John B Holcomb

Summary

Affiliation: Walter Reed Army Medical Center
Country: USA

Publications

  1. ncbi request reprint Damage control resuscitation: directly addressing the early coagulopathy of trauma
    John B Holcomb
    USAISR, Fort Sam Houston, TX 78234 6315, USA
    J Trauma 62:307-10. 2007
  2. ncbi request reprint Use of recombinant FVIIa for intraperitoneal coagulopathic bleeding in a septic patient
    John B Holcomb
    Department of Surgery, University of Texas Health Sciences Center at Houston, Houston, Texas, USA
    Curr Surg 60:423-7. 2003
  3. ncbi request reprint Use of recombinant activated factor VII to treat the acquired coagulopathy of trauma
    John B Holcomb
    Trauma Division, United States Army Institute of Surgical Research, San Antonio, TX 78234 6315, USA
    J Trauma 58:1298-303. 2005
  4. ncbi request reprint Manual vital signs reliably predict need for life-saving interventions in trauma patients
    John B Holcomb
    US Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    J Trauma 59:821-8; discussion 828-9. 2005
  5. ncbi request reprint Understanding combat casualty care statistics
    John B Holcomb
    US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    J Trauma 60:397-401. 2006
  6. ncbi request reprint Prehospital physiologic data and lifesaving interventions in trauma patients
    John B Holcomb
    University of Texas Health Sciences Center, Houston, TX 77030, USA
    Mil Med 170:7-13. 2005
  7. doi request reprint Clinical outcomes from the war: introduction
    John B Holcomb
    US Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 64:S1. 2008
  8. doi request reprint Needle versus tube thoracostomy in a swine model of traumatic tension hemopneumothorax
    John B Holcomb
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    Prehosp Emerg Care 13:18-27. 2009
  9. ncbi request reprint Damage control resuscitation
    John B Holcomb
    Department of Surgery, The University of Texas Health Science Center at San Antonio, TX, USA
    J Trauma 62:S36-7. 2007
  10. pmc Causes of death in U.S. Special Operations Forces in the global war on terrorism: 2001-2004
    John B Holcomb
    U S Army Institute of Surgical Research, 3400 Rawley E Chambers Avenue, Fort Sam Houston, TX 78234, USA
    Ann Surg 245:986-91. 2007

Collaborators

Detail Information

Publications130 found, 100 shown here

  1. ncbi request reprint Damage control resuscitation: directly addressing the early coagulopathy of trauma
    John B Holcomb
    USAISR, Fort Sam Houston, TX 78234 6315, USA
    J Trauma 62:307-10. 2007
  2. ncbi request reprint Use of recombinant FVIIa for intraperitoneal coagulopathic bleeding in a septic patient
    John B Holcomb
    Department of Surgery, University of Texas Health Sciences Center at Houston, Houston, Texas, USA
    Curr Surg 60:423-7. 2003
  3. ncbi request reprint Use of recombinant activated factor VII to treat the acquired coagulopathy of trauma
    John B Holcomb
    Trauma Division, United States Army Institute of Surgical Research, San Antonio, TX 78234 6315, USA
    J Trauma 58:1298-303. 2005
    ..This review describes those studies and reiterates the need for well designed prospective randomized human trauma studies...
  4. ncbi request reprint Manual vital signs reliably predict need for life-saving interventions in trauma patients
    John B Holcomb
    US Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    J Trauma 59:821-8; discussion 828-9. 2005
    ..In this study, we determined whether the addition of diagnostic equipment improved the predictive power of vital signs and scores obtained only by physical examination...
  5. ncbi request reprint Understanding combat casualty care statistics
    John B Holcomb
    US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    J Trauma 60:397-401. 2006
    ..These definitions and equations, consistently applied to the JTTR, will allow meaningful comparisons and help direct future research and appropriate application of personnel...
  6. ncbi request reprint Prehospital physiologic data and lifesaving interventions in trauma patients
    John B Holcomb
    University of Texas Health Sciences Center, Houston, TX 77030, USA
    Mil Med 170:7-13. 2005
    ..We hypothesized that simple physiologic data available immediately upon scene arrival would prove predictive of the need for a LSI...
  7. doi request reprint Clinical outcomes from the war: introduction
    John B Holcomb
    US Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 64:S1. 2008
  8. doi request reprint Needle versus tube thoracostomy in a swine model of traumatic tension hemopneumothorax
    John B Holcomb
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    Prehosp Emerg Care 13:18-27. 2009
    ..We conducted this study to compare the immediate results and prolonged effectiveness of two methods of treatment for traumatic tension hemopneumothorax in a swine model...
  9. ncbi request reprint Damage control resuscitation
    John B Holcomb
    Department of Surgery, The University of Texas Health Science Center at San Antonio, TX, USA
    J Trauma 62:S36-7. 2007
  10. pmc Causes of death in U.S. Special Operations Forces in the global war on terrorism: 2001-2004
    John B Holcomb
    U S Army Institute of Surgical Research, 3400 Rawley E Chambers Avenue, Fort Sam Houston, TX 78234, USA
    Ann Surg 245:986-91. 2007
    ..Effective combat trauma management strategies depend upon an understanding of the epidemiology of death on the battlefield...
