G Yosipovitch

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi How to treat that nasty itch
    Gil Yosipovitch
    Department of Dermatology, Wake Forest University School and Medicine, Winston Salem, NC 271S7, USA
    Exp Dermatol 14:478-9. 2005
  2. doi Topical capsaicin. The fire of a 'hot' medicine is reignited
    Alexandru D P Papoiu
    Department of Dermatology, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Expert Opin Pharmacother 11:1359-71. 2010
  3. doi A comparative study of clinical characteristics, work-up, treatment, and association to malignancy in dermatomyositis between two tertiary skin centers in the USA and Singapore
    Gil Yosipovitch
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, NC 27157 0001, USA
    Int J Dermatol 52:813-9. 2013
  4. ncbi Transient receptor potential channels and dermatological disorders
    Rodrigo Valdés-Rodríguez
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1071, USA
    Curr Top Med Chem 13:335-43. 2013
  5. ncbi Do ethnicity and gender have an impact on pain thresholds in minor dermatologic procedures? A study on thermal pain perception thresholds in Asian ethinic groups
    Gil Yosipovitch
    Department of Dermatology and Neuroscience, Wake Forest University Health Sciences Center, Winston Salem, NC 27157, USA
    Skin Res Technol 10:38-42. 2004
  6. doi The brain processing of scratching
    Gil Yosipovitch
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Invest Dermatol 128:1806-11. 2008
  7. ncbi Study of psychological stress, sebum production and acne vulgaris in adolescents
    Gil Yosipovitch
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Acta Derm Venereol 87:135-9. 2007
  8. ncbi Circadian and ultradian (12 h) variations of skin blood flow and barrier function in non-irritated and irritated skin-effect of topical corticosteroids
    Gil Yosipovitch
    Department of Dermatology Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    J Invest Dermatol 122:824-9. 2004
  9. doi Report from the 4th International Workshop for the Study of Itch
    Gil Yosipovitch
    Department of Dermatology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    J Invest Dermatol 128:256-7. 2008
  10. ncbi Scratching and noxious heat stimuli inhibit itch in humans: a psychophysical study
    G Yosipovitch
    Department of Dermatology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 25157, USA
    Br J Dermatol 156:629-34. 2007

Collaborators

Detail Information

Publications82

  1. ncbi How to treat that nasty itch
    Gil Yosipovitch
    Department of Dermatology, Wake Forest University School and Medicine, Winston Salem, NC 271S7, USA
    Exp Dermatol 14:478-9. 2005
  2. doi Topical capsaicin. The fire of a 'hot' medicine is reignited
    Alexandru D P Papoiu
    Department of Dermatology, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Expert Opin Pharmacother 11:1359-71. 2010
    ..Substantial efforts in drug discovery are at present directed at vanilloid receptors for finding new remedies for pain and itch...
  3. doi A comparative study of clinical characteristics, work-up, treatment, and association to malignancy in dermatomyositis between two tertiary skin centers in the USA and Singapore
    Gil Yosipovitch
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, NC 27157 0001, USA
    Int J Dermatol 52:813-9. 2013
    ..To date, no study has compared the clinical characteristics, malignancy associations, and treatment of dermatomyositis in predominantly Caucasian vs. Asian populations...
  4. ncbi Transient receptor potential channels and dermatological disorders
    Rodrigo Valdés-Rodríguez
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1071, USA
    Curr Top Med Chem 13:335-43. 2013
    ..Moreover, mutations in TRPs have recently been related to rare skin conditions such as Olmsted syndrome. This review will cover the role of TRPs in dermatologic conditions with special emphasis on itch and skin inflammatory diseases...
  5. ncbi Do ethnicity and gender have an impact on pain thresholds in minor dermatologic procedures? A study on thermal pain perception thresholds in Asian ethinic groups
    Gil Yosipovitch
    Department of Dermatology and Neuroscience, Wake Forest University Health Sciences Center, Winston Salem, NC 27157, USA
    Skin Res Technol 10:38-42. 2004
    ..Little is known about how these differences affect the perception of experimental pain. The purpose of this study was to determine experimental pain perception differences in three distinct East Asian ethnic populations...
  6. doi The brain processing of scratching
    Gil Yosipovitch
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Invest Dermatol 128:1806-11. 2008
    ..Future studies that investigate the central effects of scratching in chronic itch conditions will be of high clinical relevance...
