Peter B Jahrling

Summary

Affiliation: Walter Reed Army Medical Center
Country: USA

Publications

  1. pmc Interferon-beta 1a and SARS coronavirus replication
    Lisa E Hensley
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA
    Emerg Infect Dis 10:317-9. 2004
  2. pmc Exploring the potential of variola virus infection of cynomolgus macaques as a model for human smallpox
    Peter B Jahrling
    Headquarters, U S Army Research Institute of Infectious Diseases, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 101:15196-200. 2004
  3. pmc Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection
    Thomas W Geisbert
    United States Army Medical Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Am J Pathol 163:2347-70. 2003
  4. ncbi request reprint Postexposure protection against Marburg haemorrhagic fever with recombinant vesicular stomatitis virus vectors in non-human primates: an efficacy assessment
    Kathleen M Daddario-DiCaprio
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
    Lancet 367:1399-404. 2006
  5. ncbi request reprint Postexposure protection of guinea pigs against a lethal ebola virus challenge is conferred by RNA interference
    Thomas W Geisbert
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 5011, USA
    J Infect Dis 193:1650-7. 2006
  6. ncbi request reprint Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys
    Thomas W Geisbert
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
    Lancet 362:1953-8. 2003
  7. pmc Pathogenesis of Ebola hemorrhagic fever in primate models: evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells
    Thomas W Geisbert
    United States Army Medical Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Am J Pathol 163:2371-82. 2003
  8. ncbi request reprint Recombinant human activated protein C for the postexposure treatment of Ebola hemorrhagic fever
    Lisa E Hensley
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
    J Infect Dis 196:S390-9. 2007
  9. pmc Drug discovery technologies and strategies for Machupo virus and other New World arenaviruses
    Sheli R Radoshitzky
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA
    Expert Opin Drug Discov 7:613-32. 2012
  10. pmc Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNA
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick IRF Frederick, Division of Clinical Research DCR, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, B 8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA
    Arch Virol 159:1229-37. 2014

Detail Information

Publications76

  1. pmc Interferon-beta 1a and SARS coronavirus replication
    Lisa E Hensley
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA
    Emerg Infect Dis 10:317-9. 2004
    ..Here, we report that recombinant human interferon-beta 1a potently inhibits SARS coronavirus replication in vitro...
  2. pmc Exploring the potential of variola virus infection of cynomolgus macaques as a model for human smallpox
    Peter B Jahrling
    Headquarters, U S Army Research Institute of Infectious Diseases, Frederick, MD 21702, USA
    Proc Natl Acad Sci U S A 101:15196-200. 2004
    ..A more precise understanding of disease pathogenesis should provide targets for therapeutic intervention, to be used alone or in combination with inhibitors of variola virus replication...
  3. pmc Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection
    Thomas W Geisbert
    United States Army Medical Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Am J Pathol 163:2347-70. 2003
    ..The sequence of pathogenetic events identified in this study should provide new targets for rational prophylactic and chemotherapeutic interventions...
  4. ncbi request reprint Postexposure protection against Marburg haemorrhagic fever with recombinant vesicular stomatitis virus vectors in non-human primates: an efficacy assessment
    Kathleen M Daddario-DiCaprio
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
    Lancet 367:1399-404. 2006
    ..We aimed to test the efficacy of a replication-competent vaccine based on attenuated recombinant vesicular stomatitis virus (rVSV), as a postexposure treatment for MARV haemorrhagic fever...
  5. ncbi request reprint Postexposure protection of guinea pigs against a lethal ebola virus challenge is conferred by RNA interference
    Thomas W Geisbert
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 5011, USA
    J Infect Dis 193:1650-7. 2006
    ..Here, we describe the development of a potential therapy for EBOV infection that is based on small interfering RNAs (siRNAs)...
  6. ncbi request reprint Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys
    Thomas W Geisbert
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
    Lancet 362:1953-8. 2003
    ..Here, we tested the notion that blockade of fVIIa/tissue factor is beneficial after infection with Ebola virus...
