Mark S Johnson

Summary

Affiliation: Walter Reed Army Medical Center
Country: USA

Publications

  1. ncbi request reprint Subacute toxicity of oral 2,6-dinitrotoluene and 1,3,5-trinitro-1,3,5-triazine (RDX) exposure to the northern bobwhite (Colinus virginianus)
    Mark S Johnson
    tU S Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, Maryland 21010, USA
    Environ Toxicol Chem 26:1481-7. 2007
  2. ncbi request reprint Effects of 2,4,6-trinitrotoluene in a holistic environmental exposure regime on a terrestrial salamander, Ambystoma tigrinum
    M S Johnson
    US Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, Maryland 21010 5403, USA
    Toxicol Pathol 28:334-41. 2000
  3. ncbi request reprint Fate and the biochemical effects of 2,4,6-trinitrotoluene exposure to tiger salamanders (Ambystoma tigrinum)
    M S Johnson
    United States Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, Maryland 21010, USA
    Ecotoxicol Environ Saf 46:186-91. 2000
  4. ncbi request reprint Lead accumulation in woodchucks (Marmota monax) at small arms and skeet ranges
    Mark S Johnson
    US Army Center for Health Promotion and Preventive Medicine MCHB TS THE, Toxicology Directorate, 5158 Blackhawk Road, Aberdeen Proving Ground, MD 21010 5422, USA
    Ecotoxicol Environ Saf 59:232-6. 2004
  5. ncbi request reprint Toxicologic and histopathologic response of the terrestrial salamander Plethodon cinereus to soil exposures of 1,3,5-trinitrohexahydro-1,3,5-triazine
    M S Johnson
    United States Army Center for Health Promotion and Preventive Medicine, 5158 Blackhawk Rd, Toxicology Directorate, Aberdeen Proving Ground, Maryland 21010 5403, USA
    Arch Environ Contam Toxicol 47:496-501. 2004
  6. doi request reprint Multiple environmental stressors elicit complex interactive effects in the western fence lizard (Sceloporus occidentalis)
    Craig A McFarland
    Health Effects Research Program, Toxicology Portfolio, U S Army Institute of Public Health, Aberdeen Proving Ground, MD 21010 5403, USA
    Ecotoxicology 21:2372-90. 2012
  7. doi request reprint Toxicological responses of red-backed salamander (Plethodon cinereus) exposed to aged and amended soils containing lead
    Matthew A Bazar
    Toxicity Evaluation Program, Directorate of Toxicology, US Army Center for Health Promotion and Preventive Medicine, 5158 Blackhawk Road, ATTN MCHB TS TTE, Aberdeen Proving Ground, MD 21010 5403, USA
    Arch Environ Contam Toxicol 58:1040-7. 2010
  8. doi request reprint Interspecific effects of 4A-DNT (4-amino-2,6-dinitrotoluene) and RDX (1,3,5-trinitro-1,3,5-triazine) in Japanese quail, Northern bobwhite, and Zebra finch
    Michael J Quinn
    US Army Public Health Command, Toxicology Portfolio, Aberdeen Proving Ground, MD 21010, USA
    Ecotoxicology 22:231-9. 2013
  9. doi request reprint Genotoxicity assessment of ethylenediamine dinitrate (EDDN) and diethylenetriamine trinitrate (DETN)
    Gunda Reddy
    Army Institute of Public Health, Aberdeen Proving Ground, MD, USA
    Mutat Res 726:169-74. 2011
  10. doi request reprint Toxicity of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) in three vertebrate species
    Mark S Johnson
    United States Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, Aberdeen, MD 21010, USA
    Arch Environ Contam Toxicol 58:836-43. 2010

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Subacute toxicity of oral 2,6-dinitrotoluene and 1,3,5-trinitro-1,3,5-triazine (RDX) exposure to the northern bobwhite (Colinus virginianus)
    Mark S Johnson
    tU S Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, Maryland 21010, USA
    Environ Toxicol Chem 26:1481-7. 2007
    ..Together, these data suggest that RDX is more toxic from short, repeated exposures than 2,6-DNT, resulting in central nervous system-related effects, whereas 2,6-DNT causes gastrointestinal disturbances at higher exposures...