  7. ncbi Study of psychological stress, sebum production and acne vulgaris in adolescents
    Gil Yosipovitch
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Acta Derm Venereol 87:135-9. 2007
    ..The study suggests a significant association between stress and severity of acne papulopustulosa, especially in males. Increased acne severity associated with stress may result from factors other than sebum quantity...
  8. ncbi Circadian and ultradian (12 h) variations of skin blood flow and barrier function in non-irritated and irritated skin-effect of topical corticosteroids
    Gil Yosipovitch
    Department of Dermatology Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    J Invest Dermatol 122:824-9. 2004
    ..Circadian and ultradian rhythms are maintained during treatment with high-potency and mid-potency CS in healthy skin. These rhythms persist during stratum corneum disruption with and without CS application...
  9. doi Report from the 4th International Workshop for the Study of Itch
    Gil Yosipovitch
    Department of Dermatology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    J Invest Dermatol 128:256-7. 2008
  10. ncbi Scratching and noxious heat stimuli inhibit itch in humans: a psychophysical study
    G Yosipovitch
    Department of Dermatology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 25157, USA
    Br J Dermatol 156:629-34. 2007
    ..Patients who suffer from chronic itch employ creative techniques to alleviate their itch, often using painful thermal stimuli, such as hot and very cold showers, as well as mechanical stimuli, such as scratching...
  11. ncbi The pruritus receptor unit: a target for novel therapies
    Gil Yosipovitch
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Invest Dermatol 127:1857-9. 2007
    ..Identification of new itch mediators and their respective receptors within the skin will undoubtedly be the focus of future drug development for this distressing symptom...
  12. ncbi Obesity and the skin: skin physiology and skin manifestations of obesity
    Gil Yosipovitch
    Departments of Dermatology, Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Am Acad Dermatol 56:901-16; quiz 917-20. 2007
    ..We review the clinical features, evidence for association with obesity, and management of these various dermatoses and highlight the profound impact of obesity in clinical dermatology...
  13. ncbi Skin barrier structure and function and their relationship to pruritus in end-stage renal disease
    Gil Yosipovitch
    Department of Dermatology, Wake Forest University Medical Center, Medical Center Boulevard, Winston Salem, North Carolina, 27157, USA
    Nephrol Dial Transplant 22:3268-72. 2007
    ..The purpose of the present study was to assess the function and structure of the skin barrier in patients with ESRD and to correlate any abnormalities with uraemic pruritus...
  14. ncbi Chronic itch and chronic pain: Analogous mechanisms
    Gil Yosipovitch
    Department of Dermatology, Neurobiology and Anatomy, and Regenerative Medicine, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Pain 131:4-7. 2007
  15. doi Neuropathic and psychogenic itch
    Gil Yosipovitch
    Department of Dermatology, Wake Forest University Health Sciences, Winston Salem, NC, USA
    Dermatol Ther 21:32-41. 2008
    ..Although no controlled studies have been conducted for treatment of neuropathic and psychogenic itch, medications that are part of the treatment armentarium for neuropathic pain, depression, and anxiety seem to be effective...
  16. ncbi Noxious heat and scratching decrease histamine-induced itch and skin blood flow
    Gil Yosipovitch
    Department of Dermatology, Wake Forest University Medical Center, Winston Salem, North Carolina 27157, USA
    J Invest Dermatol 125:1268-72. 2005
    ..Sub-noxious warming the skin did not affect the skin blood flow or itch intensity. These findings suggest that heat pain and scratching may inhibit itch through a neurogenic mechanism that also affects skin blood flow...
  17. ncbi Itch
    Gil Yosipovitch
    Department of Dermatology, Wake Forest University, Winston Salem, North Carolina 27517, USA
    Lancet 361:690-4. 2003
    ..We describe the clinical classification of itch, new findings on neuropathophysiology of itch, methods for assessment, and improved treatments...
  18. pmc Chronic pruritus: a paraneoplastic sign
    Gil Yosipovitch
    Department of Dermatology, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Dermatol Ther 23:590-6. 2010
    ..Combinative therapies reducing itch sensitization and transmission using selective serotonin and neuroepinephrine reuptake inhibitors, Kappa opioids, and neuroleptics are of prime importance in reducing this bothersome symptom...
  19. ncbi Topical capsaicin for the treatment of acute lipodermatosclerosis and lobular panniculitis
    G Yosipovitch
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1071, USA
    J Dermatolog Treat 16:178-80. 2005
    ..075% capsaicin cream...
  20. ncbi Itch associated with skin disease: advances in pathophysiology and emerging therapies
    Gil Yosipovitch
    Department of Dermatology, Wake Forest University, Winston Salem, North Carolina, USA
    Am J Clin Dermatol 4:617-22. 2003
    ..With the new information it seems we will be able to better help our dermatologic patients who have itch, however we are not closer to identifying a single agent specifically targetable to this symptom...
