Connie S Schmaljohn

Summary

Affiliation: Walter Reed Army Medical Center
Country: USA

Publications

  1. ncbi request reprint DNA vaccines for HFRS: Laboratory and clinical studies
    Connie S Schmaljohn
    U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA Electronic address
    Virus Res 187:91-6. 2014
  2. pmc High-resolution functional mapping of the venezuelan equine encephalitis virus genome by insertional mutagenesis and massively parallel sequencing
    Brett F Beitzel
    The United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America
    PLoS Pathog 6:e1001146. 2010
  3. pmc Endothelial cell permeability during hantavirus infection involves factor XII-dependent increased activation of the kallikrein-kinin system
    Shannon L Taylor
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America
    PLoS Pathog 9:e1003470. 2013
  4. pmc Military vaccines in today's environment
    Connie S Schmaljohn
    Office of the Senior Scientists, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD USA
    Hum Vaccin Immunother 8:1126-8. 2012
  5. pmc A fusion-inhibiting peptide against Rift Valley fever virus inhibits multiple, diverse viruses
    Jeffrey W Koehler
    United States Army Medical Research Institute of Infectious Diseases, Virology Division, Fort Detrick, Maryland, United States of America
    PLoS Negl Trop Dis 7:e2430. 2013
  6. pmc A DNA vaccine for venezuelan equine encephalitis virus delivered by intramuscular electroporation elicits high levels of neutralizing antibodies in multiple animal models and provides protective immunity to mice and nonhuman primates
    Lesley C Dupuy
    Virology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 5011, USA
    Clin Vaccine Immunol 18:707-16. 2011
  7. doi request reprint Immunogenicity and protective efficacy of a DNA vaccine against Venezuelan equine encephalitis virus aerosol challenge in nonhuman primates
    Lesley C Dupuy
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 5011, USA
    Vaccine 28:7345-50. 2010
  8. pmc A multiagent filovirus DNA vaccine delivered by intramuscular electroporation completely protects mice from ebola and Marburg virus challenge
    Rebecca J Grant-Klein
    U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
    Hum Vaccin Immunother 8:1703-6. 2012
  9. pmc Nuclear relocalization of polyadenylate binding protein during rift valley fever virus infection involves expression of the NSs gene
    Anna Maria Copeland
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA
    J Virol 87:11659-69. 2013
  10. doi request reprint Novel plant-derived recombinant human interferons with broad spectrum antiviral activity
    Jeffrey W Koehler
    U S Army Medical Research Institute of Infectious Diseases, Virology Division, Fort Detrick, MD 21702, USA
    Antiviral Res 92:461-9. 2011

