Yuang Taung Juang

Summary

Affiliation: Walter Reed Army Medical Center
Country: USA

Publications

  1. ncbi request reprint Defective production of functional 98-kDa form of Elf-1 is responsible for the decreased expression of TCR zeta-chain in patients with systemic lupus erythematosus
    Yuang Taung Juang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Immunol 169:6048-55. 2002
  2. ncbi request reprint Antisense cyclic adenosine 5'-monophosphate response element modulator up-regulates IL-2 in T cells from patients with systemic lupus erythematosus
    Klaus Tenbrock
    Department of Cellular Injury, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    J Immunol 169:4147-52. 2002
  3. ncbi request reprint The cyclic adenosine 5'-monophosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanism
    Klaus Tenbrock
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Immunol 170:2971-6. 2003
  4. pmc Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV
    Yuang Taung Juang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    J Clin Invest 115:996-1005. 2005
  5. pmc Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus
    Christina G Katsiari
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    J Clin Invest 115:3193-204. 2005
  6. ncbi request reprint Geldanamycin treatment inhibits hemorrhage-induced increases in KLF6 and iNOS expression in unresuscitated mouse organs: role of inducible HSP70
    Juliann G Kiang
    Department of Cellular Injury, Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    J Appl Physiol (1985) 97:564-9. 2004
  7. ncbi request reprint Dissecting the molecular mechanisms of TCR zeta chain downregulation and T cell signaling abnormalities in human systemic lupus erythematosus
    Madhusoodana P Nambiar
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, and Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Int Rev Immunol 23:245-63. 2004
  8. ncbi request reprint Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus
    Yansong Li
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Immunol 178:1938-47. 2007
  9. ncbi request reprint Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus
    Vasileios C Kyttaris
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Immunol 178:1960-6. 2007
  10. ncbi request reprint N(omega)-nitro-L-arginine inhibits inducible HSP-70 via Ca(2+), PKC, and PKA in human intestinal epithelial T84 cells
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring 20910 7500, USA
    Am J Physiol Gastrointest Liver Physiol 282:G415-23. 2002

