J H McDonough

Summary

Affiliation: Walter Reed Army Medical Center
Country: USA

Publications

  1. ncbi request reprint Anticonvulsant treatment of nerve agent seizures: anticholinergics versus diazepam in soman-intoxicated guinea pigs
    J H McDonough
    Pharmacology Division, U S Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010 5400, USA
    Epilepsy Res 38:1-14. 2000
  2. ncbi request reprint The effects of repeated low-dose sarin exposure
    T M Shih
    Pharmacology Branch, Research Division, U S Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010 5400, USA
    Toxicol Appl Pharmacol 215:119-34. 2006
  3. ncbi request reprint Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication
    T M Shih
    Pharmacology Division, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010 5400, USA
    Arch Toxicol 74:165-72. 2000
  4. ncbi request reprint Pharmacological modulation of soman-induced seizures
    J H McDonough
    Biochemical Pharmacology Branch, U S Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010 5425
    Neurosci Biobehav Rev 17:203-15. 1993
  5. ncbi request reprint Intramuscular diazepam pharmacokinetics in soman-exposed guinea pigs
    B R Capacio
    Pharmacology Division, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010-5425, USA
    J Appl Toxicol 21:S67-74. 2001
  6. ncbi request reprint Pharmacokinetic studies of intramuscular midazolam in guinea pigs challenged with soman
    Benedict R Capacio
    U S Army Medical Research Institute of Chemical Defense, 3100 Ricketts Road, Aberdeen Proving Ground, MD 21010 5400, USA
    Drug Chem Toxicol 27:95-110. 2004
  7. doi request reprint A liquid chromatographic-mass spectrometric (LC-MS) method for the analysis of the bis-pyridinium oxime ICD-585 in plasma: application in a guinea pig model
    B R Capacio
    US Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 5400, United States
    J Chromatogr B Analyt Technol Biomed Life Sci 878:1420-5. 2010
  8. ncbi request reprint The dose-response effects of repeated subacute sarin exposure on guinea pigs
    S W Hulet
    Neurotoxicology and Applied Pharmacology Branches, US Army Medical Research Institute of Chemical Defense, MCMR UV PN, Aberdeen Proving Grounds, MD 21010 5400, USA
    Pharmacol Biochem Behav 72:835-45. 2002
  9. ncbi request reprint Pharmacokinetics of intramuscularly administered biperiden in guinea pigs challenged with soman
    B R Capacio
    U S Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010 5400, USA
    Drug Chem Toxicol 26:1-13. 2003

Detail Information

Publications9

  1. ncbi request reprint Anticonvulsant treatment of nerve agent seizures: anticholinergics versus diazepam in soman-intoxicated guinea pigs
    J H McDonough
    Pharmacology Division, U S Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010 5400, USA
    Epilepsy Res 38:1-14. 2000
    ..For diazepam, the time to terminate the seizure was the same whether it was given at the 5- or 40-min delay. In contrast, most anticholinergics were significantly slower in terminating seizure activity when..
  2. ncbi request reprint The effects of repeated low-dose sarin exposure
    T M Shih
    Pharmacology Branch, Research Division, U S Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010 5400, USA
    Toxicol Appl Pharmacol 215:119-34. 2006
    ..4 x LD(50) sarin as well as in control animals. No evidence of brain or heart pathology was found in any guinea pig that survived all 10 sarin injections...
  3. ncbi request reprint Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication
    T M Shih
    Pharmacology Division, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010 5400, USA
    Arch Toxicol 74:165-72. 2000
    ..The present study demonstrates that all nerve agents can produce status epilepticus and that the therapeutic effectiveness of atropine and biperiden roughly paralleled the seizurogenic potential of these agents...
  4. ncbi request reprint Pharmacological modulation of soman-induced seizures
    J H McDonough
    Biochemical Pharmacology Branch, U S Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010 5425
    Neurosci Biobehav Rev 17:203-15. 1993
    ..Benactyzine and trihexyphenidyl represent compounds that possibly have both anticholinergic and NMDA antagonistic properties...
  5. ncbi request reprint Intramuscular diazepam pharmacokinetics in soman-exposed guinea pigs
    B R Capacio
    Pharmacology Division, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010-5425, USA
    J Appl Toxicol 21:S67-74. 2001
    ..The data from our current study suggest that a higher dose (and corresponding Cmax) is necessary to terminate ongoing seizure activity...
  6. ncbi request reprint Pharmacokinetic studies of intramuscular midazolam in guinea pigs challenged with soman
    Benedict R Capacio
    U S Army Medical Research Institute of Chemical Defense, 3100 Ricketts Road, Aberdeen Proving Ground, MD 21010 5400, USA
    Drug Chem Toxicol 27:95-110. 2004
    ..m. injection of midazolam is effective at terminating ongoing soman-induced seizure activity. Additionally, the relatively short Tmax and latency to seizure termination demonstrate the rapidity of drug absorption and action respectively...
  7. doi request reprint A liquid chromatographic-mass spectrometric (LC-MS) method for the analysis of the bis-pyridinium oxime ICD-585 in plasma: application in a guinea pig model
    B R Capacio
    US Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Rd, Aberdeen Proving Ground, MD 21010 5400, United States
    J Chromatogr B Analyt Technol Biomed Life Sci 878:1420-5. 2010
    ..The method has been demonstrated to be applicable to the analysis of plasma from nerve agent-exposed guinea pigs...
  8. ncbi request reprint The dose-response effects of repeated subacute sarin exposure on guinea pigs
    S W Hulet
    Neurotoxicology and Applied Pharmacology Branches, US Army Medical Research Institute of Chemical Defense, MCMR UV PN, Aberdeen Proving Grounds, MD 21010 5400, USA
    Pharmacol Biochem Behav 72:835-45. 2002
    ..In summary, the guinea pigs receiving the 0.4 x LD(50) and 0.5 x LD(50) doses of sarin failed to habituate to some aspects of the functional observational battery testing...
  9. ncbi request reprint Pharmacokinetics of intramuscularly administered biperiden in guinea pigs challenged with soman
    B R Capacio
    U S Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010 5400, USA
    Drug Chem Toxicol 26:1-13. 2003
    ..3 and 1.7 times greater, respectively, than that in plasma. The time for maximal plasma concentration was found to corresponded well with the mean time to seizure termination following drug administration...