  2. ncbi request reprint Effects of 2,4,6-trinitrotoluene in a holistic environmental exposure regime on a terrestrial salamander, Ambystoma tigrinum
    M S Johnson
    US Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, Maryland 21010 5403, USA
    Toxicol Pathol 28:334-41. 2000
    ..This investigation presents a realistic approach and preliminary data for investigating the effects of xenobiotic exposure in a soil matrix on a terrestrial vertebrate...
  3. ncbi request reprint Fate and the biochemical effects of 2,4,6-trinitrotoluene exposure to tiger salamanders (Ambystoma tigrinum)
    M S Johnson
    United States Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, Maryland 21010, USA
    Ecotoxicol Environ Saf 46:186-91. 2000
    ..Furthermore, results indicate that tiger salamanders possess considerable levels of xenobiotic metabolizing and antioxidant enzymes in these tissues but are not sensitive indicators of TNT exposure...
  4. ncbi request reprint Lead accumulation in woodchucks (Marmota monax) at small arms and skeet ranges
    Mark S Johnson
    US Army Center for Health Promotion and Preventive Medicine MCHB TS THE, Toxicology Directorate, 5158 Blackhawk Road, Aberdeen Proving Ground, MD 21010 5422, USA
    Ecotoxicol Environ Saf 59:232-6. 2004
    ..Further analysis of other ranges with higher lead concentrations and of small mammal species with smaller home ranges is recommended to further elucidate trends that could be extrapolated to other sites...
  5. ncbi request reprint Toxicologic and histopathologic response of the terrestrial salamander Plethodon cinereus to soil exposures of 1,3,5-trinitrohexahydro-1,3,5-triazine
    M S Johnson
    United States Army Center for Health Promotion and Preventive Medicine, 5158 Blackhawk Rd, Toxicology Directorate, Aberdeen Proving Ground, Maryland 21010 5403, USA
    Arch Environ Contam Toxicol 47:496-501. 2004
    ....
  6. doi request reprint Multiple environmental stressors elicit complex interactive effects in the western fence lizard (Sceloporus occidentalis)
    Craig A McFarland
    Health Effects Research Program, Toxicology Portfolio, U S Army Institute of Public Health, Aberdeen Proving Ground, MD 21010 5403, USA
    Ecotoxicology 21:2372-90. 2012
    ..Ultimately, our study indicates the potential for effects modulation when environmental stressors are combined...
  7. doi request reprint Toxicological responses of red-backed salamander (Plethodon cinereus) exposed to aged and amended soils containing lead
    Matthew A Bazar
    Toxicity Evaluation Program, Directorate of Toxicology, US Army Center for Health Promotion and Preventive Medicine, 5158 Blackhawk Road, ATTN MCHB TS TTE, Aberdeen Proving Ground, MD 21010 5403, USA
    Arch Environ Contam Toxicol 58:1040-7. 2010
    ..At 16,967 mg/kg there was evidence of soil avoidance and decreased growth. These data suggest marked differences in toxicity and bioavailability of the lead-amended soil in contrast to the field-collected soil containing lead...
  8. doi request reprint Interspecific effects of 4A-DNT (4-amino-2,6-dinitrotoluene) and RDX (1,3,5-trinitro-1,3,5-triazine) in Japanese quail, Northern bobwhite, and Zebra finch
    Michael J Quinn
    US Army Public Health Command, Toxicology Portfolio, Aberdeen Proving Ground, MD 21010, USA
    Ecotoxicology 22:231-9. 2013
    ..This study suggests that sensitivity among species is chemical-specific and provides data that could be used to refine current avian sensitivity models used in ecological risk assessments...
  9. doi request reprint Genotoxicity assessment of ethylenediamine dinitrate (EDDN) and diethylenetriamine trinitrate (DETN)
    Gunda Reddy
    Army Institute of Public Health, Aberdeen Proving Ground, MD, USA
    Mutat Res 726:169-74. 2011
    ..DETN was not genotoxic in all in vitro and in vivo tests. These results show the in vitro and in vivo genotoxicity potential of these chemicals...
  10. doi request reprint Toxicity of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) in three vertebrate species
    Mark S Johnson
    United States Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, Aberdeen, MD 21010, USA
    Arch Environ Contam Toxicol 58:836-43. 2010
    ....