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Defective production of functional 98-kDa form of Elf-1 is responsible for the decreased expression of TCR zeta-chain in patients with systemic lupus erythematosus
    Yuang Taung Juang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Immunol 169:6048-55. 2002
    ....
  2. ncbi request reprint Antisense cyclic adenosine 5'-monophosphate response element modulator up-regulates IL-2 in T cells from patients with systemic lupus erythematosus
    Klaus Tenbrock
    Department of Cellular Injury, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    J Immunol 169:4147-52. 2002
    ..Our data demonstrate that antisense constructs can be used to effectively eliminate the expression of a transcriptional repressor. This approach can be used therapeutically in conditions where increased production of IL-2 is desired...
  3. ncbi request reprint The cyclic adenosine 5'-monophosphate response element modulator suppresses IL-2 production in stimulated T cells by a chromatin-dependent mechanism
    Klaus Tenbrock
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Immunol 170:2971-6. 2003
    ..CREM, in turn, binds protein 300 and cAMP response element binding protein, but CREM is unable to activate its histone acetyltransferase activity, which results in condensation of chromatin and down-regulation of IL-2 production...
  4. pmc Systemic lupus erythematosus serum IgG increases CREM binding to the IL-2 promoter and suppresses IL-2 production through CaMKIV
    Yuang Taung Juang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    J Clin Invest 115:996-1005. 2005
    ....
  5. pmc Protein phosphatase 2A is a negative regulator of IL-2 production in patients with systemic lupus erythematosus
    Christina G Katsiari
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    J Clin Invest 115:3193-204. 2005
    ..We propose the use of PP2Ac-siRNA as a novel tool to correct T cell IL-2 production in SLE patients...
  6. ncbi request reprint Geldanamycin treatment inhibits hemorrhage-induced increases in KLF6 and iNOS expression in unresuscitated mouse organs: role of inducible HSP70
    Juliann G Kiang
    Department of Cellular Injury, Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    J Appl Physiol (1985) 97:564-9. 2004
    ..These results suggest that GA may be therapeutically useful for reducing hemorrhage-induced injury when used as a presurgical treatment or when added to resuscitation fluids...
  7. ncbi request reprint Dissecting the molecular mechanisms of TCR zeta chain downregulation and T cell signaling abnormalities in human systemic lupus erythematosus
    Madhusoodana P Nambiar
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, and Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland, USA
    Int Rev Immunol 23:245-63. 2004
    ....
  8. ncbi request reprint Phosphorylated ERM is responsible for increased T cell polarization, adhesion, and migration in patients with systemic lupus erythematosus
    Yansong Li
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Immunol 178:1938-47. 2007
    ..These data prove that increased ERM phosphorylation represents a key molecular abnormality that guides T cell adhesion and migration in SLE patients...
  9. ncbi request reprint Increased levels of NF-ATc2 differentially regulate CD154 and IL-2 genes in T cells from patients with systemic lupus erythematosus
    Vasileios C Kyttaris
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Immunol 178:1960-6. 2007
    ..The absence of important transcriptional activators (AP-1, NF-kappaBeta) and the presence of transcriptional repressors (cAMP response element modulator) on the IL-2 promoter explain this dichotomous effect...
  10. ncbi request reprint N(omega)-nitro-L-arginine inhibits inducible HSP-70 via Ca(2+), PKC, and PKA in human intestinal epithelial T84 cells
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring 20910 7500, USA
    Am J Physiol Gastrointest Liver Physiol 282:G415-23. 2002
    ..These results suggest that L-NNA inhibits HSP-70i by reducing [Ca(2+)](i) and decreasing PKC and PKA activity, thereby blocking HSF1 translocation from the cytosol to the nucleus...
  11. ncbi request reprint Direct transfer of p65 into T lymphocytes from systemic lupus erythematosus patients leads to increased levels of interleukin-2 promoter activity
    Thomas M Herndon
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    Clin Immunol 103:145-53. 2002
    ....
  12. pmc Protein kinase A enhances, whereas glycogen synthase kinase-3 beta inhibits, the activity of the exon 2-encoded transactivator domain of heterogeneous nuclear ribonucleoprotein D in a hierarchical fashion
    Mate Tolnay
    Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Biochem J 363:127-36. 2002
    ....
  13. ncbi request reprint Elf-1 binds to GGAA elements on the FcRgamma promoter and represses its expression
    Yuang Taung Juang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Immunol 179:4884-9. 2007
    ....
  14. pmc Differential expression and molecular associations of Syk in systemic lupus erythematosus T cells
    Sandeep Krishnan
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Immunol 181:8145-52. 2008
    ..Thus, we propose molecular targeting of Syk as a measure to control abnormal T cell responses in SLE...
  15. ncbi request reprint Increased expression of STAT3 in SLE T cells contributes to enhanced chemokine-mediated cell migration
    Tatsuhiro Harada
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Autoimmunity 40:1-8. 2007
    ..Our data suggest that inhibition of STAT3 expression may reverse the signaling aberrations involved in SLE T cell migration...
  16. ncbi request reprint Immune cells and cytokines in systemic lupus erythematosus: an update
    Vasileios C Kyttaris
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
    Curr Opin Rheumatol 17:518-22. 2005
    ..This article reviews recent studies unraveling the complex interplay between cytokines and lymphocytes in systemic lupus erythematosus...
