Thomas J Balkin

Summary

Affiliation: Walter Reed Army Medical Center
Country: USA

Publications

  1. ncbi request reprint On the importance of countermeasures in sleep and performance models
    Thomas J Balkin
    Department of Behavioral Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Aviat Space Environ Med 75:A155-7. 2004
  2. ncbi request reprint The process of awakening: a PET study of regional brain activity patterns mediating the re-establishment of alertness and consciousness
    Thomas J Balkin
    Department of Behavioral Biology, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
    Brain 125:2308-19. 2002
  3. ncbi request reprint Comparative utility of instruments for monitoring sleepiness-related performance decrements in the operational environment
    Thomas J Balkin
    Department of Behavioral Biology, Division of Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Sleep Res 13:219-27. 2004
  4. doi request reprint Effects of dextroamphetamine, caffeine and modafinil on psychomotor vigilance test performance after 44 h of continuous wakefulness
    William D S Killgore
    Department of Behavioral Biology, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    J Sleep Res 17:309-21. 2008
  5. pmc Sustaining executive functions during sleep deprivation: A comparison of caffeine, dextroamphetamine, and modafinil
    William D S Killgore
    Department of Behavioral Biology, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Sleep 32:205-16. 2009
  6. doi request reprint Sex differences in cognitive estimation during sleep deprivation: effects of stimulant countermeasures
    William D S Killgore
    Department of Behavioral Biology, Walter Reed Army Institute of Research, Belmont, MA, USA
    Int J Neurosci 118:1547-57. 2008
  7. ncbi request reprint Sleep deprivation reduces perceived emotional intelligence and constructive thinking skills
    William D S Killgore
    Department of Behavioral Biology, Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Sleep Med 9:517-26. 2008
  8. ncbi request reprint Caffeine effects on risky decision making after 75 hours of sleep deprivation
    William D S Killgore
    Department of Behavioral Biology, Walter Reed Army Institute of Research WRAIR, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Aviat Space Environ Med 78:957-62. 2007
  9. ncbi request reprint The trait of Introversion-Extraversion predicts vulnerability to sleep deprivation
    William D S Killgore
    Department of Behavioral Biology, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    J Sleep Res 16:354-63. 2007
  10. pmc Trait-like vulnerability to total and partial sleep loss
    Tracy L Rupp
    Behavioral Biology Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Sleep 35:1163-72. 2012

Detail Information

Publications53

  1. ncbi request reprint On the importance of countermeasures in sleep and performance models
    Thomas J Balkin
    Department of Behavioral Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Aviat Space Environ Med 75:A155-7. 2004
  2. ncbi request reprint The process of awakening: a PET study of regional brain activity patterns mediating the re-establishment of alertness and consciousness
    Thomas J Balkin
    Department of Behavioral Biology, Walter Reed Army Institute of Research, Washington, DC 20307 5100, USA
    Brain 125:2308-19. 2002
    ..Conversely, stable post-awakening correlations--such as those found between the anterior cingulate cortex (ACC) and most other brain regions--may denote the pattern of functional connectivity that underlies consciousness itself...
  3. ncbi request reprint Comparative utility of instruments for monitoring sleepiness-related performance decrements in the operational environment
    Thomas J Balkin
    Department of Behavioral Biology, Division of Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Sleep Res 13:219-27. 2004
    ....
  4. doi request reprint Effects of dextroamphetamine, caffeine and modafinil on psychomotor vigilance test performance after 44 h of continuous wakefulness
    William D S Killgore
    Department of Behavioral Biology, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    J Sleep Res 17:309-21. 2008
    ....
  5. pmc Sustaining executive functions during sleep deprivation: A comparison of caffeine, dextroamphetamine, and modafinil
    William D S Killgore
    Department of Behavioral Biology, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Sleep 32:205-16. 2009
    ....
  6. doi request reprint Sex differences in cognitive estimation during sleep deprivation: effects of stimulant countermeasures
    William D S Killgore
    Department of Behavioral Biology, Walter Reed Army Institute of Research, Belmont, MA, USA
    Int J Neurosci 118:1547-57. 2008
    ..Women receiving placebo or caffeine scored significantly worse than males, while modafinil and dextroamphetamine were effective at sustaining BCET performance of men and women...
