W Kenneth Ward

Summary

Country: USA

Publications

  1. pmc Discomfort from an alkaline formulation delivered subcutaneously in humans: albumin at pH 7 versus pH 10
    W Kenneth Ward
    Legacy Health and Legacy Research Institute, Portland, OR, USA
    Clin Drug Investig 32:433-8. 2012
  2. pmc A controlled study of the effectiveness of an adaptive closed-loop algorithm to minimize corticosteroid-induced stress hyperglycemia in type 1 diabetes
    Joseph El Youssef
    Oregon Health and Science University, Portland, Oregon, USA
    J Diabetes Sci Technol 5:1312-26. 2011
  3. pmc Continuous glucose monitoring in subjects with type 1 diabetes: improvement in accuracy by correcting for background current
    Joseph El Youssef
    Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Diabetes Technol Ther 12:921-8. 2010
  4. doi request reprint Development of a fully automated closed loop artificial pancreas control system with dual pump delivery of insulin and glucagon
    Peter G Jacobs
    Portland VA Medical Center and the Oregon Health and Sciences University, Portland, OR 97239, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:397-400. 2011
  5. pmc Safe glycemic management during closed-loop treatment of type 1 diabetes: the role of glucagon, use of multiple sensors, and compensation for stress hyperglycemia
    W Kenneth Ward
    Oregon Health and Science University, Portland, Oregon 97239, USA
    J Diabetes Sci Technol 5:1373-80. 2011
  6. pmc The accuracy benefit of multiple amperometric glucose sensors in people with type 1 diabetes
    Jessica R Castle
    Department of Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, Oregon Health and Science University, Portland, Oregon, USA
    Diabetes Care 35:706-10. 2012
  7. pmc Factors influencing the effectiveness of glucagon for preventing hypoglycemia
    Jessica R Castle
    Oregon Health and Science University, Portland, Oregon 97239, USA
    J Diabetes Sci Technol 4:1305-10. 2010
  8. doi request reprint Stable liquid glucagon formulations for rescue treatment and bi-hormonal closed-loop pancreas
    Melanie A Jackson
    Oregon Health and Science University OHSU, 3181 SW Sam Jackson Park Road, OP05DC, Portland, OR 97239, USA
    Curr Diab Rep 12:705-10. 2012
  9. pmc In vitro and in vivo evaluation of native glucagon and glucagon analog (MAR-D28) during aging: lack of cytotoxicity and preservation of hyperglycemic effect
    W Kenneth Ward
    Legacy Health System Research, Portland, Oregon 97232, USA
    J Diabetes Sci Technol 4:1311-21. 2010
  10. pmc Novel use of glucagon in a closed-loop system for prevention of hypoglycemia in type 1 diabetes
    Jessica R Castle
    Department of Medicine, Division of Endocrinology, Oregon Health and Science University, Portland, Oregon, USA
    Diabetes Care 33:1282-7. 2010

Collaborators

  • Jessica R Castle
  • B Wayne Bequette
  • Joseph El Youssef
  • Peter G Jacobs
  • Melanie A Jackson
  • Deborah L Branigan
  • Ryan G Massoud
  • Julia M Engle
  • Charles T Roberts
  • Larry L David
  • Nicholas Caputo
  • Phillip Johnson
  • Matthew E Breen
  • Ryan Massoud
  • Apurv Kamath

