Research Topics
Species | Rasha HammamiehSummaryAffiliation: Walter Reed Army Medical Center Country: USA Publications
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Detail Information
Publications
Genetic variations in peripheral blood mononuclear cells in piglets used as an animal model for staphylococcal enterotoxin exposuresRasha Hammamieh
Division of Pathology, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
OMICS 7:401-9. 2003..Some of these varying genes are involved in stress response, immune response, and transcription. This study facilitates the characterization of gene expression base line needed for meaningful interpretation of microarray data...
Control of the growth of human breast cancer cells in culture by manipulation of arachidonate metabolismRasha Hammamieh
Walter Reed Army Institute of Research, Silver Spring, MD, USA
BMC Cancer 7:138. 2007..Production of bioactive lipids are frequently initiated by the enzyme phospholipase A2 which releases arachidonic acid (AA) that is rapidly metabolized by cyclooxygenases (COX) or lipoxygenases (LO) to other highly potent lipids...- Blood genomic profiles of exposures to Venezuelan equine encephalitis in Cynomolgus macaques (Macaca fascicularis)Rasha Hammamieh
Division of Pathology, Walter Reed Army Institute of Research, Silver Spring, MD, USA
Virol J 4:82. 2007..Screening for host mRNA obtained from blood samples after exposure to VEEV may provide the means for early detection of surrogate markers of the impending illness and provide appropriate strategies for treatment... - Molecular impacts of antisense complementary to the liver fatty acid binding protein (FABP) mRNA in DU 145 prostate cancer cells in vitroRasha Hammamieh
Walter Reed Army Institute of Research, Division of Pathology, Silver Spring, MD 20910, USA
J Exp Ther Oncol 4:195-202. 2004..This suggests a possible use of these antisense ODNs as therapeutic agents for prostate cancer in future... - Students investigating the antiproliferative effects of synthesized drugs on mouse mammary tumor cellsRasha Hammamieh
Division of Pathology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
Cell Biol Educ 4:221-34. 2005.... 
The cellular and molecular immune response of the weanling piglet to staphylococcal enterotoxin BShuguang Bi
Department of Molecular Pathology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
Exp Biol Med (Maywood) 234:1305-15. 2009..From this work it is clear that there is not one absolute cell-mediated pathway contributing to the pathology these animals exhibit as a result of SEB exposure...- Early indicators of exposure to biological threat agents using host gene profiles in peripheral blood mononuclear cellsRina Das
Division of Pathology, Walter Reed Army Institute of Research, Silver Spring, MD, USA
BMC Infect Dis 8:104. 2008.... - Expression patterns of fatty acid binding proteins in breast cancer cellsRasha Hammamieh
Department of Molecular Pathology, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
J Exp Ther Oncol 5:133-43. 2005..Genes related to cell growth, proliferation and angiogenesis showed significant variations. This suggests a possible use of these antisense ODNs as therapeutic agents for breast cancer in future... - Differential effects of omega-3 and omega-6 Fatty acids on gene expression in breast cancer cellsRasha Hammamieh
Division of Pathology, Walter Reed Army Institute of Research, 503 Robert Grant Road, Silver Spring, MD 20910, USA
Breast Cancer Res Treat 101:7-16. 2007..and thus presented an important pool of biomarkers for the differential effect of omega-3 and omega-6EFAs... - Modeling of SEB-induced host gene expression to correlate in vitro to in vivo responsesRasha Hammamieh
Division of Pathology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
Biosens Bioelectron 20:719-27. 2004.... - Functional piglet model for the clinical syndrome and postmortem findings induced by staphylococcal enterotoxin BYvonne A van Gessel
Division of Pathology, Department of Molecular Pathology, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
Exp Biol Med (Maywood) 229:1061-71. 2004..The use of this piglet model will continue to elucidate the pathogenesis of SEB intoxication and facilitate the testing of new therapeutic regimens that may better correlate with human lesions... - Activity of the Bacillus anthracis 20 kDa protective antigen componentRasha Hammamieh
Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
BMC Infect Dis 8:124. 2008..Both proteolytically cleaved protective antigens (PA63 and PA20 fragments) are found in the blood of infected animals. The 63 kDa protective antigen PA63 fragment has been thoroughly studied while little is known about the PA20... - Modulation of cholinergic pathways and inflammatory mediators in blast-induced traumatic brain injuryManojkumar Valiyaveettil
Blast Induced Neurotrauma Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA Electronic address