  7. pmc Pathogenesis of Ebola hemorrhagic fever in primate models: evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells
    Thomas W Geisbert
    United States Army Medical Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Am J Pathol 163:2371-82. 2003
    ..Together, these data suggest that coagulation abnormalities associated with EBOV HF are not the direct result of EBOV-induced cytolysis of endothelial cells, and are likely triggered by immune-mediated mechanisms...
  8. ncbi request reprint Recombinant human activated protein C for the postexposure treatment of Ebola hemorrhagic fever
    Lisa E Hensley
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
    J Infect Dis 196:S390-9. 2007
    ..The aim of this study was to test the efficacy of rhAPC as a potential treatment for ZHF...
  9. pmc Drug discovery technologies and strategies for Machupo virus and other New World arenaviruses
    Sheli R Radoshitzky
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, MD 21702, USA
    Expert Opin Drug Discov 7:613-32. 2012
    ..All of these viruses are Risk Group 4 biosafety pathogens. MACV causes human disease outbreak with high case-fatality rates. To date, at least 1,200 cases with ≈200 fatalities have been recorded...
  10. pmc Virus nomenclature below the species level: a standardized nomenclature for filovirus strains and variants rescued from cDNA
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick IRF Frederick, Division of Clinical Research DCR, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, B 8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA
    Arch Virol 159:1229-37. 2014
    ..EBOV" would suffice if only one EBOV strain/variant/isolate is addressed. ..
  11. ncbi request reprint Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key event
    Thomas W Geisbert
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA 21702 5011
    J Infect Dis 188:1618-29. 2003
    ..Thus, chemotherapeutic strategies aimed at controlling overexpression of TF may ameliorate the effects of EBOV hemorrhagic fever...
  12. pmc A replication-deficient rabies virus vaccine expressing Ebola virus glycoprotein is highly attenuated for neurovirulence
    Amy B Papaneri
    Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD 21702, USA
    Virology 434:18-26. 2012
    ..In summary, our findings indicate that RV-GP retains the attenuation phenotype of the live-attenuated RABV vaccine, and RVΔG-GP would appear to be an even safer alternative for use in wildlife or consideration for human use...
  13. ncbi request reprint Pathologic findings associated with delayed death in nonhuman primates experimentally infected with Zaire Ebola virus
    Thomas Larsen
    Pathology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
    J Infect Dis 196:S323-8. 2007
    ..We suggest that treatment extended the time course of the disease and permitted the virus to infect tissues not usually affected in the typical model...
  14. pmc Demonstration of cross-protective vaccine immunity against an emerging pathogenic Ebolavirus Species
    Lisa E Hensley
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    PLoS Pathog 6:e1000904. 2010
    ....
  15. pmc Virus nomenclature below the species level: a standardized nomenclature for laboratory animal-adapted strains and variants of viruses assigned to the family Filoviridae
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick IRF Frederick, Division of Clinical Research DCR, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, B 8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA
    Arch Virol 158:1425-32. 2013
    ..EBOV" would suffice if only one EBOV strain/variant/isolate is addressed...
  16. pmc Antiviral potential of ERK/MAPK and PI3K/AKT/mTOR signaling modulation for Middle East respiratory syndrome coronavirus infection as identified by temporal kinome analysis
    Jason Kindrachuk
    Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland, USA
    Antimicrob Agents Chemother 59:1088-99. 2015
    ..Taken together, our data suggest that ERK/MAPK and PI3K/AKT/mTOR signaling responses play important roles in MERS-CoV infection and may represent novel drug targets for therapeutic intervention strategies. ..
  17. ncbi request reprint Detection and identification of Variola virus in fixed human tissue after prolonged archival storage
    Randal J Schoepp
    Diagnostic Systems Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702 5011, USA
    Lab Invest 84:41-8. 2004
    ....
  18. pmc Nonhuman transferrin receptor 1 is an efficient cell entry receptor for Ocozocoautla de Espinosa virus
    Yingyun Cai
    Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA
    J Virol 87:13930-5. 2013
    ..Interestingly, OCEV and Tacaribe virus could use bat, but not human, TfR1. Replacing three human TfR1 amino acids with their bat ortholog counterparts transformed human TfR1 into an efficient OCEV and Tacaribe virus receptor. ..
