Kristina K Peachman

Summary

Affiliation: Walter Reed Army Medical Center
Country: USA

Publications

  1. ncbi request reprint Functional microtubules are required for antigen processing by macrophages and dendritic cells
    Kristina K Peachman
    Department of Membrane Biochemistry, Division of Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Road, Silver Spring, MD 20910 7500, USA
    Immunol Lett 95:13-24. 2004
  2. ncbi request reprint Human dendritic cells and macrophages exhibit different intracellular processing pathways for soluble and liposome-encapsulated antigens
    Kristina K Peachman
    Department of Vaccine Production and Delivery, Division of Retrovirology, Walter Reed Army Institute of Research, US Military HIV Research Program, 13 Taft Court Suite 200, Rockville, MD 20850, USA
    Immunobiology 210:321-33. 2005
  3. pmc Anthrax vaccine antigen-adjuvant formulations completely protect New Zealand white rabbits against challenge with Bacillus anthracis Ames strain spores
    Kristina K Peachman
    U S Military HIV Research Program, Henry M Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, USA
    Clin Vaccine Immunol 19:11-6. 2012
  4. ncbi request reprint Depletion of cellular cholesterol interferes with intracellular trafficking of liposome-encapsulated ovalbumin
    Mangala Rao
    Departments of Membrane Biochemistry and Blood Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Immunol Cell Biol 81:415-23. 2003
  5. doi request reprint Liposome-encapsulated HIV-1 Gag p24 containing lipid A induces effector CD4+ T-cells, memory CD8+ T-cells, and pro-inflammatory cytokines
    Nicholas J Steers
    Division of Retrovirology, USMHRP, Walter Reed Army Institute of Research, Rockville, MD 20850, USA
    Vaccine 27:6939-49. 2009
  6. doi request reprint The effect of sCD4 on the binding and accessibility of HIV-1 gp41 MPER epitopes to human monoclonal antibodies
    Kristina K Peachman
    Henry M Jackson Foundation for the Advancement of Military Medicine, 1600 East Gude Drive, Rockville, MD, 20850, USA
    Virology 408:213-23. 2010
  7. doi request reprint Highly effective generic adjuvant systems for orphan or poverty-related vaccines
    Mangala Rao
    Division of Retrovirology, U S Military HIV Research Program, Walter Reed Army Institute of Research, 1600 East Gude Drive, Rockville, MD 20850, USA
    Vaccine 29:873-7. 2011
  8. doi request reprint Dengue virus infection promotes translocation of high mobility group box 1 protein from the nucleus to the cytosol in dendritic cells, upregulates cytokine production and modulates virus replication
    Edwin Kamau
    Division of Viral Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Gen Virol 90:1827-35. 2009
  9. pmc Human immunodeficiency virus type 1 Gag p24 alters the composition of immunoproteasomes and affects antigen presentation
    Nicholas J Steers
    Henry M Jackson Foundation, Division of Retrovirology, USMHRP, Walter Reed Army Institute of Research, Rockville, MD 20850, USA
    J Virol 83:7049-61. 2009
  10. doi request reprint The importance of antibody isotype in HIV-1 virus capture assay and in TZM-bl neutralization
    Kristina K Peachman
    Henry M Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, USA
    Viral Immunol 23:627-32. 2010