  21. ncbi Meeting report of the 3rd International Workshop for the Study of Itch
    Gil Yosipovitch
    Department of Dermatology, Wake Forest University Health Sciences, Winston Salem, North Carolina, 27157, USA
    J Invest Dermatol 126:1928-30. 2006
  22. ncbi Thermosensory abnormalities and blood flow dysfunction in psoriatic skin
    G Yosipovitch
    Department of Dermatology, Wake Forest University Health Sciences, Winston Salem, NC 21757, USA
    Br J Dermatol 149:492-7. 2003
    ..Although ample evidence of structural and biochemical data exist no studies have been done on assessing the function of small nerve fibres in this disease...
  23. ncbi What causes itch in atopic dermatitis?
    Gil Yosipovitch
    Departments of Dermatology and Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Curr Allergy Asthma Rep 8:306-11. 2008
    ..This review covers the peripheral and central mechanisms and mediators involved in pathogenesis of itch in atopic dermatitis...
  24. doi Ethnic differences in pain, itch and thermal detection in response to topical capsaicin: African Americans display a notably limited hyperalgesia and neurogenic inflammation
    H Wang
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Br J Dermatol 162:1023-9. 2010
    ..Topical application of capsaicin commonly produces burning, stinging and itching as well as hyperalgesia to heat stimuli via activation of transient receptor potential vanilloid subtype 1...
  25. doi Aberrant C nerve fibre function of the healthy scalp
    G A Bin Saif
    Department of Dermatology, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Br J Dermatol 167:485-9. 2012
    ..Previous studies have shown the scalp is highly innervated compared with other body areas. However, limited data are available on sensory testing associated with C nerve fibres of the healthy scalp...
  26. pmc Distinct patterns of brain activity evoked by histamine-induced itch reveal an association with itch intensity and disease severity in atopic dermatitis
    Y Ishiuji
    Department of Dermatology, Wake Forest Univeristy School of Medicine, Winston Salem, NC 27157, USA
    Br J Dermatol 161:1072-80. 2009
    ..Little is known about brain mechanisms supporting the experience of chronic puritus in disease states...
  27. pmc Contagious itch in humans: a study of visual 'transmission' of itch in atopic dermatitis and healthy subjects
    A D P Papoiu
    Department of Dermatology Neurobiology and Anatomy Regenerative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Br J Dermatol 164:1299-303. 2011
    ..Anecdotal evidence suggests that 'contagious' itch occurs in daily life when we see other people itch and scratch. This phenomenon has not previously been studied systematically, and factors which can amplify itch perception were unknown...
  28. doi Itch characteristics in atopic dermatitis: results of a web-based questionnaire
    A Dawn
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Br J Dermatol 160:642-4. 2009
    ..Itch significantly impairs the quality of life of patients with atopic dermatitis. However, only a few previous studies have examined the specific characteristics of itch in atopic dermatitis...
  29. ncbi Repetitive scratching and noxious heat do not inhibit histamine-induced itch in atopic dermatitis
    Y Ishiuji
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Br J Dermatol 158:78-83. 2008
    ..However, no psychophysical studies have been performed in AD to assess the effects of repetitive heat pain stimuli and scratching on histamine-induced itch...
  30. ncbi Treating itch in psoriasis
    Aerlyn Dawn
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Dermatol Nurs 18:227-33. 2006
    ..Using these therapies can benefit psoriasis patients in the outpatient clinical setting...
  31. ncbi Pharmacologic advances in the systemic treatment of itch
    Brett T Summey
    Department of Dermatology and Neuroscience Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1071, USA
    Dermatol Ther 18:328-32. 2005
    ..In addition, research focused on the neuromediators of itch transmission has led to the development of novel targets for itch reduction and great potential for future therapies...
  32. pmc Central centrifugal cicatricial alopecia severity is associated with cowhage-induced itch
    G A Bin Saif
    Department of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia
    Br J Dermatol 168:253-6. 2013
    ..Patients with central centrifugal cicatricial alopecia (CCCA) often suffer from varying degrees of itch, pain and burning sensations. However, the neural component of these skin sensations has not been assessed...
  33. ncbi Nocturnal itch: why do we itch at night?
    Tejesh Patel
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Acta Derm Venereol 87:295-8. 2007
    ..This review describes the scale of the problem associated with nocturnal pruritus, the impact it has on patients, possible underlying mechanisms and, lastly, treatment options...