  19. ncbi request reprint Ebola hemorrhagic fever: evaluation of passive immunotherapy in nonhuman primates
    Peter B Jahrling
    Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD, USA
    J Infect Dis 196:S400-3. 2007
    ..These data cast further doubt on the value of passive immunotherapy for the treatment of EBOV infection...
  20. pmc Development of a new vaccine for the prevention of Lassa fever
    Thomas W Geisbert
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    PLoS Med 2:e183. 2005
    ..Currently, there are no licensed vaccines for Lassa fever, and no experimental vaccine has completely protected nonhuman primates against a lethal challenge...
  21. ncbi request reprint Depletion of peripheral blood T lymphocytes and NK cells during the course of ebola hemorrhagic Fever in cynomolgus macaques
    Douglas S Reed
    Center for Aerobiological Sciences, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA
    Viral Immunol 17:390-400. 2004
    ....
  22. pmc Nomenclature- and database-compatible names for the two Ebola virus variants that emerged in Guinea and the Democratic Republic of the Congo in 2014
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD 21702, USA
    Viruses 6:4760-99. 2014
    ....
  23. pmc Simian hemorrhagic fever virus cell entry is dependent on CD163 and uses a clathrin-mediated endocytosis-like pathway
    Yingyun Cai
    Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, USA
    J Virol 89:844-56. 2015
    ....
  24. ncbi request reprint Evidence against an important role for infectivity-enhancing antibodies in Ebola virus infections
    Thomas W Geisbert
    Pathology Division, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 5011, USA
    Virology 293:15-9. 2002
    ..Taken together with in vivo observations that early deaths were not observed in animals immunized with various viral vectors expressing EBOV GP, it is unlikely that any EBOV-enhancing antibodies profoundly affected EBOV pathogenesis...
  25. pmc Evaluation in nonhuman primates of vaccines against Ebola virus
    Thomas W Geisbert
    U S Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702 5011, USA
    Emerg Infect Dis 8:503-7. 2002
    ..The disease observed in primates differed from that in rodents, suggesting that rodent models of EBOV may not predict the efficacy of candidate vaccines in primates and that protection of primates may require different mechanisms...
  26. pmc Evaluation of perceived threat differences posed by filovirus variants
    Jens H Kuhn
    National Institutes of Health, National Institute of Allergy and Infectious Diseases, Division of Clinical Research, Integrated Research Facility at Fort Detrick, Frederick, Maryland, USA
    Biosecur Bioterror 9:361-71. 2011
    ....
  27. pmc Filovirus RefSeq entries: evaluation and selection of filovirus type variants, type sequences, and names
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD 21702, USA
    Viruses 6:3663-82. 2014
    ....
  28. pmc The NIAID Integrated Research Facility at Frederick, Maryland: a unique international resource to facilitate medical countermeasure development for BSL-4 pathogens
    Peter B Jahrling
    Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD, USA Emerging Viral Pathogens Section, Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA
    Pathog Dis 71:213-9. 2014
    ....
  29. pmc Smallpox and pan-orthopox virus detection by real-time 3'-minor groove binder TaqMan assays on the roche LightCycler and the Cepheid smart Cycler platforms
    David A Kulesh
    Diagnostic Systems Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 5011
    J Clin Microbiol 42:601-9. 2004
    ..The early detection of a smallpox outbreak is crucial whether the incident is an act of bioterrorism or an accidental occurrence...
  30. ncbi request reprint Comparison of the protective efficacy of DNA and baculovirus-derived protein vaccines for EBOLA virus in guinea pigs
    Jenny L Mellquist-Riemenschneider
    Department of Molecular Virology, Virology Division, Division U S Army Medical Research Institute of Infectious Diseases, 1301 Ditto Ave, Ft Detrick, Frederick 21702, MD, USA
    Virus Res 92:187-93. 2003
    ..These data indicate that a vaccine approach that was effective for MARV is not effective for EBOV in guinea pigs...
  31. pmc CD26/DPP4 cell-surface expression in bat cells correlates with bat cell susceptibility to Middle East respiratory syndrome coronavirus (MERS-CoV) infection and evolution of persistent infection
    Yingyun Cai
    Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, Maryland, United States of America
    PLoS ONE 9:e112060. 2014
    ..Together, these results imply that bats indeed could be among the MERS-CoV host spectrum, and that cellular restriction of MERS-CoV is determined by CD26/DPP4 expression rather than by downstream restriction factors. ..
