Research Topics
Species | Michael N SawkaSummaryAffiliation: Walter Reed Army Medical Center Country: USA Publications
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Publications
Human water needsMichael N Sawka
Thermal and Mountain Medicine Division, US Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
Nutr Rev 63:S30-9. 2005..7 L for adult women meets the needs of the vast majority of persons. However, strenuous physical exercise and heat stress can greatly increase daily water needs, and the individual variability between athletes can be substantial...
Efficacy of body ventilation system for reducing strain in warm and hot climatesTroy D Chinevere
US Army Research Institute of Environmental Medicine, Natick, Boston, MA 01757, USA
Eur J Appl Physiol 103:307-14. 2008..05), but not HW. These results indicate that BVS(On) reduces physiological strain in all three environments by a similar amount; however, in hot-dry conditions the BVS(Off) increases physiological strain...
Intermittent microclimate cooling during exercise-heat stress in US army chemical protective clothingBruce S Cadarette
U S Army Research Institute of Environmental Medicine, Kansas St, Natick, MA 01760 5007, USA
Ergonomics 49:209-19. 2006..m(-2)) ( p < 0.05). These findings suggest that IC provided a favourable skin to LCG gradient for heat dissipation by conduction and reduced heat strain comparable to CC during exercise-heat stress in chemical protective clothing...
Prior heat stress: effect on subsequent 15-min time trial performance in the heatRobert W Kenefick
US Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
Med Sci Sports Exerc 41:1311-6. 2009..The impact of prior heat stress on subsequent aerobic exercise-heat performance has not been studied...
Effect of hypohydration and altitude exposure on aerobic exercise performance and acute mountain sicknessJohn W Castellani
Thermal and Mountain Medicine Division, U S Army Research Institute of Environmental Medicine, 42 Kansas St, Natick, MA 01760 5007, USA
J Appl Physiol 109:1792-800. 2010..07). In conclusion, hypohydration at 3,048 m 1) degrades aerobic performance in an additive manner with that induced by ALT; and 2) did not appear to increase the prevalence/severity of AMS symptoms...
Seven intermittent exposures to altitude improves exercise performance at 4300 mBeth A Beidleman
Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
Med Sci Sports Exerc 40:141-8. 2008....
DEET insect repellent: effects on thermoregulatory sweating and physiological strainRobert W Kenefick
Thermal and Mountain Medicine Division, US Army Research Institute of Environmental Medicine, Kansas Street, Natick, MA 01760, USA
Eur J Appl Physiol 111:3061-8. 2011..DEET can be safely worn during military, occupational and recreational activities in hot, insect infested environments...
Impact of a protective vest and spacer garment on exercise-heat strainSamuel N Cheuvront
Thermal and Mountain Medicine Division, US Army Research Institute of Environmental Medicine, Kansas Street, Natick, MA 01760 5007, USA
Eur J Appl Physiol 102:577-83. 2008..05). SR was higher (P < 0.05) in P and S versus B, but the magnitude of differences was small. A protective vest increases physiological strain independent of added load, while a spacer garment does not alter this outcome...
No effect of nutritional adenosine receptor antagonists on exercise performance in the heatSamuel N Cheuvront
U S Army Research Institute of Environmental Medicine, Thermal and Mountain Medicine Division, Kansas St, Natick, MA 01760 5007, USA
Am J Physiol Regul Integr Comp Physiol 296:R394-401. 2009..05) or the self-selected pacing strategy employed. These findings indicate that the nutritional adenosine receptor antagonists caffeine and quercetin do not enhance endurance exercise performance during compensable heat stress...
Serum S-100beta response to exercise-heat strain before and after acclimationSamuel N Cheuvront
US Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
Med Sci Sports Exerc 40:1477-82. 2008..However, the explanatory power of exercise with marked environmental heat stress on the appearance of S-100beta is questionable. It is possible that the process of heat acclimation might afford additional insight...
