James F Dillman

Summary

Affiliation: Walter Reed Army Medical Center
Country: USA

Publications

  1. ncbi request reprint Sulfur mustard induces the formation of keratin aggregates in human epidermal keratinocytes
    James F Dillman
    Applied Pharmacology Branch, U S Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010 5400, USA
    Toxicol Appl Pharmacol 193:228-36. 2003
  2. ncbi request reprint An inhibitor of p38 MAP kinase downregulates cytokine release induced by sulfur mustard exposure in human epidermal keratinocytes
    James F Dillman
    Applied Pharmacology Branch, US Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, MCMR U, Aberdeen Proving Ground, MD 21010 5400, USA
    Toxicol In Vitro 18:593-9. 2004
  3. ncbi request reprint Genomic analysis of rodent pulmonary tissue following bis-(2-chloroethyl) sulfide exposure
    James F Dillman
    Applied Pharmacology and Neurotoxicology Branches, U S Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, Aberdeen Proving Ground, Maryland 21010 5400, USA
    Chem Res Toxicol 18:28-34. 2005
  4. ncbi request reprint Comparison of non-human primate and human whole blood tissue gene expression profiles
    James F Dillman
    Applied Pharmacology Branch, U S Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland 21010 5400, USA
    Toxicol Sci 87:306-14. 2005
  5. pmc Transcriptional responses of the nerve agent-sensitive brain regions amygdala, hippocampus, piriform cortex, septum, and thalamus following exposure to the organophosphonate anticholinesterase sarin
    Kimberly D Spradling
    Cell and Molecular Biology Branch, US Army Medical Research Institute of Chemical Defense USAMRICD, 3100 Ricketts Point Road, Aberdeen Proving Ground, MD 21010 5400, USA
    J Neuroinflammation 8:84. 2011
  6. ncbi request reprint Microarray analysis of mouse ear tissue exposed to bis-(2-chloroethyl) sulfide: gene expression profiles correlate with treatment efficacy and an established clinical endpoint
    James F Dillman
    Cell and Molecular Biology Branch, United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010 5400, USA
    J Pharmacol Exp Ther 317:76-87. 2006
  7. ncbi request reprint Bifunctional alkylating agent-induced p53 and nonclassical nuclear factor kappaB responses and cell death are altered by caffeic acid phenethyl ester: a potential role for antioxidant/electrophilic response-element signaling
    Gary D Minsavage
    Cell and Molecular Biology Branch, U S Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, Aberdeen Proving Ground, MD 21010 5400, USA
    J Pharmacol Exp Ther 321:202-12. 2007
  8. ncbi request reprint Genomic analysis of murine pulmonary tissue following carbonyl chloride inhalation
    Alfred M Sciuto
    Pharmacology Division, U S Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland 21010 5400, USA
    Chem Res Toxicol 18:1654-60. 2005
  9. pmc Transcriptional analysis of rat piriform cortex following exposure to the organophosphonate anticholinesterase sarin and induction of seizures
    Kimberly D Spradling
    Cell and Molecular Biology Branch, US Army Medical Research Institute of Chemical Defense USAMRICD, 3100 Ricketts Point Road, Aberdeen Proving Ground, MD 21010 5400, USA
    J Neuroinflammation 8:83. 2011
  10. doi request reprint Global gene expression in rat brain and liver after oral exposure to the explosive hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)
    Desmond I Bannon
    Directorate of Toxicology, US Army Center for Health Promotion and Preventive Medicine CHPPM, Aberdeen Proving Ground, Maryland 21010 5403, USA
    Chem Res Toxicol 22:620-5. 2009

