Aysegul Nalca

Summary

Affiliation: Walter Reed Army Medical Center
Country: USA

Publications

  1. doi request reprint Evaluation of orally delivered ST-246 as postexposure prophylactic and antiviral therapeutic in an aerosolized rabbitpox rabbit model
    Aysegul Nalca
    Center for Aerobiological Sciences, U S Army Medical Research Institute of Infectious Diseases USAMRIID, Fort Detrick, MD, United States
    Antiviral Res 79:121-7. 2008
  2. ncbi request reprint Reemergence of monkeypox: prevalence, diagnostics, and countermeasures
    Aysegul Nalca
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    Clin Infect Dis 41:1765-71. 2005
  3. pmc A characterization of aerosolized Sudan virus infection in African green monkeys, cynomolgus macaques, and rhesus macaques
    Elizabeth E Zumbrun
    Center for Aerobiological Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA
    Viruses 4:2115-36. 2012
  4. pmc Development of a murine model for aerosolized ebolavirus infection using a panel of recombinant inbred mice
    Elizabeth E Zumbrun
    Center for Aerobiological Sciences, U S Army Medical Research Institute of Infectious Diseases USAMRIID, 1425 Porter Street, Fort Detrick, Maryland 21702, USA
    Viruses 4:3468-93. 2012
  5. pmc Proteomic basis of the antibody response to monkeypox virus infection examined in cynomolgus macaques and a comparison to human smallpox vaccination
    Sarah Keasey
    United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
    PLoS ONE 5:e15547. 2010
  6. pmc Evaluation of the efficacy of modified vaccinia Ankara (MVA)/IMVAMUNE against aerosolized rabbitpox virus in a rabbit model
    Nicole L Garza
    Center for Aerobiological Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, United States
    Vaccine 27:5496-504. 2009
  7. pmc Application of the Ibis-T5000 pan-Orthopoxvirus assay to quantitatively detect monkeypox viral loads in clinical specimens from macaques experimentally infected with aerosolized monkeypox virus
    Rebecca J Grant
    U S Army Medical Research Institute of Infectious Diseases, 1301 Ditto Avenue, Fort Detrick, MD 21702, USA
    Am J Trop Med Hyg 82:318-23. 2010
  8. doi request reprint Rabbitpox: a model of airborne transmission of smallpox
    Aysegul Nalca
    Center for Aerobiological Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    J Gen Virol 92:31-5. 2011
  9. pmc Aerosol exposure to Rift Valley fever virus causes earlier and more severe neuropathology in the murine model, which has important implications for therapeutic development
    Christopher Reed
    United States Army Medical Research Institute of Infectious Diseases USAMRIID, Fort Detrick, Maryland, USA
    PLoS Negl Trop Dis 7:e2156. 2013
  10. pmc ACAM2000: the new smallpox vaccine for United States Strategic National Stockpile
    Aysegul Nalca
    Center for Aerobiological Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
    Drug Des Devel Ther 4:71-9. 2010