  32. doi request reprint Systems kinomics for characterizing host responses to high-consequence pathogens at the NIH/NIAID Integrated Research Facility-Frederick
    Jason Kindrachuk
    Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD, USA
    Pathog Dis 71:190-98. 2014
    ..To this end, enhanced technical capabilities at the IRF-Frederick provide the unique capability for characterizing host responses to HCP insult during the course of infection and identify novel targets for therapeutic intervention. ..
  33. pmc The International Code of Virus Classification and Nomenclature (ICVCN): proposal for text changes for improved differentiation of viral taxa and viruses
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick IRF Frederick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases NIH, B 8200 Research Plaza, Fort Detrick, Frederick, MD 21702, USA
    Arch Virol 158:1621-9. 2013
    ..Here, Code text changes are proposed to address this problem. ..
  34. pmc Inhibition of monkeypox virus replication by RNA interference
    Abdulnaser Alkhalil
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick MD, 21702, USA
    Virol J 6:188. 2009
    ..These results emphasis the essential role of A6R gene in viral replication, and demonstrate the potential of RNAi as a therapeutic approach for developing oligonucleotide-based drug therapy for MPV and other orthopox viruses...
  35. ncbi request reprint Towards a vaccine against Ebola virus
    Thomas W Geisbert
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Expert Rev Vaccines 2:777-89. 2003
    ..This review takes a brief historic look at attempts to develop an efficacious vaccine, provides an overview of current vaccine candidates and highlights strategies that have the greatest potential for commercial development...
  36. pmc Small particle aerosol inoculation of cowpox Brighton Red in rhesus monkeys results in a severe respiratory disease
    Reed F Johnson
    Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, MD 21702, USA
    Virology 481:124-35. 2015
    ..While the small particle aerosol inoculation route does not accurately mimic human smallpox, the data suggest that CT can be used as a tool to monitor real-time disease progression for evaluation of animal models for human diseases. ..
  37. pmc Taxonomic reorganization of the family Bornaviridae
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick IRF Frederick, Division of Clinical Research DCR, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, B 8200 Research Plaza, Fort Detrick, MD, USA
    Arch Virol 160:621-32. 2015
    ..Finally, we propose new virus names and abbreviations when necessary to achieve clear differentiation and unique identification. ..
  38. pmc ABSL-4 aerobiology biosafety and technology at the NIH/NIAID integrated research facility at Fort Detrick
    Matthew G Lackemeyer
    Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, Frederick, MD 21702, USA
    Viruses 6:137-50. 2014
    ..Here, we provide a brief overview of the animal biosafety level 4 Aerobiology Core at the NIH/NIAID Integrated Research Facility at Fort Detrick, Maryland, USA. ..
  39. pmc Clinical management of filovirus-infected patients
    Danielle V Clark
    NIH NIAID Integrated Research Facility, Fort Detrick, MD, USA
    Viruses 4:1668-86. 2012
    ..This review will summarize the management approaches used in filovirus outbreaks and provide recommendations for collecting the information necessary for evaluating and potentially improving patient outcomes in the future...
  40. ncbi request reprint Ebola and Marburg viruses: pathogenesis and development of countermeasures
    Lisa E Hensley
    Virology Division, U S Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702 5011, USA
    Curr Mol Med 5:761-72. 2005
    ..In addition, substantial progress has been made in developing recombinant vaccines against these viruses...
  41. ncbi request reprint Proinflammatory response during Ebola virus infection of primate models: possible involvement of the tumor necrosis factor receptor superfamily
    Lisa E Hensley
    Pathology Division, US Army Medical Research Institute of Infectious Diseases USAMRIID, Attn MCMR UIP D, 1425 Porter Street, Fort Detrick, MD 21702 5011, USA
    Immunol Lett 80:169-79. 2002
    ..Identification of cytokine/chemokine, nitric oxide, and reactive oxygen species involvement in the observed filoviral pathogenesis may lend insight into the rational design of therapeutic countermeasures of filoviral pathogenesis...