Chem Biol Interact 203:371-5. 2013..Acute changes in molecules involved in the modulation of cholinergic and inflammatory pathways after blast TBI can cause long-term central and peripheral pathophysiological changes... - Altered gene expression in asymptomatic SHIV-infected rhesus macaques (Macacca mulatta)Erica E Carroll
Division of Pathology, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA
Virol J 3:74. 2006..The gene expression differences in SHIV-infected animals relative to uninfected animals offer additional clues to the pathogenesis of altered immune function in response to secondary infection... - Staphylococcal enterotoxin B causes differential expression of Rnd3 and RhoA in renal proximal tubule epithelial cells while inducing actin stress fiber assembly and apoptosisBoris Ionin
Department of Molecular Pathology, Division of Pathology, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
Microb Pathog 45:303-9. 2008..Furthermore, these data implicate the involvement of the Rho family proteins in the molecular signaling pathway induced by SEB in RPTEC... - Adipocyte-fatty acid binding protein induces apoptosis in DU145 prostate cancer cellsMarta L De Santis
Department of Molecular Pathology, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
J Exp Ther Oncol 4:91-100. 2004.... - Excel2SVM: a stand-alone Python tool for data analysis via support vector machinesMatthew Hellman
Walter Reed Army Institute of Research, Molecular Pathology, Silver Spring, Maryland 20910, USA
OMICS 12:93-8. 2008..kernel-machines.org. This software provides a useful graphical user interface that has proven to provide kernel models with accurate results and data classification through a decision boundary... - Staphylococcal enterotoxin B initiates protein kinase C translocation and eicosanoid metabolism while inhibiting thrombin-induced aggregation in human plateletsUyen Tran
Department of Molecular Pathology, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, Maryland 20910, USA
Mol Cell Biochem 288:171-8. 2006..These data indicate that SEB is able to induce platelet dysfunction, and these effects may be mediated through activation of PKC... - Gene expression profiling of monkeypox virus-infected cells reveals novel interfaces for host-virus interactionsAbdulnaser Alkhalil
United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA
Virol J 7:173. 2010..Our results highlight the role of histones, actin, cell cycle regulators, and ion channels in MPV infection, and propose these host functions as attractive research focal points in identifying novel drug intervention sites... - Alpha-defensin-like product and asymmetric dimethylarginine increase in mesenteric lymph after hemorrhage in anesthetized ratJames L Atkins
Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
Shock 30:411-6. 2008.... - GeneCite: a stand-alone open source tool for high-throughput literature and pathway miningRasha Hammamieh
Walter Reed Army Institute of Research, Molecular Pathology, Silver Spring, Maryland 20910, USA
OMICS 11:143-51. 2007..The software is free and currently available online www.bioinformatics.org; www.wrair.army.mil/Resources... - Preliminary studies on differential expression of auditory functional genes in the brain after repeated blast exposuresManojkumar Valiyaveettil
Blast Induced Neurotrauma Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
J Rehabil Res Dev 49:1153-62. 2012..In summary, mice exposed to repeated blasts showed injury to the auditory cortex and significant alterations in multiple genes in the brain known to be involved in age- or noise-induced hearing impairment... - Early blood profiles of virus infection in a monkey model for Lassa feverMahmoud M Djavani
Institute of Human Virology, University of Maryland Biotechnology Institute, 725 West Lombard St, Baltimore, MD 21201, USA
J Virol 81:7960-73. 2007..Major transcription changes have been given preliminary confirmation by quantitative PCR and protein studies and will be valuable candidates for future validation as biomarkers for arenavirus disease... - Identification of staphylococcal enterotoxin B domains involved in binding to cultured human kidney proximal tubular cells: imparting proliferation and deathSubroto Chatterjee
Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland 21205, USA
Exp Biol Med (Maywood) 232:1142-51. 2007..SEB 130-160 mediated apoptosis was mitigated by preincubation of cells with antibody against SEB and an SEB 130-160 antibody... - Modeling the effects of a Staphylococcal Enterotoxin B (SEB) on the apoptosis pathwayBrandon W Higgs
Emerging Technologies Office, The MITRE Corporation, McLean, VA, USA
BMC Microbiol 6:48. 2006..Such comparisons can expose both the proteins most susceptible to alteration by the agent as well as the most critical reaction rates to better instill control on a biological network... - Induction of immunomodulator transcriptional responses by cholera toxinAtabak R Royaee
Department of Chemistry, Georgetown University, 654 Reiss Science Bldg, Washington, DC 20057, USA
Mol Immunol 43:1020-8. 2006..The results suggest that immunomodulatory genes were among the genes that were affected the most by CT, and induction of these genes may contribute to the CT adjuvanticity...