medicine, Division of Rheumatology, Washington University School of Medicine, St Louis, MO 63110, USA
    Br J Haematol 143:336-48. 2008
    ....
  17. pmc Complement-dependent neutrophil recruitment is critical for the development of elastase-induced abdominal aortic aneurysm
    Monica B Pagano
    Department of Surgery, Section of Vascular Surgery, Washington University School of Medicine, St Louis, MO, USA
    Circulation 119:1805-13. 2009
    ..In this study, we tested the hypothesis that complement participates in the development of AAA by providing the necessary chemotactic signal that recruits neutrophils to the aortic wall...
  18. pmc Properdin homeostasis requires turnover of the alternative complement pathway
    Xiaobo Wu
    Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:19444-8. 2010
    ..These findings represent an instructive example of how a positive regulator of an innate immune recognition and effector pathway is controlled. A rationale for such a means to supply properdin for immune reactions is proposed...
  19. pmc West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H
    Kyung Min Chung
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:19111-6. 2006
    ..Accordingly, extracellular NS1 may function to minimize immune system targeting of West Nile virus by decreasing complement recognition of infected cells...
  20. ncbi request reprint Cutting edge: treatment of complement regulatory protein deficiency by retroviral in vivo gene therapy
    Dirk Spitzer
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 177:4953-6. 2006
    ..Thus, gene therapy with targeted regulators represents a treatment option to provide a long-term and sustained protein supply for the site-specific blockade of undesirable complement activation...
  21. ncbi request reprint Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells
    Maria L Barilla-LaBarca
    Division of Rheumatology, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 168:6298-304. 2002
    ..However, if the alternative pathway mediates C3b deposition, then MCP's cofactor activity is sufficient to restrict complement activation...
  22. ncbi request reprint Synergy between two active sites of human complement receptor type 1 (CD35) in complement regulation: implications for the structure of the classical pathway C3 convertase and generation of more potent inhibitors
    Malgorzata Krych-Goldberg
    Division of Rheumatology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 175:4528-35. 2005
    ..These observations increase our understanding of the mechanism of DAA. In addition, a more potent decay-accelerating form of CR1 was generated...
  23. pmc CD46-induced human Treg enhance B-cell responses
    Anja Fuchs
    Department of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St Louis, MO, USA
    Eur J Immunol 39:3097-109. 2009
    ..Thus, the lack of cTreg function in optimizing B-cell responses could explain why some CD46-deficient patients develop common variable immunodeficiency...
  24. ncbi request reprint Human complement receptor type 1 (CR1) binds to a major malarial adhesin
    Malgorzata Krych-Goldberg
    Division of Rheumatology, Washington University School of Medicine, St Louis, MO 63110, USA
    Trends Mol Med 8:531-7. 2002
    ..Furthermore, structural differences in erythrocyte CR1 between human and non-human primates are probably explained by the selective pressure of malaria...
  25. ncbi request reprint ScFv-mediated in vivo targeting of DAF to erythrocytes inhibits lysis by complement
    Dirk Spitzer
    Division of Rheumatology, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8045, St Louis, MO 63110, USA
    Mol Immunol 40:911-9. 2004
    ..This approach should therefore be applicable for diseases caused by a membrane protein deficiency such as paroxysmal nocturnal hemoglobinuria (PNH)...
  26. pmc Targeted and restricted complement activation on acrosome-reacted spermatozoa
    Rebecca C Riley-Vargas
    Department of Medicine, Rheumatology Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:1241-9. 2005
    ..In addition, we speculate that this "targeted and restricted" form of complement activation on host cells is a common strategy to handle modified self...
  27. ncbi request reprint T-cell stimulation and regulation: with complements from CD46
    Claudia Kemper
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunol Res 32:31-43. 2005
    ..Herein, we review this pathway for the induction of Tregs, focusing on a role for the complement system and especially signaling through CD46 on human T-cells...
  28. pmc Secreted NS1 of dengue virus attaches to the surface of cells via interactions with heparan sulfate and chondroitin sulfate E
    Panisadee Avirutnan
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Pathog 3:e183. 2007
    ..Differential binding of soluble NS1 by tissue endothelium and subsequent recognition by anti-NS1 antibodies could contribute to the selective vascular leakage syndrome that occurs during severe secondary DENV infection...
  29. ncbi request reprint Emerging roles and new functions of CD46
    M Kathryn Liszewski
    Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8045, St Louis, MO 63110, USA
    Springer Semin Immunopathol 27:345-58. 2005
    ..Finally, highlighting its importance in protecting cells against excessive complement activation is the discovery that even a heterozygous deficiency of CD46 predisposes to hemolytic uremic syndrome...
  30. ncbi request reprint In vivo correction of complement regulatory protein deficiency with an inhibitor targeting the red blood cell membrane
    Dirk Spitzer
    Department of Internal Medicine, Division of Rheumatology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 175:7763-70. 2005
    ..These results suggest the possibility of using the single-chain Ab fragment-mediated targeting concept of complement regulatory proteins to restrict complement inhibition to the site of its excessive activation...
  31. ncbi request reprint Implications of the initial mutations in membrane cofactor protein (MCP; CD46) leading to atypical hemolytic uremic syndrome
    Anna Richards
    Department of Medicine, Division of Rheumatology, Washington University School of Medicine, Campus Box 8045, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Mol Immunol 44:111-22. 2007
    ..This highlights the importance of defining and characterizing the underlying genetic defects in patients with aHUS...
  32. ncbi request reprint T-cell regulation: with complements from innate immunity
    Claudia Kemper
    Washington University School of Medicine, Department of Internal Medicine, Division of Rheumatology, Campus Box 8045, 660 South Euclid Avenue, Saint Louis, Missouri 63110, USA
    Nat Rev Immunol 7:9-18. 2007
    ..This Review focuses on the evolving role of the complement system in the regulation of T-cell responses, from directing the initiation phase, through driving lineage commitment, to regulating the contraction phase...

Research Grants2

  1. ZAP70 IN T CELL DEVELOPMENT
    John Atkinson; Fiscal Year: 2002
    ..Moreover, these studies may provide additional mechanistic information for therapeutic interventions in drug design for T cell lymphomas, immunodeficiencies, autoimmune diseases, and transplantation rejection. ..