  11. ncbi request reprint Influence of oral 2,4-dinitrotoluene exposure to the northern bobwhite (Colinus virginianus)
    Mark S Johnson
    U S Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, Maryland 21010 5402, USA
    Int J Toxicol 24:265-74. 2005
    ..These data suggest that oral 2,4-DNT exposures are more acutely toxic and has a different etiology than 2,4,6-trinitrotoluene in birds...
  12. doi request reprint Genotoxicity assessment of two hypergolic energetic propellant compounds
    Gunda Reddy
    Directorate of Toxicology, U S Army Public Health Command Provisional, 5158 Blackhawk Road, Aberdeen Proving Ground, MD 21010 5403, USA
    Mutat Res 700:26-31. 2010
    ..These studies demonstrate that DMAZ is mutagenic in specific strains of Salmonella. However, both compounds were negative for induction of chromosomal aberrations in CHO cells in vitro and in the in vivo mouse micronucleus assay...
  13. doi request reprint Sublethal effects of subacute exposure to RDX (1,3,5-trinitro-1,3,5-triazine) in the northern bobwhite (Colinus virginianus)
    Michael J Quinn
    U S Army Center for Health Promotion and Preventive Medicine, Health Effects Research Program, Aberdeen Proving Ground, Maryland 21010, USA
    Environ Toxicol Chem 28:1266-70. 2009
    ..Degeneration of testicular and splenic tissue also was observed. The no-observed-adverse-effects and lowest-observed-adverse-effects levels were determined as 3.0 and 8.0 mg/kg/d, respectively...
  14. doi request reprint Toxic effects of oral hexahydro-1,3,5-trinitro-1,3,5-triazine in the western fence lizard (Sceloporus occidentalis)
    Craig A McFarland
    U S Army Center for Health Promotion and Preventive Medicine, Health Effects Research Program, Aberdeen Proving Ground, Maryland 21010, USA
    Environ Toxicol Chem 28:1043-50. 2009
    ..Based on survival, growth rate, food intake, and testes to brain weight ratios, these data suggest a lowest-observed-adverse effect level of 5 mg/kg/d and a no-observed-adverse effect level of 2.5 mg/kg/d...
  15. ncbi request reprint Effects of subchronic exposure to 2,6-dinitrotoluene in the northern bobwhite (Colinus virginianus)
    Michael J Quinn
    U S Army Center for Health Promotion and Preventive Medicine, Health Effects Research Program, Aberdeen Proving Ground, Maryland 21010 5403, USA
    Environ Toxicol Chem 26:2202-7. 2007
    ..The lowest-observed-adverse-effect level is 40 mg/ kg/d based on hematological measures, and the no-observed-adverse-effect level is 10 mg/kg/d based on the absence of results indicative of adverse effects...
  16. doi request reprint Toxicologic characterization of a novel explosive, guanidinium 3,4-dinitropyrazolate (GDNP), in female rats and Ames mutagenicity assay
    Larry R Williams
    Army Institute of Public Health, US Army Public Health Command, Portfolio of Toxicology, Health Effects Research Program MCHB IP THE, 5158 Blackhawk Rd, Aberdeen Proving Ground, MD 21010 5403, USA
    Int J Toxicol 31:441-53. 2012
    ..In this study, the lowest-observed-adverse-effect-level from oral exposure to GDNP for 14 days was 500 mg/kg per d and the no-observable-adverse-effect-level was 152 mg/kg per d...
  17. ncbi request reprint Responses of oral 2,4,6-trinitrotoluene (TNT) exposure to the common pigeon (Columba livia): a phylogenic and methodological comparison
    Mark S Johnson
    U S Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, Maryland 21010 5422, USA
    Int J Toxicol 24:221-9. 2005
    ..Chemical analysis of blood detected concentrations of the two primary reduction metabolites, but not parent compound, suggesting that toxicity may be due to the bioaccumulation of a toxic intermediate...
  18. doi request reprint Toxic effects of oral 2-amino-4,6-dinitrotoluene in the Western fence lizard (Sceloporus occidentalis)
    Craig A McFarland
    US Army Public Health Command Prov, Aberdeen Proving Ground, MD 21010, USA
    Environ Pollut 159:466-73. 2011
    ..Based on survival, loss of body weight, diminished food intake, changes in liver, kidney, and testes, and increased blood urea nitrogen, these data suggest a LOAEL of 15 mg/kg-d and a NOAEL of 5 mg/kg-d in S. occidentalis...