  11. ncbi request reprint Fluid resuscitation in modern combat casualty care: lessons learned from Somalia
    John B Holcomb
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    J Trauma 54:S46-51. 2003
    ..The resuscitation algorithm presented in this article represents a consensus of military and civilian trauma experts...
  12. doi request reprint Use of recombinant factor VIIa in US military casualties for a five-year period
    Charles E Wade
    Center for Translational Injury Research and Department of Surgery, University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma 69:353-9. 2010
    ..This study was undertaken to assess how deployed physicians are using rFVIIa and its impact on casualty outcomes...
  13. doi request reprint Admission rapid thrombelastography predicts development of pulmonary embolism in trauma patients
    Bryan A Cotton
    Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 72:1470-5; discussion 1475-7. 2012
    ..The purpose of this study was to identify whether admission rapid-thrombelastography (r-TEG) could identify patients at risk of developing pulmonary embolism (PE) during their hospital stay...
  14. doi request reprint Heart-rate complexity for prediction of prehospital lifesaving interventions in trauma patients
    Leopoldo C Cancio
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
    J Trauma 65:813-9. 2008
    ..To improve our ability to forecast the need for prehospital lifesaving interventions (LSIs), we applied heart-rate complexity (HRC) analysis to the electrocardiogram (ECG) of patients en route to trauma centers...
  15. doi request reprint The impact of missing trauma data on predicting massive transfusion
    Amber W Trickey
    Department of Surgery, Inova Fairfax Hospital, Falls Church, Virginia, USA
    J Trauma Acute Care Surg 75:S68-74. 2013
    ..Three blood transfusion prediction models were evaluated using an observational trauma data set with valid missing data...
  16. pmc Application of the Berlin definition in PROMMTT patients: the impact of resuscitation on the incidence of hypoxemia
    Bryce R H Robinson
    Division of Trauma Critical Care, Department of Surgery, College of Medicine, University of Cincinnati, Cincinnati, Ohio 45267, USA
    J Trauma Acute Care Surg 75:S61-7. 2013
    ..Acute lung injury following trauma resuscitation remains a concern despite recent advances. With the use of the PROMMTT study population, the risk of hypoxemia and potential modifiable risk factors are studied...
  17. pmc A latent class model for defining severe hemorrhage: experience from the PROMMTT study
    Mohammad H Rahbar
    Biostatistics Epidemiology Research Design Core, Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, Texas, USA
    J Trauma Acute Care Surg 75:S82-8. 2013
    ..We show how a latent class model could improve the accuracy of identifying the SH patients...
  18. pmc Do-not-resuscitate orders in trauma patients may bias mortality-based effect estimates: an evaluation using the PROMMTT study
    Charles E Wade
    Center for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 75:S89-96. 2013
    ..We determined the frequency, timing, and impact on mortality-based effect estimates for patients with DNR orders in the Prospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study...
  19. doi request reprint Impact of closure at the first take back: complication burden and potential overutilization of damage control laparotomy
    Quinton M Hatch
    Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma 71:1503-11. 2011
    ....
  20. ncbi request reprint The ratio of blood products transfused affects mortality in patients receiving massive transfusions at a combat support hospital
    Matthew A Borgman
    Brooke Army Medical Center, Fort Sam Houston, TX, USA
    J Trauma 63:805-13. 2007
    ..The risk of death from hemorrhagic shock increases in this population. To treat the coagulopathy of trauma, some have suggested early, aggressive correction using a 1:1 ratio of plasma to red blood cell (RBC) units...
  21. doi request reprint A novel biologic hemostatic dressing (fibrin patch) reduces blood loss and resuscitation volume and improves survival in hypothermic, coagulopathic Swine with grade V liver injury
    Angel V Delgado
    US Army Institute of Surgical Research, San Antonio, Texas, USA
    J Trauma 64:75-80. 2008
    ..This study evaluated the efficacy of a biologic hemostatic fibrin patch (FP) to control coagulopathic bleeding and prevent death in a porcine model of severe liver injury with hemodilution and hypothermia...
  22. doi request reprint Effect of hemodilution on coagulation and recombinant factor VIIa efficacy in human blood in vitro
    Daniel N Darlington
    Damage Control Resuscitation and Blood Programs, US Army Institute of Surgical Research, San Antonio, Texas 78234 6315, USA
    J Trauma 71:1152-63. 2011
    ..This study evaluates the effect of hemodilution by various common resuscitation fluids, and the efficacy of activated recombinant factor VII (rFVIIa) on coagulation parameters in human blood in vitro...
  23. doi request reprint The effect of recombinant activated factor VII on mortality in combat-related casualties with severe trauma and massive transfusion
    Philip C Spinella
    US Army Institute of Surgical Research, San Antonio, Texas, USA
    J Trauma 64:286-93; discussion 293-4. 2008
    ....
