Research Topics
| Gerald AndrioleSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Detail Information
Publications
The effect of increasing doses of saw palmetto fruit extract on serum prostate specific antigen: analysis of the CAMUS randomized trialGerald L Andriole
Division of Urologic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Urol 189:486-92. 2013..We determined whether higher doses of saw palmetto as studied in the CAMUS (Complementary and Alternative Medicine for Urologic Symptoms) trial affect serum prostate specific antigen levels...
Overdiagnosis of prostate cancerGurdarshan S Sandhu
Division of Urologic Surgery, Washington University School of Medicine, 4960 Children s Place, St Louis, MO 63110, USA
J Natl Cancer Inst Monogr 2012:146-51. 2012..Future prospects to prevent overtreatment, including better biopsy and molecular characterization of newly diagnosed cancer and the role of active surveillance, are discussed...
Chemoprevention of prostate cancer in men at high risk: rationale and design of the reduction by dutasteride of prostate cancer events (REDUCE) trialGerald Andriole
Division of Urologic Surgery, Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Urol 172:1314-7. 2004..It represents a biologically plausible target for chemoprevention through the inhibition of 5alpha-reductase isoenzymes...- Effect of dutasteride on the risk of prostate cancerGerald L Andriole
Division of Urology, Washington University School of Medicine in St Louis, St Louis, MO 63110, USA
N Engl J Med 362:1192-202. 2010..We conducted a study to determine whether dutasteride reduces the risk of incident prostate cancer, as detected on biopsy, among men who are at increased risk for the disease... - The prostate, lung, colon, and ovarian (PLCO) cancer screening trial: Status and promiseGerald L Andriole
Division of Urologic Surgery, Washington University School of Medicine, Washington University in St Louis, 4960 Children s Place, Campus Box 8242, St Louis, MO 63110, USA
Urol Oncol 22:358-61. 2004..Together, the data derived from the intervention and control arms and material in the biorepository provide a valuable resource to allow identification and testing of novel biomarkers for human disease... - Overview of pivotal studies for prostate cancer risk reduction, past and presentGerald L Andriole
Division of Urology, Department of Surgery, Washington University School of Medicine, Barnes Jewish Hospital, Siteman Cancer Center, St Louis, Missouri 63110, USA
Urology 73:S36-43. 2009.... - The effect of dutasteride on the usefulness of prostate specific antigen for the diagnosis of high grade and clinically relevant prostate cancer in men with a previous negative biopsy: results from the REDUCE studyGerald L Andriole
Department of Surgery, Washington University School of Medicine in St Louis, St Louis, Missouri 63110, USA
J Urol 185:126-31. 2011..We assessed whether dutasteride enhances the usefulness of total prostate specific antigen for diagnosing clinically significant prostate cancer... - Is there a better way to biopsy the prostate? Prospects for a novel transrectal systematic biopsy approachGerald L Andriole
Division of Urologic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
Urology 70:22-6. 2007..Its reproducibility from operator to operator suggests that it may be useful for guiding rebiopsy of specific locations within the prostate and for providing targeted focal prostate cancer therapy... - Dihydrotestosterone and the prostate: the scientific rationale for 5alpha-reductase inhibitors in the treatment of benign prostatic hyperplasiaGerald Andriole
Division of Urological Surgery, Washington University in St. Louis, St. Louis, Missouri 63110, USA
J Urol 172:1399-403. 2004..CONCLUSIONS: DHT appears to have an obligatory role in the development of BPH. The role of 5alpha-reductase inhibitors in the treatment of BPH has been firmly established with an adverse events profile that is suitable for long-term use... - Relating biopsy and clinical variables to radical prostatectomy findings: can insignificant and advanced prostate cancer be predicted in a screening population?Jason W Anast
Division of Urologic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
Urology 64:544-50. 2004.... - Serum testosterone and dihydrotestosterone and prostate cancer risk in the placebo arm of the Reduction by Dutasteride of Prostate Cancer Events trialRoberto L Muller
Division of Urologic Surgery, Department of Surgery, Duke University School of Medicine, Durham, NC 27710, USA