  19. doi request reprint Toxicological responses of red-backed salamanders (Plethodon cinereus) to soil exposures of copper
    Matthew A Bazar
    US Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, MD 21010 5403, USA
    Arch Environ Contam Toxicol 57:116-22. 2009
    ..2 mg/kg results in reduced survival, whereas hematology analyses suggest that a concentration of and exceeding 803.3 +/- 98.4 mg/kg might result in reduced total white blood cell count. No effects were observed at 283.3 +/- 36.7 mg/kg...
  20. doi request reprint Reproductive and developmental effects and physical and chemical properties of pentaerythritol tetranitrate (PETN) in the rat
    Michael J Quinn
    Directorate of Toxicology, U S Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, MD 21010, USA
    Birth Defects Res B Dev Reprod Toxicol 86:65-71. 2009
    ..Additionally, biotic processes are most likely faster in breaking down PETN than the abiotic processes involved in dissolving PETN in water...
  21. ncbi request reprint Toxicological responses of red-backed salamanders (Plethodon cinereus) to subchronic soil exposures of 2,4-dinitrotoluene
    Mark S Johnson
    US Army Center for Health Promotion and Preventive Medicine, Health Effects Research Program, MCHB TS THE, Aberdeen Proving Ground, MD 21010 5403, USA
    Environ Pollut 147:604-8. 2007
    ..These results suggest that only high soil concentrations of 2,4-DNT have the potential to cause overtly toxic effects in terrestrial salamanders...
  22. doi request reprint Lead and copper in pigeons (Columbia livia) exposed to a small arms-range soil
    Desmond I Bannon
    United States Army Public Health Command, Aberdeen Proving Ground, Aberdeen, MD 21010 5403, USA
    Arch Environ Contam Toxicol 60:351-60. 2011
    ..Overall, this study showed that intake of SAR soils contaminated with Pb and Cu causes an increase in Pb body burdens in birds and that the response can be modulated by amending soils with salts of metals...
  23. doi request reprint Toxicity of oral exposure to 2,4,6-trinitrotoluene in the western fence lizard (Sceloporus occidentalis)
    Craig A McFarland
    U S Army Center for Health Promotion and Preventive Medicine, Health Effects Research Program, Aberdeen Proving Ground, MD 21010 5402, USA
    Environ Toxicol Chem 27:1102-11. 2008
    ..Together, these data suggest a lowest-observed-adverse effect level of 25 mg/kg/d and a no-observed-adverse effect level of 15 mg/kg/d in S. occidentalis...
  24. doi request reprint Toxicological responses of red-backed salamanders (Plethodon cinereus) to subchronic soil exposures of 2,4,6-trinitrotoluene
    Mathew A Bazar
    U S Army Center for Health Promotion and Preventatitve Medicine, Directorate of Toxicology, Aberdeen Proving Ground, MD 21010 5403, USA
    Environ Toxicol Chem 27:1393-8. 2008
    ..Splenic congestion also was observed in salamanders from these groups. These data suggest that soil TNT concentrations of 373 +/- 41.0 mg/kg or greater result in reduced body mass, reduced feed intake, and hematological effects...
  25. doi request reprint A preliminary assessment of relative sensitivities to foreign red blood cell challenges in the northern bobwhite for potential evaluation of immunotoxicity
    Michael J Quinn
    U S Army Center Health Promotion and Preventive Medicine, Health Effects Research Program, Aberdeen Proving Ground, Maryland 21222, USA
    J Immunotoxicol 6:171-3. 2009
    ..We found that rabbit erythrocytes elicited the strongest responses with the least amount of variability between individuals. Rabbit RBCs, therefore, appear to be the ideal antigen for this test of the humoral response in this species...
  26. doi request reprint Unsuitability of the northern bobwhite as a model species for the assessment of reproductive behavior in toxicological studies
    Michael J Quinn
    US Army Center Health Promotion and Preventive Medicine, Health Effects Research Program, Directorate of Toxicology, Aberdeen Proving Ground, MD 21222, USA
    Toxicol Mech Methods 19:40-3. 2009
    ....
