Rebecca L Aft

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: mechanism of cell death
    R L Aft
    Department of Surgery, Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, MO 63110, USA
    Br J Cancer 87:805-12. 2002
  2. ncbi request reprint Enhancing targeted radiotherapy by copper(II)diacetyl- bis(N4-methylthiosemicarbazone) using 2-deoxy-D-glucose
    Rebecca L Aft
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 63:5496-504. 2003
  3. pmc A longitudinal study of factors associated with perceived risk of recurrence in women with ductal carcinoma in situ and early-stage invasive breast cancer
    Ying Liu
    Division of Health Behavior Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63108, USA
    Breast Cancer Res Treat 124:835-44. 2010
  4. pmc Disease recurrence in sentinel node-positive breast cancer patients forgoing axillary lymph node dissection
    Amy Cyr
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Ann Surg Oncol 19:3185-91. 2012
  5. pmc Accuracy of ultrasonography and mammography in predicting pathologic response after neoadjuvant chemotherapy for breast cancer
    Jason D Keune
    Department of Surgery, Division of Health Behavior Research, Washington University School of Medicine, St Louis, MO, USA
    Am J Surg 199:477-84. 2010
  6. pmc The impact of breast MRI on surgical decision-making: are patients at risk for mastectomy?
    Kelli Pettit
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Surg Oncol 100:553-8. 2009
  7. pmc Neoadjuvant chemotherapy is associated with improved survival compared with adjuvant chemotherapy in patients with triple-negative breast cancer only after complete pathologic response
    Carla S Fisher
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Ann Surg Oncol 19:253-8. 2012
  8. pmc Changes in sexual problems over time in women with and without early-stage breast cancer
    Maria Perez
    Division of Health Behavior Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63108, USA
    Menopause 17:924-37. 2010
  9. pmc Compromised margins following mastectomy for stage I-III invasive breast cancer
    Jennifer Yu
    Department of Surgery, Washington University, School of Medicine, St Louis, Missouri 63110, USA
    J Surg Res 177:102-8. 2012
  10. pmc Correlates of fear of cancer recurrence in women with ductal carcinoma in situ and early invasive breast cancer
    Ying Liu
    Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO, 63110, USA
    Breast Cancer Res Treat 130:165-73. 2011