A simple and valid method to determine thermoregulatory sweating threshold and sensitivitySamuel N Cheuvront
US Army Research Institute of Environmental Medicine, Thermal and Mountain Medicine Division, Kansas St, Natick, MA 01760 5007, USA
J Appl Physiol 107:69-75. 2009..Rater and SReg were not different by conventional t-test (P > 0.05). SReg provides a simple, valid, and standardized way to determine sweating threshold temperature and sweating sensitivity values for thermoregulatory studies...
Mechanisms of aerobic performance impairment with heat stress and dehydrationSamuel N Cheuvront
US Army Research Institute of Environmental Medicine, Thermal and Mountain Medicine Division, Kansas St, Natick, MA 01760 5007, USA
J Appl Physiol 109:1989-95. 2010..Dehydration augments hyperthermia and plasma volume reductions, which combine to accentuate cardiovascular strain and reduce Vo(2max). Importantly, the negative performance consequences of dehydration worsen as T(sk) increases...
White blood cell and hormonal responses to 4300 m altitude before and after intermittent altitude exposureBeth A Beidleman
Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
Clin Sci (Lond) 111:163-9. 2006..This method of pre-acclimatization can therefore be highly recommended for inducing altitude acclimatization without the 'altitude residency' requirement...
Comparison of sweat loss estimates for women during prolonged high-intensity runningSamuel N Cheuvront
Thermal and Mountain Medicine Division, U.S. Army Research Institute of Environmental Medicine, Natick, MA, USA
Med Sci Sports Exerc 34:1344-50. 2002..Neither prediction equation provided accurate estimates of TSL in warm or cool conditions for women runners. These results illustrate the difficulty of accurately estimating and predicting sweat losses in the field...
Biological and analytical variation of the human sweating response: implications for study design and analysisRobert W Kenefick
US Army Research Institute of Environmental Medicine, Thermal and Mountain Medicine Division, Kansas St Natick, MA 01760, USA
Am J Physiol Regul Integr Comp Physiol 302:R252-8. 2012..changes in SR. These findings provide a quantitative basis for study design and optimization of power/sample size analysis in the evaluation of thermoregulatory sweating...
Hydration effects on cognitive performance during military tasks in temperate and cold environmentsGina E Adam
U S Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
Physiol Behav 93:748-56. 2008..Moderate HYP had no effect on cognitive and psychomotor performance in either environment, cold exposure produced equivocal effects, and aerobic exercise improved some aspects of military task performance...
High skin temperature and hypohydration impair aerobic performanceMichael N Sawka
Thermal and Mountain Medicine Division, US Army Research Institute of Environmental Medicine, 42 Kansas Street, Natick, MA 01760, USA
Exp Physiol 97:327-32. 2012....
No effect of moderate hypohydration or hyperthermia on anaerobic exercise performanceSamuel N Cheuvront
U S Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
Med Sci Sports Exerc 38:1093-7. 2006..This study examined the effects of hypohydration and moderate hyperthermia (core temperature elevation) on anaerobic exercise performance in a temperate environment...
Hydration at the work siteRobert W Kenefick
United States Army Research Institute of Environmental Medicine, 42 Kansas Street, Natick, MA 01760, USA
J Am Coll Nutr 26:597S-603S. 2007..Improved occupational guidelines for fluid and electrolyte replacement during hot weather occupational activities should be developed to include recommendations for fluid consumption before, during, and after work...
Hypohydration impairs endurance exercise performance in temperate but not cold airSamuel N Cheuvront
US Army Research Institute of Environmental Medicine, Thermal and Mountain Medicine Division, Kansas St, Natick, MA 01760 5007, USA
J Appl Physiol 99:1972-6. 2005..05). These data demonstrate that 1) HYP impairs endurance exercise performance in temperate but not cold air but 2) cold stress per se does not...
Aerobic performance is degraded, despite modest hyperthermia, in hot environmentsBrett R Ely
Thermal and Mountain Medicine Division, US Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
Med Sci Sports Exerc 42:135-41. 2010..Environmental heat stress degrades aerobic performance; however, little research has focused on performance when the selected task elicits modest elevations in core body temperature (<38.5 degrees C)...
Limitations of salivary osmolality as a marker of hydration statusBrett R Ely
US Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
Med Sci Sports Exerc 43:1080-4. 2011..Salivary osmolality (Sosm) is a potentially useful hydration marker but may be confounded by oral artifacts...
