Leonard Wartofsky

Summary

Country: USA

Publications

  1. ncbi request reprint Levothyroxine: therapeutic use and regulatory issues related to bioequivalence
    Leonard Wartofsky
    Department of Medicine, Washington Hospital Center, Washington, DC 20010 2975, USA
    Expert Opin Pharmacother 3:727-32. 2002
  2. pmc Levothyroxine treatment in pregnancy: indications, efficacy, and therapeutic regimen
    Joanna Klubo-Gwiezdzinska
    Section of Endocrinology, Department of Medicine, Washington Hospital Center, Washington, DC 20010, USA
    J Thyroid Res 2011:843591. 2011
  3. doi request reprint Combination L-T3 and L-T4 therapy for hypothyroidism
    Leonard Wartofsky
    Department of Medicine, Washington Hospital Center, Georgetown University, Washington, District of Columbia, USA
    Curr Opin Endocrinol Diabetes Obes 20:460-6. 2013
  4. ncbi request reprint Myxedema coma
    Leonard Wartofsky
    Department of Medicine, Washington Hospital Center, Washington, DC 20010 2975, USA
    Endocrinol Metab Clin North Am 35:687-98, vii-viii. 2006
  5. ncbi request reprint Overt and 'subclinical' hypothyroidism in women
    Leonard Wartofsky
    Uniformed Services University, Bethesda, Maryland, USA
    Obstet Gynecol Surv 61:535-42. 2006
  6. ncbi request reprint The evidence for a narrower thyrotropin reference range is compelling
    Leonard Wartofsky
    Department of Medicine, Washington Hospital Center, 110 Irving Street NW, Washington, D C 20010 2975, USA
    J Clin Endocrinol Metab 90:5483-8. 2005
  7. ncbi request reprint Management of low-risk well-differentiated thyroid cancer based only on thyroglobulin measurement after recombinant human thyrotropin
    Leonard Wartofsky
    Department of Medicine, Washington Hospital Center, Washington, DC 20010 2975, USA
    Thyroid 12:583-90. 2002
  8. doi request reprint Recombinant human thyroid-stimulating hormone versus thyroid hormone withdrawal in the identification of metastasis in differentiated thyroid cancer with 131I planar whole-body imaging and 124I PET
    Douglas Van Nostrand
    Division of Nuclear Medicine, Washington Hospital Center, Washington, DC 20010, USA
    J Nucl Med 53:359-62. 2012
  9. doi request reprint Treatment with metformin is associated with higher remission rate in diabetic patients with thyroid cancer
    Joanna Klubo-Gwiezdzinska
    Department of Pediatrics, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814 4712, USA
    J Clin Endocrinol Metab 98:3269-79. 2013
  10. doi request reprint The expression of translocator protein in human thyroid cancer and its role in the response of thyroid cancer cells to oxidative stress
    Joanna Klubo-Gwiezdzinska
    Division of Endocrinology, Department of Medicine, Washington Hospital Center, Washington, District of Columbia 20010 2910, USA
    J Endocrinol 214:207-16. 2012

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Levothyroxine: therapeutic use and regulatory issues related to bioequivalence
    Leonard Wartofsky
    Department of Medicine, Washington Hospital Center, Washington, DC 20010 2975, USA
    Expert Opin Pharmacother 3:727-32. 2002
    ..The history and status of the recent request by the FDA for a new drug application for all levothyroxine products, and its impact on the market leader Synthroid, is also discussed...
  2. pmc Levothyroxine treatment in pregnancy: indications, efficacy, and therapeutic regimen
    Joanna Klubo-Gwiezdzinska
    Section of Endocrinology, Department of Medicine, Washington Hospital Center, Washington, DC 20010, USA
    J Thyroid Res 2011:843591. 2011
    ..The beneficial effects of levothyroxine therapy on pregnancy outcomes and offspring development are discussed with a proposed treatment regimen and follow up strategy...