Eur Urol 62:757-64. 2012..Androgens may affect prostate-specific antigen (PSA) levels, thereby influencing biopsy recommendations. Also, androgens may stimulate prostate growth at very low levels with no additional effects at higher levels (saturation model)... - The effects of 5alpha-reductase inhibitors on the natural history, detection and grading of prostate cancer: current state of knowledgeGerald Andriole
Division of Urologic Surgery, School of Medicine, Washington University St Louis, 4960 Children s Place, St Louis, MO 63110, USA
J Urol 174:2098-104. 2005..However, Gleason score 7-10 tumors were significantly more common in the finasteride vs the placebo group. We considered data on the effects of 5ARIs on prostate cancer natural history and detection... - Emerging drug therapies for benign prostatic hyperplasiaTravis L Bullock
Division of Urology, Washington University School of Medicine, St Louis, MO 63110, USA
Expert Opin Emerg Drugs 11:111-23. 2006..The aim of this review is to examine current pharmacotherapies as well as to highlight emerging drugs that may improve our treatment of patients with LUTS secondary to BPH... - Prostate-specific antigen density predicts adverse pathology and increased risk of biochemical failureMohamed H Radwan
Division of Urology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Urology 69:1121-7. 2007.... - Obesity is associated with increased prostate growth and attenuated prostate volume reduction by dutasterideRoberto L Muller
Division of Urologic Surgery, Department of Surgery, Duke University School of Medicine, Durham, NC, USA Urology Section, Veterans Affairs Medical Center, Durham, NC, USA Electronic address
Eur Urol 63:1115-21. 2013..Although obesity has been associated with larger prostate volumes (PV), few studies have actually investigated whether obesity enhances PV growth, especially among men using 5α-reductase inhibitors... - Patterns of multiple recurrences of superficial (Ta/T1) transitional cell carcinoma of bladder and effects of clinicopathologic and biochemical factorsYan Yan
Division of Urologic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
Cancer 95:1239-46. 2002.... - Pure laparoscopic radical heminephrectomy and partial isthmusectomy for renal cell carcinoma in a horseshoe kidney: case report and technical considerationsSam B Bhayani
Division of Urology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Urology 66:880. 2005..Preoperative angiography may aid surgical planning. A pure transperitoneal approach to cancer surgery of the horseshoe kidney is effective... - Clinical usefulness of serum prostate specific antigen for the detection of prostate cancer is preserved in men receiving the dual 5alpha-reductase inhibitor dutasterideGerald L Andriole
Division of Urologic Surgery, Washington University, St Louis, Missouri 63110, USA
J Urol 175:1657-62. 2006..We determined whether the decrease in serum PSA seen with 5alpha-reductase inhibitors affects the clinical usefulness of PSA for prostate cancer screening using data from 2 dutasteride benign prostatic hyperplasia studies... - Prostate Cancer Screening in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial: findings from the initial screening round of a randomized trialGerald L Andriole
Division of Urologic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
J Natl Cancer Inst 97:433-8. 2005..We describe the population enrolled in the PLCO trial, their baseline PSA and DRE screening results, and diagnostic follow-up results during the first year of follow-up... - Prospective randomized comparison of cutting and dilating disposable trocars for access during laparoscopic renal surgeryRamakrishna Venkatesh
Washington University School of Medicine, Division of Urology, St Louis, Missouri 63110, USA
JSLS 11:198-203. 2007..More recently, trocars applying tissue dilation have been used that create a smaller defect, seldom requiring fascial wound closure. Four 12-mm commercially available single-use trocar designs were evaluated for postoperative pain... - Laparoscopic partial nephrectomy for renal masses: effect of tumor locationRamakrishna Venkatesh
Division of Urology, Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
Urology 67:1169-74; discussion 1174. 2006..To report our single institutional experience of laparoscopic partial nephrectomy (LPN) for enhancing renal masses and evaluate outcomes and histopathologic findings with respect to the location of the renal mass... - Evaluation of a novel precision template-guided biopsy system for detecting prostate cancerIfeanyichukwu I Megwalu
Division of Urology, Washington University School of Medicine, St Louis, MO 63105, USA
BJU Int 102:546-50. 2008.... - 11C-acetate PET imaging of prostate cancer: detection of recurrent disease at PSA relapseNobuyuki Oyama
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S. Kingshighway Boulevard, St. Louis, MO 63110, USA