  7. ncbi request reprint Sleep deprivation reduces perceived emotional intelligence and constructive thinking skills
    William D S Killgore
    Department of Behavioral Biology, Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Sleep Med 9:517-26. 2008
    ....
  8. ncbi request reprint Caffeine effects on risky decision making after 75 hours of sleep deprivation
    William D S Killgore
    Department of Behavioral Biology, Walter Reed Army Institute of Research WRAIR, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Aviat Space Environ Med 78:957-62. 2007
    ..However, it is unknown to what extent such deficits are exacerbated in a dose-response manner by increasing levels of sleepiness, and the extent to which such sleep-loss-induced deficits can be reversed by caffeine...
  9. ncbi request reprint The trait of Introversion-Extraversion predicts vulnerability to sleep deprivation
    William D S Killgore
    Department of Behavioral Biology, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    J Sleep Res 16:354-63. 2007
    ....
  10. pmc Trait-like vulnerability to total and partial sleep loss
    Tracy L Rupp
    Behavioral Biology Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Sleep 35:1163-72. 2012
    ..To determine the extent to which individual differences in vulnerability to total sleep deprivation also reflect individual differences in vulnerability to multiple nights of sleep restriction...
  11. ncbi request reprint Performance and alertness effects of caffeine, dextroamphetamine, and modafinil during sleep deprivation
    Nancy J Wesensten
    Division of Psychiatry and Neuroscience, Department of Behavioral Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Sleep Res 14:255-66. 2005
    ..The duration of these benefits vary in accordance with the different elimination rates of the drugs. Whether caffeine, dextroamphetamine, and modafinil differentially restore executive functions during sleep deprivation remains unclear...
  12. ncbi request reprint Baseline odor identification ability predicts degradation of psychomotor vigilance during 77 hours of sleep deprivation
    William D S Killgore
    Department of Behavioral Biology Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Washington, DC, USA
    Int J Neurosci 118:1207-25. 2008
    ..Individual differences in trait-like functioning of the orbitofrontal cortex are predictive of the ability to sustain alertness and vigilance during continuous wakefulness...
  13. pmc Infraslow EEG oscillations organize large-scale cortical-subcortical interactions during sleep: a combined EEG/fMRI study
    Dante Picchioni
    Department of Behavioral Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Brain Res 1374:63-72. 2011
    ..This pattern of correlations suggests a mechanism by which infraslow oscillations may organize sleep-dependent neuroplastic processes including consolidation of episodic memory...
  14. pmc Banking sleep: realization of benefits during subsequent sleep restriction and recovery
    Tracy L Rupp
    Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Sleep 32:311-21. 2009
    ..Determine whether sleep extension (a) improves alertness and performance during subsequent sleep restriction and (b) impacts the rate at which alertness and performance are restored by post-restriction recovery sleep...
  15. ncbi request reprint The effects of 53 hours of sleep deprivation on moral judgment
    William D S Killgore
    Division of Psychiatry and Neuroscience, Department of Behavioral Biology, Walter Reed Army Institute of Research WRAIR, Silver Spring, MD 20910, USA
    Sleep 30:345-52. 2007
    ..Activity in this region has also been shown to decline significantly during sleep loss. We therefore examined the effects of 2 nights of sleep deprivation on several aspects of moral judgment...
  16. ncbi request reprint Caffeine effects on recovery sleep following 27 h total sleep deprivation
    Cynthia M LaJambe
    Department of Behavioral Biology, Division of Neurosciences, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Aviat Space Environ Med 76:108-13. 2005
    ..Caffeine is widely used to reverse alertness and performance decrements. However, caffeine's effects on subsequent recovery sleep and post-recovery performance are not well documented and, therefore, were evaluated...
  17. ncbi request reprint Maintaining alertness and performance during sleep deprivation: modafinil versus caffeine
    Nancy Jo Wesensten
    Department of Neurobiology and Behaviour, Division of Neuropsychiatry, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
    Psychopharmacology (Berl) 159:238-47. 2002
    ..The performance and alertness effects of modafinil were evaluated to determine whether modafinil should replace caffeine for restoring performance and alertness during total sleep deprivation in otherwise healthy adults...
