NADA ABUMRAD

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint CD36 expression and brain function: does CD36 deficiency impact learning ability?
    Nada A Abumrad
    Department of Physiology, Biophysics and Psychology, Stony Brook University, NY 11794, USA
    Prostaglandins Other Lipid Mediat 77:77-83. 2005
  2. pmc CD36 may determine our desire for dietary fats
    Nada A Abumrad
    Department of Medicine, Division of Nutritional Science, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:2965-7. 2005
  3. pmc Parkin reinvents itself to regulate fatty acid metabolism by tagging CD36
    Nada A Abumrad
    Department of Medicine, Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 121:3389-92. 2011
  4. pmc Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol
    Latisha Love-Gregory
    Department of Medicine, Center for Human Nutrition, Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 17:1695-704. 2008
  5. pmc CD36-dependent regulation of muscle FoxO1 and PDK4 in the PPAR delta/beta-mediated adaptation to metabolic stress
    Zaher Nahle
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biol Chem 283:14317-26. 2008
  6. pmc Opposite regulation of CD36 ubiquitination by fatty acids and insulin: effects on fatty acid uptake
    Jill Smith
    Department of Medicine, Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 283:13578-85. 2008
  7. ncbi request reprint CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine
    Fatiha Nassir
    Department of Medicine, Division of Nutritional Science, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 282:19493-501. 2007
  8. pmc Enhanced hepatic apoA-I secretion and peripheral efflux of cholesterol and phospholipid in CD36 null mice
    Pin Yue
    Department of Medicine, Washington University School of Medicine, Center for Human Nutrition, St Louis, Missouri, United States of America
    PLoS ONE 5:e9906. 2010
  9. pmc Common CD36 SNPs reduce protein expression and may contribute to a protective atherogenic profile
    Latisha Love-Gregory
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 20:193-201. 2011
  10. pmc Myocardial recovery from ischemia is impaired in CD36-null mice and restored by myocyte CD36 expression or medium-chain fatty acids
    Hiroshi Irie
    Department of Physiology and Biophysics, Stony Brook University, NY 11794, USA
    Proc Natl Acad Sci U S A 100:6819-24. 2003

Research Grants

  1. CD36 and Intestinal Fat Absorption
    NADA ABUMRAD; Fiscal Year: 2009
  2. CD36 and Intestinal Fat Absorption
    NADA ABUMRAD; Fiscal Year: 2005
  3. Fatty Acid Transporter: Regulation, Identification
    NADA ABUMRAD; Fiscal Year: 2007
  4. CD36 and Intestinal Fat Absorption
    NADA ABUMRAD; Fiscal Year: 2007
  5. FATTY ACID TRANSPORTER: REGULATION, IDENTIFICATION
    Nada A Abumrad; Fiscal Year: 2010
  6. CD36 and Intestinal Fat Absorption
    Nada A Abumrad; Fiscal Year: 2010
  7. FATTY ACID TRANSPORTER--REGULATION, IDENTIFICATION
    NADA ABUMRAD; Fiscal Year: 1993
  8. FATTY ACID TRANSPORTER--REGULATION, IDENTIFICATION
    NADA ABUMRAD; Fiscal Year: 2001
  9. FATTY ACID TRANSPORTER: REGULATION, IDENTIFICATION
    Nada A Abumrad; Fiscal Year: 2010