  42. pmc Nyamiviridae: proposal for a new family in the order Mononegavirales
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick IRF Frederick, Division of Clinical Research DCR, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, B 8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA
    Arch Virol 158:2209-26. 2013
    ..Here, we review the current knowledge about all three viruses and propose classifying them as members of a new mononegaviral family, Nyamiviridae. ..
  43. pmc The International Code of Virus Classification and Nomenclature (ICVCN): proposal to delete Rule 3.41
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick IRF Frederick, Division of Clinical Research DCR, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, Fort Detrick, Frederick, MD, USA
    Arch Virol 158:297-9. 2013
    ..It is proposed to delete Rule 3.41 of the International Code of Virus Classification and Nomenclature, which requires the name of a virus taxon to precede the term for the taxonomic unit...
  44. pmc Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection
    Julie Dyall
    Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland, USA
    Antimicrob Agents Chemother 58:4885-93. 2014
    ..The drugs identified in these screens provide new targets for in vivo studies as well as incorporation into ongoing clinical studies. ..
  45. ncbi request reprint Exotic emerging viral diseases: progress and challenges
    Thomas W Geisbert
    Virology Division, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Maryland 21702 5011, USA
    Nat Med 10:S110-21. 2004
    ..Of equal importance, these comparisons highlight critical gaps in our knowledge of these pathogens...
  46. pmc Virus nomenclature below the species level: a standardized nomenclature for natural variants of viruses assigned to the family Filoviridae
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick IRF Frederick, Division of Clinical Research DCR, National Institute of Allergy and Infectious Diseases NIAID, National Institutes of Health NIH, B 8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA
    Arch Virol 158:301-11. 2013
    ..Most importantly, it would counter the increasing confusion in genetic variant naming due to the identification of ever more sequences through technological breakthroughs in high-throughput sequencing and environmental sampling...
  47. pmc Proposal for a revised taxonomy of the family Filoviridae: classification, names of taxa and viruses, and virus abbreviations
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, National Interagency Biodefense Campus, B 8200 Research Plaza, Fort Detrick, Frederick, MD 21702, USA
    Arch Virol 155:2083-103. 2010
    ..Furthermore, we explain the etymological derivation of individual names, their pronunciation, and their correct use, and we elaborate on demarcation criteria for each taxon and virus...
  48. pmc Further characterization of the immune response in mice to inactivated and live rabies vaccines expressing Ebola virus glycoprotein
    Amy B Papaneri
    Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD 21702, USA
    Vaccine 30:6136-41. 2012
    ..The ability of these novel vaccines to induce strong humoral and cellular immunity indicates that they should be further evaluated in additional animal models of infection...
  49. doi request reprint Characterizing monkeypox virus specific CD8+ T cell epitopes in rhesus macaques
    Haifeng Song
    Integrated Research Facility, NIAID NIH, Frederick, MD 21702, USA Electronic address
    Virology 447:181-6. 2013
    ....
  50. ncbi request reprint Commentary on Dr. Alan zelicoff's Analysis of the Aralsk outbreak (No. 4)
    Peter B Jahrling
    U S Army Medical Research Institute of Infectious Disease, 1425 Porter Street, Frederick, MD 21702 5011, USA
    Crit Rev Microbiol 29:171-2; discussion 183-90. 2003
  51. pmc Ebola virus modulates transforming growth factor β signaling and cellular markers of mesenchyme-like transition in hepatocytes
    Jason Kindrachuk
    Emerging Viral Pathogens Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA Integrated Research Facility, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Frederick, Maryland, USA
    J Virol 88:9877-92. 2014
    ..From these observations, we propose a model for a broader role of TGF-β-mediated signaling responses in the pathogenesis of Ebola virus disease...
  52. pmc Clarification and guidance on the proper usage of virus and virus species names
    Jens H Kuhn
    Integrated Research Facility at Fort Detrick IRF Frederick, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, B 8200 Research Plaza, Fort Detrick, Frederick, MD 21702, USA
    Arch Virol 155:445-53. 2010
    ....
