T W Geisbert

Summary

Affiliation: Walter Reed Army Medical Center
Country: USA

Publications

  1. pmc Effective post-exposure treatment of Ebola infection
    Heinz Feldmann
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    PLoS Pathog 3:e2. 2007
  2. pmc Pathogenesis of Ebola hemorrhagic fever in primate models: evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells
    Thomas W Geisbert
    United States Army Medical Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Am J Pathol 163:2371-82. 2003
  3. ncbi request reprint Postexposure protection of guinea pigs against a lethal ebola virus challenge is conferred by RNA interference
    Thomas W Geisbert
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 5011, USA
    J Infect Dis 193:1650-7. 2006
  4. pmc Development of a new vaccine for the prevention of Lassa fever
    Thomas W Geisbert
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    PLoS Med 2:e183. 2005
  5. ncbi request reprint Exotic emerging viral diseases: progress and challenges
    Thomas W Geisbert
    Virology Division, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Maryland 21702 5011, USA
    Nat Med 10:S110-21. 2004
  6. ncbi request reprint Ebola virus: new insights into disease aetiopathology and possible therapeutic interventions
    Thomas W Geisbert
    Department of Viral Pathology and Ultrastructure, Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Expert Rev Mol Med 6:1-24. 2004
  7. ncbi request reprint Towards a vaccine against Ebola virus
    Thomas W Geisbert
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Expert Rev Vaccines 2:777-89. 2003
  8. ncbi request reprint Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys
    Thomas W Geisbert
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
    Lancet 362:1953-8. 2003
  9. ncbi request reprint Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key event
    Thomas W Geisbert
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA 21702 5011
    J Infect Dis 188:1618-29. 2003
  10. pmc Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection
    Thomas W Geisbert
    United States Army Medical Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Am J Pathol 163:2347-70. 2003

Collaborators

Detail Information

Publications56

  1. pmc Effective post-exposure treatment of Ebola infection
    Heinz Feldmann
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
    PLoS Pathog 3:e2. 2007
    ....
  2. pmc Pathogenesis of Ebola hemorrhagic fever in primate models: evidence that hemorrhage is not a direct effect of virus-induced cytolysis of endothelial cells
    Thomas W Geisbert
    United States Army Medical Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Am J Pathol 163:2371-82. 2003
    ..Together, these data suggest that coagulation abnormalities associated with EBOV HF are not the direct result of EBOV-induced cytolysis of endothelial cells, and are likely triggered by immune-mediated mechanisms...
  3. ncbi request reprint Postexposure protection of guinea pigs against a lethal ebola virus challenge is conferred by RNA interference
    Thomas W Geisbert
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 5011, USA
    J Infect Dis 193:1650-7. 2006
    ..Here, we describe the development of a potential therapy for EBOV infection that is based on small interfering RNAs (siRNAs)...
  4. pmc Development of a new vaccine for the prevention of Lassa fever
    Thomas W Geisbert
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    PLoS Med 2:e183. 2005
    ..Currently, there are no licensed vaccines for Lassa fever, and no experimental vaccine has completely protected nonhuman primates against a lethal challenge...
  5. ncbi request reprint Exotic emerging viral diseases: progress and challenges
    Thomas W Geisbert
    Virology Division, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Maryland 21702 5011, USA
    Nat Med 10:S110-21. 2004
    ..Of equal importance, these comparisons highlight critical gaps in our knowledge of these pathogens...
  6. ncbi request reprint Ebola virus: new insights into disease aetiopathology and possible therapeutic interventions
    Thomas W Geisbert
    Department of Viral Pathology and Ultrastructure, Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Expert Rev Mol Med 6:1-24. 2004
    ..This review summarises our current understanding of EBOV pathogenesis and discusses various approaches to therapeutic intervention based on our current understanding of how EBOV produces a lethal infection...
  7. ncbi request reprint Towards a vaccine against Ebola virus
    Thomas W Geisbert
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Expert Rev Vaccines 2:777-89. 2003
    ..This review takes a brief historic look at attempts to develop an efficacious vaccine, provides an overview of current vaccine candidates and highlights strategies that have the greatest potential for commercial development...
  8. ncbi request reprint Treatment of Ebola virus infection with a recombinant inhibitor of factor VIIa/tissue factor: a study in rhesus monkeys
    Thomas W Geisbert
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA
    Lancet 362:1953-8. 2003
    ..Here, we tested the notion that blockade of fVIIa/tissue factor is beneficial after infection with Ebola virus...