  3. doi request reprint Combination L-T3 and L-T4 therapy for hypothyroidism
    Leonard Wartofsky
    Department of Medicine, Washington Hospital Center, Georgetown University, Washington, District of Columbia, USA
    Curr Opin Endocrinol Diabetes Obes 20:460-6. 2013
    ..A strong argument for the addition of L-T3 to L-T4 monotherapy has been lacking until recent genetic studies indicated a rationale for such therapy among a small fraction of the hypothyroid patient population...
  4. ncbi request reprint Myxedema coma
    Leonard Wartofsky
    Department of Medicine, Washington Hospital Center, Washington, DC 20010 2975, USA
    Endocrinol Metab Clin North Am 35:687-98, vii-viii. 2006
    ..Adjunctive measures, such as ventilation, warming, fluids, antibiotics, pressors, and corticosteroids, may be essential for survival...
  5. ncbi request reprint Overt and 'subclinical' hypothyroidism in women
    Leonard Wartofsky
    Uniformed Services University, Bethesda, Maryland, USA
    Obstet Gynecol Surv 61:535-42. 2006
    ....
  6. ncbi request reprint The evidence for a narrower thyrotropin reference range is compelling
    Leonard Wartofsky
    Department of Medicine, Washington Hospital Center, 110 Irving Street NW, Washington, D C 20010 2975, USA
    J Clin Endocrinol Metab 90:5483-8. 2005
    ..Recognition and establishment of a more precise and true normal range for TSH have important implications for both screening and treatment of thyroid disease in general and subclinical thyroid disease in particular...
  7. ncbi request reprint Management of low-risk well-differentiated thyroid cancer based only on thyroglobulin measurement after recombinant human thyrotropin
    Leonard Wartofsky
    Department of Medicine, Washington Hospital Center, Washington, DC 20010 2975, USA
    Thyroid 12:583-90. 2002
    ..A strategy is presented for incorporation of this approach into the management of patients with low-risk well-differentiated thyroid cancer...
  8. doi request reprint Recombinant human thyroid-stimulating hormone versus thyroid hormone withdrawal in the identification of metastasis in differentiated thyroid cancer with 131I planar whole-body imaging and 124I PET
    Douglas Van Nostrand
    Division of Nuclear Medicine, Washington Hospital Center, Washington, DC 20010, USA
    J Nucl Med 53:359-62. 2012
    ..The objective of this study was to evaluate these 2 methods of patient preparation for the detection of metastases from differentiated thyroid cancer (DTC) using (131)I WB imaging and (124)I PET...
  9. doi request reprint Treatment with metformin is associated with higher remission rate in diabetic patients with thyroid cancer
    Joanna Klubo-Gwiezdzinska
    Department of Pediatrics, Uniformed Services University of Health Sciences, Bethesda, Maryland 20814 4712, USA
    J Clin Endocrinol Metab 98:3269-79. 2013
    ..Clinical trials demonstrated that metformin increases the efficiency of systemic therapy in cancer patients...
  10. doi request reprint The expression of translocator protein in human thyroid cancer and its role in the response of thyroid cancer cells to oxidative stress
    Joanna Klubo-Gwiezdzinska
    Division of Endocrinology, Department of Medicine, Washington Hospital Center, Washington, District of Columbia 20010 2910, USA
    J Endocrinol 214:207-16. 2012
    ..Implication of TSPO in the thyroid cancer cell response to oxidative stress suggested its potential role in the regulation of thyroid cancer cell response to treatment with radioiodine and warrants further investigation...
  11. doi request reprint Efficacy of dosimetric versus empiric prescribed activity of 131I for therapy of differentiated thyroid cancer
    Joanna Klubo-Gwiezdzinska
    Division of Nuclear Medicine, Washington Hospital Center, Washington, DC 20010 2910, USA
    J Clin Endocrinol Metab 96:3217-25. 2011
    ..The prescribed activity of (131)I can be determined using two approaches: 1) empiric prescribed activity of (131)I (E-Rx); and 2) dosimetry-based prescribed activity of (131)I (D-Rx)...
  12. doi request reprint Radioiodine treatment of metastatic thyroid cancer: relative efficacy and side effect profile of preparation by thyroid hormone withdrawal versus recombinant human thyrotropin
    Joanna Klubo-Gwiezdzinska
    Division of Endocrinology, Department of Medicine, Washington Hospital Center, Washington, District of Columbia 20010 2910, USA
    Thyroid 22:310-7. 2012
    ..The aim of our study was to compare the relative efficacy and side effect profile of rhTSH versus THW preparation for RAI therapy of metastatic DTC...