Collaborators

Detail Information

Publications19

  1. ncbi request reprint DNA vaccines for HFRS: Laboratory and clinical studies
    Connie S Schmaljohn
    U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA Electronic address
    Virus Res 187:91-6. 2014
    ..Despite these advantages, issues relating to inconsistent immunogenicity and immune interference remain to be addressed. ..
  2. pmc High-resolution functional mapping of the venezuelan equine encephalitis virus genome by insertional mutagenesis and massively parallel sequencing
    Brett F Beitzel
    The United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America
    PLoS Pathog 6:e1001146. 2010
    ..The recombinant ts mutants will be valuable tools for further studies of VEEV replication and virulence. Moreover, the method that we developed is applicable for generating such tools for any virus with a robust reverse genetics system...
  3. pmc Endothelial cell permeability during hantavirus infection involves factor XII-dependent increased activation of the kallikrein-kinin system
    Shannon L Taylor
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, United States of America
    PLoS Pathog 9:e1003470. 2013
    ..These data are the first to demonstrate KKS activation during hantavirus infection and could have profound implications for treatment of hantavirus infections. ..
  4. pmc Military vaccines in today's environment
    Connie S Schmaljohn
    Office of the Senior Scientists, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD USA
    Hum Vaccin Immunother 8:1126-8. 2012
    ..Without innovative vaccine technologies, streamlined regulatory strategies, and coordinating efforts for use in civilian populations where appropriate, the military vaccine development program is in jeopardy...
  5. pmc A fusion-inhibiting peptide against Rift Valley fever virus inhibits multiple, diverse viruses
    Jeffrey W Koehler
    United States Army Medical Research Institute of Infectious Diseases, Virology Division, Fort Detrick, Maryland, United States of America
    PLoS Negl Trop Dis 7:e2430. 2013
    ..These results could provide novel insights into conserved features among the three classes of viral fusion proteins and offer direction for the future development of broadly active fusion inhibitors. ..
  6. pmc A DNA vaccine for venezuelan equine encephalitis virus delivered by intramuscular electroporation elicits high levels of neutralizing antibodies in multiple animal models and provides protective immunity to mice and nonhuman primates
    Lesley C Dupuy
    Virology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 5011, USA
    Clin Vaccine Immunol 18:707-16. 2011
    ..Taken together, our results demonstrate that this DNA vaccine provides a potent means of protecting against VEEV infections and represents an attractive candidate for further development...
  7. doi request reprint Immunogenicity and protective efficacy of a DNA vaccine against Venezuelan equine encephalitis virus aerosol challenge in nonhuman primates
    Lesley C Dupuy
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 5011, USA
    Vaccine 28:7345-50. 2010
    ..Therefore, although the sample size was small in this pilot study, these results indicate that a VEEV DNA vaccine administered by PMED can at least partially protect nonhuman primates against an aerosol VEEV challenge...
  8. pmc A multiagent filovirus DNA vaccine delivered by intramuscular electroporation completely protects mice from ebola and Marburg virus challenge
    Rebecca J Grant-Klein
    U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
    Hum Vaccin Immunother 8:1703-6. 2012
    ..These data suggest that further analysis of the immune responses generated in the mice and additional protection studies in nonhuman primates are warranted...
  9. pmc Nuclear relocalization of polyadenylate binding protein during rift valley fever virus infection involves expression of the NSs gene
    Anna Maria Copeland
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA
    J Virol 87:11659-69. 2013
    ..Together, these results suggest that production of the NSs protein during RVFV infection leads to sequestration of PABP1 in the nuclear speckles, creating a state within the cell that favors viral protein production. ..
  10. doi request reprint Novel plant-derived recombinant human interferons with broad spectrum antiviral activity
    Jeffrey W Koehler
    U S Army Medical Research Institute of Infectious Diseases, Virology Division, Fort Detrick, MD 21702, USA
    Antiviral Res 92:461-9. 2011
    ..Using three-dimensional models based on a recently solved experimental structure of IFN bound to IFNAR, we show that many but not all of the amino acids that were highly selected for are predicted to improve receptor binding...
  11. doi request reprint Progress in recombinant DNA-derived vaccines for Lassa virus and filoviruses
    Rebecca J Grant-Klein
    U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
    Virus Res 162:148-61. 2011
    ..In this review, we consider the status of various recombinant DNA candidate vaccines against Lassa virus and filoviruses which have been tested in animals...
  12. doi request reprint DNA vaccines for biodefense
    Lesley C Dupuy
    Heaadquauarters, Unnited Staates Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
    Expert Rev Vaccines 8:1739-54. 2009
    ....
  13. doi request reprint Inhibition of TNF-alpha-induced activation of NF-kappaB by hantavirus nucleocapsid proteins
    Shannon L Taylor
    Science and Technology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA
    Ann N Y Acad Sci 1171:E86-93. 2009
    ..These studies provide evidence that hantaviruses differ in their abilities to interfere with host innate immune responses...
  14. doi request reprint Crimean-Congo hemorrhagic fever virus utilizes a clathrin- and early endosome-dependent entry pathway
    Aura R Garrison
    United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Maryland, USA
    Virology 444:45-54. 2013
    ..These results indicate that CCHFV likely enters cells through the early endosomal compartment. ..
  15. doi request reprint Directed molecular evolution improves the immunogenicity and protective efficacy of a Venezuelan equine encephalitis virus DNA vaccine
    Lesley C Dupuy
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
    Vaccine 27:4152-60. 2009
    ..Our results indicate that it is possible to improve the immunogenicity and protective efficacy of alphavirus DNA vaccines using directed molecular evolution...
  16. ncbi request reprint Cassette vectors for conversion of Fab fragments into full-length human IgG1 monoclonal antibodies by expression in stably transformed insect cells
    Mary C Guttieri
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 5011, USA
    Hybrid Hybridomics 22:135-45. 2003
    ..We conclude that our cassette vectors could serve as valuable tools for generating human IgG(1) antibodies...
  17. pmc IFITM-2 and IFITM-3 but not IFITM-1 restrict Rift Valley fever virus
    Rajini Mudhasani
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland USA
    J Virol 87:8451-64. 2013
    ..Collectively, our data provide new insights into the possible mechanisms by which the IFITM family members restrict distinct viruses. ..
  18. ncbi request reprint Andes virus infection of cynomolgus macaques
    Anita K McElroy
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA
    J Infect Dis 186:1706-12. 2002
    ..This study is the first demonstration of infection of nonhuman primates by an HPS-causing virus...
  19. pmc Hantaan virus nucleocapsid protein binds to importin alpha proteins and inhibits tumor necrosis factor alpha-induced activation of nuclear factor kappa B
    Shannon L Taylor
    Science and Technology Division, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA
    J Virol 83:1271-9. 2009
    ..These findings, which were obtained using cells transfected with cDNA representing the HTNV N gene, were confirmed using HTNV-infected cells...