  17. ncbi request reprint Geldanamycin prevents hemorrhage-induced ATP loss by overexpressing inducible HSP70 and activating pyruvate dehydrogenase
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Am J Physiol Gastrointest Liver Physiol 291:G117-27. 2006
    ..We conclude that agents able to increase the expression of HSP70 and PDH may be of value in reducing pathology resulting from hemorrhage-associated ATP loss...
  18. ncbi request reprint New insights into the pathogenesis of systemic lupus erythematosus
    Vasileios C Kyttaris
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Curr Rheumatol Rep 7:469-75. 2005
    ..This leads to the production of an array of inflammatory cytokines, diverse autoantibodies, and immune complexes that in turn activate effector cells and the complement system leading to the clinical manifestations of the disease...
  19. ncbi request reprint Cyclic adenosine 5'-monophosphate response element modulator is responsible for the decreased expression of c-fos and activator protein-1 binding in T cells from patients with systemic lupus erythematosus
    Vasileios C Kyttaris
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Immunol 173:3557-63. 2004
    ..We conclude that CREM represses the expression of c-fos and limits the activity of the enhancer AP-1. Thus, CREM is involved indirectly in the modulation of transcriptional regulation of multiple genes including IL-2...
  20. ncbi request reprint The cyclic AMP response element modulator regulates transcription of the TCR zeta-chain
    Klaus Tenbrock
    Department of Pediatrics, Division of Rheumatology, University Hospital, Muenster, Germany
    J Immunol 175:5975-80. 2005
    ..Our studies demonstrate that CREM alpha binds to the TCR zeta promoter and repress its activity...
  21. pmc PP2A dephosphorylates Elf-1 and determines the expression of CD3zeta and FcRgamma in human systemic lupus erythematosus T cells
    Yuang Taung Juang
    Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:3658-64. 2008
    ..Therefore, PP2A serves as a central determinant of abnormal T cell function in human lupus and may represent an appropriate treatment target...
  22. doi request reprint How signaling and gene transcription aberrations dictate the systemic lupus erythematosus T cell phenotype
    Jose C Crispin
    Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Trends Immunol 29:110-5. 2008
    ..The result is an abnormally functioning T cell that exhibits several molecular alterations that can be exploited as therapeutic or diagnostic markers...
  23. pmc Systemic lupus erythematosus: new molecular targets
    Jose C Crispin
    Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, 4 Blackfan Circle, HIM 244, Boston, MA 02115, USA
    Ann Rheum Dis 66:iii65-9. 2007
    ..The aim of this article is to review the findings that have allowed us to better understand the behaviour of the lupus T cell and highlight the molecules that represent potential therapeutic targets...
  24. ncbi request reprint Phosphorylation and O-linked glycosylation of Elf-1 leads to its translocation to the nucleus and binding to the promoter of the TCR zeta-chain
    Yuang Taung Juang
    Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    J Immunol 168:2865-71. 2002
    ..In conclusion, different forms of Elf-1 are the products of posttranslational modifications that determine its subcellular localization, activity, and metabolic degradation...
  25. ncbi request reprint Activation of the Ets transcription factor Elf-1 requires phosphorylation and glycosylation: defective expression of activated Elf-1 is involved in the decreased TCR zeta chain gene expression in patients with systemic lupus erythematosus
    George C Tsokos
    Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814, USA
    Ann N Y Acad Sci 987:240-5. 2003
    ..Therefore, a novel activation pathway for a member of the Ets family of transcription factors, which is defective in patients with systemic autoimmunity, has been revealed...
  26. ncbi request reprint Down-regulation of IL-2 production in T lymphocytes by phosphorylated protein kinase A-RIIbeta
    Michael R Elliott
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Immunol 172:7804-12. 2004
    ..In summary, our data demonstrate a novel mechanism by which serine 114 phosphorylation and nuclear localization of RIIbeta controls the regulation of gene expression in T cells...
  27. ncbi request reprint T cell abnormalities in human and mouse lupus: intrinsic and extrinsic
    George C Tsokos
    Department of Medicine, Uniformed Services University, Bethesda, Maryland, USA
    Curr Opin Rheumatol 15:542-7. 2003
    ..The works reviewed imply that self-peptides might be considered to reestablish lost tolerance, whereas correction of the aberrant biochemistry might normalize T cell function and limit disease...
  28. pmc The RNA-stabilizing protein HuR regulates the expression of zeta chain of the human T cell receptor-associated CD3 complex
    Vaishali R Moulton
    Department of Medicine, Division of Rheumatology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 283:20037-44. 2008
    ....
  29. ncbi request reprint The transcriptional repressor cAMP response element modulator alpha interacts with histone deacetylase 1 to repress promoter activity
    Klaus Tenbrock
    Department of Pediatrics, Division of Rheumatology, University Hospital, University of Muenster, Röntgenstrasse 21, 48149 Muenster, Germany
    J Immunol 177:6159-64. 2006
    ..Therefore, CREMalpha exerts its repressor activity by a mechanism that involves recruitment of HDAC1, increased deacetylation of histones, and repression of promoter activity...
  30. ncbi request reprint Rewiring the T-cell: signaling defects and novel prospects for the treatment of SLE
    George C Tsokos
    Department of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA
    Trends Immunol 24:259-63. 2003