  24. pmc Resuscitate early with plasma and platelets or balance blood products gradually: findings from the PROMMTT study
    Deborah J Del Junco
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, Medical School, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 75:S24-30. 2013
    ..To differentiate the association of in-hospital mortality with early plasma or platelet transfusion from that with delayed but gradually balanced ratios, we developed a separate analytic approach...
  25. doi request reprint Hyperfibrinolysis at admission is an uncommon but highly lethal event associated with shock and prehospital fluid administration
    Bryan A Cotton
    Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 73:365-70; discussion 370. 2012
    ..To further strengthen this hypothesis, we created an in vitro hemodilution model to improve our mechanistic understanding of the early HF...
  26. ncbi request reprint Heart rate variability and its association with mortality in prehospital trauma patients
    William H Cooke
    Department of Health and Kinesiology, The University of Texas at San Antonio, San Antonio, Texas 78249, USA
    J Trauma 60:363-70; discussion 370. 2006
    ..The purpose of this study was to assess heart rate variability and its association with mortality in prehospital trauma patients...
  27. doi request reprint Fasciotomy rates in operations enduring freedom and iraqi freedom: association with injury severity and tourniquet use
    John F Kragh
    US Army Institute of Surgical Research USAISR, Fort Sam Houston, TX, USA
    J Orthop Trauma 25:134-9. 2011
    ..To compare fasciotomy rates and Injury Severity Scores (ISSs) before and after tourniquets were fielded for combat casualties in March 2005...
  28. ncbi request reprint Prehospital loss of R-to-R interval complexity is associated with mortality in trauma patients
    Andriy I Batchinsky
    US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
    J Trauma 63:512-8. 2007
    ..To improve our ability to identify physiologic deterioration caused by critical injury, we applied nonlinear analysis to the R-to-R interval (RRI) of the electrocardiogram of prehospital trauma patients...
  29. ncbi request reprint Hypotension begins at 110 mm Hg: redefining "hypotension" with data
    Brian J Eastridge
    U S Army Institute for Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
    J Trauma 63:291-7; discussion 297-9. 2007
    ..However, few data exist to support the rigid adherence to this arbitrary cutoff. We hypothesized that the physiologic hypoperfusion and mortality outcomes classically associated with hypotension were manifest at higher SBPs...
  30. pmc Clinical and mechanistic drivers of acute traumatic coagulopathy
    Mitchell Jay Cohen
    Division of General Surgery, Department of Surgery, School of Medicine, University of California San Francisco, San Francisco, California, USA
    J Trauma Acute Care Surg 75:S40-7. 2013
    ..The PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) study provided a unique opportunity to characterize coagulation and the effects of resuscitation on ATC after severe trauma...
  31. doi request reprint Cryoprecipitate use in the PROMMTT study
    John B Holcomb
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, Medical School, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 75:S31-9. 2013
    ..Our objectives were to identify patterns and predictors of cryoprecipitate use and determine whether transfusing cryoprecipitate was associated with improved survival...
  32. pmc Early resuscitation intensity as a surrogate for bleeding severity and early mortality in the PROMMTT study
    Elaheh Rahbar
    Center for Translational Injury Research, University of Texas Health Science Center at Houston, Houston, Texas, USA
    J Trauma Acute Care Surg 75:S16-23. 2013
    ....
  33. pmc Purposeful variable selection and stratification to impute missing Focused Assessment with Sonography for Trauma data in trauma research
    Paul A Fuchs
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, Medical School, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    J Trauma Acute Care Surg 75:S75-81. 2013
    ..Owing to variability in patients' injuries and trauma care, these data are unlikely to be missing completely at random, raising concern for validity when analyses exclude patients with missing values...
  34. doi request reprint Admission rapid thrombelastography can replace conventional coagulation tests in the emergency department: experience with 1974 consecutive trauma patients
    John B Holcomb
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    Ann Surg 256:476-86. 2012
    ..We have previously shown that admission r-TEG results are available faster than CCTs and predict pulmonary embolism. We hypothesized that r-TEGs more reliably predict blood component transfusion than CCTs...
  35. pmc Coordination and management of multicenter clinical studies in trauma: Experience from the PRospective Observational Multicenter Major Trauma Transfusion (PROMMTT) Study
    Mohammad H Rahbar
    Biostatistics, Epidemiology, and Research Design Core, Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA
    Resuscitation 83:459-64. 2012
    ....
  36. ncbi request reprint Evolution of burn resuscitation in operation Iraqi freedom
    Kevin K Chung
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Burn Care Res 27:606-11. 2006
  37. doi request reprint Effect of recombinant factor VIIa as an adjunctive therapy in damage control for wartime vascular injuries: a case control study
    Charles J Fox
    Department of Surgery, Walter Reed Army Medical Center, Washington, DC 20307, USA
    J Trauma 66:S112-9. 2009
    ..The primary aim of this study was to assess the effect of rFVIIa use during DCR for vascular trauma and the impact on vessel repair...
