Anthony J Williams

Summary

Affiliation: Walter Reed Army Medical Center
Country: USA

Publications

  1. ncbi request reprint Topiramate reduces non-convulsive seizures after focal brain ischemia in the rat
    Anthony J Williams
    Walter Reed Army Institute of Research, Department of Applied Neurobiology, Silver Spring, MD 20910, United States
    Neurosci Lett 430:7-12. 2008
  2. ncbi request reprint Neuroprotective effects of the sodium channel blocker RS100642 and attenuation of ischemia-induced brain seizures in the rat
    Anthony J Williams
    Department of Neuropharmacology and Molecular Biology, Division of Neurosciences, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Brain Res 932:45-55. 2002
  3. pmc Acute and delayed neuroinflammatory response following experimental penetrating ballistic brain injury in the rat
    Anthony J Williams
    Walter Reed Army Institute of Research, Dept of Applied Neurobiology, Silver Spring, MD, USA
    J Neuroinflammation 4:17. 2007
  4. ncbi request reprint Characterization of a new rat model of penetrating ballistic brain injury
    Anthony J Williams
    Department of Applied Neurobiology, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    J Neurotrauma 22:313-31. 2005
  5. ncbi request reprint Severity level and injury track determine outcome following a penetrating ballistic-like brain injury in the rat
    Anthony J Williams
    Walter Reed Army Institute of Research, Department of Applied Neurobiology, Silver Spring, MD 20910, USA
    Neurosci Lett 408:183-8. 2006
  6. ncbi request reprint Delayed treatment of ischemia/reperfusion brain injury: extended therapeutic window with the proteosome inhibitor MLN519
    Anthony J Williams
    Department of Neuropharmacology and Molecular Biology, Division of Neurosciences, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Stroke 35:1186-91. 2004
  7. ncbi request reprint Penetrating ballistic-like brain injury in the rat: differential time courses of hemorrhage, cell death, inflammation, and remote degeneration
    Anthony J Williams
    Department of Applied Neurobiology, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    J Neurotrauma 23:1828-46. 2006
  8. ncbi request reprint Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia
    A J Williams
    Department of Applied Neurobiology, Division of Neurosciences, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Pharmacol Exp Ther 311:220-7. 2004
  9. ncbi request reprint Neuroprotection with the proteasome inhibitor MLN519 in focal ischemic brain injury: relation to nuclear factor kappaB (NF-kappaB), inflammatory gene expression, and leukocyte infiltration
    Anthony J Williams
    Walter Reed Army Institute of Research, Department of Applied Neurobiology, Silver Spring, MD 20910, United States
    Neurochem Int 49:106-12. 2006
  10. ncbi request reprint Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats
    Anthony J Williams
    Department of Applied Neurobiology, Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Pharmacol Exp Ther 318:947-55. 2006

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Topiramate reduces non-convulsive seizures after focal brain ischemia in the rat
    Anthony J Williams
    Walter Reed Army Institute of Research, Department of Applied Neurobiology, Silver Spring, MD 20910, United States
    Neurosci Lett 430:7-12. 2008
    ..In conclusion, TPM exhibited significant efficacy for the prophylactic treatment of brain-injury induced NCS and represents a novel class of AED for treatment of this type of silent brain seizure...
  2. ncbi request reprint Neuroprotective effects of the sodium channel blocker RS100642 and attenuation of ischemia-induced brain seizures in the rat
    Anthony J Williams
    Department of Neuropharmacology and Molecular Biology, Division of Neurosciences, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Brain Res 932:45-55. 2002
    ....
  3. pmc Acute and delayed neuroinflammatory response following experimental penetrating ballistic brain injury in the rat
    Anthony J Williams
    Walter Reed Army Institute of Research, Dept of Applied Neurobiology, Silver Spring, MD, USA
    J Neuroinflammation 4:17. 2007
    ..Here we characterize and contrast both an acute and delayed phase of inflammation following experimental penetrating ballistic brain injury (PBBI) in rats out to 7 days post-injury...
  4. ncbi request reprint Characterization of a new rat model of penetrating ballistic brain injury
    Anthony J Williams
    Department of Applied Neurobiology, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    J Neurotrauma 22:313-31. 2005
    ....