Collaborators

Detail Information

Publications35

  1. pmc Evaluation of 2-deoxy-D-glucose as a chemotherapeutic agent: mechanism of cell death
    R L Aft
    Department of Surgery, Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri, MO 63110, USA
    Br J Cancer 87:805-12. 2002
    ..These data support the targeting of glucose metabolism as a site for chemotherapeutic intervention by agents such as 2-deoxy-D-glucose...
  2. ncbi request reprint Enhancing targeted radiotherapy by copper(II)diacetyl- bis(N4-methylthiosemicarbazone) using 2-deoxy-D-glucose
    Rebecca L Aft
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 63:5496-504. 2003
    ..Our data indicate that the strategy of combining tumor-specific cytotoxic agents that function by differing mechanisms can result in an effective, selective, tumor-specific cell death with minimal effect on the host...
  3. pmc A longitudinal study of factors associated with perceived risk of recurrence in women with ductal carcinoma in situ and early-stage invasive breast cancer
    Ying Liu
    Division of Health Behavior Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63108, USA
    Breast Cancer Res Treat 124:835-44. 2010
    ..Educating early-stage breast cancer patients about their actual risk could result in more realistic recurrence-risk perceptions, and increasing social support could help alleviate anxiety associated with exaggerated risk perceptions...
  4. pmc Disease recurrence in sentinel node-positive breast cancer patients forgoing axillary lymph node dissection
    Amy Cyr
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Ann Surg Oncol 19:3185-91. 2012
    ..When metastasis is identified, completion axillary lymph node dissection (CALND) is recommended. Newer data suggest that CALND may be omitted in some women as it does not improve local control or survival...
  5. pmc Accuracy of ultrasonography and mammography in predicting pathologic response after neoadjuvant chemotherapy for breast cancer
    Jason D Keune
    Department of Surgery, Division of Health Behavior Research, Washington University School of Medicine, St Louis, MO, USA
    Am J Surg 199:477-84. 2010
    ..Neoadjuvant chemotherapy reduces tumor size before surgery in women with breast cancer. The aim of this study was to assess the ability of mammography and ultrasound to predict residual tumor size following neoadjuvant chemotherapy...
  6. pmc The impact of breast MRI on surgical decision-making: are patients at risk for mastectomy?
    Kelli Pettit
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Surg Oncol 100:553-8. 2009
    ..The goal of the current study was to determine whether MRI impacts multidisciplinary treatment planning and if it leads to increased mastectomy rates...
  7. pmc Neoadjuvant chemotherapy is associated with improved survival compared with adjuvant chemotherapy in patients with triple-negative breast cancer only after complete pathologic response
    Carla S Fisher
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Ann Surg Oncol 19:253-8. 2012
    ..In patients with TNBC, we sought to compare survival outcomes between patients receiving neoadjuvant chemotherapy, with and without complete pathologic response (pCR), and those receiving adjuvant chemotherapy...
  8. pmc Changes in sexual problems over time in women with and without early-stage breast cancer
    Maria Perez
    Division of Health Behavior Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63108, USA
    Menopause 17:924-37. 2010
    ..We aimed to evaluate whether age-matched women with and without early-stage breast cancer differentially experience sexual problems over time and whether changes in patients' problems differ by type of surgical procedure...
  9. pmc Compromised margins following mastectomy for stage I-III invasive breast cancer
    Jennifer Yu
    Department of Surgery, Washington University, School of Medicine, St Louis, Missouri 63110, USA
    J Surg Res 177:102-8. 2012
    ..We investigated factors associated with positive margins following mastectomy and the impact on outcomes...
  10. pmc Correlates of fear of cancer recurrence in women with ductal carcinoma in situ and early invasive breast cancer
    Ying Liu
    Division of Public Health Sciences, Department of Surgery, Washington University School of Medicine, St Louis, MO, 63110, USA
    Breast Cancer Res Treat 130:165-73. 2011
    ..Management of anxiety, provision of social support, and patient education may help reduce FCR among DCIS and EIBC survivors, especially among younger survivors...
  11. pmc Sentinel lymph node biopsy in patients with multicentric/multifocal breast cancer: low false-negative rate and lack of axillary recurrence
    Dana M Holwitt
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Am J Surg 196:562-5. 2008
    ..Accuracy of sentinel lymph node biopsy (SLNB) and rate of axillary recurrence in multicentric/multifocal (MC/MF) breast cancer are reported...
  12. pmc Micrometastatic disease and isolated tumor cells as a predictor for additional breast cancer axillary metastatic burden
    Amy Cyr
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Ann Surg Oncol 17:303-11. 2010
    ....
  13. pmc Positive margin rates following breast-conserving surgery for stage I-III breast cancer: palpable versus nonpalpable tumors
    Jordan Atkins
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Surg Res 177:109-15. 2012
    ..Margin status is a significant risk factor for local recurrence. We sought to examine whether the method of tumor localization predicted the margin status and the need for re-excision for both nonpalpable and palpable breast cancer...
  14. pmc A gene expression signature that predicts the therapeutic response of the basal-like breast cancer to neoadjuvant chemotherapy
    Yiing Lin
    Department of Surgery, Washington University School of Medicine St Louis, 660 South Euclid Avenue, Campus Box 8109, St Louis, MO 63110, USA
    Breast Cancer Res Treat 123:691-9. 2010
    ..We identified a 23-gene signature which predicts response of basal-like breast cancer to neoadjuvant chemotherapy as well as disease-free survival. This signature is independent of tissue collection method and chemotherapeutic regimen...
  15. pmc Impact of multiple caregiving roles on elevated depressed mood in early-stage breast cancer patients and same-age controls
    Ellen H Bailey
    Department of Surgery, Vanderbilt University, Nashville, TN, USA
    Breast Cancer Res Treat 121:709-18. 2010
    ..Patients with multiple caregiving roles were more likely while controls were less likely to report elevated depressed mood over time, suggesting a need to identify patients with multiple caregiving roles early during their treatment...
  16. pmc Assessment of cellular proliferation in tumors by PET using 18F-ISO-1
    Farrokh Dehdashti
    Division of Nuclear Medicine and Radiological Sciences, Edward Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 54:350-7. 2013
    ....
  17. pmc Predictors of complete pathological response after neoadjuvant systemic therapy for breast cancer
    Marcus C Tan
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Am J Surg 198:520-5. 2009
