Wenjun Zhou Martini

Summary

Affiliation: Walter Reed Army Medical Center
Country: USA

Publications

  1. ncbi request reprint Does bicarbonate correct coagulation function impaired by acidosis in swine?
    Wenjun Z Martini
    US Army Institute of Surgical Research, Ft Sam Houston, Texas, USA
    J Trauma 61:99-106. 2006
  2. ncbi request reprint Comparisons of lactated Ringer's and Hextend resuscitation on hemodynamics and coagulation following femur injury and severe hemorrhage in pigs
    Wenjun Z Martini
    US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    J Trauma Acute Care Surg 74:732-9; discussion 739-40. 2013
  3. ncbi request reprint Different recovery profiles of coagulation factors, thrombin generation, and coagulation function after hemorrhagic shock in pigs
    Wenjun Z Martini
    US Army Institute of Surgical Research, Ft Sam Houston, San Antonio, Texas 78234, USA
    J Trauma Acute Care Surg 73:640-7. 2012
  4. doi request reprint Daily profiles of fibrinogen metabolism for 5 days following hemorrhage and lactated ringer's resuscitation in pigs
    Wenjun Z Martini
    U S Army Institute of Surgical Research, Ft Sam Houston, Texas 78234, USA
    Shock 37:605-10. 2012
  5. pmc Fibrinogen availability and coagulation function after hemorrhage and resuscitation in pigs
    Wenjun Z Martini
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    Mol Med 17:757-61. 2011
  6. doi request reprint Enhanced albumin synthesis in severely burned adults
    Wenjun Z Martini
    US Army Institute of Surgical Research, Ft Sam, Houston, TX 78234, USA
    Shock 34:364-8. 2010
  7. doi request reprint Coagulopathy by hypothermia and acidosis: mechanisms of thrombin generation and fibrinogen availability
    Wenjun Zhou Martini
    Hemostasis Program, US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    J Trauma 67:202-8; discussion 208-9. 2009
  8. pmc Fibrinogen metabolic responses to trauma
    Wenjun Zhou Martini
    US Army Institute of Surgical Research, Ft Sam Houston, TX 78234, USA
    Scand J Trauma Resusc Emerg Med 17:2. 2009
  9. ncbi request reprint Thrombelastography is better than PT, aPTT, and activated clotting time in detecting clinically relevant clotting abnormalities after hypothermia, hemorrhagic shock and resuscitation in pigs
    Wenjun Z Martini
    The US Army Institute of Surgical Research, 3400 Rawley E Chambers Avenue, Ft Sam Houston, TX 78234, USA
    J Trauma 65:535-43. 2008
  10. ncbi request reprint Effects of hemorrhage and lactated Ringer's resuscitation on coagulation and fibrinogen metabolism in swine
    Wenjun Z Martini
    US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    Shock 26:396-401. 2006