  5. ncbi request reprint Severity level and injury track determine outcome following a penetrating ballistic-like brain injury in the rat
    Anthony J Williams
    Walter Reed Army Institute of Research, Department of Applied Neurobiology, Silver Spring, MD 20910, USA
    Neurosci Lett 408:183-8. 2006
    ....
  6. ncbi request reprint Delayed treatment of ischemia/reperfusion brain injury: extended therapeutic window with the proteosome inhibitor MLN519
    Anthony J Williams
    Department of Neuropharmacology and Molecular Biology, Division of Neurosciences, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Stroke 35:1186-91. 2004
    ..In this study, we evaluated the neuroprotection TW for the proteosome inhibitor MLN519 after ischemia/reperfusion brain injury in rats as related to its antiinflammatory mechanism...
  7. ncbi request reprint Penetrating ballistic-like brain injury in the rat: differential time courses of hemorrhage, cell death, inflammation, and remote degeneration
    Anthony J Williams
    Department of Applied Neurobiology, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    J Neurotrauma 23:1828-46. 2006
    ..The similarities/differences of PBBI to other focal brain injury models are discussed...
  8. ncbi request reprint Antiepileptic drug treatment of nonconvulsive seizures induced by experimental focal brain ischemia
    A J Williams
    Department of Applied Neurobiology, Division of Neurosciences, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Pharmacol Exp Ther 311:220-7. 2004
    ..Based on combined effects on NCS, infarction, neurological recovery, and mortality, ethosuximide and gabapentin were identified as having the best therapeutic profile...
  9. ncbi request reprint Neuroprotection with the proteasome inhibitor MLN519 in focal ischemic brain injury: relation to nuclear factor kappaB (NF-kappaB), inflammatory gene expression, and leukocyte infiltration
    Anthony J Williams
    Walter Reed Army Institute of Research, Department of Applied Neurobiology, Silver Spring, MD 20910, United States
    Neurochem Int 49:106-12. 2006
    ..It is the aim of this paper to review the experimental neuroprotection data reported using MLN519 with a focus on the molecular and cellular mechanisms of anti-inflammatory action...
  10. ncbi request reprint Evaluation of gabapentin and ethosuximide for treatment of acute nonconvulsive seizures following ischemic brain injury in rats
    Anthony J Williams
    Department of Applied Neurobiology, Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Pharmacol Exp Ther 318:947-55. 2006
    ..We conclude that EXM and GBP significantly attenuate NCS in a dose-related manner and may help to improve patient outcome from brain ischemia-induced seizure activity...
  11. ncbi request reprint Recovery from ischemic brain injury in the rat following a 10 h delayed injection with MLN519
    Anthony J Williams
    Department of Applied Neurobiology, Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Room 2A40, Silver Spring, MD 20910, USA
    Pharmacol Biochem Behav 81:182-9. 2005
    ..Overall, delayed treatment with MLN519 provided significant improvement in 3 of 6 test metrics (histopathology, body weight, and neurological dysfunction) supporting improved outcome for brain-injured subjects...
  12. ncbi request reprint Delayed treatment with MLN519 reduces infarction and associated neurologic deficit caused by focal ischemic brain injury in rats via antiinflammatory mechanisms involving nuclear factor-kappaB activation, gliosis, and leukocyte infiltration
    Anthony J Williams
    Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    J Cereb Blood Flow Metab 23:75-87. 2003
    ..This improved neuroprotection profile and antiinflammatory effect of MLN519 provides an exciting avenue for potential treatment of focal ischemic brain injury in humans...
  13. ncbi request reprint Studies on neuronal apoptosis in primary forebrain cultures: neuroprotective/anti-apoptotic action of NR2B NMDA antagonists
    Jitendra R Dave
    Department of Neuropharmacology and Molecular Biology, Division of Neurosciences, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Neurotox Res 5:255-64. 2003
    ..These studies demonstrate that NR2B NMDA receptor antagonists are anti-apoptotic and may mediate their action via mechanism(s) that are dependent or independent of caspase-3 activation...