  9. ncbi request reprint Mechanisms underlying coagulation abnormalities in ebola hemorrhagic fever: overexpression of tissue factor in primate monocytes/macrophages is a key event
    Thomas W Geisbert
    Virology Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA 21702 5011
    J Infect Dis 188:1618-29. 2003
    ..Thus, chemotherapeutic strategies aimed at controlling overexpression of TF may ameliorate the effects of EBOV hemorrhagic fever...
  10. pmc Pathogenesis of Ebola hemorrhagic fever in cynomolgus macaques: evidence that dendritic cells are early and sustained targets of infection
    Thomas W Geisbert
    United States Army Medical Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Am J Pathol 163:2347-70. 2003
    ..The sequence of pathogenetic events identified in this study should provide new targets for rational prophylactic and chemotherapeutic interventions...
  11. pmc Evaluation in nonhuman primates of vaccines against Ebola virus
    Thomas W Geisbert
    U S Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702 5011, USA
    Emerg Infect Dis 8:503-7. 2002
    ..The disease observed in primates differed from that in rodents, suggesting that rodent models of EBOV may not predict the efficacy of candidate vaccines in primates and that protection of primates may require different mechanisms...
  12. ncbi request reprint Apoptosis induced in vitro and in vivo during infection by Ebola and Marburg viruses
    T W Geisbert
    Pathology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 5011, USA
    Lab Invest 80:171-86. 2000
    ....
  13. ncbi request reprint Evidence against an important role for infectivity-enhancing antibodies in Ebola virus infections
    Thomas W Geisbert
    Pathology Division, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 5011, USA
    Virology 293:15-9. 2002
    ..Taken together with in vivo observations that early deaths were not observed in animals immunized with various viral vectors expressing EBOV GP, it is unlikely that any EBOV-enhancing antibodies profoundly affected EBOV pathogenesis...
  14. ncbi request reprint Evaluation of immune globulin and recombinant interferon-alpha2b for treatment of experimental Ebola virus infections
    P B Jahrling
    United States Army Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702 5011, USA
    J Infect Dis 179:S224-34. 1999
    ..Effective treatment of Ebola infections may require a combination of drugs that inhibit viral replication in monocyte/macrophage-like cells while reversing the pathologic effects (e.g., coagulopathy) consequent to this replication...
  15. ncbi request reprint Experimental infection of guinea pigs with Venezuelan hemorrhagic fever virus (Guanarito): a model of human disease
    W C Hall
    Pathology Division, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland
    Am J Trop Med Hyg 55:81-8. 1996
    ..Intact virions and typical arenavirus inclusions were demonstrated by immunoelectron microscopy in these tissues. Based on these findings, the guinea pig appears to be a valid animal model of the human disease...
  16. ncbi request reprint Pathogenesis of experimental Ebola Zaire virus infection in BALB/c mice
    T R Gibb
    Diagnostic Systems, United States Army Medical Research Institute of Infectious Diseases (USAMRIID, Fort Detrick, Frederick, Maryland 21702-5011, USA
    J Comp Pathol 125:233-42. 2001
    ..The availability of immunodeficient, "gene-knockout" and transgenic mice will make the mouse model particularly useful for studying the early steps of Ebola pathogenesis...
  17. pmc Cross-protection against Marburg virus strains by using a live, attenuated recombinant vaccine
    Kathleen M Daddario-DiCaprio
    Virology Division, USAMRIID, Fort Detrick, MD 21702 5011, USA
    J Virol 80:9659-66. 2006
    ..These data suggest that the VSVDeltaG/MARVGP-Musoke vaccine should be sufficient to protect against all known MARV strains...
  18. pmc Vector choice determines immunogenicity and potency of genetic vaccines against Angola Marburg virus in nonhuman primates
    Thomas W Geisbert
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702 5011, USA
    J Virol 84:10386-94. 2010
    ....
  19. ncbi request reprint The pathology of experimental aerosolized monkeypox virus infection in cynomolgus monkeys (Macaca fascicularis)
    G M Zaucha
    Pathology Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, Maryland, USA
    Lab Invest 81:1581-600. 2001
    ..Concurrent bacterial septicemia, present in one monkey, was associated with increased dissemination of the virus to the liver, spleen, and bone marrow and resulted in a more rapidly fatal clinical course...
  20. pmc Immune protection of nonhuman primates against Ebola virus with single low-dose adenovirus vectors encoding modified GPs
    Nancy J Sullivan
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA
    PLoS Med 3:e177. 2006
    ..GP can exert cytopathic effects on transfected cells in vitro, and multiple GP forms have been identified in nature, raising the question of which would be optimal for a human vaccine...