    ..The aim of the current study was to identify predictors of pathologic complete response (pCR) following neoadjuvant therapy...
  18. pmc Breast cancer in elderly women (≥ 80 years): variation in standard of care?
    Amy Cyr
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    J Surg Oncol 103:201-6. 2011
    ..The study aim was to investigate the methods of breast cancer diagnosis and treatment for women at advanced ages...
  19. doi request reprint Patient and tumor characteristics associated with increased mortality in young women (< or =40 years) with breast cancer
    Ankit Bharat
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Surg Oncol 100:248-51. 2009
    ..The goal of the current study is to identify predictors responsible for mortality disparities between young (< or =40 years) and older (>40 years) women with breast cancer...
  20. pmc Predictors of primary breast abscesses and recurrence
    Ankit Bharat
    Department of Surgery, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8109, St Louis, MO 63110, USA
    World J Surg 33:2582-6. 2009
    ..We investigated the patients and microbiological risk factors that predispose to the development of primary breast abscesses and subsequent recurrence...
  21. pmc Are we overtreating papillomas diagnosed on core needle biopsy?
    Amy E Cyr
    Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, Saint Louis, MO, USA
    Ann Surg Oncol 18:946-51. 2011
    ..The literature is less clear on the management of papillomas without atypia on CNB. Our goal was to determine factors associated with pathology upgrade on excision...
  22. pmc Method of breast cancer presentation and depressed mood 1 year after diagnosis in women with locally advanced disease
    Elizabeth B Roth
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Ann Surg Oncol 16:1637-41. 2009
    ..Differences in psychological outcomes of breast cancer patients with locally advanced disease who presented with abnormal screening mammograms or palpable mass have not been reported...
  23. pmc Accuracy of perceived risk of recurrence among patients with early-stage breast cancer
    Ying Liu
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63108, USA
    Cancer Epidemiol Biomarkers Prev 19:675-80. 2010
    ..Although a few studies have examined early-stage breast cancer survivors' perceived risk of recurrence, none have assessed the accuracy of survivors' perceived risk of recurrence...
  24. doi request reprint Chemosensitizing and cytotoxic effects of 2-deoxy-D-glucose on breast cancer cells
    Fanjie Zhang
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    J Cancer Res Ther 5:S41-3. 2009
    ..This property has been exploited for imaging malignancies and as a possible anticancer therapy. The nonmetabolizable glucose analog 2-deoxyglucose (2 DG) interferes with glucose metabolism leading to breast cancer cell death...
  25. pmc Assessment of progesterone receptors in breast carcinoma by PET with 21-18F-fluoro-16α,17α-[(R)-(1'-α-furylmethylidene)dioxy]-19-norpregn-4-ene-3,20-dione
    Farrokh Dehdashti
    Divisions of Nuclear Medicine and Radiological Sciences, Edward Mallinckrodt Institute of Radiology, St Louis, MO, USA
    J Nucl Med 53:363-70. 2012
    ....
  26. pmc Scientific Presentation Award: The combination of axillary ultrasound and ultrasound-guided biopsy is an accurate predictor of axillary stage in clinically node-negative breast cancer patients
    Dana M Holwitt
    Department of Surgery, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8109, St Louis, MO 63110, USA
    Am J Surg 196:477-82. 2008
    ..The study aim was to determine the accuracy of axillary ultrasound (AUS) and fine-needle aspiration biopsy (FNAB)/needle core biopsy in axillary breast cancer staging...
  27. pmc Metastatic disease to the breast: the Washington University experience
    Aislinn Vaughan
    Department of Surgery, Washington University School of Medicine, St, Louis, MO, USA
    World J Surg Oncol 5:74. 2007
    ..The aim of this study is to characterize metastatic disease to the breast and to describe the management and prognosis of patients who present with this diagnosis...
  28. pmc Estrogen carcinogenesis: specific identification of estrogen-modified nucleobase in breast tissue from women
    Qiang Zhang
    Departments of Chemistry and Surgery, Washington University in St Louis, St Louis, Missouri 63130, USA
    Chem Res Toxicol 21:1509-13. 2008
    ..The sample size and detection limits are not yet sufficient to permit distinctions between cancer and noncancer patients...
  29. pmc Targeting Chk1 in p53-deficient triple-negative breast cancer is therapeutically beneficial in human-in-mouse tumor models
    Cynthia X Ma
    Section of Breast Oncology, Division of Oncology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    J Clin Invest 122:1541-52. 2012
    ..In addition, knockdown of p53 sensitized WU-BC3 tumors to the combination therapy. These results demonstrate that p53 is a major determinant of how TNBCs respond to therapies that combine DNA damage with Chk1 inhibition...
  30. ncbi request reprint 2-Deoxy-D-glucose-induced cytotoxicity and radiosensitization in tumor cells is mediated via disruptions in thiol metabolism
    Xiao Lin
    Section of Cancer Biology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    Cancer Res 63:3413-7. 2003
    ....
  31. doi request reprint Impact of neoadjuvant chemotherapy on rate of tissue expander/implant loss and progression to successful breast reconstruction following mastectomy
    Jonathan Mitchem
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Am J Surg 196:519-22. 2008
    ..We examined the frequency and causes of tissue expander (TE) and permanent implant (PI) reconstruction failure in patients undergoing neoadjuvant chemotherapy...
  32. doi request reprint Treatment and outcomes of patients with primary breast sarcoma
    Ryan C Fields
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Am J Surg 196:559-61. 2008
    ..Surgery is the main treatment for primary breast sarcoma (PBS). Here we characterize this disease and determine factors associated with use of adjuvant therapy...
  33. pmc IL-12p70-producing patient DC vaccine elicits Tc1-polarized immunity
    Beatriz M Carreno
    Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 123:3383-94. 2013
    ..Here, we report on the immunological and clinical outcomes upon vaccination with CD40L/IFN-γ-matured, IL-12p70-producing DCs...
  34. ncbi request reprint Disparities related to socioeconomic status and access to medical care remain in the United States among women who never had a mammogram
    Mario Schootman
    Division of Health Behavior Research, Department of Pediatrics, Washington University School of Medicine, Saint Louis, MO 63108, USA
    Cancer Causes Control 14:419-25. 2003
    ....
  35. pmc Isolation and molecular profiling of bone marrow micrometastases identifies TWIST1 as a marker of early tumor relapse in breast cancer patients
    Mark A Watson
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cancer Res 13:5001-9. 2007
    ....