Collaborators

Detail Information

Publications40

  1. ncbi request reprint CD36 expression and brain function: does CD36 deficiency impact learning ability?
    Nada A Abumrad
    Department of Physiology, Biophysics and Psychology, Stony Brook University, NY 11794, USA
    Prostaglandins Other Lipid Mediat 77:77-83. 2005
    ..However they appear to have a significant impairment in learning ability. These findings could provide a new perspective regarding the regulation of brain lipid metabolism...
  2. pmc CD36 may determine our desire for dietary fats
    Nada A Abumrad
    Department of Medicine, Division of Nutritional Science, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 115:2965-7. 2005
    ..As we gain more information regarding the function of this receptor, we may be able to devise better strategies to address the addictive potential of dietary fat...
  3. pmc Parkin reinvents itself to regulate fatty acid metabolism by tagging CD36
    Nada A Abumrad
    Department of Medicine, Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 121:3389-92. 2011
    ....
  4. pmc Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol
    Latisha Love-Gregory
    Department of Medicine, Center for Human Nutrition, Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 17:1695-704. 2008
    ..0059). Fifteen additional SNPs associated with HDL-C (P = 0.0028-0.044). We conclude that CD36 variants may impact MetS pathophysiology and HDL metabolism, both predictors of the risk of heart disease and type 2 diabetes...
  5. pmc CD36-dependent regulation of muscle FoxO1 and PDK4 in the PPAR delta/beta-mediated adaptation to metabolic stress
    Zaher Nahle
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biol Chem 283:14317-26. 2008
    ..The findings could have implications in the chronic abnormalities of fatty acid metabolism associated with obesity and diabetes...
  6. pmc Opposite regulation of CD36 ubiquitination by fatty acids and insulin: effects on fatty acid uptake
    Jill Smith
    Department of Medicine, Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 283:13578-85. 2008
    ..In conclusion, fatty acids and insulin induce opposite alterations in CD36 ubiquitination, modulating CD36 level and fatty acid uptake. Altered CD36 turnover may contribute to abnormal fatty acid uptake in the insulin-resistant muscle...
  7. ncbi request reprint CD36 is important for fatty acid and cholesterol uptake by the proximal but not distal intestine
    Fatiha Nassir
    Department of Medicine, Division of Nutritional Science, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 282:19493-501. 2007
    ..The findings support the role of CD36 in proximal absorption of dietary fatty acid and cholesterol for optimal chylomicron formation, whereas CD36-independent mechanisms predominate in distal segments...
  8. pmc Enhanced hepatic apoA-I secretion and peripheral efflux of cholesterol and phospholipid in CD36 null mice
    Pin Yue
    Department of Medicine, Washington University School of Medicine, Center for Human Nutrition, St Louis, Missouri, United States of America
    PLoS ONE 5:e9906. 2010
    ..In conclusion, CD36 influences reverse cholesterol transport and hepatic ApoA-I production. Both pathways are enhanced in CD36 deficiency, increasing HDL concentrations, which suggests the potential benefit of CD36 inhibition...
  9. pmc Common CD36 SNPs reduce protein expression and may contribute to a protective atherogenic profile
    Latisha Love-Gregory
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 20:193-201. 2011
    ..The SNPs in this study may have predictive potential on CD36 expression and disease susceptibility in African Americans. Further studies are warranted to validate and determine whether these findings are population specific...
  10. pmc Myocardial recovery from ischemia is impaired in CD36-null mice and restored by myocyte CD36 expression or medium-chain fatty acids
    Hiroshi Irie
    Department of Physiology and Biophysics, Stony Brook University, NY 11794, USA
    Proc Natl Acad Sci U S A 100:6819-24. 2003
    ..It would be important to determine whether the findings apply to the human situation where polymorphisms of the CD36 gene are relatively common...
  11. pmc Cellular fatty acid uptake: a pathway under construction
    Xiong Su
    Department of Medicine, Center for Human Nutrition, Washington University, St Louis, MO 63110, USA
    Trends Endocrinol Metab 20:72-7. 2009
    ..In addition, variants in the CD36 gene were shown recently to influence susceptibility for the metabolic syndrome, which greatly increases the risk of diabetes and heart disease...
  12. pmc A novel multiprotein complex is required to generate the prechylomicron transport vesicle from intestinal ER
    Shahzad Siddiqi
    Division of Gastroenterology, Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, USA
    J Lipid Res 51:1918-28. 2010
    ..The data support the conclusion that the PCTV budding complex in intestinal ER is composed of VAMP7, apoB48, CD36, and L-FABP, plus the COPII proteins...
  13. pmc Chylomicron- and VLDL-derived lipids enter the heart through different pathways: in vivo evidence for receptor- and non-receptor-mediated fatty acid uptake
    Kalyani G Bharadwaj
    Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 285:37976-86. 2010
    ..In addition, our data show that lipolysis is involved in uptake of core lipids from TG-rich lipoproteins...
