Research Topics
Species | Charles A LeathSummaryAffiliation: Walter Reed Army Medical Center Country: USA Publications
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Detail Information
Publications
A multi-institutional review of outcomes of endometrial stromal sarcomaCharles A Leath
Department of Obstetrics, Division of Gynecologic Oncology, The University of Alabama at Birmingham, Birmingham, AL, USA
Gynecol Oncol 105:630-4. 2007..To compare the clinical behavior and outcomes of low- and high-grade endometrial stromal sarcomas (LGESS and HGESS), respectively...
Patterns of failure for conservatively managed surgical stage I uterine carcinosarcoma: implications for adjuvant therapyCharles A Leath
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, AL, USA
Int J Gynecol Cancer 19:888-91. 2009..Because most patients will recur distantly, systemic chemotherapy should be considered for patients with early stage uterine carcinosarcoma...- The impact of aborted radical hysterectomy in patients with cervical carcinomaCharles A Leath
Department of Obstetrics and Gynecology, Division of Gynecology Oncology, University of Alabama at Birmingham, Birmingham, AL 35249 7333, USA
Gynecol Oncol 95:204-7. 2004..To determine the impact of an aborted radical hysterectomy on morbidity and overall survival in patients undergoing surgical treatment for early stage cervical carcinoma... - Bowel resection at the time of primary debulking for epithelial ovarian carcinoma: outcomes in patients treated with platinum and taxane-based chemotherapyJacob M Estes
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama-Birmingham, 619 19th Street South, Birmingham, AL 35249-7333, USA
J Am Coll Surg 203:527-32. 2006..Bowel resection at the time of primary cytoreductive surgery is associated with acceptable perioperative morbidity... - Immunohistochemical evaluation of the c-kit proto-oncogene in sarcomas of the uterus: a case seriesCharles A Leath
Division of Gynecologic Oncology, University of Alabama at Birmingham, USA
J Reprod Med 49:71-5. 2004..To evaluate the incidence of c-kit expression in uterine sarcomas... - Surgically managed stage I endometrial cancer in a low-volume center: outcomes and complications in a military residency programBeverly G Reed
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brooke Army Medical Center, Ft Sam Houston, TX 78234, USA
Am J Obstet Gynecol 205:356.e1-5. 2011..The purpose of this study was to compare operative outcomes and complications for patients with endometrial cancer who underwent staging by laparoscopy vs laparotomy in a low-volume facility... - Inflammatory pseudotumor of pelvic lymph nodesWhitney A Spannuth
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL, USA
Obstet Gynecol 108:779-82. 2006..Inflammatory pseudotumor is a rare benign cause of lymphadenopathy previously reported in several anatomic locations that can simulate malignant neoplasm... - A phase II trial of weekly topotecan for patients with secondary platinum-resistant recurrent epithelial ovarian carcinoma following the failure of second-line therapyWhitney A Spannuth
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, The University of Alabama at Birmingham, AL 35294, USA
Gynecol Oncol 104:591-5. 2007..To determine the response rate, progression-free survival and toxicity associated with weekly topotecan administered to patients with platinum-sensitive recurrent epithelial ovarian (EOC) in the third-line setting... - Pegylated liposomal doxorubicin consolidation therapy after platinum/paclitaxel-based chemotherapy for suboptimally debulked, advanced-stage epithelial ovarian cancer patientsRodney P Rocconi
University of Alabama at Birmingham, 35233, USA
Oncologist 11:336-41. 2006.... - Uterine papillary serous carcinoma: comparisons of outcomes in surgical Stage I patients with and without adjuvant therapyWarner K Huh
University of Alabama at Birmingham, Birmingham, AL 35249, USA
Gynecol Oncol 91:470-5. 2003..Our aim was to determine the outcomes of Stage I uterine papillary serous carcinoma (UPSC) patients with and without adjuvant therapy after comprehensive surgical staging... - Management strategies for stage IB2 cervical cancer: a cost-effectiveness analysisRodney P Rocconi
University of Alabama at Birmingham, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, 618 South 19th Street, Old Hillman Building Room 538, Birmingham, AL 35233, USA