Reference change values for monitoring dehydrationSamuel N Cheuvront
U S Army Research Institute of Environmental Medicine, Thermal and Mountain Medicine Division, Natick, MA 01760 5007, USA
Clin Chem Lab Med 49:1033-7. 2011..A secondary purpose was to validate use of the tool by dehydrating a group of volunteers...
United States Army Research Institute of Environmental Medicine: Warfighter research focusing on the past 25 yearsKent B Pandolf
United States Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760 5007, USA
Adv Physiol Educ 35:353-60. 2011..This report presents USARIEM's unique and world-class facilities, organizational changes, scientific and support personnel, and major research accomplishments, including the publication of 2,200 scientific papers over the past 25 yr...
Cold thermoregulatory responses following exertional fatigueJohn W Castellani
US Army Research Institute of Environmental Medicine, 15 Kansas Street, Natick, MA 01760 5007, USA
Front Biosci (Schol Ed) 2:854-65. 2010....
Exercise-heat acclimation in humans alters baseline levels and ex vivo heat inducibility of HSP72 and HSP90 in peripheral blood mononuclear cellsJames P McClung
US Army Research Institute of Environmental Medicine, Natick, MA, USA
Am J Physiol Regul Integr Comp Physiol 294:R185-91. 2008..These data demonstrate that physiological adaptations in humans undergoing HA are accompanied by both increases in baseline levels and changes in regulation of cytoprotective HSPs...
Reflective inserts to reduce heat strain in body armor: tests with and without irradianceBruce S Cadarette
U S Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
Aviat Space Environ Med 78:809-13. 2007..This study evaluated adding reflective thermal inserts (RTI) to reduce the physiological strain during exercise-heat stress with a radiant load. RTI were used with a U.S. Army desert battle dress uniform, body armor, and helmet...
Hypohydration reduces vertical ground reaction impulse but not jump heightSamuel N Cheuvront
Thermal and Mountain Medicine Division, US Army Research Institute of Environmental Medicine, Kansas Street, Natick, MA 01760 5007, USA
Eur J Appl Physiol 109:1163-70. 2010..05). In conclusion, this study demonstrates the failure to improve jump height when HYP can be explained by offsetting reductions in both VGRI and body mass...
Biological variation and diagnostic accuracy of dehydration assessment markersSamuel N Cheuvront
US Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
Am J Clin Nutr 92:565-73. 2010..Well-recognized markers for static (one time) or dynamic (monitoring over time) dehydration assessment have not been rigorously tested for their usefulness in clinical, military, and sports medicine communities...
Evaluation of the limits to accurate sweat loss prediction during prolonged exerciseSamuel N Cheuvront
US Army Research Institute of Environmental Medicine, Thermal and Mountain Medicine Division, Kansas Street, Natick, MA 01760 5007, USA
Eur J Appl Physiol 101:215-24. 2007..Adjustments for NSL and clothing saturation dynamics help explain SHAP errors at 2 and 8 h, respectively. These results provide a basis for future development of accurate algorithms with broader utility...
Daily body mass variability and stability in active men undergoing exercise-heat stressSamuel N Cheuvront
US Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
Int J Sport Nutr Exerc Metab 14:532-40. 2004..The data also suggest that daily BM is a sufficiently stable physiological parameter for potential daily fluid balance monitoring...
Methods of evaluating protective clothing relative to heat and cold stress: thermal manikin, biomedical modeling, and human testingCatherine O'Brien
Thermal and Mountain Medicine Division, U S Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760 5007, USA
J Occup Environ Hyg 8:588-99. 2011..By considering thermal stress early in the development process, health hazards related to temperature extremes can be mitigated while maintaining or improving the effectiveness of the PPE for protection from external hazards...
Glycerol hyperhydration: physiological responses during cold-air exposureCatherine O'Brien
Thermal Physiology and Medicine Division, US Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
J Appl Physiol 99:515-21. 2005..Differences in urine flow rate and fluid retention were the result of a greater free water clearance with WI. These data indicate glycerol can be an effective hyperhydrating agent during CAE...
