Wenfeng An

Summary

Affiliation: Washington State University
Country: USA

Publications

  1. ncbi Characterization of a synthetic human LINE-1 retrotransposon ORFeus-Hs
    Wenfeng An
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mob DNA 2:2. 2011
  2. ncbi Plug and play modular strategies for synthetic retrotransposons
    Wenfeng An
    School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA
    Methods 49:227-35. 2009
  3. ncbi Characterization of L1 retrotransposition with high-throughput dual-luciferase assays
    Yi Xie
    School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA
    Nucleic Acids Res 39:e16. 2011
  4. ncbi L1 expression and regulation in humans and rodents
    James M Rosser
    School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA
    Front Biosci (Elite Ed) 4:2203-25. 2012
  5. ncbi LINE-1-Derived Poly(A) Microsatellites Undergo Rapid Shortening and Create Somatic and Germline Mosaicism in Mice
    Fiorella C Grandi
    School of Molecular Biosciences and Center for Reproductive Biology, Washington State University
    Mol Biol Evol 30:503-12. 2013
  6. ncbi Cell division promotes efficient retrotransposition in a stable L1 reporter cell line
    Yi Xie
    School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA, 99164, USA
    Mob DNA 4:10. 2013
  7. ncbi Repeat-induced gene silencing of L1 transgenes is correlated with differential promoter methylation
    James M Rosser
    School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA
    Gene 456:15-23. 2010

Collaborators

  • Zoltan Ivics
  • James M Rosser
  • Yi Xie
  • Fiorella C Grandi
  • Sandra L Martin
  • Zsuzsanna Izsvák
  • Lajos Mátés
  • Tina L Thompson
  • Jef D Boeke

Detail Information

Publications7

  1. ncbi Characterization of a synthetic human LINE-1 retrotransposon ORFeus-Hs
    Wenfeng An
    Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Mob DNA 2:2. 2011
    ..Owing to the elevated expression of the L1 RNA/protein and its high retrotransposition ability, ORFeus-Hs and its chimeric derivatives will be useful tools for mechanistic L1 studies and mammalian genome manipulation...
  2. ncbi Plug and play modular strategies for synthetic retrotransposons
    Wenfeng An
    School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA
    Methods 49:227-35. 2009
    ....
  3. ncbi Characterization of L1 retrotransposition with high-throughput dual-luciferase assays
    Yi Xie
    School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA
    Nucleic Acids Res 39:e16. 2011
    ..Its high-throughput and short assay timeframe make it well suited for routine tests as well as large-scale screening efforts...
  4. ncbi L1 expression and regulation in humans and rodents
    James M Rosser
    School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA 99164, USA
    Front Biosci (Elite Ed) 4:2203-25. 2012
    ..Third, recent findings from transgenic mouse models of L1 are summarized and contrasted with those from endogenous L1 studies. Finally, the challenges and opportunities for L1 mouse models are discussed...
  5. ncbi LINE-1-Derived Poly(A) Microsatellites Undergo Rapid Shortening and Create Somatic and Germline Mosaicism in Mice
    Fiorella C Grandi
    School of Molecular Biosciences and Center for Reproductive Biology, Washington State University
    Mol Biol Evol 30:503-12. 2013
    ..Thus, the birth of poly(A) microsatellites from retrotransposons and the subsequent rapid and variable shortening represent a new way with which retrotransposons can modify the genetic and epigenetic architecture of our genome...
  6. ncbi Cell division promotes efficient retrotransposition in a stable L1 reporter cell line
    Yi Xie
    School of Molecular Biosciences and Center for Reproductive Biology, Washington State University, Pullman, WA, 99164, USA
    Mob DNA 4:10. 2013
    ..However, seemingly divergent conclusions were reached. The role of cell division on retrotransposition remains highly debated...
  7. ncbi Repeat-induced gene silencing of L1 transgenes is correlated with differential promoter methylation
    James M Rosser
    School of Molecular Biosciences, Washington State University, Pullman, WA 99164, USA
    Gene 456:15-23. 2010
    ..In summary, our data suggest that tandem arrayed L1 transgenes are subject to RIGS, and transgenes present at a single copy in the genome are thus recommended for modeling L1 in animals...