  18. ncbi request reprint Modafinil vs. caffeine: effects on fatigue during sleep deprivation
    Nancy Jo Wesensten
    Department of Behavioral Biology, Division of Neuroscience, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
    Aviat Space Environ Med 75:520-5. 2004
    ..The extent to which modafinil and caffeine reverse fatigue effects (defined as performance decrements with time on task) during total sleep deprivation was investigated...
  19. ncbi request reprint Effects of acute caffeine withdrawal on Short Category Test performance in sleep-deprived individuals
    William D S Killgore
    Department of Behavioral Biology, Walter Reed Army Institute of Research, USA
    Percept Mot Skills 105:1265-74. 2007
    ..These findings suggest that acute caffeine withdrawal during prolonged sleep deprivation has an adverse effect on abstract reasoning and concept formation...
  20. ncbi request reprint Positron emission tomography correlates of visually-scored electroencephalographic waveforms during non-Rapid Eye Movement sleep
    Dante Picchioni
    Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    Int J Neurosci 119:2074-99. 2009
    ..Each pattern of correlations may suggest a functional significance for these waveforms that relates to a waking outcome...
  21. ncbi request reprint Daytime sleep and performance following a zolpidem and melatonin cocktail
    Nancy Jo Wesensten
    Department of Behavioral Biology, Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Sleep 28:93-103. 2005
    ..At effective doses, zolpidem induces sleep but also impairs performance. Combining melatonin with low-dose zolpidem may promote daytime sleep without exacerbating performance impairments seen with high-dose zolpidem alone...
  22. ncbi request reprint Caffeine gum minimizes sleep inertia
    Rachel A Newman
    Department of Behavioral Biology, Center for Military Psychiatry and Neurosciences Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Percept Mot Skills 116:280-93. 2013
    ..post-awakening. Caffeinated gum is a viable means of rapidly attenuating sleep inertia, suggesting that the adenosine receptor system is involved in sleep maintenance...
  23. doi request reprint Odor identification ability predicts executive function deficits following sleep deprivation
    William D S Killgore
    Department of Behavioral Biology, Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Washington, DC, USA
    Int J Neurosci 120:328-34. 2010
    ..Odor identification ability may provide an unobtrusive method for assessing vulnerability to sleep deprivation...
  24. ncbi request reprint Patterns of performance degradation and restoration during sleep restriction and subsequent recovery: a sleep dose-response study
    Gregory Belenky
    Division of Neuropsychiatry, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910 7500, USA
    J Sleep Res 12:1-12. 2003
    ..These adaptive changes are hypothesized to restrict brain operational capacity and to persist for several days after normal sleep duration is restored, delaying recovery...
  25. pmc Socializing by Day May Affect Performance by Night: Vulnerability to Sleep Deprivation is Differentially Mediated by Social Exposure in Extraverts vs Introverts
    Tracy L Rupp
    Behavioral Biology Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Sleep 33:1475-85. 2010
    ..to examine the effects of socially enriched versus socially impoverished environments on performance and alertness decline during sleep deprivation in extraverts versus introverts...
  26. ncbi request reprint Ampakine (CX717) effects on performance and alertness during simulated night shift work
    Nancy J Wesensten
    Department of Behavioral Biology, Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910 7500, USA
    Aviat Space Environ Med 78:937-43. 2007
    ..The potential performance and objective alertness-enhancing effects of CX717 (a novel cognitive enhancer currently being tested in Phase II clinical trials) were evaluated using a simulated night shift work paradigm...
  27. ncbi request reprint The effects of caffeine, dextroamphetamine, and modafinil on humor appreciation during sleep deprivation
    William D S Killgore
    Division of Neuroscience, Department of Behavioral Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Sleep 29:841-7. 2006
    ....
  28. ncbi request reprint Sex differences in self-reported risk-taking propensity on the Evaluation of Risks scale
    William D S Killgore
    Walter Reed Army Institute of Research, USA
    Psychol Rep 106:693-700. 2010
    ..Although the higher scores exhibited by men are consistent with prior research on other measures of risk-taking, further research on this scale with samples including women is warranted...
  29. doi request reprint PER3 and ADORA2A polymorphisms impact neurobehavioral performance during sleep restriction
    Tracy L Rupp
    Behavioral Biology Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Sleep Res 22:160-5. 2013
    ..Given the small sample size these results are preliminary and require replication...