  21. ncbi request reprint Lymphocyte death in a mouse model of Ebola virus infection
    Steven B Bradfute
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
    J Infect Dis 196:S296-304. 2007
    ..In a mouse model of ZEBOV infection, lymphocyte death is a prominent finding; however, the mechanism of death and the lymphocyte subsets that are targeted remain unknown...
  22. doi request reprint Cellular immune response to Marburg virus infection in cynomolgus macaques
    Elizabeth A Fritz
    United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland, USA
    Viral Immunol 21:355-63. 2008
    ..IL-6 production was detected late in the infection in CD14(+) spleen cells. These results suggest a robust innate immune response to MARV; however, this response was delayed relative to the infection...
  23. ncbi request reprint Depletion of peripheral blood T lymphocytes and NK cells during the course of ebola hemorrhagic Fever in cynomolgus macaques
    Douglas S Reed
    Center for Aerobiological Sciences, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland, USA
    Viral Immunol 17:390-400. 2004
    ....
  24. pmc Interferon-beta 1a and SARS coronavirus replication
    Lisa E Hensley
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, Maryland 21702, USA
    Emerg Infect Dis 10:317-9. 2004
    ..Here, we report that recombinant human interferon-beta 1a potently inhibits SARS coronavirus replication in vitro...
  25. ncbi request reprint Proinflammatory response during Ebola virus infection of primate models: possible involvement of the tumor necrosis factor receptor superfamily
    Lisa E Hensley
    Pathology Division, US Army Medical Research Institute of Infectious Diseases USAMRIID, Attn MCMR UIP D, 1425 Porter Street, Fort Detrick, MD 21702 5011, USA
    Immunol Lett 80:169-79. 2002
    ..Identification of cytokine/chemokine, nitric oxide, and reactive oxygen species involvement in the observed filoviral pathogenesis may lend insight into the rational design of therapeutic countermeasures of filoviral pathogenesis...
  26. pmc Inhibition of heat-shock protein 90 reduces Ebola virus replication
    Darci R Smith
    U S Army Medical Research Institute of Infectious Diseases, Virology Division, Fort Detrick, MD, United States
    Antiviral Res 87:187-94. 2010
    ..These results validated that Hsp90 is an important host factor for the replication of filoviruses and suggest that Hsp90 inhibitors may be therapeutically effective in treating EBOV infection...
  27. ncbi request reprint Detection and identification of Variola virus in fixed human tissue after prolonged archival storage
    Randal J Schoepp
    Diagnostic Systems Division, United States Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702 5011, USA
    Lab Invest 84:41-8. 2004
    ....
  28. ncbi request reprint Development of treatment strategies to combat Ebola and Marburg viruses
    Jason Paragas
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Expert Rev Anti Infect Ther 4:67-76. 2006
    ..In this review, select technologies and approaches will be highlighted as part of the critical path for the development of therapeutics to ameliorate the invariably devastating outcomes of human filoviral infections...
  29. ncbi request reprint Marburg hemorrhagic fever: report of a case studied by immunohistochemistry and electron microscopy
    T W Geisbert
    Pathology Division, United States Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702 5011, USA
    Ultrastruct Pathol 22:3-17. 1998
    ..This case demonstrates the value of transmission electron microscopy as a tool for assisting in the definitive diagnosis of Marburg or Ebola hemorrhagic fever, as well as providing insight into the pathogenesis of these agents...
  30. ncbi request reprint Recombinant human activated protein C for the postexposure treatment of Ebola hemorrhagic fever
    Lisa E Hensley
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
    J Infect Dis 196:S390-9. 2007
    ..The aim of this study was to test the efficacy of rhAPC as a potential treatment for ZHF...
  31. ncbi request reprint Ebola hemorrhagic fever: evaluation of passive immunotherapy in nonhuman primates
    Peter B Jahrling
    Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD, USA
    J Infect Dis 196:S400-3. 2007
    ..These data cast further doubt on the value of passive immunotherapy for the treatment of EBOV infection...
  32. ncbi request reprint Marburg virus Angola infection of rhesus macaques: pathogenesis and treatment with recombinant nematode anticoagulant protein c2
    Thomas W Geisbert
    Integrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Fort Detrick, MD, USA
    J Infect Dis 196:S372-81. 2007
    ....
  33. ncbi request reprint The contribution of the endothelium to the development of coagulation disorders that characterize Ebola hemorrhagic fever in primates
    Lisa E Hensley
    Virology Division, U S Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
    Thromb Haemost 94:254-61. 2005
    ..Some of the remaining and key unanswered questions relating to the role of the vascular system in the pathogenesis of this disease, that need to be addressed in further research, are highlighted...