  38. ncbi request reprint Infectious complications of noncombat trauma patients provided care at a military trauma center
    Heather C Yun
    San Antonio Military Medical Center, Fort Sam Houston, TX, USA
    Mil Med 175:317-23. 2010
    ..In burned patients, infection was associated with total body surface area burned and preexisting conditions (p < 0.01). Enhanced infection control in targeted trauma populations may improve outcomes...
  39. pmc Waiver of consent in noninterventional, observational emergency research: the PROMMTT experience
    Erin E Fox
    Biostatistics Epidemiology Research Design Core, Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston, Houston, TX 77030, USA
    J Trauma Acute Care Surg 75:S3-8. 2013
    ..The goal of this article was to examine the rationale and tradeoffs of using waiver of consent in PROMMTT...
  40. doi request reprint Global evacuation of burn patients does not increase the incidence of venous thromboembolic complications
    Kevin K Chung
    Clinical Division, U S Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 65:19-24. 2008
    ..We hypothesized global evacuation results in increased VTE rates...
  41. ncbi request reprint Recombinant factor VIIa increases the pressure at which rebleeding occurs in porcine uncontrolled aortic hemorrhage model
    Jill L Sondeen
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    Shock 22:163-8. 2004
    ....
  42. ncbi request reprint Fresh whole blood transfusions in coalition military, foreign national, and enemy combatant patients during Operation Iraqi Freedom at a U.S. combat support hospital
    Philip C Spinella
    U S Army Institute of Surgical Research, San Antonio, Texas, USA
    World J Surg 32:2-6. 2008
    ....
  43. doi request reprint A predictive model for massive transfusion in combat casualty patients
    Daniel F McLaughlin
    United States Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    J Trauma 64:S57-63; discussion S63. 2008
    ..We postulated that evaluation of clinical variables routinely assessed upon admission would allow identification of these patients for earlier, more effective intervention...
  44. doi request reprint Increased platelet:RBC ratios are associated with improved survival after massive transfusion
    John B Holcomb
    Division of Acute Care Surgery, Center for Translational Injury Research, University of Texas Health Sciences Center, Houston, Texas 77030, USA
    J Trauma 71:S318-28. 2011
    ..However, outcomes associated with platelet transfusions are poorly characterized. We hypothesized that increased platelet:red blood cells (RBC) ratios would decrease hemorrhagic death and improve survival after massive transfusion (MT)...
  45. pmc The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks
    John B Holcomb
    Center for Translational Injury Research, Division of Acute Care Surgery, Department of Surgery, University of Texas Health Science Center at Houston, 6410 Fannin, Ste 1100, Houston, TX 77030, USA
    JAMA Surg 148:127-36. 2013
    ..To relate in-hospital mortality to early transfusion of plasma and/or platelets and to time-varying plasma:red blood cell (RBC) and platelet:RBC ratios...
  46. doi request reprint Survival with emergency tourniquet use to stop bleeding in major limb trauma
    John F Kragh
    US Army Institute of Surgical Research, Fort Sam Houston, TX, USA
    Ann Surg 249:1-7. 2009
    ..The purpose of this study was to determine if emergency tourniquet use saved lives...
  47. doi request reprint Damage control resuscitation for vascular surgery in a combat support hospital
    Charles J Fox
    Department of Surgery, Walter Reed Army Medical Center, Washington, DC, USA
    J Trauma 65:1-9. 2008
    ..We hypothesized that limb preservation could be successful when the damage control approach combines advanced resuscitative strategies and modern vascular techniques...
  48. doi request reprint Incidence and severity of combat hand burns after All Army Activity message
    Travis L Hedman
    United States Army Institute of Surgical Research, Burn Center, Fort Sam Houston, TX 78234, USA
    J Trauma 64:S169-72; discussion S172-3. 2008
    ..Our purpose was to assess the effectiveness of the ALARACT in reducing the incidence and severity of hand burns...
  49. doi request reprint Causes of mortality by autopsy findings of combat casualties and civilian patients admitted to a burn unit
    Ruben Gomez
    Brooke Army Medical Center, Fort Sam Houston, TX 78234, USA
    J Am Coll Surg 208:348-54. 2009
    ..Approximately 5% of combat-related injuries include burns. Previous studies have shown similar mortality rates between military and civilian burn casualties; but causes of death were not detailed...
  50. doi request reprint Abdominal complications after severe burns
    Katharine W Markell
    United States Army Institute of Surgical Research, Fort Sam Houston, TX, USA
    J Am Coll Surg 208:940-7; discussion 947-9. 2009
    ..We sought to define incidence, outcomes, and associated factors, such as excessive resuscitation volume and treatment issues...
  51. doi request reprint New hemostatic agents in the combat setting
    E Darrin Cox
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
    Transfusion 49:248S-55S. 2009
    ..This article reports recent clinical observations regarding the efficacy and evolution of use of two new hemostatic bandages employed in the global war on terrorism...
