Research Topics
Species | L A SonnaSummaryAffiliation: Walter Reed Army Medical Center Country: USA Publications
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Detail Information
Publications
The prevalence of exercise-induced bronchospasm among US Army recruits and its effects on physical performanceL A Sonna
US Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
Chest 119:1676-84. 2001..To measure the prevalence of exercise-induced bronchospasm (EIB) and to determine its effect on the physical performance response to training in otherwise healthy young adults...
Exertional heat injury and gene expression changes: a DNA microarray analysis studyLarry A Sonna
Thermal and Mountain Medicine Div, United States Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
J Appl Physiol 96:1943-53. 2004..The molecular evidence from these patients is thus consistent with the hypothesis that EHI can result from cumulative effects of multiple adverse interacting stimuli...
Effect of hypoxia on gene expression by human hepatocytes (HepG2)Larry A Sonna
Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
Physiol Genomics 12:195-207. 2003....
Effect of acute heat shock on gene expression by human peripheral blood mononuclear cellsLarry A Sonna
Thermal and Mountain Medicine Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760, USA
J Appl Physiol 92:2208-20. 2002..We conclude that heat shock causes extensive gene expression changes in PBMCs, affecting all functional categories of the heat shock response...
Invited review: Effects of heat and cold stress on mammalian gene expressionLarry A Sonna
Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760, USA
J Appl Physiol 92:1725-42. 2002..The similarities and differences between the cellular responses to heat and cold may yield key insights into how cells, and by extension tissues and organisms, survive and adapt to stress...
Pulmonary oedema at moderately high altitudesLarry A Sonna
Thermal and Mountain Medicine Division, US Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
Lancet 359:276-7. 2002
Angiotensin-converting enzyme genotype and physical performance during US Army basic trainingL A Sonna
Thermal and Mountain Medicine Division, US Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760, USA
J Appl Physiol 91:1355-63. 2001..We conclude that ACE genotype does not have a strong effect on aerobic power or muscular endurance in healthy, young American adults drawn from an ethnically and geographically diverse population...
Exertional heat illness and human gene expressionLarry A Sonna
Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Prog Brain Res 162:321-46. 2007....
DNA sequence variants in epithelium-specific ETS-2 and ETS-3 are not associated with asthmaRebecca M Baron
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
Am J Respir Crit Care Med 166:927-32. 2002..This study suggests that epithelium-specific ETS-2 and ETS-3 genes are unlikely to contain polymorphic loci that have a major impact on asthma susceptibility in our population...
DNA microarray analysis of vitamin D-induced gene expression in a human colon carcinoma cell lineRichard J Wood
Mineral Bioavailability Laboratory, Jean Mayer United States Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Boston 02111, USA
Physiol Genomics 17:122-9. 2004..The known function of these genes suggests that many of them could be involved in the antiproliferative effects of 1,25-dihydroxyvitamin D3...
Effect of moderate hypothermia on gene expression by THP-1 cells: a DNA microarray studyLarry A Sonna
Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts, USA
Physiol Genomics 26:91-8. 2006..These in vitro findings suggest that prolonged hypothermia in vivo might be capable of producing physiologically relevant changes in gene expression by circulating leukocytes...
Effects of allergen challenge on airway epithelial cell gene expressionCraig M Lilly
Pulmonary and Critical Care Division, Brigham and Women s Hospital, 75 Francis Street, Thorn 826C, Boston, MA 02115, USA
Am J Respir Crit Care Med 171:579-86. 2005....
Role of prostanoid DP receptor variants in susceptibility to asthmaTsuyoshi Oguma
Combined Program in Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
N Engl J Med 351:1752-63. 2004..A study of a mouse model suggests that the receptor is required for the expression of the asthma phenotype. Our associations of asthma with functional genetic variants of PTGDR link these observations...
Monocyte chemotactic protein-4 (MCP-4; CCL-13): a biomarker of asthmaOmer Kalayci
The Combined Program in Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Asthma 41:27-33. 2004..Elevated MCP-4 levels identify a group of asthmatics with systemic evidence of allergic inflammation who may be at risk for exacerbations or may benefit from abrogation of MCP-4...
Exercise, genetics, and blood pressure: focus on "physical exercise and blood pressure with reference to the angiotensinogen M235T polymorphism" and on "angiotensinogen M235T polymorphism associates with exercise hemodynamics in postmenopauLarry A Sonna
Physiol Genomics 10:45-7. 2002
Heat shock protein 90beta: a novel mediator of vitamin D actionGiana Angelo
Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Mineral Bioavailability Laboratory, 711 Washington Street, Boston, MA 02111, USA
Biochem Biophys Res Commun 367:578-83. 2008..These findings indicate that Hsp90beta is needed for optimal vitamin D responsiveness in the enterocyte and demonstrate a specific role for Hsp90beta in VDR signaling...