  34. ncbi request reprint Postexposure protection against Marburg haemorrhagic fever with recombinant vesicular stomatitis virus vectors in non-human primates: an efficacy assessment
    Kathleen M Daddario-DiCaprio
    Virology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
    Lancet 367:1399-404. 2006
    ..We aimed to test the efficacy of a replication-competent vaccine based on attenuated recombinant vesicular stomatitis virus (rVSV), as a postexposure treatment for MARV haemorrhagic fever...
  35. ncbi request reprint Pathologic findings associated with delayed death in nonhuman primates experimentally infected with Zaire Ebola virus
    Thomas Larsen
    Pathology Division, US Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD, USA
    J Infect Dis 196:S323-8. 2007
    ..We suggest that treatment extended the time course of the disease and permitted the virus to infect tissues not usually affected in the typical model...
  36. ncbi request reprint Ebola and Marburg viruses: pathogenesis and development of countermeasures
    Lisa E Hensley
    Virology Division, U S Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, MD 21702 5011, USA
    Curr Mol Med 5:761-72. 2005
    ..In addition, substantial progress has been made in developing recombinant vaccines against these viruses...
  37. pmc Lipid raft microdomains: a gateway for compartmentalized trafficking of Ebola and Marburg viruses
    Sina Bavari
    Dept of Cell Biology and Biochemistry, U S Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702 5011, USA
    J Exp Med 195:593-602. 2002
    ....
  38. ncbi request reprint Epitopes required for antibody-dependent enhancement of Ebola virus infection
    Ayato Takada
    Department of Global Epidemiology, Research Center for Zoonosis Control, Hokkaido University, Sapporo 060 0818, Japan
    J Infect Dis 196:S347-56. 2007
    ..These data suggest that GP lacking the ADE-inducing epitopes may increase the potential of GP as a vaccine antigen...
  39. ncbi request reprint Emerging viruses: advances and challenges
    Thomas W Geisbert
    Curr Mol Med 5:733-4. 2005
  40. pmc The host response to smallpox: analysis of the gene expression program in peripheral blood cells in a nonhuman primate model
    Kathleen H Rubins
    Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
    Proc Natl Acad Sci U S A 101:15190-5. 2004
    ..These results provide a detailed picture of the host transcriptional response during smallpox infection, and may help guide the development of diagnostic, therapeutic, and prophylactic strategies...
  41. pmc Reverse genetics with a full-length infectious cDNA of severe acute respiratory syndrome coronavirus
    Boyd Yount
    Department of Epidemiology and Microbiology, University of North Carolina, Chapel Hill, NC 27599 7435, USA
    Proc Natl Acad Sci U S A 100:12995-3000. 2003
    ....
  42. doi request reprint New opportunities for field research on the pathogenesis and treatment of Lassa fever
    Sheik Humarr Khan
    Kenema Government Hospital, Ministry of Health and Sanitation, Kenema, Sierra Leone
    Antiviral Res 78:103-15. 2008
    ..Here, we review the present literature on treatment and pathogenesis of LF and outline priorities for future research in the field made possible by the improved research capacity of the MRU LFN...
  43. pmc Recombinant vesicular stomatitis virus vector mediates postexposure protection against Sudan Ebola hemorrhagic fever in nonhuman primates
    Thomas W Geisbert
    National Emerging Infectious Diseases Laboratories Institute, Boston, Massachusetts, USA
    J Virol 82:5664-8. 2008
    ..This is the first demonstration of complete postexposure protection against an Ebola virus in nonhuman primates and provides further evidence that postexposure vaccination may have utility in treating exposures to filoviruses...
  44. ncbi request reprint Accelerated vaccination for Ebola virus haemorrhagic fever in non-human primates
    Nancy J Sullivan
    Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bldg 40, Room 4502, MSC 3005, 40 Convent Drive, Bethesda, Maryland 20892 3005, USA
    Nature 424:681-4. 2003
    ..This accelerated vaccine provides an intervention that may help to limit the epidemic spread of Ebola, and is applicable to other viruses...
  45. ncbi request reprint In vitro and in vivo characterization of recombinant Ebola viruses expressing enhanced green fluorescent protein
    Hideki Ebihara
    Department of Special Pathogens, International Research Center for Infectious Diseases, University of Tokyo, Tokyo, Japan
    J Infect Dis 196:S313-22. 2007
    ..These findings demonstrate that the incorporation of a foreign gene will attenuate ZEBOV in vivo but that these viruses still have potential for in vitro and in vivo research applications...