  52. doi request reprint The ratio of fibrinogen to red cells transfused affects survival in casualties receiving massive transfusions at an army combat support hospital
    Harry K Stinger
    Brooke Army Medical Center, U S Army Institute of Surgical Research, San Antonio, TX 78234 6200, USA
    J Trauma 64:S79-85; discussion S85. 2008
    ..Our objective was to determine whether increased ratios of fibrinogen to red blood cells (RBCs) decreased mortality in combat casualties requiring massive transfusion...
  53. doi request reprint Better hemostatic profiles of never-frozen liquid plasma compared with thawed fresh frozen plasma
    Nena Matijevic
    Center for Translational Injury Research, Department of Surgery, University of Texas Health Science Center at Houston, Texas 77030, USA
    J Trauma Acute Care Surg 74:84-90; discussion 90-1. 2013
    ..We characterized changes in LQP hemostatic potential during 26 days of cold storage...
  54. pmc Aged plasma transfusion increases mortality in a rat model of uncontrolled hemorrhage
    Phillip A Letourneau
    Center for Translational Injury Research, University of Texas Health Science Center, Houston, Texas, USA
    J Trauma 71:1115-9. 2011
    ..We hypothesized that FFP5 would increase bleeding and mortality compared with FFP0 in a rodent bioassay model of uncontrolled liver hemorrhage...
  55. ncbi request reprint Fresh frozen plasma should be given earlier to patients requiring massive transfusion
    Ernest A Gonzalez
    Department of Surgery, University of Texas Houston Medical School, Houston, Texas, USA
    J Trauma 62:112-9. 2007
    ..The hypothesis for this study is that our pre-intensive care unit (ICU) massive transfusion (MT) protocol does not adequately correct coagulopathy, and that early uncorrected coagulopathy is predictive of mortality...
  56. doi request reprint Thrombelastography is better than PT, aPTT, and activated clotting time in detecting clinically relevant clotting abnormalities after hypothermia, hemorrhagic shock and resuscitation in pigs
    Wenjun Z Martini
    The US Army Institute of Surgical Research, 3400 Rawley E Chambers Avenue, Ft Sam Houston, TX 78234, USA
    J Trauma 65:535-43. 2008
    ..In this study, we investigated the independent and combined effects of hypothermia and hemorrhage with resuscitation on coagulation in swine and evaluated clinically relevant tests of coagulation...
  57. doi request reprint Management of coagulopathy in the patients with multiple injuries: results from an international survey of clinical practice
    David B Hoyt
    Department of Surgery, University of California, Irvine, Orange, CA 92868, USA
    J Trauma 65:755-64; discussion 764-5. 2008
    ..Bleeding is one of the leading causes of preventable death after traumatic injury. Trauma-associated coagulopathy complicates the control of bleeding. The published approaches on the management of this coagulopathy differ significantly...
  58. ncbi request reprint Effect of recombinant FVIIa in hypothermic, coagulopathic pigs with liver injuries
    Harold G Klemcke
    U S Army Institute of Surgical Research, Fort Sam Houston, TX 78234 6315, USA
    J Trauma 59:155-61; discussion 161. 2005
    ..The objectives were to evaluate further the hemostatic efficacy and safety of rFVIIa administration after traumatic, uncontrolled hemorrhage...
  59. doi request reprint Predictors of early acute lung injury at a combat support hospital: a prospective observational study
    Jason W Edens
    United States Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    J Trauma 69:S81-6. 2010
    ..The purpose of this study was to determine whether this strategy is associated with an increased incidence of ALI...
  60. doi request reprint Prolonged prothrombin time after recombinant activated factor VII therapy in critically bleeding trauma patients is associated with adverse outcomes
    Neil R McMullin
    US Army Institute of Surgical Research, BAMC Fort Sam Houston, Texas, USA
    J Trauma 69:60-9. 2010
    ....
  61. doi request reprint Glucose variability is associated with high mortality after severe burn
    Heather F Pidcoke
    Department of Surgery, University of Texas Health Science Center, San Antonio, Texas 78234 6315, USA
    J Trauma 67:990-5. 2009
    ..High glucose variability creates challenges to glycemic control and may be a marker of poor outcome. We wondered whether glycemic variability alone might identify patients at higher risk of death...
  62. ncbi request reprint Longterm outcomes after combat casualty emergency department thoracotomy
    Jason W Edens
    United States Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    J Am Coll Surg 209:188-97. 2009
    ..The incidence, survival, and blood product use after emergency department thoracotomy (EDT) in combat casualties is unknown...
  63. ncbi request reprint Both primary and secondary abdominal compartment syndrome can be predicted early and are harbingers of multiple organ failure
    Zsolt Balogh
    Department of Surgery, Memorial Hermann Hospital, University of Texas at Houston Medical School, 77030, USA
    J Trauma 54:848-59; discussion 859-61. 2003
    ..The purpose of this study was to compare the epidemiology of primary and secondary ACS and develop early prediction models in a high-risk cohort who were treated in a similar fashion...