Collaborators

  • Chris A Whitehouse
  • Lisa E Hensley
  • Robert G Ulrich
  • Darci R Smith
  • Sina Bavari
  • Mark W Eshoo
  • Rangarajan Sampath
  • Anne W Rimoin
  • Barry Schweitzer
  • M Bray
  • B S Graham
  • Jay W Hooper
  • Victor E Buckwold
  • Dennis Hruby
  • Robert Jordan
  • Elizabeth E Zumbrun
  • Yvette Edghill-Smith
  • Donald K Nichols
  • Nicole L Garza
  • Christopher Reed
  • Jody Manischewitz
  • Hana Golding
  • Genoveffa Franchini
  • Lisa R King
  • Holly A Bloomfield
  • Rebecca J Grant
  • Sarah Keasey
  • Virginia Livingston
  • Jean Michel Heraud
  • David Venzon
  • Anna Hryniewicz
  • Mark E Merchant
  • Job C Tharappel
  • Joshua Shamblin
  • Kenny Lin
  • Ginger Donnelly
  • Ashley Keeney
  • Brian Friedrich
  • Gene Olinger
  • Catherine Wilhelmsen
  • Taylor B Chance
  • Ty C Hunter
  • John M Dye
  • Nicholas R Bramel
  • Roger D Williams
  • Paige E Harrison
  • Paul A Dabisch
  • Reese J Baker
  • Malak Kotb
  • Nourtan F Abdeltawab
  • Gengxin Chen
  • Scott Zoll
  • Lawrence B Blyn
  • Alexander Tikhonov
  • Christine Pugh
  • Heather Matthews
  • Carson D Baldwin
  • Josh M Hatkin
  • Diana Fisher
  • Ariane Volkmann
  • Paul J Chaplin
  • Wen Po Tsai
  • Victor Ayala
  • Christopher J Trindade
  • Irene Kalisz
  • Meredith Hassett
  • Vaniambadi S Kalyanaraman
  • Peter Silvera
  • Monica Vaccari
  • Janie Parrino
  • Mark G Lewis
  • Dorothy Scott
  • Melanie Pallansch
  • Jay B Wells
  • Jay Wells
  • Susan H Zwiers
  • John Huggins
  • David Miller
  • Clement Meseda
  • Robin L Paulman
  • Joern E Schmitz
  • Keith A Reimann
  • Marjorie Robert-Guroff
  • Eric Mucker
  • Jerry Weir
  • Roger Ptak
  • Brett T Spear
  • Elizabeth C Konz
  • Howard P Glauert
  • Leila Ghabrial

