Teresa Krakauer

Summary

Affiliation: Walter Reed Army Medical Center
Country: USA

Publications

  1. pmc Update on staphylococcal superantigen-induced signaling pathways and therapeutic interventions
    Teresa Krakauer
    Department of Immunology, Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 5011, USA
    Toxins (Basel) 5:1629-54. 2013
  2. doi request reprint Determination of C5a in murine models of staphylococcal enterotoxin B-induced toxic shock
    Teresa Krakauer
    Integrated Toxicology Division, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
    J Immunoassay Immunochem 34:30-8. 2013
  3. pmc PI3K/Akt/mTOR, a pathway less recognized for staphylococcal superantigen-induced toxicity
    Teresa Krakauer
    Department of Immunology, Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA
    Toxins (Basel) 4:1343-66. 2012
  4. ncbi request reprint Yin zi huang, an injectable multicomponent chinese herbal medicine, is a potent inhibitor of T-cell activation
    Xin Chen
    Basic Research Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    J Altern Complement Med 10:519-26. 2004
  5. ncbi request reprint Triptolide attenuates endotoxin- and staphylococcal exotoxin-induced T-cell proliferation and production of cytokines and chemokines
    Teresa Krakauer
    Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, Bldg 1425, Fort Detrick, Frederick, MD 21702 5011, USA
    Immunopharmacol Immunotoxicol 27:53-66. 2005
  6. doi request reprint Central roles for IL-2 and MCP-1 following intranasal exposure to SEB: a new mouse model
    Louis M Huzella
    Pathology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, United States
    Res Vet Sci 86:241-7. 2009
  7. pmc Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferation
    Teresa Krakauer
    Department of Immunology and Molecular Biology, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Clin Diagn Lab Immunol 11:621-4. 2004
  8. pmc Proinflammatory mediators of toxic shock and their correlation to lethality
    Teresa Krakauer
    Integrated Toxicology Division, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Mediators Inflamm 2010:517594. 2010
  9. pmc Rapamycin protects mice from staphylococcal enterotoxin B-induced toxic shock and blocks cytokine release in vitro and in vivo
    Teresa Krakauer
    Dept of Immunology, Bldg 1425, USAMRIID, Fort Detrick, Frederick, MD 21702 5011, USA
    Antimicrob Agents Chemother 54:1125-31. 2010
  10. ncbi request reprint Murine models of staphylococcal enterotoxin B-induced toxic shock
    Teresa Krakauer
    Integrated Toxicology Division, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Mil Med 175:917-22. 2010