J Nucl Med 44:549-55. 2003..CONCLUSION: AC PET demonstrates marked uptake in prostate cancer and has higher sensitivity than (18)F-FDG PET. These preliminary data show that (11)C-acetate is a promising tracer for detection of recurrent prostate cancer... - Update on chemoprevention for prostate cancerSeth A Strope
Division of Urology, Washington University, 4960 Children s Place, Saint Louis, MO 63110, USA
Curr Opin Urol 20:194-7. 2010..Interest in prostate cancer prevention and risk reduction continues among both patients and clinicians. Recent studies on primary and secondary prevention of prostate cancer will be addressed... - Risk of urinary incontinence following prostatectomy: the role of physical activity and obesityKathleen Y Wolin
Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Urol 183:629-33. 2010..We evaluated the association of obesity and lack of physical activity with urinary incontinence in a sample of men who had undergone radical prostatectomy... - Safety and tolerability of the dual 5alpha-reductase inhibitor dutasteride in the treatment of benign prostatic hyperplasiaGerald L Andriole
Division of Urologic Surgery, Washington University School of Medicine, 4960 Children s Place, Campus Box 8242, St Louis, MO 63110, USA
Eur Urol 44:82-8. 2003..The objective of this paper is to examine safety and tolerability data from a number of recently completed clinical trials with the novel, dual 5alpha-reductase inhibitor, dutasteride... - Prostate cancer diagnosisPeter A Humphrey
Washington University School of Medicine in St Louis, USA
Mo Med 107:107-12. 2010..This article reviews clinical and pathological approaches to prostate cancer diagnosis, with a focus on clinically localized disease and needle biopsy diagnosis... - Prostate cancer screening in the Prostate, Lung, Colorectal and Ovarian cancer screening trial: update on findings from the initial four rounds of screening in a randomized trialRobert L Grubb
Division of Urologic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
BJU Int 102:1524-30. 2008.... - Serum prostate-specific antigen hemodilution among obese men undergoing screening in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening TrialRobert L Grubb
Division of Urologic Surgery, Washington University School of Medicine, 4960 Children s Place, Campus Box 8242, St Louis, MO 63110, USA
Cancer Epidemiol Biomarkers Prev 18:748-51. 2009..We examined this hypothesis in a cohort of men enrolled in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial... - Mortality results from a randomized prostate-cancer screening trialGerald L Andriole
Washington University School of Medicine, St Louis, USA
N Engl J Med 360:1310-9. 2009..This is the first report from the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial on prostate-cancer mortality... - Renal hypothermia achieved by retrograde endoscopic cold saline perfusion: technique and initial clinical applicationJaime Landman
Division of Urology, Washington University School of Medicine, St. Louis, Missouri, USA
Urology 61:1023-5. 2003..The technique requires no novel equipment or special surgical skills. This method can be applied to patients undergoing open or laparoscopic complex renal ablative and reconstructive procedures that require renal hypothermia... - Use of gelatin matrix to rapidly repair diaphragmatic injury during laparoscopySam B Bhayani
Division of Urology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Urology 60:514. 2002..The presented case and technique should be considered in selected small diaphragmatic injuries... - Can preoperative PSA doubling time and PSA velocity predict outcomes following radical prostatectomy?Robert L Grubb
Division of Urologic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
Nat Clin Pract Urol 3:306-7. 2006 - Radiation therapy for increasing prostate-specific antigen levels after radical prostatectomyCarlos A Perez
Department of Radiation Oncology, Mallinckrodt, Institute of Radiology, St Louis, MO 63108, USA
Clin Prostate Cancer 1:235-41. 2003..Prostate bed irradiation is an effective treatment in a significant proportion of patients who present with a biochemical failure after radical prostatectomy... - Prostate cancer: to screen or not to screen?Alex Shteynshlyuger
Division of Urologic Surgery, Department of Surgery, Washington University School of Medicine, Barnes Jewish Hospital, Siteman Cancer Center, 4960 Children s Place, Campus Box 8242, St Louis, MO 63110, USA
Urol Clin North Am 37:1-9, Table of Contents. 2010..Efforts to improve screening with better markers and more selective treatment may make population-based screening more effective... - Application of a fixed retractor system to facilitate laparoscopic radical prostatectomyJaime Landman