Detail Information

Publications18

  1. ncbi request reprint Does bicarbonate correct coagulation function impaired by acidosis in swine?
    Wenjun Z Martini
    US Army Institute of Surgical Research, Ft Sam Houston, Texas, USA
    J Trauma 61:99-106. 2006
    ..Acidosis can be neutralized with intravascular bicarbonate, but it is unclear if the coagulation defect is rapidly reversed. The effects of acidosis and bicarbonate neutralization on coagulation function were investigated in vivo...
  2. ncbi request reprint Comparisons of lactated Ringer's and Hextend resuscitation on hemodynamics and coagulation following femur injury and severe hemorrhage in pigs
    Wenjun Z Martini
    US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    J Trauma Acute Care Surg 74:732-9; discussion 739-40. 2013
    ..This study compared coagulation function after resuscitation with Hextend and lactated Ringer's (LR) solution in pigs with tissue injury and hemorrhagic shock...
  3. ncbi request reprint Different recovery profiles of coagulation factors, thrombin generation, and coagulation function after hemorrhagic shock in pigs
    Wenjun Z Martini
    US Army Institute of Surgical Research, Ft Sam Houston, San Antonio, Texas 78234, USA
    J Trauma Acute Care Surg 73:640-7. 2012
    ..Hemorrhagic shock contributes to coagulopathy after trauma. We investigated daily changes of coagulation components and coagulation function for 5 days in hemorrhaged and resuscitated pigs...
  4. doi request reprint Daily profiles of fibrinogen metabolism for 5 days following hemorrhage and lactated ringer's resuscitation in pigs
    Wenjun Z Martini
    U S Army Institute of Surgical Research, Ft Sam Houston, Texas 78234, USA
    Shock 37:605-10. 2012
    ..The increase in fibrinogen appeared primarily due to a sustained increase in fibrinogen synthesis...
  5. pmc Fibrinogen availability and coagulation function after hemorrhage and resuscitation in pigs
    Wenjun Z Martini
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    Mol Med 17:757-61. 2011
    ..The rebound of fibrinogen at 24 h restored clot strength despite platelet deficit. These data suggest the potential compensatory role of fibrinogen in restoring coagulation function in vivo after hemorrhagic shock...
  6. doi request reprint Enhanced albumin synthesis in severely burned adults
    Wenjun Z Martini
    US Army Institute of Surgical Research, Ft Sam, Houston, TX 78234, USA
    Shock 34:364-8. 2010
    ..6 ± 0.2 mg · kg-1 · h-1) was enhanced compared with controls (2.2 ± 0.2 mg · kg-1 · h-1; P < 0.05). Despite the decrease in albumin concentration, albumin synthesis was enhanced in severely burned patients during the flow phase...
  7. doi request reprint Coagulopathy by hypothermia and acidosis: mechanisms of thrombin generation and fibrinogen availability
    Wenjun Zhou Martini
    Hemostasis Program, US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    J Trauma 67:202-8; discussion 208-9. 2009
    ..A better understanding of the underlying mechanisms will facilitate the search for effective therapeutic approaches when this lethal triad cannot be avoided...
  8. pmc Fibrinogen metabolic responses to trauma
    Wenjun Zhou Martini
    US Army Institute of Surgical Research, Ft Sam Houston, TX 78234, USA
    Scand J Trauma Resusc Emerg Med 17:2. 2009
    ..Future prospective clinical trials are needed to confirm the beneficial effects of fibrinogen supplementation in trauma patients with bleeding complications...
  9. ncbi request reprint Thrombelastography is better than PT, aPTT, and activated clotting time in detecting clinically relevant clotting abnormalities after hypothermia, hemorrhagic shock and resuscitation in pigs
    Wenjun Z Martini
    The US Army Institute of Surgical Research, 3400 Rawley E Chambers Avenue, Ft Sam Houston, TX 78234, USA
    J Trauma 65:535-43. 2008
    ..In this study, we investigated the independent and combined effects of hypothermia and hemorrhage with resuscitation on coagulation in swine and evaluated clinically relevant tests of coagulation...
  10. ncbi request reprint Effects of hemorrhage and lactated Ringer's resuscitation on coagulation and fibrinogen metabolism in swine
    Wenjun Z Martini
    US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    Shock 26:396-401. 2006
    ..Thus, effective treatment of hemorrhage should include combining standard-of-care resuscitation with interventions to correct alterations in coagulation...
  11. ncbi request reprint Acidosis and coagulopathy: the differential effects on fibrinogen synthesis and breakdown in pigs
    Wenjun Z Martini
    US Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    Ann Surg 246:831-5. 2007
    ..This study was designed to investigate the effects of acidosis on fibrinogen metabolism and coagulation function in a swine model...
  12. ncbi request reprint Evaluation of tris-hydroxymethylaminomethane on reversing coagulation abnormalities caused by acidosis in pigs
    Wenjun Z Martini
    U S Army Institute of Surgical Research, Ft Sam Houston, TX, USA
    Crit Care Med 35:1568-74. 2007
    ..To investigate the effect of tris-hydroxymethylaminomethane (THAM) pH neutralization on reversing coagulation abnormalities caused by acidosis...
  13. ncbi request reprint The effects of hypothermia on fibrinogen metabolism and coagulation function in swine
    Wenjun Znou Martini
    The US Army Institute of Surgical Research, Ft Sam Houston, TX 78234, USA
    Metabolism 56:214-21. 2007
    ..Our data support the current practices of rewarming and prescribing recombinant factor VIIa for hypothermic patients with coagulation defects...
  14. ncbi request reprint Independent contributions of hypothermia and acidosis to coagulopathy in swine
    Wenjun Z Martini
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    J Trauma 58:1002-9; discussion 1009-10. 2005
    ..An improved understanding of coagulopathy should facilitate hemorrhage control...
  15. ncbi request reprint Acute changes in fibrinogen metabolism and coagulation after hemorrhage in pigs
    Wenjun Z Martini
    The US Army Institute of Surgical Research, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234, USA
    Am J Physiol Endocrinol Metab 289:E930-4. 2005
    ..05). No changes were found in liver enzyme activities. We conclude that the observed changes in coagulation after hemorrhagic shock are mechanistically related to the acute acceleration of fibrinogen degradation...
  16. doi request reprint The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital
    Harry K Stinger
    Brooke Army Medical Center, U S Army Institute of Surgical Research, San Antonio, TX 78234 6200, USA
    J Trauma 64:S79-85; discussion S85. 2008
    ..Our objective was to determine whether increased ratios of fibrinogen to red blood cells (RBCs) decreased mortality in combat casualties requiring massive transfusion...
  17. pmc Thromboelastography as a better indicator of hypercoagulable state after injury than prothrombin time or activated partial thromboplastin time
    Myung S Park
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 67:266-75; discussion 275-6. 2009
    ..We hypothesized that a hypercoagulable state exists in patients early after severe injury and that the pattern of clotting and fibrinolysis are similar between burned and nonburn trauma patients...
  18. ncbi request reprint Dietary fat composition alters pulmonary function in pigs
    Robert R Wolfe
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas, USA
    Nutrition 18:647-53. 2002
    ..We investigated the effect of various dietary fats on pulmonary surfactant composition and lung function changes that occur before and after endotoxin infusion in pigs...