  46. ncbi request reprint Ebola virus: the role of macrophages and dendritic cells in the pathogenesis of Ebola hemorrhagic fever
    Mike Bray
    Biodefense Clinical Research Branch, Office of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Int J Biochem Cell Biol 37:1560-6. 2005
    ..These findings suggest that modifying host responses would be an effective therapeutic strategy, and treatment of infected macaques with a tissue-factor inhibitor reduced both inflammation and viral replication and improved survival...
  47. ncbi request reprint Outbreaks of filovirus hemorrhagic fever: time to refocus on the patient
    Daniel G Bausch
    Tulane School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA
    J Infect Dis 196:S136-41. 2007
    ..A summary of the opportunities for and challenges to improving treatment of filovirus hemorrhagic fevers is presented here...
  48. ncbi request reprint Analysis of the expressed heavy chain variable-region genes of Macaca fascicularis and isolation of monoclonal antibodies specific for the Ebola virus' soluble glycoprotein
    Chris Druar
    Cangene Corporation, 3404 American Drive, Mississauga, Ontario L4V 1T4, Canada
    Immunogenetics 57:730-8. 2005
    ..In summary, the study provides new insight into the M. fascicularis V region gene repertoire and further supports the idea that macaque-derived mAbs may be of therapeutic value to humans...
  49. pmc Neutralizing antibody fails to impact the course of Ebola virus infection in monkeys
    Wendelien B Oswald
    Departments of Immunology and Molecular Biology, The Scripps Research Institute, La Jolla, California, United States of America
    PLoS Pathog 3:e9. 2007
    ..It appears that Ebola virus has a mechanism of infection propagation in vivo in macaques that is uniquely insensitive even to high concentrations of neutralizing antibody...
  50. ncbi request reprint Development of vaccines for Marburg hemorrhagic fever
    Daniel G Bausch
    Department of Tropical Medicine, SL 17, Tulane School of Public Health and Tropical Medicine, 1430 Tulane Avenue, New Orleans, LA 70112, USA
    Expert Rev Vaccines 6:57-74. 2007
    ..In particular, a vaccine based on attenuated recombinant vesicular stomatitis virus was recently shown to have both preventive and postexposure efficacy...
  51. ncbi request reprint Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses
    Steven M Jones
    Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, 1015 Arlington Street, Winnipeg, Manitoba R3E 3R2, Canada
    Nat Med 11:786-90. 2005
    ..No evidence of EBOV or MARV replication was detected in any of the protected animals after challenge. Our data suggest that these vaccine candidates are safe and highly efficacious in a relevant animal model...
  52. pmc The temporal program of peripheral blood gene expression in the response of nonhuman primates to Ebola hemorrhagic fever
    Kathleen H Rubins
    Department of Microbiology and Immunology, 299 Campus Dr, Stanford University School of Medicine, Stanford, California 94305, USA
    Genome Biol 8:R174. 2007
    ..Infection with Ebola virus (EBOV) causes a fulminant and often fatal hemorrhagic fever. In order to improve our understanding of EBOV pathogenesis and EBOV-host interactions, we examined the molecular features of EBOV infection in vivo...
  53. pmc Proteolytic processing of the Ebola virus glycoprotein is not critical for Ebola virus replication in nonhuman primates
    Gabriele Neumann
    Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin Madison, 2015 Linden Drive, Madison, WI 53706, USA
    J Virol 81:2995-8. 2007
    ..We conclude that glycoprotein cleavage by subtilisin-like endoproteases is not critical for Ebola virus infectivity and virulence in nonhuman primates...
  54. ncbi request reprint Viral hemorrhagic fevers
    Aileen M Marty
    Battelle Memorial Institute, Suite 601, 1550 Crystal Drive, Arlington, VA 22202 4172, USA
    Clin Lab Med 26:345-86, viii. 2006
    ..While significant progress has been made over the last several years in dissecting out the molecular biology and pathogenesis of the HF viruses, there are currently no vaccines or drugs licensed available for most of the VHFs...
  55. pmc MassTag polymerase chain reaction for differential diagnosis of viral hemorrhagic fever
    Gustavo Palacios
    Columbia University, New York, New York 10032, USA
    Emerg Infect Dis 12:692-5. 2006
    ..We describe a diagnostic system for rapid, multiplex polymerase chain reaction identification of 10 different causes of viral hemorrhagic fevers...
  56. pmc Panmicrobial oligonucleotide array for diagnosis of infectious diseases
    Gustavo Palacios
    Columbia University, New York, New York 10032, USA
    Emerg Infect Dis 13:73-81. 2007
    ....