Department of Surgery, Division of Urology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Urol 171:783-5. 2004..We report application of a fixed retractor system for reduction of the steep Trendelenberg position required to achieve deep pelvic access for laparoscopic radical prostatectomy... - Managing the local complications of locally advanced prostate cancerJason W Anast
Division of Urologic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
Curr Urol Rep 8:211-6. 2007..Surgical intervention for locally advanced prostate cancer can provide significant improvement in quality of life and should not be restricted to patients who have curable disease... - Laparoscopic partial nephrectomy with a novel electrosurgical snare in a porcine modelWilliam C Collyer
Division of Urology, Washington University School of Medicine, St. Louis, Missouri, USA
J Endourol 16:673-9. 2002..CONCLUSIONS: Laparoscopic partial nephrectomy with the arcing-gap electrosurgical snare is feasible in a porcine model. Application of the snare provides excellent hemostasis without the need to control the renal vasculature... - Single-setting bilateral laparoscopic renal surgery: assessment of single-stage procedureKaren Reisiger
Division of Urology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Urology 65:892-7; discussion 897. 2005..Bilateral single-setting laparoscopic surgery should only be performed if the primary procedure has been completed expeditiously and without complications... - Surgical treatment of renal neoplasia: evolving toward a laparoscopic standard of careSam B Bhayani
Division of Urology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Urology 62:821-6. 2003..At our institution, the laparoscopic approach has become the standard of care when radical nephrectomy is needed for T1 or T2 renal cancer... - The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasiaJohn D McConnell
University of Texas Southwestern Medical Center, Dallas, TX 75390-9110, USA
N Engl J Med 349:2387-98. 2003..Combination therapy and finasteride alone reduced the long-term risk of acute urinary retention and the need for invasive therapy... - Long-term 6-year experience with finasteride in patients with benign prostatic hyperplasiaFranklin C Lowe
Department of Urology, Saint Luke's-Roosevelt Hospital Center, New York, NY 10019, USA
Urology 61:791-6. 2003..CONCLUSIONS: Treatment with finasteride leads to durable improvement in urinary tract symptoms, flow rate, and prostate volume, with no increase in the prevalence of drug-related adverse events over time... - Benign prostatic hyperplasia: a progressive disease of aging menMark Emberton
Institute of Urology and Nephrology, University College, London, United Kingdom
Urology 61:267-73. 2003 - The dual 5-alpha-reductase inhibitor dutasteride induces atrophic changes and decreases relative cancer volume in human prostateKenneth A Iczkowski
Department of Pathology and Laboratory Medicine, Veterans Affairs Medical Center, Gainesville, Florida 32608 1197, USA
Urology 65:76-82. 2005..To perform the first evaluation of the effects of the 5-alpha-reductase inhibitor class of drugs on cancer histopathologic features at radical prostatectomy in a placebo-controlled multicenter trial... - Prostate biopsy following a positive screen in the prostate, lung, colorectal and ovarian cancer screening trialPaul F Pinsky
Division of Cancer Prevention, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
J Urol 173:746-50; discussion 750-1. 2005..Followup of positive screens in PLCO is done by subject personal physicians and it is outside of trial control. We describe the pattern of prostate biopsy in men with positive screens in PLCO... - The interpretation of serum prostate specific antigen in men receiving 5alpha-reductase inhibitors: a review and clinical recommendationsLeonard S Marks
Department of Urology, School of Medicine, University of California Los Angeles, Los Angeles, CA, USA
J Urol 176:868-74. 2006.... - High-grade prostate cancer in the Prostate Cancer Prevention Trial: fact or artifact?Gerald L Andriole
J Natl Cancer Inst 99:1355-6. 2007 - Group consensus reports from the Consensus Conference on Focal Treatment of Prostatic Carcinoma, Celebration, Florida, February 24, 2006David G Bostwick
Bostwick Laboratories, Richmond, Virginia 23060, USA
Urology 70:42-4. 2007 - Prevention of benign prostatic hyperplasia diseaseLeonard S Marks
Urological Sciences Research Foundation and Department of Urology, Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90232, USA
