T Krakauer

Summary

Affiliation: Walter Reed Army Medical Center
Country: USA

Publications

  1. pmc Doxycycline is anti-inflammatory and inhibits staphylococcal exotoxin-induced cytokines and chemokines
    Teresa Krakauer
    Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 5011, USA
    Antimicrob Agents Chemother 47:3630-3. 2003
  2. pmc Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferation
    Teresa Krakauer
    Department of Immunology and Molecular Biology, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Clin Diagn Lab Immunol 11:621-4. 2004
  3. ncbi request reprint Molecular therapeutic targets in inflammation: cyclooxygenase and NF-kappaB
    Teresa Krakauer
    Department of Molecular Biology and Immunology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 5011, USA
    Curr Drug Targets Inflamm Allergy 3:317-24. 2004
  4. ncbi request reprint Triptolide attenuates endotoxin- and staphylococcal exotoxin-induced T-cell proliferation and production of cytokines and chemokines
    Teresa Krakauer
    Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, Bldg 1425, Fort Detrick, Frederick, MD 21702 5011, USA
    Immunopharmacol Immunotoxicol 27:53-66. 2005
  5. ncbi request reprint Chemotherapeutics targeting immune activation by staphylococcal superantigens
    Teresa Krakauer
    Department of Immunology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 5011, USA
    Med Sci Monit 11:RA290-5. 2005
  6. pmc Stimulant-dependent modulation of cytokines and chemokines by airway epithelial cells: cross talk between pulmonary epithelial and peripheral blood mononuclear cells
    Teresa Krakauer
    Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 5011, USA
    Clin Diagn Lab Immunol 9:126-31. 2002
  7. ncbi request reprint The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines
    T Krakauer
    Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, USA
    FEBS Lett 500:52-5. 2001
  8. pmc Dexamethasone attenuates staphylococcal enterotoxin B-induced hypothermic response and protects mice from superantigen-induced toxic shock
    Teresa Krakauer
    Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Antimicrob Agents Chemother 50:391-5. 2006
  9. pmc Suppression of endotoxin- and staphylococcal exotoxin-induced cytokines and chemokines by a phospholipase C inhibitor in human peripheral blood mononuclear cells
    T Krakauer
    Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Fort Detrick, Maryland 21702 5011, USA
    Clin Diagn Lab Immunol 8:449-53. 2001
  10. pmc Coordinate suppression of superantigen-induced cytokine production and T-cell proliferation by a small nonpeptidic inhibitor of class II major histocompatibility complex and CD4 interaction
    T Krakauer
    Department of Immunology and Molecular Biology, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Antimicrob Agents Chemother 44:1067-9. 2000