Collaborators

Detail Information

Publications28

  1. pmc Update on staphylococcal superantigen-induced signaling pathways and therapeutic interventions
    Teresa Krakauer
    Department of Immunology, Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 5011, USA
    Toxins (Basel) 5:1629-54. 2013
    ..This article presents a concise review of superantigen-activated signaling pathways and focuses on the therapeutic challenges against bacterial superantigens. ..
  2. doi request reprint Determination of C5a in murine models of staphylococcal enterotoxin B-induced toxic shock
    Teresa Krakauer
    Integrated Toxicology Division, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
    J Immunoassay Immunochem 34:30-8. 2013
    ..This assay provides easy, quantifiable data for complement activation and its role in various SEB-induced toxic shock models...
  3. pmc PI3K/Akt/mTOR, a pathway less recognized for staphylococcal superantigen-induced toxicity
    Teresa Krakauer
    Department of Immunology, Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA
    Toxins (Basel) 4:1343-66. 2012
    ..This article reviews the signaling molecules induced by superantigens in the activation of PI3K/Akt/mTOR pathways leading to staphylococcal superantigen-induced toxicity and updates potential therapeutics against superantigens...
  4. ncbi request reprint Yin zi huang, an injectable multicomponent chinese herbal medicine, is a potent inhibitor of T-cell activation
    Xin Chen
    Basic Research Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    J Altern Complement Med 10:519-26. 2004
    ..The effects of 10 ingredient components of YZH were also evaluated...
  5. ncbi request reprint Triptolide attenuates endotoxin- and staphylococcal exotoxin-induced T-cell proliferation and production of cytokines and chemokines
    Teresa Krakauer
    Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, Bldg 1425, Fort Detrick, Frederick, MD 21702 5011, USA
    Immunopharmacol Immunotoxicol 27:53-66. 2005
    ..It also may be therapeutically useful for mitigating the pathogenic effects of these microbial products by downregulating the signaling pathways activated by both bacterial exotoxins and endotoxins...
  6. doi request reprint Central roles for IL-2 and MCP-1 following intranasal exposure to SEB: a new mouse model
    Louis M Huzella
    Pathology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, United States
    Res Vet Sci 86:241-7. 2009
    ..Lethality of SEB in C3H/HeJ mice was neutralized with SEB-specific antibodies, suggesting potential utility of this model for future therapeutic studies...
  7. pmc Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferation
    Teresa Krakauer
    Department of Immunology and Molecular Biology, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Clin Diagn Lab Immunol 11:621-4. 2004
    ..These data suggest that caspase inhibitors may represent a novel therapeutic modality for treating SE-induced toxic shock...
  8. pmc Proinflammatory mediators of toxic shock and their correlation to lethality
    Teresa Krakauer
    Integrated Toxicology Division, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Mediators Inflamm 2010:517594. 2010
    ..Overall, synergistic action of SEB and LPS resulted in higher and prolonged levels of these key cytokines leading to toxic shock...
  9. pmc Rapamycin protects mice from staphylococcal enterotoxin B-induced toxic shock and blocks cytokine release in vitro and in vivo
    Teresa Krakauer
    Dept of Immunology, Bldg 1425, USAMRIID, Fort Detrick, Frederick, MD 21702 5011, USA
    Antimicrob Agents Chemother 54:1125-31. 2010
    ..The serum levels of MCP-1 and IL-6, after intranasal exposure to SEB, were significantly reduced in mice given rapamycin versus controls. Additionally, rapamycin diminished the weight loss and temperature fluctuations elicited by SEB...
  10. ncbi request reprint Murine models of staphylococcal enterotoxin B-induced toxic shock
    Teresa Krakauer
    Integrated Toxicology Division, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Mil Med 175:917-22. 2010
    ..The hypothermic response, weight loss, and induction of serum monocyte chemoattractant protein 1 (MCP-1), interleukin 2 (IL-2), and IL-6 correlated with mortality in all three models...
  11. ncbi request reprint The potency of anti-oxidants in attenuating superantigen-induced proinflammatory cytokines correlates with inactivation of NF-kappaB
    Teresa Krakauer
    Department of Immunology, Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Immunopharmacol Immunotoxicol 30:163-79. 2008
    ..Our results suggest that anti-oxidants might be useful to mitigate the pathogenic effects of SE by blocking transcriptional signaling activated by superantigens...
  12. doi request reprint Critical timing, location and duration of glucocorticoid administration rescue mice from superantigen-induced shock and attenuate lung injury
    Teresa Krakauer
    Integrated Toxicology Division, USAMRIID, Fort Detrick, MD 21702 5011, USA
    Int Immunopharmacol 9:1168-74. 2009
    ..This optimal dosing and schedule of glucocorticoid treatment mitigated lung inflammation and resulted in 100% survival in this intranasal mouse model of SEB-mediated shock...
  13. ncbi request reprint Measurement of proinflammatory cytokines and T-cell proliferative response in superantigen-activated human peripheral blood mononuclear cells
    Teresa Krakauer
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Methods Mol Biol 214:137-49. 2003