Effect of heat acclimation on sweat mineralsTroy D Chinevere
U S Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
Med Sci Sports Exerc 40:886-91. 2008..This study examined the impact of 10 d of exercise-heat acclimation on sweat mineral concentrations...
Branched-chain amino acid supplementation and human performance when hypohydrated in the heatSamuel N Cheuvront
U S Army Research Institute of Environmental Medicine, Thermal and Mountain Medicine Division, Kansas St, Natick, MA 01760 5007, USA
J Appl Physiol 97:1275-82. 2004..BC did not alter time-trial performance, cognitive performance, mood, perceived exertion, or perceived thermal comfort. We conclude that BCAA does not alter exercise or cognitive performance in the heat when subjects are hypohydrated...
Heat exhaustion and dehydration as causes of marathon collapseRobert W Kenefick
US Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760, USA
Sports Med 37:378-81. 2007..Other factors contributing to post-race collapse might include reduced skeletal muscle pump activity and dehydration and prior heat stress mediated changes in cerebrovascular responses to orthostatic challenges...
Fluid replacement and performance during the marathonSamuel N Cheuvront
US Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760 5007, USA
Sports Med 37:353-7. 2007..Recommendations are provided to individualise fluid intakes with the goal of preventing excessive dehydration (>2% body mass) as well as weight gain. The minor importance of 'matters of debate' to fluid replacement is also discussed...
Thermal face protection delays finger cooling and improves thermal comfort during cold air exposureCatherine O'Brien
Thermal and Mountain Medicine Division, U S Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
Eur J Appl Physiol 111:3097-105. 2011....
Epidemiology of hospitalizations and deaths from heat illness in soldiersRobert Carter
Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
Med Sci Sports Exerc 37:1338-44. 2005..Serious heat illness has received considerable recent attention due to catastrophic heat waves in the United States and Europe, the deaths of high-profile athletes, and military deployments...
Hypohydration and prior heat stress exacerbates decreases in cerebral blood flow velocity during standingRobert Carter
Thermal and Mountain Medicine Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760, USA
J Appl Physiol 101:1744-50. 2006..These observations suggest that hypohydration and prior heat stress are associated with greater reductions in CBFV with greater CVR, which likely contribute to orthostatic intolerance...
Ventilation after supplemental oxygen administration at high altitudeStephen R Muza
US Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
Wilderness Environ Med 15:18-24. 2004..The present study assessed the effects of acute hyperoxia on resting-minute ventilation (VE) during altitude acclimatization to 4300 m...
Efficacy of intermittent, regional microclimate coolingSamuel N Cheuvront
United States Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760 5007, USA
J Appl Physiol 94:1841-8. 2003..These findings indicate that the IRC approach to MCC is a more efficient means of cooling when compared with CC paradigms and can improve MCC capacity by reducing power requirements...
Intermittent altitude exposures improve muscular performance at 4,300 mBeth A Beidleman
Biophysics and Biomedical Modeling Division, United States Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760, USA
J Appl Physiol 95:1824-32. 2003..IAE may therefore be used as an alternative to chronic altitude residence to facilitate improvements in muscular performance in athletes, soldiers, mountaineers, shift workers, and others that are deployed to altitude...
Exertional heat injury and gene expression changes: a DNA microarray analysis studyLarry A Sonna
Thermal and Mountain Medicine Div, United States Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
J Appl Physiol 96:1943-53. 2004..The molecular evidence from these patients is thus consistent with the hypothesis that EHI can result from cumulative effects of multiple adverse interacting stimuli...
Pituitary-adrenal and pituitary-thyroid hormone responses during exercise-cold exposure after 7 days of exhaustive exerciseJohn W Castellani
US Army Research Institute of Environmental Medicine, Thermal and Mountain Medicine Division, Natick, MA 01760 5007, USA
Aviat Space Environ Med 73:544-50. 2002..The effects of exertional fatigue on pituitary-adrenal hormones and thyroid hormone responses to exercise-cold stress are unknown...
Heat strain reduction by ice-based and vapor compression liquid cooling systems with a toxic agent protective uniformBruce S Cadarette
U S Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
Aviat Space Environ Med 73:665-72. 2002..It was hypothesized that the cooling systems would be equally effective, and total body cooling would allow 4 h of physical work in the heat while wearing STEPO...