  64. pmc An emergency department thawed plasma protocol for severely injured patients
    Zayde A Radwan
    Center for Translational Injury Research, The University of Texas Health Science Center, 6410 Fannin St, 1100 20 UPB, Houston, TX 77030, USA
    JAMA Surg 148:170-5. 2013
    ....
  65. doi request reprint Differential expression of the immunoinflammatory response in trauma patients: burn vs. non-burn
    James E Mace
    U S Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    Burns 38:599-606. 2012
    ..Although previous studies evaluated cytokine levels after trauma, differences between patients with burn and non-burn trauma have not been assessed systematically...
  66. ncbi request reprint Comparison of hemorrhage control agents applied to lethal extremity arterial hemorrhages in swine
    Eric M Acheson
    US Army Institute of Surgical Research, Fort Sam Houston, TX, 78234, USA
    J Trauma 59:865-74; discussion 874-5. 2005
    ..Our objective was to evaluate the hemostatic efficacy of these three products in a model of severe extremity arterial hemorrhage that could not be stopped by standard gauze treatment...
  67. doi request reprint Incidence of systemic fungal infection and related mortality following severe burns
    Clinton K Murray
    Infectious Disease Service, San Antonio Military Medical Center, Brooke Army Medical Center, 3851 Roger Brooke Drive, Fort Sam Houston, TX 78234, USA
    Burns 34:1108-12. 2008
    ....
  68. ncbi request reprint The impact of intensive insulin protocols and restrictive blood transfusion strategies on glucose measurement in American Burn Association (ABA) verified burn centers
    Elizabeth A Mann
    United States Army Institute of Surgical Research, Brooke Army Medical Center, San Antonio, TX, USA
    J Burn Care Res 29:718-23. 2008
    ..The combination of a higher prevalence of hypoglycemia in the presence of near universal anemia is concerning, particularly given the pervasiveness of glucometer use among burn centers...
  69. doi request reprint Determination of efficacy of new hemostatic dressings in a model of extremity arterial hemorrhage in swine
    Bijan S Kheirabadi
    Damage Control Resuscitation Division, US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    J Trauma 67:450-9; discussion 459-60. 2009
    ..In this study, four new dressings (preselected) that are more suitable for battlefield application were evaluated. The efficacy and acute safety of the dressings were tested in our standard arterial hemorrhage model...
  70. ncbi request reprint Rapid thrombelastography delivers real-time results that predict transfusion within 1 hour of admission
    Bryan A Cotton
    Department of Surgery, The University of Texas Health Science Center, Houston, Texas 77030, USA
    J Trauma 71:407-14; discussion 414-7. 2011
    ..The purpose of this pilot study was to evaluate the timeliness of r-TEG results, their correlation with CCTs, and the ability of r-TEG to predict early blood transfusion...
  71. doi request reprint Comparison of new hemostatic granules/powders with currently deployed hemostatic products in a lethal model of extremity arterial hemorrhage in swine
    Bijan S Kheirabadi
    US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
    J Trauma 66:316-26; discussion 327-8. 2009
    ..The new products were compared with the most advanced forms of HC and QC products...
  72. doi request reprint Joint Theater Trauma System implementation of burn resuscitation guidelines improves outcomes in severely burned military casualties
    Jody L Ennis
    United States Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    J Trauma 64:S146-51; discussion S151-2. 2008
    ..To help standardize care, burn resuscitation guidelines (BRG) were devised along with a burn flow sheet (BFS) and disseminated via the new operational Joint Theater Trauma System to assist deployed providers...
  73. doi request reprint Combining early coagulation and inflammatory status improves prediction of mortality in burned and nonburned trauma patients
    Myung S Park
    US Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    J Trauma 64:S188-94. 2008
    ..We hypothesized that combining markers of these processes and standard clinical indices would improve early prediction of in- hospital mortality in burned and nonburned trauma patients...
  74. doi request reprint Practical use of emergency tourniquets to stop bleeding in major limb trauma
    John F Kragh
    US Army Institute of Surgical Research, Fort Sam Houston, TX 78234 6315, USA
    J Trauma 64:S38-49; discussion S49-50. 2008
    ..Previously we showed that tourniquets were lifesaving devices in the current war. Few studies, however, describe their actual morbidity in combat casualties. The purpose of this study was to measure tourniquet use and complications...
  75. ncbi request reprint Evaluation of tris-hydroxymethylaminomethane on reversing coagulation abnormalities caused by acidosis in pigs
    Wenjun Z Martini
    U S Army Institute of Surgical Research, Ft Sam Houston, TX, USA
    Crit Care Med 35:1568-74. 2007
    ..To investigate the effect of tris-hydroxymethylaminomethane (THAM) pH neutralization on reversing coagulation abnormalities caused by acidosis...