Gynecol Oncol 97:387-94. 2005..To assess the potential effectiveness and medical costs of three common strategies to manage Stage IB2 squamous cell carcinoma of the cervix (CXCA)... - Infectivity enhanced adenoviral-mediated mda-7/IL-24 gene therapy for ovarian carcinomaCharles A Leath
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 901 19th Street South, Birmingham, AL 35294, USA
Gynecol Oncol 94:352-62. 2004..Infectivity enhanced CD40- and EGFR-retargeted Ad.mda-7 augments apoptosis induction, thus increasing the therapeutic index and translational potential of Ad.mda-7 gene therapy... - Serous fallopian tube carcinoma: a retrospective, multi-institutional case-control comparison to serous adenocarcinoma of the ovaryKathleen N Moore
University of Oklahoma, Division of Gynecologic Oncology, 920 SL Young Blvd, Oklahoma City, OK 73104, USA
Gynecol Oncol 107:398-403. 2007..Primary carcinoma of the fallopian tube (PCFT) is a rare malignancy comprising 1% of genital tract cancers. We sought to compare survival trends between PCFT and ovarian carcinoma (OC) patients (pts) in a matched, case-control comparison... - Conservative management of postoperative Fever in gynecologic patients undergoing major abdominal or vaginal operationsJames E Kendrick
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Alabama at Birmingham, AL 35249 7333, USA
J Am Coll Surg 207:393-7. 2008..To develop a standardized protocol for management of postoperative fever in gynecology patients to decrease unnecessary diagnostic workups and empiric use of antibiotics... - Surgical staging in endometrial cancerTyler O Kirby
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35233 7333, USA
Oncology (Williston Park) 20:45-50; discussion 50, 53-4, 63. 2006..Finally, resection of occult metastasis with surgical staging may improve survival... - Synchronous primary endometrial and ovarian carcinoma in a patient with marantic endocarditisT Michael Numnum
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Alabama at Birmingham, AL, USA
Obstet Gynecol 108:748-50. 2006..There is limited information about the clinical course of patients with NBTE because the majority of cases are found at the time of autopsy... - Radical hysterectomy and pelvic lymphadenectomy for stage IB2 cervical cancerLaura J Havrilesky
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, NC 27710, USA
Gynecol Oncol 93:429-34. 2004..We wished to evaluate survival and adverse outcomes of patients with stage IB2 cervical cancer treated primarily with radical hysterectomy and lymphadenectomy... - Transcriptional blocks limit adenoviral replication in primary ovarian tumorMeredith A Preuss
Division of Human Gene Therapy and The Gene Therapy Center, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
Clin Cancer Res 10:3189-94. 2004..Identification of factors leading to abortive infection will be crucial to understanding the low viral replication in patient samples... - Weekly topotecan and daily thalidomide in patients with recurrent epithelial ovarian cancer: a report of 2 casesNeil T Phippen
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, 3851 Roger Brooke Drive, Ft Sam Houston, TX 78234, USA
J Reprod Med 54:583-6. 2009..Recently the combination of topotecan and thalidomide was shown to be superior to topotecan alone in terms of response and progression-free survival... - Cost effectiveness of concurrent gemcitabine and cisplatin with radiation followed by adjuvant gemcitabine and cisplatin in patients with stages IIB to IVA carcinoma of the cervixNeil T Phippen
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, San Antonio Military Medical Center, Fort Sam Houston, TX 78234, USA
Gynecol Oncol 127:267-72. 2012..We evaluate the cost effectiveness (CE) of these treatment regimens... - Completed versus aborted radical hysterectomy for node-positive stage IB cervical cancer in the modern era of chemoradiation therapyAngela J Ziebarth
University of Alabama at Birmingham, Birmingham, AL, USA
Gynecol Oncol 126:69-72. 2012..Debate continues about optimal management of patients with node-positive stage I cervical cancer. Our objective was to determine if patient outcomes are affected by radical hysterectomy in the modern era of adjuvant chemoradiation... - Conservative management of stage I endometrial carcinoma after surgical stagingJ Michael Straughn