  14. pmc P43/pro-EMAPII: a potential biomarker for discriminating traumatic versus ischemic brain injury
    Changping Yao
    Department of Applied Neurobiology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Neurotrauma 26:1295-305. 2009
    ....
  15. ncbi request reprint Broad spectrum neuroprotection profile of phosphodiesterase inhibitors as related to modulation of cell-cycle elements and caspase-3 activation
    Ren Wu Chen
    Department of Applied Neurobiology, Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Neurosci Lett 418:165-9. 2007
    ..Overall, these data indicate that PDEIs are broad-spectrum neuroprotective agents acting through modulation of cell cycle elements and may offer a novel mode of therapy against acute injury to the brain...
  16. ncbi request reprint Quantitative real-time RT-PCR analysis of inflammatory gene expression associated with ischemia-reperfusion brain injury
    Rossana Berti
    Neuropharmacology and Molecular Biology Department, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
    J Cereb Blood Flow Metab 22:1068-79. 2002
    ....
  17. doi request reprint NNZ-2566, a glypromate analog, attenuates brain ischemia-induced non-convulsive seizures in rats
    Xi Chun M Lu
    Department of Applied Neurobiology, Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    J Cereb Blood Flow Metab 29:1924-32. 2009
    ..Results indicate that NNZ-2566 possesses a unique therapeutic potential as a safe prophylactic agent that synergistically provides neuroprotection and reduces injury-induced seizures...
  18. ncbi request reprint Effects of delayed intrathecal infusion of an NMDA receptor antagonist on ischemic injury and peri-infarct depolarizations
    X C May Lu
    Division of Psychiatry and Neurosciences, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910, USA
    Brain Res 1056:200-8. 2005
    ..Results suggest that post-reperfusion PIDs play a substantial, though still undefined pathogenic role in delayed maturation of cerebral infarction and NMDA receptor-targeted neuroprotection...
  19. ncbi request reprint Neuroprotection assessment by topographic electroencephalographic analysis: effects of a sodium channel blocker to reduce polymorphic delta activity following ischaemic brain injury in rats
    Anthony J Williams
    Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Fundam Clin Pharmacol 17:581-93. 2003
    ..These methods of EEG analysis may be helpful tools to evaluate the physiological recovery of the brain from injury in humans following treatment with an experimental neuroprotective compound...
  20. doi request reprint Detection of protein biomarkers using high-throughput immunoblotting following focal ischemic or penetrating ballistic-like brain injuries in rats
    Changping Yao
    Department of Applied Neurobiology, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Brain Inj 22:723-32. 2008
    ..Recent efforts have been aimed at developing a panel of protein biomarkers for the diagnosis/prognosis of the neurological damage associated with acute brain injury...
  21. doi request reprint Neuroprotective profile of dextromethorphan in an experimental model of penetrating ballistic-like brain injury
    Deborah A Shear
    Walter Reed Army Institute of Research, Department of Applied Neurobiology, Silver Spring, MD 21045, USA
    Pharmacol Biochem Behav 94:56-62. 2009
    ..Although post-injury administration of DM (all doses) failed to reduce core lesion size, the maximum dose of DM (10 mg/kg) was effective in reducing silver-stained axonal fiber degeneration in the cortical regions adjacent to the injury...
  22. ncbi request reprint Microarray analysis of acute and delayed gene expression profile in rats after focal ischemic brain injury and reperfusion
    X C May Lu
    Division of Neuroscience, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    J Neurosci Res 77:843-57. 2004
    ....
  23. ncbi request reprint Occurrence of nonconvulsive seizures, periodic epileptiform discharges, and intermittent rhythmic delta activity in rat focal ischemia
    Jed A Hartings
    Division of Neurosciences, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Exp Neurol 179:139-49. 2003
    ....
  24. doi request reprint Modeling cerebral ischemia in neuroproteomics
    Jitendra R Dave
    Department of Applied Neurobiology, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Methods Mol Biol 566:25-40. 2009
    ..Identification of proteins can be achieved by comparing the mass-to-charge data to protein sequences in respective databases...