  13. doi request reprint (124)I positron emission tomography versus (131)I planar imaging in the identification of residual thyroid tissue and/or metastasis in patients who have well-differentiated thyroid cancer
    Douglas Van Nostrand
    Division of Nuclear Medicine, Washington Hospital Center, Washington, DC 20010, USA
    Thyroid 20:879-83. 2010
    ..The objective of this study was to compare the ability of diagnostic (124)I PET images versus (131)I planar whole-body imaging in detecting residual thyroid tissue and/or metastatic well-differentiated thyroid cancer (WDTC)...
  14. doi request reprint The magnitude of increased levothyroxine requirements in hypothyroid pregnant women depends upon the etiology of the hypothyroidism
    Jennifer A Loh
    Division of Endocrinology, Washington Hospital Center, Washington, District of Columbia 20010, USA
    Thyroid 19:269-75. 2009
    ..We hypothesized that dosage requirements during pregnancy might differ depending upon the nature of the underlying hypothyroidism...
  15. doi request reprint Graves' disease and thymic hyperplasia: the relationship of thymic volume to thyroid function
    Geanina Popoveniuc
    Division of Endocrinology, Department of Medicine, Georgetown University Hospital, Washington, DC 20010, USA
    Thyroid 20:1015-8. 2010
    ..We present two patients with Graves' disease and relatively rapid resolution of thymic enlargement after successful treatment of their hyperthyroidism...
  16. doi request reprint Does an undetectable rhTSH-stimulated Tg level 12 months after initial treatment of thyroid cancer indicate remission?
    Joanna Klubo-Gwiezdzinska
    Department of Medicine, Washington Hospital Center, DC 20010 2910, USA
    Clin Endocrinol (Oxf) 74:111-7. 2011
    ..The aim of our study was to evaluate the utility of repeated rhTSH-stimulated Tg measurements in patients with DTC who have had no evidence of disease at their initial rhTSH stimulation test performed 1 year after the treatment...
  17. doi request reprint Utility of the radioiodine whole-body retention at 48 hours for modifying empiric activity of 131-iodine for the treatment of metastatic well-differentiated thyroid carcinoma
    Douglas Van Nostrand
    Division of Nuclear Medicine, Department of Medicine, Washington Hospital Center, Washington, District of Columbia 20010, USA
    Thyroid 19:1093-8. 2009
    ..in 2003 for increasing or decreasing activity, and to determine the relationship between %WBR(48hr) and maximum tolerated activity (MTA)...
  18. doi request reprint Salivary gland malignancy and radioiodine therapy for thyroid cancer
    Joanna Klubo-Gwiezdzinska
    Department of Medicine, Washington Hospital Center, Washington, DC 20010 2910, USA
    Thyroid 20:647-51. 2010
    ..RAI residency within salivary tissues is known to have both acute and chronic consequences on salivary function, but secondary neoplasia is quite unusual...
  19. doi request reprint Detectability of foci of radioiodine uptake in the thyroid bed and neck comparing pinhole with parallel-hole collimators
    Kanchan Kulkarni
    Division of Nuclear Medicine, Washington Hospital Center, MedStar Research Institute, Washington, District of Columbia, USA
    Nucl Med Commun 32:369-74. 2011
    ....
  20. doi request reprint Potential use of recombinant human thyrotropin in the treatment of distant metastases in patients with differentiated thyroid cancer
    Joanna Klubo-Gwiezdzinska
    Division of Endocrinology, Department of Medicine, Washington Hospital Center, Washington, DC 20010, USA
    Endocr Pract 19:139-48. 2013
    ..The goal of this review is to present current data on the relative efficacy and side effects profile of rhTSH-aided versus THW-aided RAI therapy for the treatment of patients with distant metastases of DTC...