  30. doi request reprint Sleep loss and sleepiness: current issues
    Thomas J Balkin
    Department of Behavioral Biology, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Chest 134:653-60. 2008
    ..Individual differences in habitual sleep duration appear to be a trait-like characteristic that is determined by several factors, including genetic polymorphisms...
  31. ncbi request reprint Handedness correlates with actigraphically measured sleep in a controlled environment
    William D S Killgore
    Walter Reed Army Institute of Research, Harvard Medical School, USA
    Percept Mot Skills 109:395-400. 2009
    ....
  32. doi request reprint Sleep history affects task acquisition during subsequent sleep restriction and recovery
    Tracy L Rupp
    Department of Behavioral Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Sleep Res 19:289-97. 2010
    ..In sum, 1 week of sleep extension improved resilience during subsequent sleep restriction and facilitated task acquisition during recovery, demonstrating that nightly sleep duration exerts long-term (days, weeks) effects...
  33. ncbi request reprint Impaired decision making following 49 h of sleep deprivation
    William D S Killgore
    Department of Behavioral Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Sleep Res 15:7-13. 2006
    ....
  34. doi request reprint Caffeine protects against increased risk-taking propensity during severe sleep deprivation
    William D S Killgore
    Department of Behavioral Biology, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    J Sleep Res 20:395-403. 2011
    ..These results suggest that 3 nights of total sleep deprivation led to a significant increase in behavioral risk-taking but not self-reported perception of risk-propensity. Overnight caffeine prevented this increase in risky behavior...
  35. doi request reprint Oral appliance titration in patients with obstructive sleep apnea induces the appearance of periodic limb movements
    Melanie L Guerrero
    Department of Behavioral Biology, Walter Reed Army Institute of Research, USA corrected
    Sleep Breath 14:359-63. 2010
    ..Herein, we describe the incidence of PLM in patients with OSA who underwent oral appliance therapy titration...
  36. ncbi request reprint Automated Neuropsychological Assessment Metrics: repeated assessment with two military samples
    Stephanie E Eonta
    Naval Medical Research Center, Silver Spring, MD 20910 7500, USA
    Aviat Space Environ Med 82:34-9. 2011
    ..of this report was to evaluate performance following multiple administrations of the ANAM4 TBI Battery: does performance in a repeated measures paradigm constitute a stable, interpretable indication of baseline neurocognitive ability?..
  37. ncbi request reprint Age and individual variability in performance during sleep restriction
    Paul D Bliese
    Department of Behavioral Biology, Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Sleep Res 15:376-85. 2006
    ....
  38. doi request reprint Comparison of Motionlogger Watch and Actiwatch actigraphs to polysomnography for sleep/wake estimation in healthy young adults
    Tracy L Rupp
    Behavioral Biology Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Behav Res Methods 43:1152-60. 2011
    ....
  39. ncbi request reprint The effects of sleep deprivation on symptoms of psychopathology in healthy adults
    Ellen T Kahn-Greene
    Department of Behavioral Biology, Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research WRAIR, 503 Robert Grant Avenue, Silver Spring, MD 20910, USA
    Sleep Med 8:215-21. 2007
    ..However, the extent to which sleep deprivation may be associated with the emergence of clinical symptoms of psychopathology in healthy normal individuals is not clear...
  40. pmc fMRI differences between early and late stage-1 sleep
    Dante Picchioni
    Division of Psychiatry and Neuroscience, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    Neurosci Lett 441:81-5. 2008
    ..These differences may also have specific relevance to understanding the process of sleep onset as well as the neural mechanisms of performance lapses during sleep deprivation...
  41. ncbi request reprint Discontinuous growth modeling of adaptation to sleep setting changes: individual differences and age
    Paul D Bliese
    U S Army Medical Research Unit Europe, Heidelberg, Germany
    Aviat Space Environ Med 78:485-92. 2007
    ..In addition, we examined whether the individual difference variable of participant age (a continuous variable ranging from 19-29 yr) was related to sleep patterns...
  42. pmc Behavioral biomarkers of sleepiness
    Thomas J Balkin
    Department of Behavioral Biology, Walter Reed Army Institute of Research, Silver Spring, MD 20910, USA
    J Clin Sleep Med 7:S12-5. 2011
    ....