Detail Information

Publications17

  1. doi request reprint Evaluation of orally delivered ST-246 as postexposure prophylactic and antiviral therapeutic in an aerosolized rabbitpox rabbit model
    Aysegul Nalca
    Center for Aerobiological Sciences, U S Army Medical Research Institute of Infectious Diseases USAMRIID, Fort Detrick, MD, United States
    Antiviral Res 79:121-7. 2008
    ..e., survival was 67% and 33%, respectively. This work suggests that ST-246 is a very potent antiviral compound against aerosolized rabbitpox in rabbits and should be investigated for further development for all orthopoxvirus diseases...
  2. ncbi request reprint Reemergence of monkeypox: prevalence, diagnostics, and countermeasures
    Aysegul Nalca
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    Clin Infect Dis 41:1765-71. 2005
    ..This has led to fears that monkeypox virus could be used as a bioterrorism agent. Effective prevention relies on limiting the contact with infected patients or animals and limiting the respiratory exposure to infected patients...
  3. pmc A characterization of aerosolized Sudan virus infection in African green monkeys, cynomolgus macaques, and rhesus macaques
    Elizabeth E Zumbrun
    Center for Aerobiological Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA
    Viruses 4:2115-36. 2012
    ..Overall, the results indicate that the disease course after exposure to aerosolized SUDV is similar for all three species of NHP...
  4. pmc Development of a murine model for aerosolized ebolavirus infection using a panel of recombinant inbred mice
    Elizabeth E Zumbrun
    Center for Aerobiological Sciences, U S Army Medical Research Institute of Infectious Diseases USAMRIID, 1425 Porter Street, Fort Detrick, Maryland 21702, USA
    Viruses 4:3468-93. 2012
    ..Preliminary quantitative trait loci (QTLs) were identified that are likely to harbor genes involved in modulating differential susceptibility to Ebola infection...
  5. pmc Proteomic basis of the antibody response to monkeypox virus infection examined in cynomolgus macaques and a comparison to human smallpox vaccination
    Sarah Keasey
    United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, United States of America
    PLoS ONE 5:e15547. 2010
    ....
  6. pmc Evaluation of the efficacy of modified vaccinia Ankara (MVA)/IMVAMUNE against aerosolized rabbitpox virus in a rabbit model
    Nicole L Garza
    Center for Aerobiological Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, United States
    Vaccine 27:5496-504. 2009
    ..This study shows that IMVAMUNE can be a very effective vaccine against aerosolized RPXV...
  7. pmc Application of the Ibis-T5000 pan-Orthopoxvirus assay to quantitatively detect monkeypox viral loads in clinical specimens from macaques experimentally infected with aerosolized monkeypox virus
    Rebecca J Grant
    U S Army Medical Research Institute of Infectious Diseases, 1301 Ditto Avenue, Fort Detrick, MD 21702, USA
    Am J Trop Med Hyg 82:318-23. 2010
    ..This platform provides a new tool for the diagnosis and monitoring of orthopoxviral loads during vaccine or antiviral studies, but also could provide rapid identification during natural outbreaks or bioterrorism attacks...
  8. doi request reprint Rabbitpox: a model of airborne transmission of smallpox
    Aysegul Nalca
    Center for Aerobiological Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    J Gen Virol 92:31-5. 2011
    ..This model can therefore be utilized to test drugs and vaccines against variola virus and other aerosolized orthopoxviruses...
  9. pmc Aerosol exposure to Rift Valley fever virus causes earlier and more severe neuropathology in the murine model, which has important implications for therapeutic development
    Christopher Reed
    United States Army Medical Research Institute of Infectious Diseases USAMRIID, Fort Detrick, Maryland, USA
    PLoS Negl Trop Dis 7:e2156. 2013
    ....
  10. pmc ACAM2000: the new smallpox vaccine for United States Strategic National Stockpile
    Aysegul Nalca
    Center for Aerobiological Sciences, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
    Drug Des Devel Ther 4:71-9. 2010
    ..This review of ACAM2000 addresses the production, characterization, clinical trials, and adverse events associated with this new smallpox vaccine...
  11. ncbi request reprint Antiviral activity of CHO-SS cell-derived human omega interferon and other human interferons against HCV RNA replicons and related viruses
    Victor E Buckwold
    Veracity Biotechnology, LLC, 401 Rosemont Avenue, Third Floor Rosenstock Hall, Frederick, MD 21701, USA
    Antiviral Res 73:118-25. 2007
    ..The activation of these additional TFs by glycosylated IFN-omega might contribute to its high potency...
  12. ncbi request reprint Subunit recombinant vaccine protects against monkeypox
    Jean Michel Heraud
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, MD 20892, USA
    J Immunol 177:2552-64. 2006
    ..Their identification may guide future efforts to develop simpler, safer, and more effective vaccines for monkeypox and smallpox...
  13. ncbi request reprint Smallpox vaccine-induced antibodies are necessary and sufficient for protection against monkeypox virus
    Yvette Edghill-Smith
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, 41 D804, Bethesda, Maryland 20892, USA
    Nat Med 11:740-7. 2005
    ..Thus, vaccines able to induce long-lasting protective antibody responses may constitute realistic alternatives to the currently available smallpox vaccine (Dryvax)...
  14. ncbi request reprint Antiviral activity of serum from the American alligator (Alligator mississippiensis)
    Mark E Merchant
    Department of Chemistry, McNeese State University, Box 90455, Lake Charles, LA 70609, USA
    Antiviral Res 66:35-8. 2005
    ..HIV-1 antiviral action was heat-sensitive, and thus possibly due to the action of serum complement, while the anti-WNV and anti-HSV-1 activities were not heat labile and thus probably not complement mediated...
  15. ncbi request reprint Smallpox vaccine does not protect macaques with AIDS from a lethal monkeypox virus challenge
    Yvette Edghill-Smith
    Animal Models and Retroviral Vaccines Section, National Cancer Institute, Bethesda, Maryland 20892, USA
    J Infect Dis 191:372-81. 2005
    ..Thus, vaccination strategies that bypass CD4(+) cell help are needed to elicit IgG antibodies with high affinity and adequate tissue distribution and to restore protection against smallpox in severely immunocompromised individuals...
  16. ncbi request reprint Antiviral activity of hop constituents against a series of DNA and RNA viruses
    Victor E Buckwold
    Infectious Disease Research Department, Southern Research Institute, 431 Aviation Way, Frederick, MD 21701, USA
    Antiviral Res 61:57-62. 2004
    ..These hop constituents might serve as interesting lead compounds from which more active anti-HCV, anti-Rhino and anti-herpesvirus antiviral agents could be synthesized...
  17. ncbi request reprint Cell proliferation and apoptosis are altered in mice deficient in the NF-kappaB p50 subunit after treatment with the peroxisome proliferator ciprofibrate
    Job C Tharappel
    Graduate Center for Nutritional Sciences, University of Kentucky, Lexington, Kentucky 40536, USA
    Toxicol Sci 75:300-8. 2003
    ..These data indicate that NF-kappaB contributes to the proliferative and apoptotic changes that occur in the liver in response to ciprofibrate...