James L Atkins

Summary

Affiliation: Walter Reed Army Medical Center
Country: USA

Publications

  1. ncbi request reprint Brisk production of nitric oxide and associated formation of S-nitrosothiols in early hemorrhage
    James L Atkins
    Division of Military Casualty Research, Walter Reed Army Institute of Research, Bldg 503, Rm 1N80, 503 Robert Grant Ave, Silver Spring, MD 20910 7500, USA
    J Appl Physiol 100:1267-77. 2006
  2. ncbi request reprint Cardiovascular responses to oxygen inhalation after hemorrhage in anesthetized rats: hyperoxic vasoconstriction
    James L Atkins
    Division of Military Casualty Research, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910, USA
    Am J Physiol Heart Circ Physiol 292:H776-85. 2007
  3. doi request reprint Alpha-defensin-like product and asymmetric dimethylarginine increase in mesenteric lymph after hemorrhage in anesthetized rat
    James L Atkins
    Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Shock 30:411-6. 2008
  4. ncbi request reprint Geldanamycin prevents hemorrhage-induced ATP loss by overexpressing inducible HSP70 and activating pyruvate dehydrogenase
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Am J Physiol Gastrointest Liver Physiol 291:G117-27. 2006
  5. ncbi request reprint Geldanamycin treatment inhibits hemorrhage-induced increases in KLF6 and iNOS expression in unresuscitated mouse organs: role of inducible HSP70
    Juliann G Kiang
    Department of Cellular Injury, Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    J Appl Physiol 97:564-9. 2004
  6. ncbi request reprint Spatial coordination of cell-adhesion molecules and redox cycling of iron in the microvascular inflammatory response to pulmonary injury
    Nikolai V Gorbunov
    Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    Antioxid Redox Signal 9:483-95. 2007
  7. ncbi request reprint Choice of fluid influences outcome in prolonged hypotensive resuscitation after hemorrhage in awake rats
    Michael T Handrigan
    Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    Shock 23:337-43. 2005
  8. doi request reprint Ferrous iron is found in mesenteric lymph bound to TIMP-2 following hemorrhage/resuscitation
    James L Atkins
    Closed Head Brain Injury Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910 7500, USA
    Biometals 24:279-89. 2011
  9. ncbi request reprint Resuscitation with lactated Ringer solution limits the expression of molecular events associated with lung injury after hemorrhage
    Juliann G Kiang
    Division of Military Casualty Research, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Rm 1N07, Silver Spring, MD 20910 7500, USA
    J Appl Physiol 98:550-6. 2005
  10. ncbi request reprint Inflammatory leukocytes and iron turnover in experimental hemorrhagic lung trauma
    Nikolai V Gorbunov
    Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Exp Mol Pathol 80:11-25. 2006

Detail Information

Publications13

  1. ncbi request reprint Brisk production of nitric oxide and associated formation of S-nitrosothiols in early hemorrhage
    James L Atkins
    Division of Military Casualty Research, Walter Reed Army Institute of Research, Bldg 503, Rm 1N80, 503 Robert Grant Ave, Silver Spring, MD 20910 7500, USA
    J Appl Physiol 100:1267-77. 2006
    ..The results indicate that the initial compensatory response to H is more complicated than previously realized, and it involves an orchestrated balance between intense vasoconstrictor and vasodilatory components...
  2. ncbi request reprint Cardiovascular responses to oxygen inhalation after hemorrhage in anesthetized rats: hyperoxic vasoconstriction
    James L Atkins
    Division of Military Casualty Research, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910, USA
    Am J Physiol Heart Circ Physiol 292:H776-85. 2007
    ..We conclude that the therapeutic value of oxygen needs to be separately evaluated for late hemorrhage...
  3. doi request reprint Alpha-defensin-like product and asymmetric dimethylarginine increase in mesenteric lymph after hemorrhage in anesthetized rat
    James L Atkins
    Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Shock 30:411-6. 2008
    ....
  4. ncbi request reprint Geldanamycin prevents hemorrhage-induced ATP loss by overexpressing inducible HSP70 and activating pyruvate dehydrogenase
    Juliann G Kiang
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Am J Physiol Gastrointest Liver Physiol 291:G117-27. 2006
    ..We conclude that agents able to increase the expression of HSP70 and PDH may be of value in reducing pathology resulting from hemorrhage-associated ATP loss...
  5. ncbi request reprint Geldanamycin treatment inhibits hemorrhage-induced increases in KLF6 and iNOS expression in unresuscitated mouse organs: role of inducible HSP70
    Juliann G Kiang
    Department of Cellular Injury, Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    J Appl Physiol 97:564-9. 2004
    ..These results suggest that GA may be therapeutically useful for reducing hemorrhage-induced injury when used as a presurgical treatment or when added to resuscitation fluids...
  6. ncbi request reprint Spatial coordination of cell-adhesion molecules and redox cycling of iron in the microvascular inflammatory response to pulmonary injury
    Nikolai V Gorbunov
    Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    Antioxid Redox Signal 9:483-95. 2007
    ..The studies suggested that a part of the proinflammatory action of iron in the lung resulted from its stimulation of the redox-sensitive factors...
  7. ncbi request reprint Choice of fluid influences outcome in prolonged hypotensive resuscitation after hemorrhage in awake rats
    Michael T Handrigan
    Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    Shock 23:337-43. 2005
    ..4x EBV), survival was no better than C and it resulted in the most significant acidosis. These results support the decision to use Hextend for Hypo, a strategy currently being applied on the battlefield...
  8. doi request reprint Ferrous iron is found in mesenteric lymph bound to TIMP-2 following hemorrhage/resuscitation
    James L Atkins
    Closed Head Brain Injury Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910 7500, USA
    Biometals 24:279-89. 2011
    ..In summary, there is a large increase in extracellular ferrous iron in the gut in H/R demonstrating dysregulation of iron homeostasis. We have identified, for the first time, the binding of extracellular iron to TIMP-2...
  9. ncbi request reprint Resuscitation with lactated Ringer solution limits the expression of molecular events associated with lung injury after hemorrhage
    Juliann G Kiang
    Division of Military Casualty Research, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Rm 1N07, Silver Spring, MD 20910 7500, USA
    J Appl Physiol 98:550-6. 2005
    ..Our results demonstrate that resuscitation with LR can reverse the expression of genes and their products that are thought to contribute to hemorrhage-induced lung injury...
  10. ncbi request reprint Inflammatory leukocytes and iron turnover in experimental hemorrhagic lung trauma
    Nikolai V Gorbunov
    Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
    Exp Mol Pathol 80:11-25. 2006
    ....
  11. ncbi request reprint Small-volume fluid resuscitation for the far-forward combat environment: current concepts
    Michael A Dubick
    U S Army Institute of Surgical Research, San Antonio, Texas 78234 6315, USA
    J Trauma 54:S43-5. 2003
    ..For the military, such observations have important implications toward the development of optimal fluid resuscitation strategies under austere battlefield conditions for stabilization of the combat casualty...
  12. doi request reprint Regional citrate anticoagulation for hemorrhage experiments in rats
    James L Atkins
    Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    J Surg Res 179:e197-202. 2013
    ..We describe the design of such a catheter and evaluate its function in studies of hemorrhagic shock in rats...
  13. ncbi request reprint Transcriptional activation of the human inducible nitric-oxide synthase promoter by Kruppel-like factor 6
    Vishal G Warke
    Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
    J Biol Chem 278:14812-9. 2003
    ..These findings indicate that KLF6 is a potential transactivator of the human iNOS promoter in diverse pathophysiological conditions...