  25. ncbi request reprint Selective NR2B NMDA receptor antagonists are protective against staurosporine-induced apoptosis
    Anthony J Williams
    Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Eur J Pharmacol 452:135-6. 2002
    ..01-10 microM) but 34-64% cellular survival was provided by ifenprodil (0.01-10 microM), another NR2B subunit-selective antagonist. These results suggest a novel anti-apoptotic mechanism linked to the NR2B receptor subunit...
  26. ncbi request reprint Intrathecal CGX-1007 is neuroprotective in a rat model of focal cerebral ischemia
    Anthony J Williams
    Department of Neuropharmacology and Molecular Biology, Division of Neurosciences, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Neuroreport 13:821-4. 2002
    ..Critically, this is the first comprehensive report of a neuroprotective agent that can be administered i.t. to ameliorate experimental brain injury and potentially provide an excellent therapeutic window as a neuroprotection treatment...
  27. ncbi request reprint Treatment with the snail peptide CGX-1007 reduces DNA damage and alters gene expression of c-fos and bcl-2 following focal ischemic brain injury in rats
    A J Williams
    Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Exp Brain Res 153:16-26. 2003
    ..In conclusion, CGX-1007 effectively attenuated gene expression associated with delayed cell death as related to a neuroprotective relief of cerebral ischemia...
  28. ncbi request reprint Central neuro-inflammatory gene response following soman exposure in the rat
    A J Williams
    Walter Reed Army Institute of Research, Division of Neurosciences, Silver Spring, MD 20910, USA
    Neurosci Lett 349:147-50. 2003
    ..In conclusion, an acute and transient upregulation of the inflammatory gene response is activated following soman exposure that may be involved in the soman-induced brain injury process...
  29. ncbi request reprint Quantitative electroencephalography spectral analysis and topographic mapping in a rat model of middle cerebral artery occlusion
    X C Lu
    Department of Neuropharmacology and Molecular Biology, Division of Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Neuropathol Appl Neurobiol 27:481-95. 2001
    ..The similarities of rat qEEG profiles identified in this study to that of stroke patients and the application of topographic mapping broaden our research technology for preclinical experimental studies of brain injury...
  30. ncbi request reprint Down-regulation of the sodium channel Na(v)1.1 alpha-subunit following focal ischemic brain injury in rats: in situ hybridization and immunohistochemical analysis
    C Yao
    Department of Applied Neurobiology, Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Room 2A40, Silver Spring, MD 20910 7500, USA
    Life Sci 77:1116-29. 2005
    ..1 immunoreactivity was in neurons. In conclusion, these data map the time-dependent loss of Na(v)1.1 mRNA and protein following focal ischemic brain injury in the rat out to 48 h post-injury...
  31. ncbi request reprint The sodium channel blocker RS100642 reverses down-regulation of the sodium channel alpha-subunit Na(v) 1.1 expression caused by transient ischemic brain injury in rats
    C Yao
    Division of Neurosciences, Walter Reed Army Institute of Research, 503 Robert Grant Ave Rm 2W14, Silver Spring, MD 20910 7500, USA
    Neurotox Res 5:245-53. 2003
    ..1 NaCh Alpha-subunit may play a key role in the neuronal injury/recovery process...
  32. ncbi request reprint Effect of the proteasome inhibitor MLN519 on the expression of inflammatory molecules following middle cerebral artery occlusion and reperfusion in the rat
    R Berti
    Division of Neurosciences, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Neurotox Res 5:505-14. 2003
    ....
  33. ncbi request reprint Electroencephalogram analysis and neuroprotective profile of the N-acetylated-alpha-linked acidic dipeptidase inhibitor, GPI5232, in normal and brain-injured rats
    A J Williams
    Department of Neuropharmacology and Molecular Biology, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
    J Pharmacol Exp Ther 299:48-57. 2001
    ..These results show GPI5232 to be an effective neuroprotective treatment when given postinjury by reducing brain infarction and ameliorating the pathological EEG associated with focal brain ischemia...
  34. ncbi request reprint Is there a link between calcium oxalate crystalluria, orlistat and acute tubular necrosis?
    Lazarus Karamadoukis
    Nephrol Dial Transplant 23:1778-9. 2008