Research Topics
| James F DillmanSummaryAffiliation: Walter Reed Army Medical Center Country: USA Publications
| Collaborators
|
Detail Information
Publications
Sulfur mustard induces the formation of keratin aggregates in human epidermal keratinocytesJames F Dillman
Applied Pharmacology Branch, U S Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010 5400, USA
Toxicol Appl Pharmacol 193:228-36. 2003..These studies demonstrate that sulfur mustard induces keratin aggregation in keratinocytes and support further investigation into the role of keratin aggregation in sulfur mustard-induced vesication...- An inhibitor of p38 MAP kinase downregulates cytokine release induced by sulfur mustard exposure in human epidermal keratinocytesJames F Dillman
Applied Pharmacology Branch, US Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, MCMR U, Aberdeen Proving Ground, MD 21010 5400, USA
Toxicol In Vitro 18:593-9. 2004..These results show that p38 MAP kinase plays a role in SM-induced cytokine production in HEK and suggest that inhibiting this pathway may alleviate the profound inflammatory response elicited by cutaneous SM exposure... - Genomic analysis of rodent pulmonary tissue following bis-(2-chloroethyl) sulfide exposureJames F Dillman
Applied Pharmacology and Neurotoxicology Branches, U S Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, Aberdeen Proving Ground, Maryland 21010 5400, USA
Chem Res Toxicol 18:28-34. 2005..Thus, SM exposure induces transcriptional changes that reveal the cellular response to this potent alkylating agent... - Comparison of non-human primate and human whole blood tissue gene expression profilesJames F Dillman
Applied Pharmacology Branch, U S Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland 21010 5400, USA
Toxicol Sci 87:306-14. 2005..These results show that human genechips can be used for expression profiling of NHP samples and provide a foundation for the development of tools for comparing human and NHP gene expression profiles... - Transcriptional responses of the nerve agent-sensitive brain regions amygdala, hippocampus, piriform cortex, septum, and thalamus following exposure to the organophosphonate anticholinesterase sarinKimberly D Spradling
Cell and Molecular Biology Branch, US Army Medical Research Institute of Chemical Defense USAMRICD, 3100 Ricketts Point Road, Aberdeen Proving Ground, MD 21010 5400, USA
J Neuroinflammation 8:84. 2011.... - Microarray analysis of mouse ear tissue exposed to bis-(2-chloroethyl) sulfide: gene expression profiles correlate with treatment efficacy and an established clinical endpointJames F Dillman
Cell and Molecular Biology Branch, United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010 5400, USA
J Pharmacol Exp Ther 317:76-87. 2006..These data provide a basis for elucidating the mechanisms of response to SM and drug treatment and also provide a basis for developing strategies to accelerate development of effective SM medical countermeasures... - Bifunctional alkylating agent-induced p53 and nonclassical nuclear factor kappaB responses and cell death are altered by caffeic acid phenethyl ester: a potential role for antioxidant/electrophilic response-element signalingGary D Minsavage
Cell and Molecular Biology Branch, U S Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, Aberdeen Proving Ground, MD 21010 5400, USA
J Pharmacol Exp Ther 321:202-12. 2007.... - Genomic analysis of murine pulmonary tissue following carbonyl chloride inhalationAlfred M Sciuto
Pharmacology Division, U S Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland 21010 5400, USA
Chem Res Toxicol 18:1654-60. 2005..We are also investigating other pathways that are responsive to phosgene exposure to identify mechanisms of toxicity and potential therapeutic targets... - Transcriptional analysis of rat piriform cortex following exposure to the organophosphonate anticholinesterase sarin and induction of seizuresKimberly D Spradling
Cell and Molecular Biology Branch, US Army Medical Research Institute of Chemical Defense USAMRICD, 3100 Ricketts Point Road, Aberdeen Proving Ground, MD 21010 5400, USA
J Neuroinflammation 8:83. 2011..Therefore, there is a need to discover drug treatments that are effective when administered after the onset of seizures and secondary responses that lead to brain injury... - Global gene expression in rat brain and liver after oral exposure to the explosive hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX)Desmond I Bannon
Directorate of Toxicology, US Army Center for Health Promotion and Preventive Medicine CHPPM, Aberdeen Proving Ground, Maryland 21010 5403, USA
Chem Res Toxicol 22:620-5. 2009.... - Sulfur mustard induced cytokine production and cell death: investigating the potential roles of the p38, p53, and NF-kappaB signaling pathways with RNA interferenceAlbert L Ruff
Cell and Molecular Biology Branch, Research Division, U S Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, Aberdeen Proving Ground, MD 21010 5400, USA
J Biochem Mol Toxicol 24:155-64. 2010..Interestingly, inhibition of p53 by RNAi potentiated SM-induced cell death, suggesting that the role of p53 in SM injury, may be complex and not simply prodeath... - Genomics and proteomics in chemical warfare agent research: recent studies and future applicationsPatrick A Everley
Research Division, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010, USA
Toxicol Lett 198:297-303. 2010..Here we present an overview of how genomics and proteomics technologies have been applied to CWA research and also provide a series of questions focused on how these techniques could further our understanding of CWA toxicity... - A large-scale quantitative proteomic approach to identifying sulfur mustard-induced protein phosphorylation cascadesPatrick A Everley
Research Division, United States Army Medical Research Institute of Chemical Defense, 3100 Ricketts Point Road, Aberdeen Proving Ground, Maryland 21010, USA
Chem Res Toxicol 23:20-5. 2010..Further de novo analysis of these phosphoproteins using interaction mapping software revealed both known and novel pathways that may serve as future therapeutic targets of SM exposure... - Gene expression profiling of rat hippocampus following exposure to the acetylcholinesterase inhibitor somanJames F Dillman
Cell and Molecular Biology Branch, US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland 21010 5400, USA
Chem Res Toxicol 22:633-8. 2009..These data provide important insights into the molecular pathways involved in soman-induced neuropathology and a basis for generating hypotheses about the mechanism of soman-induced neurodegeneration... - A system-based approach to interpret dose- and time-dependent microarray data: quantitative integration of gene ontology analysis for risk assessmentXiaozhong Yu
Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, 98105, USA
Toxicol Sci 92:560-77. 2006....