  21. doi request reprint Utility of PET/neck MRI digital fusion images in the management of recurrent or persistent thyroid cancer
    Laura Seiboth
    Endocrine Medicine Section, Washington Hospital Center, Georgetown University Medical Center, Washington, DC 20010, USA
    Thyroid 18:103-11. 2008
    ..We define standard imaging as a neck sonogram, 131I scan, computed tomography, and MRI...
  22. doi request reprint The utility of radioiodine scans prior to iodine 131 ablation in patients with well-differentiated thyroid cancer
    Douglas Van Nostrand
    Department of Medicine, Washington Hospital Center, District of Columbia 20010, USA
    Thyroid 19:849-55. 2009
    ..The utility of radioiodine (RAI) scans prior to (131)I ablation is controversial. The objective of this study was to evaluate the utility of RAI scans prior to (131)I ablation in patient with well-differentiated thyroid cancer...
  23. doi request reprint Metastases of well-differentiated thyroid cancer to the gastrointestinal system
    Joanna Klubo-Gwiezdzinska
    Department of Medicine, Washington Hospital Center, Washington, DC, USA
    Thyroid 20:381-7. 2010
    ..Of all sites for distant metastasis, gastrointestinal metastases of thyroid cancer are very uncommon and account for 0.5-1% of all distant metastases...
  24. doi request reprint Thyroid emergencies
    Joanna Klubo-Gwiezdzinska
    Division of Endocrinology, Department of Medicine, Washington Hospital Center, Washington, DC 20010 2910, USA
    Med Clin North Am 96:385-403. 2012
    ..Understanding the pathogenesis of these conditions, appropriate recognition of the clinical signs and symptoms, and their prompt and accurate diagnosis and treatment are crucial in optimizing survival...
  25. doi request reprint Salivary gland protection with sialagogues: a case study
    Douglas Van Nostrand
    Division Nuclear Medicine, Washington Hospital Center, Washington, District of Columbia 20010, USA
    Thyroid 19:1005-8. 2009
    ..One proposed mechanism is that sialagogues increased salivation and salivary blood flow resulting in greater radioiodine uptake in the salivary glands-a rebound effect. This case study demonstrates no rebound effect...
  26. doi request reprint Metformin inhibits growth and decreases resistance to anoikis in medullary thyroid cancer cells
    Joanna Klubo-Gwiezdzinska
    Department of Pediatrics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, Maryland 20814 4712, USA
    Endocr Relat Cancer 19:447-56. 2012
    ..Expression of metformin's molecular targets in human MTC cells suggests its potential utility for the treatment of MTC in patients...
  27. doi request reprint Clinical review: Ectopic cervical thyroid carcinoma--review of the literature with illustrative case series
    Joanna Klubo-Gwiezdzinska
    Department of Endocrinology, Washington Hospital Center, Washington, DC 20910, USA
    J Clin Endocrinol Metab 96:2684-91. 2011
    ....
  28. ncbi request reprint Radioiodine in the treatment of thyroid cancer
    Douglas Van Nostrand
    Division of Nuclear Medicine, Washington Hospital Center, and Georgetown University Medical Center, Washington, DC 20010, USA
    Endocrinol Metab Clin North Am 36:807-22, vii-viii. 2007
    ....
  29. ncbi request reprint The case for more aggressive screening and treatment of mild thyroid failure
    Alejandro R Ayala
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA
    Cleve Clin J Med 69:313-20. 2002
    ..We believe it should be screened for more aggressively in the general population, and treated with levothyroxine...
  30. doi request reprint Does lemon juice increase radioiodine reaccumulation within the parotid glands more than if lemon juice is not administered?
    Kanchan Kulkarni
    Divisions of aNuclear Medicine bEndocrinology, Medstar Washington Hospital Center cDivision of Statistics, MedStar Health Research Institute, Washington, District of Columbia, USA
    Nucl Med Commun 35:210-6. 2014
    ..The present study examined PG radiopharmacokinetics within 2-4 h after radioiodine administration to evaluate whether sialagogues cause a 'rebound effect'...