Detail Information

Publications24

  1. pmc Doxycycline is anti-inflammatory and inhibits staphylococcal exotoxin-induced cytokines and chemokines
    Teresa Krakauer
    Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 5011, USA
    Antimicrob Agents Chemother 47:3630-3. 2003
    ..These results suggest that the antibiotic doxycycline has anti-inflammatory effects and is therapeutically useful for mitigating the pathogenic effects of SE...
  2. pmc Caspase inhibitors attenuate superantigen-induced inflammatory cytokines, chemokines, and T-cell proliferation
    Teresa Krakauer
    Department of Immunology and Molecular Biology, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Clin Diagn Lab Immunol 11:621-4. 2004
    ..These data suggest that caspase inhibitors may represent a novel therapeutic modality for treating SE-induced toxic shock...
  3. ncbi request reprint Molecular therapeutic targets in inflammation: cyclooxygenase and NF-kappaB
    Teresa Krakauer
    Department of Molecular Biology and Immunology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 5011, USA
    Curr Drug Targets Inflamm Allergy 3:317-24. 2004
    ....
  4. ncbi request reprint Triptolide attenuates endotoxin- and staphylococcal exotoxin-induced T-cell proliferation and production of cytokines and chemokines
    Teresa Krakauer
    Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, Bldg 1425, Fort Detrick, Frederick, MD 21702 5011, USA
    Immunopharmacol Immunotoxicol 27:53-66. 2005
    ..It also may be therapeutically useful for mitigating the pathogenic effects of these microbial products by downregulating the signaling pathways activated by both bacterial exotoxins and endotoxins...
  5. ncbi request reprint Chemotherapeutics targeting immune activation by staphylococcal superantigens
    Teresa Krakauer
    Department of Immunology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 5011, USA
    Med Sci Monit 11:RA290-5. 2005
    ..Early blockade of these targets proves to be useful in vitro and in vivo testing of therapeutics against SEB-induced toxic shock will also be reviewed...
  6. pmc Stimulant-dependent modulation of cytokines and chemokines by airway epithelial cells: cross talk between pulmonary epithelial and peripheral blood mononuclear cells
    Teresa Krakauer
    Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 5011, USA
    Clin Diagn Lab Immunol 9:126-31. 2002
    ....
  7. ncbi request reprint The flavonoid baicalin inhibits superantigen-induced inflammatory cytokines and chemokines
    T Krakauer
    Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD 21702 5011, USA
    FEBS Lett 500:52-5. 2001
    ..These data suggest that baicalin may be therapeutically useful for mitigating the pathogenic effects of SE by inhibiting the signaling pathways activated by superantigens...
  8. pmc Dexamethasone attenuates staphylococcal enterotoxin B-induced hypothermic response and protects mice from superantigen-induced toxic shock
    Teresa Krakauer
    Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Antimicrob Agents Chemother 50:391-5. 2006
    ..Dexamethasone, an anti-inflammatory agent, attenuated staphylococcal enterotoxin B (SEB)-induced hypothermia and serum proinflammatory cytokines and improved survival from 0% to 86% in a lethal mouse model of SEB-mediated shock...
  9. pmc Suppression of endotoxin- and staphylococcal exotoxin-induced cytokines and chemokines by a phospholipase C inhibitor in human peripheral blood mononuclear cells
    T Krakauer
    Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter St, Fort Detrick, Maryland 21702 5011, USA
    Clin Diagn Lab Immunol 8:449-53. 2001
    ..These data suggest a potential role for D609 in the treatment of septic shock...
  10. pmc Coordinate suppression of superantigen-induced cytokine production and T-cell proliferation by a small nonpeptidic inhibitor of class II major histocompatibility complex and CD4 interaction
    T Krakauer
    Department of Immunology and Molecular Biology, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Antimicrob Agents Chemother 44:1067-9. 2000
    ..These data suggest that TJU103 may be useful for mitigating the pathogenic effects of SE...
  11. pmc Pentoxifylline inhibits superantigen-induced toxic shock and cytokine release
    T Krakauer
    Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Clin Diagn Lab Immunol 6:594-8. 1999
    ..Thus, in addition to treating endotoxemias, the cumulative in vitro and in vivo data suggest that pentoxifylline may also be useful in abrogating the ill effects of staphylococcal enterotoxins and TSST-1...
  12. ncbi request reprint Differential immune responses to staphylococcal enterotoxin B mutations in a hydrophobic loop dominating the interface with major histocompatibility complex class II receptors
    M A Woody
    Department of Immunology and Molecular Biology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    J Infect Dis 177:1013-22. 1998