A case report of idiosyncratic hyperthermia and review of U.S. Army heat stroke hospitalizationsRobert Carter
CRRSA, Department of Human Factors, France
J Sport Rehabil 16:238-43. 2007..S. Army. It is known that prior infection is a risk factor for heat illness and some of the 37 heat stroke deaths cited infections (eg, pneumonia, influenza) in the medical records...
Effectiveness of revised fluid replacement guidelines for military training in hot weatherMargaret A Kolka
Thermal and Mountain Medicine Division, U S Army Research Institute of Environmental Medicine, Natick, MA 01760 5001, USA
Aviat Space Environ Med 74:242-6. 2003..S. Army fluid replacement guidelines (REV) with the old guidelines (OLD) on daily changes in serum sodium concentration (Na+) and body mass (BM) during Basic Combat Training at Fort Benning, GA during two successive summers...
Hydration assessment using the cardiovascular response to standingSamuel N Cheuvront
Thermal and Mountain Medicine Division, US Army Research Institute of Environmental Medicine, Kansas Street, Natick, MA, 01760 5007, USA
Eur J Appl Physiol 112:4081-9. 2012..SSΔHR increased significantly in response to severe hypertonic hypohydration and moderate isotonic hypohydration, but not moderate hypertonic hypohydration. However, the 20 beats/min cut point afforded only marginal diagnostic accuracy...
Water-deficit equation: systematic analysis and improvementSamuel N Cheuvront
US Army Research Institute of Environmental Medicine, Natick, MA 01760 5007, USA
Am J Clin Nutr 97:79-85. 2013..Several equation assumptions may limit its accuracy, but none have been systematically tested...
Fluid balance and endurance exercise performanceSamuel N Cheuvront
US Army Research Institute of Environmental Medicine, Thermal and Mountain Medicine Division, 42 Kansas Street, Natick, MA 01760 5007, USA
Curr Sports Med Rep 2:202-8. 2003..This can usually be achieved with fluid intakes of under 1 L x h(-1)...
Thermoregulatory function during the marathonRobert W Kenefick
Thermal and Mountain Medicine Division, Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760, USA
Sports Med 37:312-5. 2007..The combined challenge of exercise and environment associated with marathon running can substantially challenge the human thermoregulatory system...
Intermittent altitude exposures reduce acute mountain sickness at 4300 mBeth A Beidleman
Biophysics and Biomedical Modeling Division, United States Army Research Institute of Environmental Medicine, Natick, MA 01760, USA
Clin Sci (Lond) 106:321-8. 2004..In conclusion, our findings suggest that 3 weeks of IAE provide an effective alternative to chronic altitude residence for increasing resting ventilation and reducing the incidence and severity of AMS...
Upper body cooling during exercise-heat stress wearing the improved toxicological agent protective system for HAZMAT operationsBruce S Cadarette
U S Army Research Institute of Environmental Medicine, Kansas St, Natick, MA 01760 5007, USA
AIHA J (Fairfax, Va) 64:510-5. 2003..PICS could also be used with civilian Levels A and B PPE increasing work time and worker safety...
Exertional heat illness and human gene expressionLarry A Sonna
Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
Prog Brain Res 162:321-46. 2007....
Does dehydration impair exercise performance?Michael N Sawka
U S Army Research Institute of Environmental Medicine Natick, MA, USA
Med Sci Sports Exerc 39:1209-17. 2007
American College of Sports Medicine position stand. Exercise and fluid replacementMichael N Sawka
Med Sci Sports Exerc 39:377-90. 2007..After exercise, the goal is to replace any fluid electrolyte deficit. The speed with which rehydration is needed and the magnitude of fluid electrolyte deficits will determine if an aggressive replacement program is merited...
Water and electrolyte needs for football training and match-playSusan M Shirreffs
School of Sport and Exercise Sciences, Loughborough University, UK
J Sports Sci 24:699-707. 2006....
How hot is the human body?Michael N Sawka
J Appl Physiol 103:419-20. 2007