  76. doi request reprint Physiological and medical monitoring for en route care of combat casualties
    Victor A Convertino
    US Army Institute of Surgical Research, Fort Sam Houston, TX 78234 6315, USA
    J Trauma 64:S342-53. 2008
    ....
  77. doi request reprint Effects of synthetic versus natural colloid resuscitation on inducing dilutional coagulopathy and increasing hemorrhage in rabbits
    Bijan S Kheirabadi
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Trauma 64:1218-28; discussion 1228-9. 2008
    ..We investigated the effects of resuscitation with this fluid, as well as other colloids, on coagulation and uncontrolled bleeding in rabbits subjected to a splenic injury...
  78. doi request reprint Utilizing a trauma systems approach to benchmark and improve combat casualty care
    Brian J Eastridge
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
    J Trauma 69:S5-9. 2010
    ..S. civilian trauma system models. The purpose of this analysis was to develop battlefield injury outcome benchmark metrics and to evaluate the impact of JTTS-driven performance improvement interventions...
  79. doi request reprint Long range transport of war-related burn casualties
    Evan M Renz
    United States Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    J Trauma 64:S136-44; discussion S144-5. 2008
    ..This study characterizes the military burn casualties transported by each team and reports associated outcomes...
  80. doi request reprint Infections in combat casualties during Operations Iraqi and Enduring Freedom
    Clinton K Murray
    Infectious Disease Service, Brooke Army Medical Center, Fort Sam Houston, Texas 78234, USA
    J Trauma 66:S138-44. 2009
    ..The Joint Theater Trauma Registry (JTTR) has been established to collect injury specific medical data from casualties in Iraq and Afghanistan...
  81. doi request reprint Injuries from explosions: physics, biophysics, pathology, and required research focus
    Howard R Champion
    Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, MD, USA
    J Trauma 66:1468-77; discussion 1477. 2009
    ....
  82. ncbi request reprint The effect of recombinant factor VIIa on coagulopathic pigs with grade V liver injuries
    Martin A Schreiber
    Michael E DeBakey Department of Surgery, Baylor College of Medicine, University of Texas at Houston, Houston, Texas, USA
    J Trauma 53:252-7; discussion 257-9. 2002
    ....
  83. ncbi request reprint Independent contributions of hypothermia and acidosis to coagulopathy in swine
    Wenjun Z Martini
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas 78234, USA
    J Trauma 58:1002-9; discussion 1009-10. 2005
    ..An improved understanding of coagulopathy should facilitate hemorrhage control...
  84. ncbi request reprint Combat burn life support: a military burn-education program
    David J Barillo
    US Army Institute of Surgical Research, Fort Sam Houston, Texas, USA
    J Burn Care Rehabil 26:162-5. 2005
    ..Although intended for a military audience, the course material is equally applicable to civilian terrorist or mass casualty situations...
  85. ncbi request reprint Burn support for Operation Iraqi Freedom and related operations, 2003 to 2004
    Leopoldo C Cancio
    US Army Institute of Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
    J Burn Care Rehabil 26:151-61. 2005
    ..This experience highlights the importance of anticipating the burn care needs of both combatants and the local civilian population during war...
  86. ncbi request reprint Base deficit and alveolar-arterial gradient during resuscitation contribute independently but modestly to the prediction of mortality after burn injury
    Leopold C Cancio
    U S Army Institute of Surgical Research, Fort Sam Houston, Texas 78234 6315, USA
    J Burn Care Res 27:289-96; discussion 296-7. 2006
    ..The inclusion of these variables did not improve predictive accuracy. Whether therapies targeted at these endpoints would improve outcome is unknown...
  87. ncbi request reprint Acute changes in fibrinogen metabolism and coagulation after hemorrhage in pigs
    Wenjun Z Martini
    The US Army Institute of Surgical Research, 3400 Rawley E Chambers Ave, Ft Sam Houston, TX 78234, USA
    Am J Physiol Endocrinol Metab 289:E930-4. 2005
    ..05). No changes were found in liver enzyme activities. We conclude that the observed changes in coagulation after hemorrhagic shock are mechanistically related to the acute acceleration of fibrinogen degradation...
  88. ncbi request reprint Effects of low temperature on shear-induced platelet aggregation and activation
    Jian ning Zhang
    Section of Thrombosis Research, Department of Medicine, Baylor College of Medicine, Houston, Texas 77030, USA
    J Trauma 57:216-23. 2004
    ....
  89. ncbi request reprint Structural design of the dry fibrin sealant dressing and its impact on the hemostatic efficacy of the product
    Anthony E Pusateri
    US Army Institute of Surgical Research, Fort Sam Houston, San Antonio, Texas 78234 6315, USA
    J Biomed Mater Res B Appl Biomater 70:114-21. 2004
    ..The structural design of DFSD-2 did not meet the efficacy requirement for release of the product. The subsequent change incorporated in DFSD-3 improved all hemostatic parameters of the dressings equal to those of the prototype product...