  14. pmc Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity
    Elisa Fabbrini
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:15430-5. 2009
    ..Furthermore, alterations in tissue fatty acid transport could be involved in the pathogenesis of ectopic triglyceride accumulation by redirecting plasma fatty acid uptake from adipose tissue toward other tissues...
  15. ncbi request reprint CD36 in myocytes channels fatty acids to a lipase-accessible triglyceride pool that is related to cell lipid and insulin responsiveness
    Claire C Bastie
    Physiology and Biophysics, Stony Brook University, Stony Brook, NY 11794 8661, USA
    Diabetes 53:2209-16. 2004
    ..The findings provide a new perspective related to the etiology of lipid accumulation and insulin resistance in myocytes...
  16. doi request reprint Inhibition of Foxo1 protects pancreatic islet beta-cells against fatty acid and endoplasmic reticulum stress-induced apoptosis
    Sara C Martinez
    Division of Endocrinology, Metabolism, and Lipid Research, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8127, St Louis, MO 63110, USA
    Diabetes 57:846-59. 2008
    ....
  17. pmc Regulation of fatty acid uptake into tissues: lipoprotein lipase- and CD36-mediated pathways
    Ira J Goldberg
    Division of Preventive Medicine and Nutrition, Department of Medicine, Columbia University, New York, NY, USA
    J Lipid Res 50:S86-90. 2009
    ..CD36 is regulated by some of the same factors that regulate LPL, including insulin, muscle contraction, and fasting, in part, via ubiquitination. LPL and CD36 actions in various tissues coordinate biodistribution of fat-derived calories...
  18. pmc Increased CD36 expression signals monocyte activation among patients with type 2 diabetes
    Yijuan Sun
    Department of Medicine, Veteran Affairs Medical Center, Albuquerque, New Mexico, USA
    Diabetes Care 33:2065-7. 2010
    ..To explore the hypothesis that CD36, a scavenger receptor and fatty acid translocase, is upregulated in peripheral blood mononuclear cells (PBMCs) among patients with type 2 diabetes and is a biomarker of PBMC activation and inflammation...
  19. pmc Genetic ablation of calcium-independent phospholipase A2gamma leads to alterations in mitochondrial lipid metabolism and function resulting in a deficient mitochondrial bioenergetic phenotype
    David J Mancuso
    Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 282:34611-22. 2007
    ..We conclude that iPLA(2)gamma is essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition...
  20. pmc Evidence against the presence of an anandamide transporter
    Sherrye T Glaser
    Department of Biochemistry and Cell Biology, Stony Brook University, Stony Brook, NY 11794, USA
    Proc Natl Acad Sci U S A 100:4269-74. 2003
    ..In summary, these data suggest that anandamide uptake is a process of simple diffusion. This process is driven by metabolism and other downstream events, rather than by a specific membrane-associated anandamide carrier...
  21. pmc CD36 mediates both cellular uptake of very long chain fatty acids and their intestinal absorption in mice
    Victor A Drover
    Department of Pharmacology, State University of New York, Stony Brook, New York 11794, USA
    J Biol Chem 283:13108-15. 2008
    ..Together, these findings represent the first direct evidence for protein-facilitated FA absorption in the intestine and identify a novel therapeutic target for the treatment of diseases characterized by elevated VLCFA levels...
  22. ncbi request reprint CD36-facilitated fatty acid uptake inhibits leptin production and signaling in adipose tissue
    Tahar Hajri
    Department of Surgery, Vanderbilt University, Nashville, Tennessee, USA
    Diabetes 56:1872-80. 2007
    ..In addition, expression of leptin-sensitive fatty acid oxidative enzymes is enhanced. Targeting adipocyte CD36 may offer a way to uncouple leptin production and adiposity...
  23. pmc CD36 is important for chylomicron formation and secretion and may mediate cholesterol uptake in the proximal intestine
    Andromeda M Nauli
    Department of Pathology and Laboratory Medicine, Genome Research Institute, University of Cincinnati College of Medicine, 2120 Galbraith Road, Cincinnati, OH 45237, USA
    Gastroenterology 131:1197-207. 2006
    ..Studies are aimed to determine the role of CD36 in intestinal lipid absorption...
  24. pmc New insights into long-chain fatty acid uptake by heart muscle: a crucial role for fatty acid translocase/CD36
    Joep F F Brinkmann
    Cardiovascular Research Institute Maastricht CARIM, Department of Physiology, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    Biochem J 367:561-70. 2002
    ....
  25. ncbi request reprint A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians
    Xiaowei Ma
    Research Division, Joslin Diabetes Center, Harvard Medical School, Boston, MA, USA
    Hum Mol Genet 13:2197-205. 2004
    ..In conclusion, this comprehensive study of CD36 variability indicates that the common polymorphisms at this locus modulate lipid metabolism and cardiovascular risk in Caucasians...
  26. ncbi request reprint Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic beta-cells and mediates fatty acid effects on insulin secretion
    Houtan Noushmehr
    Division Endocrinology and DiabetesMetabolism, Cedars Sinai Medical Center, 8723 Alden Dr, SSB 290, Los Angeles, CA 90048, USA
    Diabetes 54:472-81. 2005