  27. doi request reprint Acute, subacute, and subchronic exposure to 2A-DNT (2-amino-4,6-dinitrotoluene) in the northern bobwhite (Colinus virginianus)
    Michael J Quinn
    U S Army Center for Health Promotion and Preventive Medicine, Aberdeen, USA
    Ecotoxicology 19:945-52. 2010
    ..The lowest observed adverse effects level (LOAEL) was determined to be 14 mg/kg/day based on mortality, and the no observed adverse effects level (NOAEL) was determined to be 3 mg/kg/day based on lack of effects at this exposure level...
  28. doi request reprint Neurotoxicogenomic investigations to assess mechanisms of action of the munitions constituents RDX and 2,6-DNT in Northern bobwhite (Colinus virginianus)
    Kurt A Gust
    U S Army Corps of Engineers, Environmental Laboratory, EP P, Vicksburg, MS 39180, USA
    Toxicol Sci 110:168-80. 2009
    ....
  29. ncbi request reprint Are songbirds at risk from lead at small arms ranges? An application of the spatially explicit exposure model
    Mark S Johnson
    U S Army Center for Health Promotion and Preventive Medicine, Health Effects Research Program, Aberdeen Proving Ground, Maryland 21010 5403, USA
    Environ Toxicol Chem 26:2215-25. 2007
    ..The present study provides support for the application of spatial methods over conventional deterministic methods...
  30. doi request reprint Toxicity assessment of 4-amino-2-nitrotoluene
    John T Houpt
    US Army Public Health Command, Army Institute of Public Health, Toxicology Portfolio, Aberdeen Proving Ground, MD 21010, USA
    Int J Toxicol 32:113-22. 2013
    ..5 mg/kg/d were calculated for male rats, which were used to derive an oral reference dose (RfD). The human RfD of 1.26 μg/kg/d was derived using current United States Environmental Protection Agency guidelines...
  31. doi request reprint Genotoxicity assessment of an energetic propellant compound, 3-nitro-1,2,4-triazol-5-one (NTO)
    Gunda Reddy
    U S Army Public Health Command, Aberdeen Proving Ground, MD, USA
    Mutat Res 719:35-40. 2011
    ..These studies reveal that NTO was not genotoxic in either in vitro or in vivo tests and suggest a low risk of genetic hazards associated with exposure...
  32. ncbi request reprint Food avoidance behavior to dietary octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine (HMX) exposure in the northern bobwhite (Colinusvirginianus)
    Mark S Johnson
    US Army Center for Health Promotion and Preventative Medicine, Health Effects Research Program, Aberdeen Proving Ground, Maryland 21010 5403, USA
    J Toxicol Environ Health A 68:1349-57. 2005
    ..These results suggest that HMX concentration is responsible for intense feed aversion behavior and thus not likely a factor that would appreciably contribute to risk for wild birds at military ranges...
  33. ncbi request reprint Dietary oral exposure to l,3,5-trinitro-1,3,5-triazine in the northern bobwhite (Colinus virginianus)
    Obert M Gogal
    Virginia Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia 24061, USA
    Environ Toxicol Chem 22:381-7. 2003
    ..These collective data suggest that quail may respond differently to oral RDX exposure compared with mammals...
  34. ncbi request reprint Influence of dietary 2,4,6-trinitrotoluene exposure in the northern bobwhite (Colinus virginianus)
    Robert M Gogal
    Virginia Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia 24061, USA
    Environ Toxicol Chem 21:81-6. 2002
    ..However, since these treatments had concentrations that were a log-fold or more than doses in similar studies using mammals, these data suggest that northern bobwhite are less sensitive to oral exposures of TNT than mammals...
  35. pmc Mental health, family function and obesity in African-American women
    Esa M Davis
    Department of Family Medicine, Case Western Reserve University and Case Comprehensive Cancer Center, Cleveland, OH 44106, USA
    J Natl Med Assoc 97:478-82. 2005
    ..African-American women are disproportionately affected by obesity and its related diseases. How psychological and psychosocial factors that affect this population differ across weight categories remains poorly understood...
  36. ncbi request reprint Two synergistic activation mechanisms of alpha2beta1 integrin-mediated collagen binding
    Wendy L Connors
    Department of Biochemistry and Food Chemistry, University of Turku, Turku, Finland
    J Biol Chem 282:14675-83. 2007
    ....