Division of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, Alabama 35249, USA
Gynecol Oncol 84:194-200. 2002..The aim of this study was to determine the outcomes of Stage I endometrial carcinoma patients who are managed without adjuvant radiation after comprehensive surgical staging... - Efficacy and toxicity of the novel chemotherapeutic agent KW-2170 in recurrent epithelial ovarian cancerJacob M Estes
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 618 South 19th Street, Old Hillman Building-Room 538, Birmingham, AL 35233, USA
Gynecol Oncol 102:338-42. 2006..Whether KW-2170 would have greater clinical activity in a more treatment naive group of patients at an increased dose awaits clinical trial evaluation... - Primary extrarenal rhabdoid tumor of the ovary. A case reportCharles A Leath
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 340 Old Hillman Building, 619 19th Street South, Birmingham, AL 35249 7333, USA
J Reprod Med 48:283-6. 2003..Although extrarenal rhabdoid tumors have been documented at multiple extrarenal sites, to our knowledge no primary ovarian cases have been reported... - The role of radical parametrectomy in the treatment of occult cervical carcinoma after extrafascial hysterectomyCharles A Leath
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35249 7333, USA
Gynecol Oncol 92:215-9. 2004..To assess the morbidity and efficacy of radical parametrectomy (RP) performed following extrafascial hysterectomy in patients with occult cervical carcinoma... - Predictors of outcomes for women with cervical carcinomaCharles A Leath
Department of Obstetrics and Gynecology, Division of Gynecology Oncology, University of Alabama at Birmingham, 619 19th Street South, OHB538, Birmingham, AL 35249 7333, USA
Gynecol Oncol 99:432-6. 2005..To determine the impact of race and other factors on the management and outcomes of women treated for cervical cancer in a rural state... - A prospective evaluation of "see and treat" in women with HSIL Pap smear results: is this an appropriate strategy?T Michael Numnum
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35294 7333, USA
J Low Genit Tract Dis 9:2-6. 2005..The objective of this study was to determine the incidence of CIN 2 and CIN 3 in patients with an HSIL (CIN 2) Pap smear using a see-and-treat protocol... - Occult choriocarcinoma discovered by positron emission tomography/computed tomography imaging following a successful pregnancyT Michael Numnum
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 619 19th Street South, OHB 340, Birmingham, AL 35294, USA
Gynecol Oncol 97:713-5. 2005..Recently, there have been reports of PET scans used in patients with Gestational Trophoblastic Disease (GTD)... - Evaluation of the Patient-Generated Subjective Global Assessment (PG-SGA) as a predictor of febrile neutropenia in gynecologic cancer patients receiving combination chemotherapy: a pilot studyNeil T Phippen
Dept of Ob Gyn, Division of Gynecologic Oncology, Ft Sam Houston, TX 78234, USA
Gynecol Oncol 123:360-4. 2011..Determine if pre-treatment Patient-Generated Subjective Global Assessment (PG-SGA) predicts febrile neutropenia (FN) in gynecologic cancer patients receiving primary combination chemotherapy... - Undifferentiated uterine sarcoma presenting as a pathologic humerus fractureMichelle N Gonzalez
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA
Mil Med 175:691-2. 2010..Undifferentiated uterine sarcomas are rare malignancies often presenting at advanced stage... - Robotic surgery applications in the management of gynecologic malignanciesWilliam J Lowery
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, San Antonio Military Medical Center, San Antonio, Texas, USA
J Surg Oncol 105:481-7. 2012..The review focuses on surgical length, blood loss, complications, recovery time, and adequacy of surgical staging of robotic-assisted surgery compared to abdominal and non-robotically assisted laparoscopic surgery for malignancies... - Uterine leiomyosarcoma metastatic to the thyroidCharles A Leath
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, Alabama 35249 7333, USA
Obstet Gynecol 100:1122-4. 2002..Uterine leiomyosarcoma is an aggressive tumor that has a propensity for distant metastasis. Distant sites of spread include the lung, liver, brain, and bone... - Reaction to a surgical implant foreign body masquerading as recurrent uterine sarcomaAbigail T Shaltz