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Functional microtubules are required for antigen processing by macrophages and dendritic cells
    Kristina K Peachman
    Department of Membrane Biochemistry, Division of Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Road, Silver Spring, MD 20910 7500, USA
    Immunol Lett 95:13-24. 2004
    ..These data suggest that trafficking of soluble and liposome-encapsulated ovalbumin requires a functional microtubule-dependent translocation system...
  2. ncbi request reprint Human dendritic cells and macrophages exhibit different intracellular processing pathways for soluble and liposome-encapsulated antigens
    Kristina K Peachman
    Department of Vaccine Production and Delivery, Division of Retrovirology, Walter Reed Army Institute of Research, US Military HIV Research Program, 13 Taft Court Suite 200, Rockville, MD 20850, USA
    Immunobiology 210:321-33. 2005
    ..These studies demonstrate that the intracellular fate of soluble and liposomal antigens can differ depending upon the antigen-presenting cell...
  3. pmc Anthrax vaccine antigen-adjuvant formulations completely protect New Zealand white rabbits against challenge with Bacillus anthracis Ames strain spores
    Kristina K Peachman
    U S Military HIV Research Program, Henry M Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, USA
    Clin Vaccine Immunol 19:11-6. 2012
    ..In summary, the needle-free skin delivery and liposomal formulation that were found to be effective in two different animal model systems appear to be promising candidates for next-generation anthrax vaccine development...
  4. ncbi request reprint Depletion of cellular cholesterol interferes with intracellular trafficking of liposome-encapsulated ovalbumin
    Mangala Rao
    Departments of Membrane Biochemistry and Blood Research, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Immunol Cell Biol 81:415-23. 2003
    ..We conclude that cholesterol depletion does not eliminate phagocytosis or MHC class I surface expression, but does affect the trafficking and consequently the MHC class I antigen-processing pathway...
  5. doi request reprint Liposome-encapsulated HIV-1 Gag p24 containing lipid A induces effector CD4+ T-cells, memory CD8+ T-cells, and pro-inflammatory cytokines
    Nicholas J Steers
    Division of Retrovirology, USMHRP, Walter Reed Army Institute of Research, Rockville, MD 20850, USA
    Vaccine 27:6939-49. 2009
    ..The results demonstrate the importance of the adjuvant liposomal lipid A for the induction of HIV-1 Gag p24 -specific CD8+ T-cells, effector CD4+ T-cells, and cytokines with a Th-1 type profile after immunization with L(p24+LA)...
  6. doi request reprint The effect of sCD4 on the binding and accessibility of HIV-1 gp41 MPER epitopes to human monoclonal antibodies
    Kristina K Peachman
    Henry M Jackson Foundation for the Advancement of Military Medicine, 1600 East Gude Drive, Rockville, MD, 20850, USA
    Virology 408:213-23. 2010
    ..However, neither binding per se nor the total envelope content per virion was a predictor of neutralization. The hidden or conformational gp41 MPER epitopes unmasked by sCD4 may provide additional targets for vaccine design...
  7. doi request reprint Highly effective generic adjuvant systems for orphan or poverty-related vaccines
    Mangala Rao
    Division of Retrovirology, U S Military HIV Research Program, Walter Reed Army Institute of Research, 1600 East Gude Drive, Rockville, MD 20850, USA
    Vaccine 29:873-7. 2011
    ..All vaccinated monkeys were protected against lethal challenge with aerosolized Ames strain spores...
  8. doi request reprint Dengue virus infection promotes translocation of high mobility group box 1 protein from the nucleus to the cytosol in dendritic cells, upregulates cytokine production and modulates virus replication
    Edwin Kamau
    Division of Viral Diseases, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Gen Virol 90:1827-35. 2009
    ..Additionally, increased HMGB1 production was associated with reduced DENV replication titres in DCs. These results suggest that HMGB1 production influences DENV infection in susceptible hosts...
  9. pmc Human immunodeficiency virus type 1 Gag p24 alters the composition of immunoproteasomes and affects antigen presentation
    Nicholas J Steers
    Henry M Jackson Foundation, Division of Retrovirology, USMHRP, Walter Reed Army Institute of Research, Rockville, MD 20850, USA
    J Virol 83:7049-61. 2009
    ..These results suggest that early antigen processing kinetics could influence the immunogenicity of CD8(+) T-cell epitopes generated...
  10. doi request reprint The importance of antibody isotype in HIV-1 virus capture assay and in TZM-bl neutralization
    Kristina K Peachman
    Henry M Jackson Foundation for the Advancement of Military Medicine, Rockville, Maryland, USA
    Viral Immunol 23:627-32. 2010
    ..Studies on the relationship between virus binding and neutralization in a TZM-bl pseudovirus assay indicated that in most cases, mAbs that exhibited neutralization also bound the virus...
  11. ncbi request reprint Restricted replication and lysosomal trafficking of yellow fever 17D vaccine virus in human dendritic cells
    Dupeh R Palmer
    Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    J Gen Virol 88:148-56. 2007
    ..These results indicate that restricted virus replication and lysosomal compartmentalization may be important contributing factors to the success of the YF-VAX vaccine...
  12. doi request reprint Liposomes containing glucosyl ceramide specifically bind T4 bacteriophage: a self-assembling nanocarrier formulation
    Carl R Alving
    Department of Adjuvant and Antigen Research, U S Military HIV Research Program, Division of Retrovirology, Walter Reed Army Institute of Research, Rockville, Maryland, USA
    J Liposome Res 21:279-85. 2011
    ..This formulation could be utilized as an easily manufactured self-assembling antigen and adjuvant carrier...
  13. pmc Human erythrocytes selectively bind and enrich infectious HIV-1 virions
    Zoltan Beck
    Division of Retrovirology, United States Military HIV Research Program, Walter Reed Army Institute of Research, Rockville, Maryland, United States of America
    PLoS ONE 4:e8297. 2009
    ..By analogy with HIV-1 bound to DC-SIGN on dendritic cells, erythrocyte-bound HIV-1 might comprise an important surface reservoir for trans infection of permissive cells...
  14. doi request reprint An anti-phosphoinositide-specific monoclonal antibody that neutralizes HIV-1 infection of human monocyte-derived macrophages
    Ousman Jobe
    Laboratory of Adjuvant and Antigen Research, US Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Virology 430:110-9. 2012
    ..WR321 did not prevent the entry of HIV-1 into MDM. However, once WR321 was internalized along with HIV-1 the mAb acted intracellulary to prevent the release of virions from MDM and also triggered the release of β-chemokines...
  15. ncbi request reprint Modulation of dengue virus infection of dendritic cells by Aedes aegypti saliva
    Daniel B Ader
    Department of Virus Diseases, Walter Reed Army Institute of Research, Silver Spring, Maryland 20810, USA
    Viral Immunol 17:252-65. 2004
    ..These data contribute to the overall understanding of the natural pathogenesis of DV infection and suggest that there is a protective role for mosquito saliva that limits viral uptake by DCs...
  16. pmc Correlation between lethal toxin-neutralizing antibody titers and protection from intranasal challenge with Bacillus anthracis Ames strain spores in mice after transcutaneous immunization with recombinant anthrax protective antigen
    Kristina K Peachman
    Department of Vaccine Production and Delivery, Division of Retrovirology, U S Military HIV Research Program, Walter Reed Army Institute of Research, 1600 East Gude Drive, Rockville, MD 20850, USA
    Infect Immun 74:794-7. 2006
    ..Future experiments with rabbits and nonhuman primates should confirm the significance of protection by this vaccine strategy...
  17. pmc Adjuvants for human vaccines
    Carl R Alving
    Laboratory of Adjuvant and Antigen Research, U S Military HIV Research Program, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Curr Opin Immunol 24:310-5. 2012
    ....
  18. ncbi request reprint Immunization with DNA through the skin
    Kristina K Peachman
    Department of Membrane Biochemistry, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Room 2A24, Silver Spring, MD 20910 7500, USA
    Methods 31:232-42. 2003
    ..With refinement, skin-DNA immunization will achieve the goal of producing a reliable and efficacious immune response to a variety of pathogens...