  53. pmc Ebolavirus delta-peptide immunoadhesins inhibit marburgvirus and ebolavirus cell entry
    Sheli R Radoshitzky
    U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702, USA
    J Virol 85:8502-13. 2011
    ..They join cathepsins and integrins as novel modulators of filovirus cell entry, might play important roles in pathogenesis, and could be exploited for the synthesis of powerful new antivirals...
  54. pmc Real-time PCR assay to detect smallpox virus
    M Sofi Ibrahim
    The United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA
    J Clin Microbiol 41:3835-9. 2003
    ..The assay may be useful for the early detection of smallpox virus infections should such infections occur as a result of a deliberate or an accidental recurrence...
  55. ncbi request reprint Virulence differences between monkeypox virus isolates from West Africa and the Congo basin
    Nanhai Chen
    Department of Molecular Microbiology and Immunology, Saint Louis University Health Sciences Center, M432, St Louis, MO 63104, USA
    Virology 340:46-63. 2005
    ..The analysis identified D10L, D14L, B10R, B14R, and B19R as possible virulence genes, with D14L (ortholog of vaccinia complement protein) as a leading candidate...
  56. pmc Hemorrhagic fever occurs after intravenous, but not after intragastric, inoculation of rhesus macaques with lymphocytic choriomeningitis virus
    Igor S Lukashevich
    Institute of Human Virology, University of Maryland, Biotech Center, Baltimore, Maryland 21201, USA
    J Med Virol 67:171-86. 2002
    ..Pathological signs of the primate i.v. infection differ significantly from guinea pig arenavirus infections and make this a superior model for human viral hemorrhagic disease...
  57. pmc Pre- and postexposure prophylaxis of Ebola virus infection in an animal model by passive transfer of a neutralizing human antibody
    Paul W H I Parren
    Department of Immunology, The Scripps Research Institute, La Jolla, California 92037, USA
    J Virol 76:6408-12. 2002
    ..KZ52 is a promising candidate for immunoprophylaxis of Ebola virus infection...
  58. pmc Smallpox research activities: U.S. interagency collaboration, 2001
    James W Leduc
    Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Emerg Infect Dis 8:743-5. 2002
  59. pmc Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus
    Boyd Yount
    Department of Epidemiology and Microbiology, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Proc Natl Acad Sci U S A 100:12995-3000. 2003
    ....
  60. ncbi request reprint Detection of antibodies against the four subtypes of ebola virus in sera from any species using a novel antibody-phage indicator assay
    Felix Meissner
    Department of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Virology 300:236-43. 2002
    ..The assay is designed to be both simple and economical to enable its use in the field...
  61. ncbi request reprint Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates
    Nancy J Sullivan
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 40, Room 4502, MSC 3005, 40 Convent Drive, Bethesda, Maryland 20892 3005, USA
    Nature 424:681-4. 2003
    ..This accelerated vaccine provides an intervention that may help to limit the epidemic spread of Ebola, and is applicable to other viruses...
  62. pmc Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys
    Wendelien B Oswald
    Departments of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS Pathog 3:e9. 2007
    ..It appears that Ebola virus has a mechanism of infection propagation in vivo in macaques that is uniquely insensitive even to high concentrations of neutralizing antibody...
  63. ncbi request reprint Immunogenicity of a highly attenuated MVA smallpox vaccine and protection against monkeypox
    Patricia L Earl
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892 0445, USA
    Nature 428:182-5. 2004
    ....
  64. pmc The host response to smallpox: analysis of the gene expression program in peripheral blood cells in a nonhuman primate model
    Kathleen H Rubins
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 101:15190-5. 2004
    ..These results provide a detailed picture of the host transcriptional response during smallpox infection, and may help guide the development of diagnostic, therapeutic, and prophylactic strategies...
  65. pmc The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever
    Kathleen H Rubins
    Department of Microbiology and Immunology, 299 Campus Dr, Stanford University School of Medicine, Stanford, California 94305, USA
    Genome Biol 8:R174. 2007
    ..Infection with Ebola virus (EBOV) causes a fulminant and often fatal hemorrhagic fever. In order to improve our understanding of EBOV pathogenesis and EBOV-host interactions, we examined the molecular features of EBOV infection in vivo...