Detail Information

Publications11

  1. pmc Discomfort from an alkaline formulation delivered subcutaneously in humans: albumin at pH 7 versus pH 10
    W Kenneth Ward
    Legacy Health and Legacy Research Institute, Portland, OR, USA
    Clin Drug Investig 32:433-8. 2012
    ..There is a paucity of data regarding tolerability of alkaline drugs administered subcutaneously. The aim of this study was to assess the tolerability of alkaline preparations of human albumin delivered subcutaneously to healthy humans...
  2. pmc A controlled study of the effectiveness of an adaptive closed-loop algorithm to minimize corticosteroid-induced stress hyperglycemia in type 1 diabetes
    Joseph El Youssef
    Oregon Health and Science University, Portland, Oregon, USA
    J Diabetes Sci Technol 5:1312-26. 2011
    ..6 ± 0.5%. We conclude that an adaptive algorithm that frequently estimates insulin sensitivity and adjusts gain factors is capable of minimizing corticosteroid-induced stress hyperglycemia...
  3. pmc Continuous glucose monitoring in subjects with type 1 diabetes: improvement in accuracy by correcting for background current
    Joseph El Youssef
    Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA
    Diabetes Technol Ther 12:921-8. 2010
    ..We also tested whether increasing the frequency of sensor calibration would improve sensor accuracy...
  4. doi request reprint Development of a fully automated closed loop artificial pancreas control system with dual pump delivery of insulin and glucagon
    Peter G Jacobs
    Portland VA Medical Center and the Oregon Health and Sciences University, Portland, OR 97239, USA
    Conf Proc IEEE Eng Med Biol Soc 2011:397-400. 2011
    ..Results from this work may ultimately lead to development of a portable, easy to use, artificial pancreas device that can enable far better glycemic control in patients with diabetes...
  5. pmc Safe glycemic management during closed-loop treatment of type 1 diabetes: the role of glucagon, use of multiple sensors, and compensation for stress hyperglycemia
    W Kenneth Ward
    Oregon Health and Science University, Portland, Oregon 97239, USA
    J Diabetes Sci Technol 5:1373-80. 2011
    ..Elements such as the use of glucagon to minimize hypoglycemia, adaptation to changes in insulin sensitivity, and sensor redundancy will likely increase safety during outpatient use of closed-loop glycemic control systems...
  6. pmc The accuracy benefit of multiple amperometric glucose sensors in people with type 1 diabetes
    Jessica R Castle
    Department of Medicine, Division of Endocrinology, Diabetes and Clinical Nutrition, Oregon Health and Science University, Portland, Oregon, USA
    Diabetes Care 35:706-10. 2012
    ..To improve glucose sensor accuracy in subjects with type 1 diabetes by using multiple sensors and to assess whether the benefit of redundancy is affected by intersensor distance...
  7. pmc Factors influencing the effectiveness of glucagon for preventing hypoglycemia
    Jessica R Castle
    Oregon Health and Science University, Portland, Oregon 97239, USA
    J Diabetes Sci Technol 4:1305-10. 2010
    ..Administration of small, intermittent doses of glucagon during closed-loop insulin delivery markedly reduces the frequency of hypoglycemia. However, in some cases, hypoglycemia occurs despite administration of glucagon in this setting...
  8. doi request reprint Stable liquid glucagon formulations for rescue treatment and bi-hormonal closed-loop pancreas
    Melanie A Jackson
    Oregon Health and Science University OHSU, 3181 SW Sam Jackson Park Road, OP05DC, Portland, OR 97239, USA
    Curr Diab Rep 12:705-10. 2012
    ..Assays for cyclic AMP (cAMP) or its downstream effector, protein kinase A (PKA), in engineered cell systems, are more reliable and suitable for inexpensive, high-throughput assessment of bioactivity...
  9. pmc In vitro and in vivo evaluation of native glucagon and glucagon analog (MAR-D28) during aging: lack of cytotoxicity and preservation of hyperglycemic effect
    W Kenneth Ward
    Legacy Health System Research, Portland, Oregon 97232, USA
    J Diabetes Sci Technol 4:1311-21. 2010
    ..However, under some conditions, solutions of glucagon can form amyloid fibrils. Currently, the usage instructions for commercially available glucagon allow only for its immediate use...
  10. pmc Novel use of glucagon in a closed-loop system for prevention of hypoglycemia in type 1 diabetes
    Jessica R Castle
    Department of Medicine, Division of Endocrinology, Oregon Health and Science University, Portland, Oregon, USA
    Diabetes Care 33:1282-7. 2010
    ..To minimize hypoglycemia in subjects with type 1 diabetes by automated glucagon delivery in a closed-loop insulin delivery system...
  11. doi request reprint Controlled release of dexamethasone from subcutaneously-implanted biosensors in pigs: localized anti-inflammatory benefit without systemic effects
    W Kenneth Ward
    Legacy Health System, Portland, Oregon, USA
    J Biomed Mater Res A 94:280-7. 2010
    ..c) 2010 Wiley Periodicals, Inc. J Biomed Mater Res, 2010...