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Brooke Army Medical Center, Fort Sam Houston, Texas, USA
Obstet Gynecol 117:450-2. 2011..The long-term nature of these products is unknown, and they may cause foreign body reactions masquerading as recurrent disease in patients with cancer... - Hospice enrollment for terminally ill patients with gynecologic malignancies: impact on outcomes and interventionsErin A Keyser
Division of Gynecologic Oncology, Brooke Army Medical Center, Ft Sam Houston, TX 78234, USA
Gynecol Oncol 118:274-7. 2010..To determine survival and interventions for patients with non-curative gynecologic malignancies based on supportive care enrollment... - Transcriptional targeting of tumors with a novel tumor-specific survivin promoterZeng B Zhu
Division of Human Gene Therapy, Department of Medicine, Pathology, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham AL 35291, USA
Cancer Gene Ther 11:256-62. 2004.... - Primary lung large cell carcinoma metastatic to the vulva: a case report and review of the literatureRodney P Rocconi
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35233, USA
Gynecol Oncol 94:829-31. 2004..Metastatic cancer to the vulva is a rare diagnosis and is estimated to account for 5-8% of all vulvar cancers... - Cervical signet-ring cell carcinoma presenting as a synchronous primary carcinoma with uterine adenocarcinomaWilliam J Lowery
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Fort Sam Houston, TX 78234, USA
Mil Med 174:212-3. 2009..Synchronous primary gynecologic tumors are relatively uncommon with the diagnosis often made following initial surgery... - Incidence of subsequent abnormal cytology in cervical cancer patients completing five-years of post treatment surveillance without evidence of recurrenceJennifer M Orr
Department of Obstetrics and Gynecology, William Beaumont Army Medical Center, Fort Bliss, TX, USA
Gynecol Oncol 122:501-4. 2011..To determine the incidence of subsequent abnormal cervical or vaginal cytology and confirmatory histology in women completing five-years of surveillance for cervical cancer without recurrence... - Protrusio acetabuli presenting as a complex pelvic mass after total hip arthroplastyCharles A Leath
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, Alabama, USA
Obstet Gynecol 104:1187-9. 2004..The differential diagnosis in an elderly woman with a complex pelvic mass includes benign and malignant diseases... - Complications of indwelling venous access devices in patients with gynecologic malignanciesJacob M Estes
Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL 35249, USA
Gynecol Oncol 91:591-5. 2003..Infection and catheter-related malfunction are more common in patients with external catheters. We recommend the use of subcutaneous ports in the majority of patients with gynecologic malignancies... - Use of a fascial prosthesis for management of abdominal compartment syndrome secondary to obstetric hemorrhageJames E Kendrick
Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, Alabama 35233, USA
Obstet Gynecol 107:493-6. 2006..Massive obstetric hemorrhage can be catastrophic, with considerable maternal morbidity and mortality... - A pilot study of ovarian cancer chemoprevention using medroxyprogesterone acetate in an avian model of spontaneous ovarian carcinogenesisMack N Barnes
Department of Gynecologic Oncology, University of Alabama at Birmingham, 538 Old Hillman Building, 618 South 20th Street, Birmingham, AL 35233, USA
Gynecol Oncol 87:57-63. 2002..The current histologic findings are consistent with the theory that a reduction of ovulatory events may prevent the development of ovarian adenocarcinoma... - Chemotherapy for advanced and recurrent cervical carcinoma: results from cooperative group trialsCharles A Leath
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, Birmingham, AL, USA
Gynecol Oncol 129:251-7. 2013..To review the clinical trial experience with chemotherapy for patients with primary Stage IVB, persistent and recurrent cervical cancer... - Single-chain antibodies: A therapeutic modality for cancer gene therapy (review)Charles A Leath
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Alabama at Birmingham, AL, USA
Int J Oncol 24:765-71. 2004..We will limit our discussion to the role of scFv in targeting molecular processes associated with carcinogenesis...