  66. pmc Immune protection of nonhuman primates against Ebola virus with single low-dose adenovirus vectors encoding modified GPs
    Nancy J Sullivan
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Med 3:e177. 2006
    ..GP can exert cytopathic effects on transfected cells in vitro, and multiple GP forms have been identified in nature, raising the question of which would be optimal for a human vaccine...
  67. pmc Cynomolgus macaque as an animal model for severe acute respiratory syndrome
    James V Lawler
    Infectious Diseases Department, National Naval Medical Center, Bethesda, Maryland, United States of America
    PLoS Med 3:e149. 2006
    ..We report the first findings of measurable clinical disease in nonhuman primates (NHPs) infected with SARS-CoV...
  68. ncbi request reprint Countermeasures to the bioterrorist threat of smallpox
    Peter B Jahrling
    National Institute of Allergy and Infectious Diseases, National Institutes of Health, 6700 B Rockledge Drive, Bethesda, MD 20892 7609, USA
    Curr Mol Med 5:817-26. 2005
    ....
  69. ncbi request reprint Analysis of the expressed heavy chain variable-region genes of Macaca fascicularis and isolation of monoclonal antibodies specific for the Ebola virus' soluble glycoprotein
    Chris Druar
    Cangene Corporation, 3404 American Drive, Mississauga, Ontario L4V 1T4, Canada
    Immunogenetics 57:730-8. 2005
    ..In summary, the study provides new insight into the M. fascicularis V region gene repertoire and further supports the idea that macaque-derived mAbs may be of therapeutic value to humans...
  70. ncbi request reprint Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses
    Steven M Jones
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba R3E 3R2, Canada
    Nat Med 11:786-90. 2005
    ..No evidence of EBOV or MARV replication was detected in any of the protected animals after challenge. Our data suggest that these vaccine candidates are safe and highly efficacious in a relevant animal model...
  71. ncbi request reprint Hemorrhagic fever viruses as biological weapons: medical and public health management
    Luciana Borio
    Johns Hopkins Center for Civilian Biodefense Strategies, Johns Hopkins Schools of Medicine and Public Health, 111 Market Pl, Suite 830, Baltimore, MD 21202, USA
    JAMA 287:2391-405. 2002
    ..To develop consensus-based recommendations for measures to be taken by medical and public health professionals if hemorrhagic fever viruses (HFVs) are used as biological weapons against a civilian population...
  72. ncbi request reprint Viral hemorrhagic fevers
    Aileen M Marty
    Battelle Memorial Institute, Suite 601, 1550 Crystal Drive, Arlington, VA 22202 4172, USA
    Clin Lab Med 26:345-86, viii. 2006
    ..While significant progress has been made over the last several years in dissecting out the molecular biology and pathogenesis of the HF viruses, there are currently no vaccines or drugs licensed available for most of the VHFs...
  73. pmc MassTag polymerase chain reaction for differential diagnosis of viral hemorrhagic fever
    Gustavo Palacios
    Columbia University, New York, New York 10032, USA
    Emerg Infect Dis 12:692-5. 2006
    ..We describe a diagnostic system for rapid, multiplex polymerase chain reaction identification of 10 different causes of viral hemorrhagic fevers...
  74. ncbi request reprint Dynamics of oliveros virus infection in rodents in central Argentina
    James N Mills
    Division of Viral and Rickettsial Diseases, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Vector Borne Zoonotic Dis 7:315-23. 2007
    ..Infection may have been associated with scars, which were also approximately equally distributed among male and female Necromys...
  75. ncbi request reprint Trigger events: enviroclimatic coupling of Ebola hemorrhagic fever outbreaks
    Jorge E Pinzon
    Biospheric Sciences Branch, Laboratory for Terrestrial Physics, National Aeronautics and Space Administration Goddard Space Flight Center, Greenbelt, MD 20771, USA
    Am J Trop Med Hyg 71:664-74. 2004
    ..These findings suggest specific directions to help understand the sylvatic cycle of the virus and may provide early warning tools to detect possible future outbreaks of this enigmatic disease...
  76. pmc Panmicrobial oligonucleotide array for diagnosis of infectious diseases
    Gustavo Palacios
    Columbia University, New York, New York 10032, USA
    Emerg Infect Dis 13:73-81. 2007
    ....