Research Topics
| James L AtkinsSummaryAffiliation: Walter Reed Army Medical Center Country: USA Publications
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Detail Information
Publications
Brisk production of nitric oxide and associated formation of S-nitrosothiols in early hemorrhageJames L Atkins
Division of Military Casualty Research, Walter Reed Army Institute of Research, Bldg 503, Rm 1N80, 503 Robert Grant Ave, Silver Spring, MD 20910 7500, USA
J Appl Physiol 100:1267-77. 2006..The results indicate that the initial compensatory response to H is more complicated than previously realized, and it involves an orchestrated balance between intense vasoconstrictor and vasodilatory components...- Cardiovascular responses to oxygen inhalation after hemorrhage in anesthetized rats: hyperoxic vasoconstrictionJames L Atkins
Division of Military Casualty Research, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910, USA
Am J Physiol Heart Circ Physiol 292:H776-85. 2007..We conclude that the therapeutic value of oxygen needs to be separately evaluated for late hemorrhage... 
Alpha-defensin-like product and asymmetric dimethylarginine increase in mesenteric lymph after hemorrhage in anesthetized ratJames L Atkins
Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
Shock 30:411-6. 2008....- Geldanamycin prevents hemorrhage-induced ATP loss by overexpressing inducible HSP70 and activating pyruvate dehydrogenaseJuliann G Kiang
Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
Am J Physiol Gastrointest Liver Physiol 291:G117-27. 2006..We conclude that agents able to increase the expression of HSP70 and PDH may be of value in reducing pathology resulting from hemorrhage-associated ATP loss... - Geldanamycin treatment inhibits hemorrhage-induced increases in KLF6 and iNOS expression in unresuscitated mouse organs: role of inducible HSP70Juliann G Kiang
Department of Cellular Injury, Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
J Appl Physiol 97:564-9. 2004..These results suggest that GA may be therapeutically useful for reducing hemorrhage-induced injury when used as a presurgical treatment or when added to resuscitation fluids... - Spatial coordination of cell-adhesion molecules and redox cycling of iron in the microvascular inflammatory response to pulmonary injuryNikolai V Gorbunov
Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
Antioxid Redox Signal 9:483-95. 2007..The studies suggested that a part of the proinflammatory action of iron in the lung resulted from its stimulation of the redox-sensitive factors... - Choice of fluid influences outcome in prolonged hypotensive resuscitation after hemorrhage in awake ratsMichael T Handrigan
Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
Shock 23:337-43. 2005..4x EBV), survival was no better than C and it resulted in the most significant acidosis. These results support the decision to use Hextend for Hypo, a strategy currently being applied on the battlefield... - Ferrous iron is found in mesenteric lymph bound to TIMP-2 following hemorrhage/resuscitationJames L Atkins
Closed Head Brain Injury Branch, Center for Military Psychiatry and Neuroscience, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Silver Spring, MD 20910 7500, USA
Biometals 24:279-89. 2011..In summary, there is a large increase in extracellular ferrous iron in the gut in H/R demonstrating dysregulation of iron homeostasis. We have identified, for the first time, the binding of extracellular iron to TIMP-2... - Resuscitation with lactated Ringer solution limits the expression of molecular events associated with lung injury after hemorrhageJuliann G Kiang
Division of Military Casualty Research, Walter Reed Army Institute of Research, 503 Robert Grant Ave, Rm 1N07, Silver Spring, MD 20910 7500, USA
J Appl Physiol 98:550-6. 2005..Our results demonstrate that resuscitation with LR can reverse the expression of genes and their products that are thought to contribute to hemorrhage-induced lung injury... - Inflammatory leukocytes and iron turnover in experimental hemorrhagic lung traumaNikolai V Gorbunov
Division of Military Casualty Research, Walter Reed Army Institute of Research, Silver Spring, MD 20910 7500, USA
Exp Mol Pathol 80:11-25. 2006.... - Small-volume fluid resuscitation for the far-forward combat environment: current conceptsMichael A Dubick
U S Army Institute of Surgical Research, San Antonio, Texas 78234 6315, USA
J Trauma 54:S43-5. 2003..For the military, such observations have important implications toward the development of optimal fluid resuscitation strategies under austere battlefield conditions for stabilization of the combat casualty... - Regional citrate anticoagulation for hemorrhage experiments in ratsJames L Atkins
Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
J Surg Res 179:e197-202. 2013..We describe the design of such a catheter and evaluate its function in studies of hemorrhagic shock in rats... - Transcriptional activation of the human inducible nitric-oxide synthase promoter by Kruppel-like factor 6Vishal G Warke
Department of Cellular Injury, Walter Reed Army Institute of Research, Silver Spring, Maryland 20910, USA
J Biol Chem 278:14812-9. 2003..These findings indicate that KLF6 is a potential transactivator of the human iNOS promoter in diverse pathophysiological conditions...