  90. pmc Optimal use of blood in trauma patients
    John B Holcomb
    Division of Acute Care Surgery, Center for Translational Injury Research, University of Texas Health Science Center, 6410 Fannin St, Suite 1100 Houston, TX 77030, USA
    Biologicals 38:72-7. 2010
    ..This review will address the issues raised above and describe recent trauma patient outcome data utilizing predetermined plasma:platelet:RBC transfusion ratios and an ongoing prospective observational trauma transfusion study...
  91. ncbi request reprint Treatment of an acquired coagulopathy with recombinant activated factor VII in a damage-control patient
    John B Holcomb
    Department of Trauma and Critical Care, University of Texas Health Science Center, Houston, TX 77030, USA
    Mil Med 170:287-90. 2005
    ..We report the use of recombinant activated factor VII for a male patient who was injured in a motor vehicle accident. We also summarize the animal studies and clinical trials that have been reported...
  92. ncbi request reprint Tracking the daily availability of burn beds for national emergencies
    David J Barillo
    US Army Institute of Surgical Research US Army Burn Center, Brooke Army Medical Center, Fort Sam Houston, Texas, USA
    J Burn Care Rehabil 26:174-82. 2005
    ..Although intended for military conflict, this system is equally applicable to civilian mass casualty situations. We advocate adoption of this or a similar bed tracking system by the ABA for use during burn mass casualty incidents...
  93. ncbi request reprint The Pope Air Force Base aircraft crash and burn disaster
    David W Mozingo
    US Army Institute of Surgical Research, Brooke Army Medical Center, Fort Sam Houston, Texas, USA
    J Burn Care Rehabil 26:132-40. 2005
    ..Lessons learned from this incident have utility in the planning of future response to such disasters...
  94. ncbi request reprint Early predictors of massive transfusion in combat casualties
    Martin A Schreiber
    Department of Surgery, Oregon Health and Science University, Portland, OR 97239, USA
    J Am Coll Surg 205:541-5. 2007
    ..The purpose of this study was to determine which variables, available early after injury, are associated with MT. We hypothesized that International Normalized Ratio and penetrating mechanism would be predictive...
  95. ncbi request reprint Recombinant factor VIIa reduces rebleed hemorrhage volume in a swine aortotomy model: a randomized double-blinded study
    Neil R McMullin
    US Army Institute of Surgical Research, San Antonio, Texas, USA
    Shock 29:703-8. 2008
    ....
  96. ncbi request reprint Wartime burn care in Iraq: 28th Combat Support Hospital, 2003
    Louis R Stout
    U S Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    Mil Med 172:1148-53. 2007
    ..Shortly after arrival, it was designated as the hospital primarily responsible for burn care for the U.S. military in Iraq. This report reviews the experience of the CSH with burn care during combat operations...
  97. ncbi request reprint The clinical and laboratory response to recombinant factor VIIA in trauma and surgical patients with acquired coagulopathy
    Neil R McMullin
    United States Army Institute of Surgical Research, Fort Sam Houston, TX 78234, USA
    Curr Surg 63:246-51. 2006
    ..In bleeding patients who are coagulopathic, the clinical response to administration of recombinant factor VIIa (rFVIIa) relates to the changes in prothrombin time (PT)...
  98. ncbi request reprint Heart period variability in trauma patients may predict mortality and allow remote triage
    William H Cooke
    Department of Health and Kinesiology, The University of Texas at San Antonio, San Antonio, TX 78249, USA
    Aviat Space Environ Med 77:1107-12. 2006
    ..We tested the hypothesis that survival is associated with low relative HF/LF, and death is associated with high relative HF/LF...
  99. doi request reprint A high ratio of plasma and platelets to packed red blood cells in the first 6 hours of massive transfusion improves outcomes in a large multicenter study
    Karen A Zink
    Department of Surgery, Trauma Critical Care Section, Oregon Health and Science University, Portland, OR 97239, USA
    Am J Surg 197:565-70; discussion 570. 2009
    ..In trauma, most hemorrhagic deaths occur within the first 6 hours. This study examined the effect on survival of high ratios of fresh frozen plasma (FFP) and platelets (PLTs) to packed red blood cells (PRBCs) in the first 6 hours...
  100. ncbi request reprint Status of trauma care in U.S. Army hospitals
    Barbara E Wojcik
    Center for Army Medical Department Strategic Studies, U S Army Medical Department Center and School, Fort Sam Houston, TX 78234 5047, USA
    Mil Med 170:141-8. 2005
    ..This study documents the recent trends and current state of inpatient trauma care in U.S. Army hospitals...
  101. ncbi request reprint Risks associated with fresh whole blood and red blood cell transfusions in a combat support hospital
    Philip C Spinella
    U S Army Institute of Surgical Research, San Antonio, TX, USA
    Crit Care Med 35:2576-81. 2007
    ..Fresh whole blood (FWB) and red blood cells (RBCs) are transfused to injured casualties in combat support hospitals. We evaluated the risks of FWB and RBCs transfused to combat-related casualties...