    ..CD36 activity appears important for uptake of FA into beta-cells as well as for mediating their modulatory effects on insulin secretion...
  27. ncbi request reprint FoxO1 stimulates fatty acid uptake and oxidation in muscle cells through CD36-dependent and -independent mechanisms
    Claire C Bastie
    Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York 11794 8661, USA
    J Biol Chem 280:14222-9. 2005
    ..Dysregulation of FoxO1 in muscle could contribute to intramuscular lipid accumulation and insulin resistance by maintaining activation of FA uptake...
  28. pmc CD36 deficiency impairs intestinal lipid secretion and clearance of chylomicrons from the blood
    Victor A Drover
    Department of Physiology and Biophysics, State University of New York at Stony Brook, USA
    J Clin Invest 115:1290-7. 2005
    ..CD36 deficiency results in hypertriglyceridemia both in the postprandial and fasting states and in humans may constitute a risk factor for diet-induced type 2 diabetes and cardiovascular disease...
  29. pmc Defective fatty acid uptake modulates insulin responsiveness and metabolic responses to diet in CD36-null mice
    Tahar Hajri
    Department of Physiology and Biophysics, State University of New York at Stony Brook, New York 11794 8661, USA
    J Clin Invest 109:1381-9. 2002
    ..In humans, CD36 deficiency may be an important factor in the metabolic adaptation to diet and in susceptibility to some forms of diet-induced pathology...
  30. ncbi request reprint DGAT1 is not essential for intestinal triacylglycerol absorption or chylomicron synthesis
    Kimberly K Buhman
    Gladstone Institute of Cardiovascular Disease, San Francisco, California 94141 9100, USA
    J Biol Chem 277:25474-9. 2002
    ..Our findings indicate that multiple mechanisms for triacylglycerol synthesis in the intestine facilitate triacylglycerol absorption...
  31. ncbi request reprint Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice
    Lisa Heron-Milhavet
    Diabetes Branch, NIDDK, Room 8D12, Building 10, National Institutes of Health, Bethesda, Maryland 20892 1758, USA
    Endocrinology 145:4667-76. 2004
    ....
  32. ncbi request reprint Fatty acid transport across membranes: relevance to nutrition and metabolic pathology
    Tahar Hajri
    Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York, 11794 8661, USA
    Annu Rev Nutr 22:383-415. 2002
    ..We are also beginning to better appreciate how disturbances in fatty acid utilization influence general metabolism and contribute to metabolic pathology...
  33. ncbi request reprint Pharmacogenetic evidence that cd36 is a key determinant of the metabolic effects of pioglitazone
    Nianning Qi
    Department of Laboratory Medicine, University of California, San Francisco, 94143, USA
    J Biol Chem 277:48501-7. 2002
    ..These findings provide direct pharmacogenetic evidence that in the SHR model, Cd36 is a key determinant of the insulin-sensitizing actions of a thiazolidinedione ligand of peroxisome proliferator-activated receptor gamma...
  34. ncbi request reprint Thyroid hormone transport by the rat fatty acid translocase
    Haidy H A G M van der Putten
    Department of Veterinary Anatomy and Physiology, Utrecht University, 3508 TD Utrecht, The Netherlands
    Endocrinology 144:1315-23. 2003
    ..In conclusion, our results demonstrate transport of T(3) and other iodothyronines by rFAT...
  35. ncbi request reprint Changes in plasma membrane properties and phosphatidylcholine subspecies of insect Sf9 cells due to expression of scavenger receptor class B, type I, and CD36
    Saj Parathath
    Department of Pharmacological Sciences, University Medical Center, State University of New York, Stony Brook, New York 11794 8651, USA
    J Biol Chem 279:41310-8. 2004
    ..Scavenger receptor-mediated changes in membrane phosphatidylcholine may contribute to the increased flux of cholesterol and other lipids elicited by these receptors...
  36. doi request reprint Genome-wide associations and metabolic disease: the big revolution
    Alessandro Doria
    Curr Opin Clin Nutr Metab Care 11:363-5. 2008
  37. doi request reprint Pharmacological activation of PPARbeta promotes rapid and calcineurin-dependent fiber remodeling and angiogenesis in mouse skeletal muscle
    Celine Gaudel
    INSERM U907, Faculté de Médecine Université de Nice Sophia Antipolis, 28 Avenue de Valombrose, Nice Cedex, France
    Am J Physiol Endocrinol Metab 295:E297-304. 2008
    ..In conclusion, the data indicate that PPARbeta activation is associated with a calcineurin-dependent effect on muscle morphology that enhances the oxidative phenotype...
  38. ncbi request reprint The metabolism of cancer cells: moonlighting proteins and growth control
    Nada A Abumrad
    Curr Opin Clin Nutr Metab Care 9:337-8. 2006
  39. ncbi request reprint Common haplotypes at the adiponectin receptor 1 (ADIPOR1) locus are associated with increased risk of coronary artery disease in type 2 diabetes
    Teresa Soccio
    Research Division, Joslin Diabetes Center, Boston, MA, USA
    Diabetes 55:2763-70. 2006
    ..001-0.014). Our findings point to genetic variability at the ADIPOR1 locus as a strong determinant of CAD susceptibility in type 2 diabetes...
  40. ncbi request reprint Role of CD36 in membrane transport of long-chain fatty acids
    Azeddine Ibrahimi
    Department of Physiology and Biophysics, State University of New York at Stony Brook, Stony Brook, New York 11794 8661, USA
    Curr Opin Clin Nutr Metab Care 5:139-45. 2002
    ....