J Urol 176:1299-306. 2006..We reviewed the evidence that benign prostatic hyperplasia is a progressive condition and men at risk for benign prostatic hyperplasia disease can be identified, treated and protected to a meaningful extent regardless of symptom status... - Supplemental and dietary vitamin E, beta-carotene, and vitamin C intakes and prostate cancer riskVictoria A Kirsh
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, MD 20892, USA
J Natl Cancer Inst 98:245-54. 2006..However, vitamin E supplementation in male smokers and beta-carotene supplementation in men with low dietary beta-carotene intakes were associated with reduced risk of this disease... - Repeat prostate biopsy in the prostate, lung, colorectal and ovarian cancer screening trialPaul F Pinsky
Division of Cancer Prevention, National Cancer Institute, NIH, DHHS, Bethesda, MD, USA
BJU Int 99:775-9. 2007..To determine patterns of repeat prostate biopsy in a cohort of men undergoing prostate cancer screening who have a negative initial biopsy... - Serum selenium and risk of prostate cancer-a nested case-control studyUlrike Peters
Cancer Prevention Program, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
Am J Clin Nutr 85:209-17. 2007..Interrelations with other antioxidative agents and oxidative stressors, such as smoking, are poorly understood... - Genome-wide association study of prostate cancer identifies a second risk locus at 8q24Meredith Yeager
SAIC Frederick, National Cancer Institute NCI Frederick Cancer Research and Development Center, Frederick, Maryland 21702, USA
Nat Genet 39:645-9. 2007..We estimate that the population attributable risk of the new locus, marked by rs6983267, is higher than the locus marked by rs1447295 (21% versus 9%)... - RNASEL Arg462Gln polymorphism and prostate cancer in PLCOSarah E Daugherty
Department of Health and Human Services, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Prostate 67:849-54. 2007..The relationship of this variant to sporadic prostate cancer remains uncertain... - A prospective study of meat and meat mutagens and prostate cancer riskAmanda J Cross
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland, USA
Cancer Res 65:11779-84. 2005..01-1.61). In conclusion, very well done meat was positively associated with prostate cancer risk. In addition, this study lends epidemiologic support to the animal studies, which have implicated PhIP as a prostate carcinogen... - Prostate volume and prostate-specific antigen levels in men enrolled in a large screening trialPaul F Pinsky
Division of Cancer Prevention, National Cancer Institute, Bethedsa, Maryland, USA
Urology 68:352-6. 2006..Here we examine the relationship between prostate volume and PSA level in a large, geographically diverse sample of men undergoing prostate cancer screening... - TNF polymorphisms and prostate cancer riskKim N Danforth
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland 20852, USA
Prostate 68:400-7. 2008..Inflammation has been hypothesized to increase prostate cancer risk. Tumor necrosis factor (TNF) is an important mediator of the inflammatory process, but the relationship between TNF variants and prostate cancer remains unclear... - Polymorphic variants in PTGS2 and prostate cancer risk: results from two large nested case-control studiesKim N Danforth
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20852, USA
Carcinogenesis 29:568-72. 2008.... - The effect of finasteride in men with benign prostatic hyperplasia. 1992Gleen J Gormley
J Urol 167:1102-7; discussion 1108. 2002 - Dairy products, calcium intake, and risk of prostate cancer in the prostate, lung, colorectal, and ovarian cancer screening trialJiyoung Ahn
Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, 6120 Executive Boulevard, Bethesda, MD 20892, USA
Cancer Epidemiol Biomarkers Prev 16:2623-30. 2007..Furthermore, we found no relationship between calcium intake and circulating vitamin D... - Endogenous sex hormones and the risk of prostate cancer: a prospective studyJocelyn M Weiss
Division of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD, USA
Int J Cancer 122:2345-50. 2008..T:SHBG ratio was related to risk in this older population of men, but the significance of this ratio in steroidal biology is unclear. (c) 2008 Wiley-Liss, Inc... - Prostate specific antigen based prostate cancer screening: accumulating evidence of efficacy but persistent uncertaintyGerald L Andriole
J Urol 174:413-4. 2005 - Multiple loci identified in a genome-wide association study of prostate cancerGilles Thomas
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892, USA
Nat Genet 40:310-5. 2008..Our findings point to multiple loci with moderate effects associated with susceptibility to prostate cancer that, taken together, in the future may predict high risk in select individuals...