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Sulfur mustard induces the formation of keratin aggregates in human epidermal keratinocytes
    James F Dillman
    Applied Pharmacology Branch, U S Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010 5400, USA
    Toxicol Appl Pharmacol 193:228-36. 2003
    ..These studies demonstrate that sulfur mustard induces keratin aggregation in keratinocytes and support further investigation into the role of keratin aggregation in sulfur mustard-induced vesication...
  2. ncbi request reprint An inhibitor of p38 MAP kinase downregulates cytokine release induced by sulfur mustard exposure in human epidermal keratinocytes
    James F Dillman
    Applied Pharmacology Branch, US Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, MCMR U, Aberdeen Proving Ground, MD 21010 5400, USA
    Toxicol In Vitro 18:593-9. 2004
    ..These results show that p38 MAP kinase plays a role in SM-induced cytokine production in HEK and suggest that inhibiting this pathway may alleviate the profound inflammatory response elicited by cutaneous SM exposure...
  3. ncbi request reprint Genomic analysis of rodent pulmonary tissue following bis-(2-chloroethyl) sulfide exposure
    James F Dillman
    Applied Pharmacology and Neurotoxicology Branches, U S Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, Aberdeen Proving Ground, Maryland 21010 5400, USA
    Chem Res Toxicol 18:28-34. 2005
    ..Thus, SM exposure induces transcriptional changes that reveal the cellular response to this potent alkylating agent...
  4. ncbi request reprint Comparison of non-human primate and human whole blood tissue gene expression profiles
    James F Dillman
    Applied Pharmacology Branch, U S Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland 21010 5400, USA
    Toxicol Sci 87:306-14. 2005
    ..These results show that human genechips can be used for expression profiling of NHP samples and provide a foundation for the development of tools for comparing human and NHP gene expression profiles...
  5. pmc Transcriptional responses of the nerve agent-sensitive brain regions amygdala, hippocampus, piriform cortex, septum, and thalamus following exposure to the organophosphonate anticholinesterase sarin
    Kimberly D Spradling
    Cell and Molecular Biology Branch, US Army Medical Research Institute of Chemical Defense USAMRICD, 3100 Ricketts Point Road, Aberdeen Proving Ground, MD 21010 5400, USA
    J Neuroinflammation 8:84. 2011
    ....
  6. ncbi request reprint Microarray analysis of mouse ear tissue exposed to bis-(2-chloroethyl) sulfide: gene expression profiles correlate with treatment efficacy and an established clinical endpoint
    James F Dillman
    Cell and Molecular Biology Branch, United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010 5400, USA
    J Pharmacol Exp Ther 317:76-87. 2006
    ..These data provide a basis for elucidating the mechanisms of response to SM and drug treatment and also provide a basis for developing strategies to accelerate development of effective SM medical countermeasures...
  7. ncbi request reprint Bifunctional alkylating agent-induced p53 and nonclassical nuclear factor kappaB responses and cell death are altered by caffeic acid phenethyl ester: a potential role for antioxidant/electrophilic response-element signaling
    Gary D Minsavage
    Cell and Molecular Biology Branch, U S Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, Aberdeen Proving Ground, MD 21010 5400, USA
    J Pharmacol Exp Ther 321:202-12. 2007
    ....
  8. ncbi request reprint Genomic analysis of murine pulmonary tissue following carbonyl chloride inhalation
    Alfred M Sciuto
    Pharmacology Division, U S Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland 21010 5400, USA
    Chem Res Toxicol 18:1654-60. 2005
    ..We are also investigating other pathways that are responsive to phosgene exposure to identify mechanisms of toxicity and potential therapeutic targets...
  9. pmc Transcriptional analysis of rat piriform cortex following exposure to the organophosphonate anticholinesterase sarin and induction of seizures
    Kimberly D Spradling
    Cell and Molecular Biology Branch, US Army Medical Research Institute of Chemical Defense USAMRICD, 3100 Ricketts Point Road, Aberdeen Proving Ground, MD 21010 5400, USA
    J Neuroinflammation 8:83. 2011
    ..Therefore, there is a need to discover drug treatments that are effective when administered after the onset of seizures and secondary responses that lead to brain injury...
  10. doi request reprint Global gene expression in rat brain and liver after oral exposure to the explosive hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)
    Desmond I Bannon
    Directorate of Toxicology, US Army Center for Health Promotion and Preventive Medicine CHPPM, Aberdeen Proving Ground, Maryland 21010 5403, USA
    Chem Res Toxicol 22:620-5. 2009
    ....
  11. doi request reprint Sulfur mustard induced cytokine production and cell death: investigating the potential roles of the p38, p53, and NF-kappaB signaling pathways with RNA interference
    Albert L Ruff
    Cell and Molecular Biology Branch, Research Division, U S Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, Aberdeen Proving Ground, MD 21010 5400, USA
    J Biochem Mol Toxicol 24:155-64. 2010
    ..Interestingly, inhibition of p53 by RNAi potentiated SM-induced cell death, suggesting that the role of p53 in SM injury, may be complex and not simply prodeath...
  12. doi request reprint Genomics and proteomics in chemical warfare agent research: recent studies and future applications
    Patrick A Everley
    Research Division, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010, USA
    Toxicol Lett 198:297-303. 2010
    ..Here we present an overview of how genomics and proteomics technologies have been applied to CWA research and also provide a series of questions focused on how these techniques could further our understanding of CWA toxicity...
  13. doi request reprint A large-scale quantitative proteomic approach to identifying sulfur mustard-induced protein phosphorylation cascades
    Patrick A Everley
    Research Division, United States Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, Aberdeen Proving Ground, Maryland 21010, USA
    Chem Res Toxicol 23:20-5. 2010
    ..Further de novo analysis of these phosphoproteins using interaction mapping software revealed both known and novel pathways that may serve as future therapeutic targets of SM exposure...
  14. doi request reprint Gene expression profiling of rat hippocampus following exposure to the acetylcholinesterase inhibitor soman
    James F Dillman
    Cell and Molecular Biology Branch, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland 21010 5400, USA
    Chem Res Toxicol 22:633-8. 2009
    ..These data provide important insights into the molecular pathways involved in soman-induced neuropathology and a basis for generating hypotheses about the mechanism of soman-induced neurodegeneration...
  15. ncbi request reprint A system-based approach to interpret dose- and time-dependent microarray data: quantitative integration of gene ontology analysis for risk assessment
    Xiaozhong Yu
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, 98105, USA
    Toxicol Sci 92:560-77. 2006
    ....