  43. doi request reprint A new metric for quantifying performance impairment on the psychomotor vigilance test
    Srinivasan Rajaraman
    DoD Biotechnology High Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, US Army Medical Research and Materiel Command, Fort Detrick, MD 21702, USA
    J Sleep Res 21:659-74. 2012
    ..Based on these findings, and that the new metric considers performance changes based on the entire set of responses relative to a baseline, we conclude that it provides a number of potential advantages over the traditional PVT metrics...
  44. doi request reprint The challenges and opportunities of technological approaches to fatigue management
    Thomas J Balkin
    Walter Reed Army Institute of Research, Dept of Behavioral Biology, Silver Spring, MD 20910, USA
    Accid Anal Prev 43:565-72. 2011
    ..Finally, we discuss future directions in next generation technology for fatigue management...
  45. ncbi request reprint The rate of absorption and relative bioavailability of caffeine administered in chewing gum versus capsules to normal healthy volunteers
    Gary H Kamimori
    Department of Neurobiology and Behavior, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Int J Pharm 234:159-67. 2002
    ..The purpose of this study was to evaluate the rate of absorption and relative bioavailability of caffeine from a Stay Alert chewing gum and capsule formulation...
  46. ncbi request reprint Metabolic origin of BOLD signal fluctuations in the absence of stimuli
    Masaki Fukunaga
    Advanced MRI, LFMI, NINDS, National Institutes of Health, Bethesda, Maryland 20892 1065, USA
    J Cereb Blood Flow Metab 28:1377-87. 2008
    ..79+/-0.54 and 1.66+/-0.67, respectively), but both were lower than the BPR during BH. These data suggest that resting-state activity, at least in part, represents a metabolic process...
  47. ncbi request reprint Restoration of risk-propensity during sleep deprivation: caffeine, dextroamphetamine, and modafinil
    William D S Killgore
    Neuroimaging Center, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Aviat Space Environ Med 79:867-74. 2008
    ..Stimulant medications are used to restore cognitive performance, but their effects on risk-taking and judgment in sleep-deprived subjects have not been explored...
  48. ncbi request reprint Individualized performance prediction of sleep-deprived individuals with the two-process model
    Srinivasan Rajaraman
    Bioinformatics Cell, Telemedicine and Advanced Technology Research Center, U S Army Medical Research and Materiel Command, MCMR ZB T, 363 Miller Dr, Fort Detrick, MD 21702, USA
    J Appl Physiol (1985) 104:459-68. 2008
    ..In addition, we show that the two-process model of sleep regulation is capable of representing performance data only when the proposed individualized model is used...
  49. ncbi request reprint Low frequency BOLD fluctuations during resting wakefulness and light sleep: a simultaneous EEG-fMRI study
    Silvina G Horovitz
    Advanced MRI Section, LFMI, NINDS, National Institutes of Health, Bethesda, Maryland, USA
    Hum Brain Mapp 29:671-82. 2008
    ..These results suggest that activity in areas such as the default-mode network and primary sensory cortex, as measured from BOLD fMRI fluctuations, does not require a level of consciousness typical of wakefulness...
  50. ncbi request reprint The use of stimulants to modify performance during sleep loss: a review by the sleep deprivation and Stimulant Task Force of the American Academy of Sleep Medicine
    Michael H Bonnet
    Dayton Department of Veterans Affairs Medical Center, Wright State University, and Kettering Medical Center, Dayton, OH 45428, USA
    Sleep 28:1163-87. 2005
  51. ncbi request reprint Modulating the homeostatic process to predict performance during chronic sleep restriction
    Michael L Johnson
    Department of Pharmacology and Internal Medicine, University of Virginia Health System, Charlottesville, VA 22908 0735, USA
    Aviat Space Environ Med 75:A141-6. 2004
    ..These findings suggest that chronic sleep restriction induces relatively long-term, slow-recovering changes in brain physiology that affect alertness and performance...
  52. ncbi request reprint Fatigue models for applied research in warfighting
    Steven R Hursh
    Science Applications International Corporation, Biomedical Modeling and Analysis Program, Joppa, MD 21085, USA
    Aviat Space Environ Med 75:A44-53; discussion A54-60. 2004
    ..The paper concludes with a discussion of several important modeling issues that remain to be addressed...
  53. ncbi request reprint An unfounded conclusion from a confounded study
    Tracy L Rupp
    J Am Board Fam Med 20:420; author repply 420-1. 2007