Research Grants30

  1. CD36 and Intestinal Fat Absorption
    NADA ABUMRAD; Fiscal Year: 2009
    ..They will provide insight into the contribution of dysfunctions in intestinal CD36 to the etiology of hypertriglyceredemia in humans. ..
  2. CD36 and Intestinal Fat Absorption
    NADA ABUMRAD; Fiscal Year: 2005
    ..The work will contribute to the understanding of intestinal FA absorption and of FA metabolism in enterocytes. It may help design new approaches aimed at preventing the obesity induced by consumption of high dietary fat. ..
  3. Fatty Acid Transporter: Regulation, Identification
    NADA ABUMRAD; Fiscal Year: 2007
    ..In humans, CD36 deficiency is as high as 18% in some subpopulations and it may be an important factor in the metabolic adaptation to diet and in susceptibility to some forms of diet-induced pathology. ..
  4. CD36 and Intestinal Fat Absorption
    NADA ABUMRAD; Fiscal Year: 2007
    ..They will provide insight into the contribution of dysfunctions in intestinal CD36 to the etiology of hypertriglyceredemia in humans. ..
  5. FATTY ACID TRANSPORTER: REGULATION, IDENTIFICATION
    Nada A Abumrad; Fiscal Year: 2010
    ..In addition common variants in the CD36 gene have been linked to dylipidemia, susceptibility to the metabolic syndrome and to cardiovascular disease. ..
  6. CD36 and Intestinal Fat Absorption
    Nada A Abumrad; Fiscal Year: 2010
    ..They will provide insight into the contribution of dysfunctions in intestinal CD36 to the etiology of hypertriglyceredemia in humans. ..
  7. FATTY ACID TRANSPORTER--REGULATION, IDENTIFICATION
    NADA ABUMRAD; Fiscal Year: 1993
    ..Understanding the molecular mechanism which mediates cellular uptake of long chain fatty acids is undoubtedly important for the general physiology of the organism in health and disease...
  8. FATTY ACID TRANSPORTER--REGULATION, IDENTIFICATION
    NADA ABUMRAD; Fiscal Year: 2001
    ..Uptake of long-chain FA is relevant to the organism in both health and disease. ..
  9. FATTY ACID TRANSPORTER: REGULATION, IDENTIFICATION
    Nada A Abumrad; Fiscal Year: 2010
    ..In addition common variants in the CD36 gene have been linked to dylipidemia, susceptibility to the metabolic syndrome and to cardiovascular disease. ..