    ..Vaccines against staphylococcal superantigens should focus on this critical leucine residue...
  13. ncbi request reprint Immuno-enhancing effects of ricin
    T Krakauer
    Disease Assessment Division, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702-5011
    Immunopharmacol Immunotoxicol 13:357-66. 1991
    ..Higher concentrations of ricin (greater than 10(-3) micrograms/ml) inhibited production of IL-1 by PBMC and the mitogen-driven proliferation of PBMC cultures...
  14. ncbi request reprint Staphylococcus aureus: the toxic presence of a pathogen extraordinaire
    E A Larkin
    Department of Immunology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    Curr Med Chem 16:4003-19. 2009
    ..aureus, with a toxic twist. There will be a particular focus upon the biological and biochemical properties of, plus current neutralization strategies targeting, staphylcoccocal superantigens like the SEs and TSST-1...
  15. ncbi request reprint Serum cytokine levels and antibody response to influenza vaccine in the elderly
    T Krakauer
    Dept of Molecular Biology and Immunology, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA
    Immunopharmacol Immunotoxicol 23:35-41. 2001
    ..Serum levels of these three cytokines were not changed significantly four weeks after vaccination (P < 0.05 for IL-6 and P < 0.01 for IL-10). In addition, there were also no age-dependent differences in serum IL-6 and IL-10 levels...
  16. ncbi request reprint The potency of anti-oxidants in attenuating superantigen-induced proinflammatory cytokines correlates with inactivation of NF-kappaB
    Teresa Krakauer
    Department of Immunology, Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Immunopharmacol Immunotoxicol 30:163-79. 2008
    ..Our results suggest that anti-oxidants might be useful to mitigate the pathogenic effects of SE by blocking transcriptional signaling activated by superantigens...
  17. ncbi request reprint Superantigen-induced cytokine release from whole-blood cell culture as a functional measure of drug efficacy after oral dosing in nonhuman primates
    Teresa Krakauer
    Integrated Toxicology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702 5011, USA
    Res Vet Sci 83:182-7. 2007
    ....
  18. pmc Bacillus anthracis edema toxin inhibits Staphylococcus aureus enterotoxin B effects in vitro: a potential protein therapeutic?
    Teresa Krakauer
    Integrated Toxicology, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 5011, USA
    Infect Immun 73:7069-73. 2005
    ..Overall, these results suggest a novel use of B. anthracis edema toxin against a bacterial superantigen...
  19. pmc Pirfenidone blocks the in vitro and in vivo effects of staphylococcal enterotoxin B
    Martha L Hale
    Toxinology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 5011, USA
    Infect Immun 70:2989-94. 2002
    ..Overall, these studies demonstrated the potential utility of pirfenidone as a therapeutic against septic shock and the biological effects of SEB...
  20. ncbi request reprint The polyphenol chlorogenic acid inhibits staphylococcal exotoxin-induced inflammatory cytokines and chemokines
    Teresa Krakauer
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    Immunopharmacol Immunotoxicol 24:113-9. 2002
    ..Naturally occurring polyphenolic compounds such as chlorogenic acid may serve as a potent anti-inflammatory agent alternative to conventional chemotherapeutics...
  21. ncbi request reprint Effects of Shuanghuanglian and Qingkailing, two multi-components of traditional Chinese medicinal preparations, on human leukocyte function
    Xin Chen
    Laboratory of Molecular Immunoregulation, Center for Cancer Research, National Cancer Institute Frederick, Fort Detrick, MD, 21702 1201, USA
    Life Sci 70:2897-913. 2002
    ..Identification of the responsible components in these two herbal preparations may yield compounds suitable for structural modification into potent novel drugs...
  22. ncbi request reprint Yin zi huang, an injectable multicomponent chinese herbal medicine, is a potent inhibitor of T-cell activation
    Xin Chen
    Basic Research Program, SAIC Frederick, Inc, National Cancer Institute Frederick, Frederick, MD 21702 1201, USA
    J Altern Complement Med 10:519-26. 2004
    ..The effects of 10 ingredient components of YZH were also evaluated...
  23. ncbi request reprint Measurement of proinflammatory cytokines and T-cell proliferative response in superantigen-activated human peripheral blood mononuclear cells
    Teresa Krakauer
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Methods Mol Biol 214:137-49. 2003
  24. ncbi request reprint RNase protection assay for the study of the differential effects of therapeutic agents in suppressing staphylococcal enterotoxin B-induced cytokines in human peripheral blood mononuclear cells
    Teresa Krakauer
    Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    Methods Mol Biol 214:151-64. 2003