  31. doi request reprint The FDA revises requirements for levothyroxine products
    Kenneth Burman
    Georgetown University, Washington, DC, USA
    Thyroid 18:487-90. 2008
  32. ncbi request reprint The nonthyroidal illness syndrome
    Suzanne Myers Adler
    Department of Medicine, Washington Hospital Center, and Georgetown University School of Medicine, Building D, Suite 232, 4000 Reservoir Road, Washington, DC 20007, USA
    Endocrinol Metab Clin North Am 36:657-72, vi. 2007
    ....
  33. ncbi request reprint Integrating fine-needle aspiration into a daily practice involving thyroid disorders: the Washington Hospital Center approach
    Yolanda C Oertel
    Department of Pathology, Washington Hospital Center, Washington, D C 20010 2975, USA
    Diagn Cytopathol 27:120-2. 2002
  34. doi request reprint Primary thyroid lymphoma: a clinical review
    Stephanie Aleskow Stein
    Endocrinology Division, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Clin Endocrinol Metab 98:3131-8. 2013
    ..We review the epidemiology, clinical presentation, diagnosis, and treatment of this rare disorder...
  35. ncbi request reprint Dosimetrically determined doses of radioiodine for the treatment of metastatic thyroid carcinoma
    Douglas Van Nostrand
    Department of Medicine, Washington Hospital Center, Washington, DC 20010, USA
    Thyroid 12:121-34. 2002
    ..This review does not address use of dosimetrically-determined doses of radioiodine for the initial ablation of thyroid tissue postoperatively...
  36. ncbi request reprint Perioperative management of patients with hypothyroidism
    Nikolaos Stathatos
    Department of Medicine, Washington Hospital Center, 110 Irving Street NW, Washington, DC 20010, USA
    Endocrinol Metab Clin North Am 32:503-18. 2003
    ..Rather, we hold that T3 treatment of various surgical and other patients with nonthyroidal illness should be deferred until proof of its therapeutic efficacy is demonstrated...
  37. doi request reprint Thyrotoxicosis-induced ventricular arrhythmias
    Powlimi J Nadkarni
    Department of Endocrinology, Washington Hospital Center, Washington, District of Columbia 20010, USA
    Thyroid 18:1111-4. 2008
    ..Ventricular arrhythmias are rarely associated with thyrotoxicosis and are considered to be secondary to intrinsic cardiac disease...
  38. ncbi request reprint Hypocortisolemia in Graves hyperthyroidism
    Michael Karl
    The Department of Medicine, Section of Endocrinology, Washington Hospital Center, Washington, DC 20010, USA
    Endocr Pract 15:220-4. 2009
    ..To assess the risk of concomitant adrenal sufficiency in 2 patients with Graves thyrotoxicosis...
  39. ncbi request reprint Cardiovascular risk and subclinical hypothyroidism: focus on lipids and new emerging risk factors. What is the evidence?
    Leonidas H Duntas
    Endocrine Unit, Evgenidion Hospital, University of Athens, Medical School, 20 Papadiamantopolou Street, Athens, Greece
    Thyroid 17:1075-84. 2007
    ....
  40. ncbi request reprint Using baseline and recombinant human TSH-stimulated Tg measurements to manage thyroid cancer without diagnostic (131)I scanning
    Leonard Wartofsky
    J Clin Endocrinol Metab 87:1486-9. 2002
  41. doi request reprint Sunitinib-associated lymphocytic thyroiditis without circulating antithyroid antibodies
    Doru T Alexandrescu
    Thyroid 18:809-12. 2008
  42. ncbi request reprint Optimal thyrotropin level: normal ranges and reference intervals are not equivalent
    Richard A Dickey
    Thyroid 15:1035-9. 2005
    ..The terminology used for TSH results is clarified in an attempt to help physicians interpret, explain, and respond to TSH test results for their patients...
  43. ncbi request reprint Combined levotriiodothyronine and levothyroxine therapy for hypothyroidism: are we a step closer to the magic formula?
    Leonard Wartofsky
    Thyroid 14:247-8. 2004
  44. ncbi request reprint Levothyroxine therapy for hypothyroidism: should we abandon conservative dosage titration?
    Leonard Wartofsky
    Arch Intern Med 165:1683-4. 2005
  45. ncbi request reprint Graves' disease
    Rebecca Bahn
    J Clin Endocrinol Metab 92:2 p following 14A. 2007