  14. pmc Doxycycline is anti-inflammatory and inhibits staphylococcal exotoxin-induced cytokines and chemokines
    Teresa Krakauer
    Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 5011, USA
    Antimicrob Agents Chemother 47:3630-3. 2003
    ..These results suggest that the antibiotic doxycycline has anti-inflammatory effects and is therapeutically useful for mitigating the pathogenic effects of SE...
  15. pmc Bacillus anthracis edema toxin inhibits Staphylococcus aureus enterotoxin B effects in vitro: a potential protein therapeutic?
    Teresa Krakauer
    Integrated Toxicology, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 5011, USA
    Infect Immun 73:7069-73. 2005
    ..Overall, these results suggest a novel use of B. anthracis edema toxin against a bacterial superantigen...
  16. pmc Intranasal rapamycin rescues mice from staphylococcal enterotoxin B-induced shock
    Teresa Krakauer
    Integrated Toxicology Division, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
    Toxins (Basel) 4:718-28. 2012
    ..Intranasal rapamycin represents a novel use of an immunosuppressant targeting directly to site of toxin exposure, reducing dosages needed and allowing a wider therapeutic window...
  17. ncbi request reprint The polyphenol chlorogenic acid inhibits staphylococcal exotoxin-induced inflammatory cytokines and chemokines
    Teresa Krakauer
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Immunopharmacol Immunotoxicol 24:113-9. 2002
    ..Naturally occurring polyphenolic compounds such as chlorogenic acid may serve as a potent anti-inflammatory agent alternative to conventional chemotherapeutics...
  18. ncbi request reprint Effects of Shuanghuanglian and Qingkailing, two multi-components of traditional Chinese medicinal preparations, on human leukocyte function
    Xin Chen
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute Frederick, Fort Detrick, MD, 21702 1201, USA
    Life Sci 70:2897-913. 2002
    ..Identification of the responsible components in these two herbal preparations may yield compounds suitable for structural modification into potent novel drugs...
  19. pmc Dexamethasone attenuates staphylococcal enterotoxin B-induced hypothermic response and protects mice from superantigen-induced toxic shock
    Teresa Krakauer
    Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Antimicrob Agents Chemother 50:391-5. 2006
    ..Dexamethasone, an anti-inflammatory agent, attenuated staphylococcal enterotoxin B (SEB)-induced hypothermia and serum proinflammatory cytokines and improved survival from 0% to 86% in a lethal mouse model of SEB-mediated shock...
  20. pmc Therapeutic down-modulators of staphylococcal superantigen-induced inflammation and toxic shock
    Teresa Krakauer
    Department of Immunology, Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, USA
    Toxins (Basel) 2:1963-83. 2010
    ....
  21. ncbi request reprint Molecular therapeutic targets in inflammation: cyclooxygenase and NF-kappaB
    Teresa Krakauer
    Department of Molecular Biology and Immunology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 5011, USA
    Curr Drug Targets Inflamm Allergy 3:317-24. 2004
    ....
  22. ncbi request reprint Superantigen-induced cytokine release from whole-blood cell culture as a functional measure of drug efficacy after oral dosing in nonhuman primates
    Teresa Krakauer
    Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 5011, USA
    Res Vet Sci 83:182-7. 2007
    ....
  23. ncbi request reprint Chemotherapeutics targeting immune activation by staphylococcal superantigens
    Teresa Krakauer
    Department of Immunology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 5011, USA
    Med Sci Monit 11:RA290-5. 2005
    ..Early blockade of these targets proves to be useful in vitro and in vivo testing of therapeutics against SEB-induced toxic shock will also be reviewed...
  24. ncbi request reprint RNase protection assay for the study of the differential effects of therapeutic agents in suppressing staphylococcal enterotoxin B-induced cytokines in human peripheral blood mononuclear cells
    Teresa Krakauer
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Methods Mol Biol 214:151-64. 2003
  25. pmc Pirfenidone blocks the in vitro and in vivo effects of staphylococcal enterotoxin B
    Martha L Hale
    Toxinology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 5011, USA
    Infect Immun 70:2989-94. 2002
    ..Overall, these studies demonstrated the potential utility of pirfenidone as a therapeutic against septic shock and the biological effects of SEB...
  26. doi request reprint Nuclear factor-kappaB: fine-tuning a central integrator of diverse biologic stimuli
    Teresa Krakauer
    Department of Immunology, Division of Integrated Toxicology, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21702 5011, USA
    Int Rev Immunol 27:286-92. 2008
    ....
  27. pmc Stimulant-dependent modulation of cytokines and chemokines by airway epithelial cells: cross talk between pulmonary epithelial and peripheral blood mononuclear cells
    Teresa Krakauer
    Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 5011, USA
    Clin Diagn Lab Immunol 9:126-31. 2002
    ....
  28. doi request reprint Efficacy of Two FDA-approved drug combination in a mouse model of staphylococcal enterotoxin B-induced shock
    Teresa Krakauer
    Integrated Toxicology Division, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 5011, USA
    Mil Med 178:1024-8. 2013
    ....