  34. ncbi Enhanced skin blood flow and sensitivity to noxious heat stimuli in papulopustular rosacea
    Daniela A Guzman-Sanchez
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Am Acad Dermatol 57:800-5. 2007
    ..Furthermore, cutaneous blood flow in these patients has not been assessed using state-of-the-art laser Doppler imaging (LDI)...
  35. doi Generalized granuloma annulare as an initial manifestation of chronic myelomonocytic leukemia: a report of 2 cases
    Michael R Hinckley
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1071, USA
    Am J Dermatopathol 30:274-7. 2008
    ..We suggest that chronic myelomonocytic leukemia should be added to the list of systemic diseases associated with generalized granuloma annulare...
  36. pmc The pleasurability of scratching an itch: a psychophysical and topographical assessment
    G A Bin Saif
    Department of Dermatology Neurobiology and Anatomy, and Regenerative Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Br J Dermatol 166:981-5. 2012
    ..However, an analysis of topographical variations in itch intensity, the effectiveness of scratching to provide itch relief and the associated pleasurability has not been performed at different body sites...
  37. pmc Targeted treatment of pruritus: a look into the future
    H L Tey
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1071, USA
    Br J Dermatol 165:5-17. 2011
    ..Clinically, management of pruritus should be instituted early and should address the skin pathology, peripheral neuropathy, central sensitization, and the cognito-affective aspects of the disease...
  38. ncbi Uremic pruritus is associated with higher kt/V and serum calcium concentration
    M I Duque
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Clin Nephrol 66:184-91. 2006
    ..The prevalence and characteristics of uremic pruritus have not recently been investigated in a US dialysis cohort. This study examined uremic pruritus and associated risk factors in hemodialysis patients treated in the year 2005...
  39. ncbi Practical management of psoriasis in the elderly: epidemiology, clinical aspects, quality of life, patient education and treatment options
    Gil Yosipovitch
    Department of Dermatology, Wake Forest Medical Center, Winston Salem, North Carolina 27157, USA
    Drugs Aging 19:847-63. 2002
    ..The ambulatory psoriasis treatment centre is an integral part of the overall cost-effective management of patients with psoriasis that can function as a 'one-stop' treatment and resource centre for the elderly patient...
  40. ncbi Practical guidelines for relief of itch
    Gil Yosipovitch
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Dermatol Nurs 16:325-8; quiz 329. 2004
    ..Using these in conjunction with practical measuresf or itch reduction can benefit patients in the outpatient clinical setting...
  41. ncbi Itching in the new millennium: highlights of the Second International Workshop for the Study of Itch, Toyoma, Japan
    Gil Yosipovitch
    Department of Dermatology and Neuroscience Center, Wake Forest Medical Center, Winston Salem, North Carolina 27157, USA
    J Am Acad Dermatol 51:625-7. 2004
  42. ncbi Over-the-counter topical antipruritic agents are commonly recommended by office-based physicians: an analysis of US practice patterns
    M I Duque
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Dermatolog Treat 15:185-8. 2004
    ..However, there are few scientific controlled studies evaluating the effect of these drugs on pruritus...
  43. ncbi Itch, pain, and burning sensation are common symptoms in mild to moderate chronic venous insufficiency with an impact on quality of life
    Maria I Duque
    Department of Dermatology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    J Am Acad Dermatol 53:504-8. 2005
    ..This study found that itch, pain, and burning sensation are common symptoms of mild to moderate chronic venous insufficiency with a significant impact on quality of life...
  44. ncbi Menthol: a refreshing look at this ancient compound
    Tejesh Patel
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Acad Dermatol 57:873-8. 2007
    ..The purpose of this review is to highlight the recent advances in the mechanism of action of menthol and to provide an overview of its dermatologic applications...
  45. ncbi Transglutaminases: the missing link in nephrogenic systemic fibrosis
    Amy C Parsons
    Department of Pathology, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157 1045, USA
    Am J Dermatopathol 29:433-6. 2007
    ..We recommend further research into the use of transglutaminase inhibitors in the treatment and prevention of NSF...
  46. doi A pramoxine-based anti-itch lotion is more effective than a control lotion for the treatment of uremic pruritus in adult hemodialysis patients
    Trudye A Young
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Dermatolog Treat 20:76-81. 2009
    ..The objective of this study was to evaluate the efficacy of a commercially available anti-itch lotion containing 1% pramoxine hydrochloride versus control lotion in the treatment of uremic pruritus in adult hemodialysis patients...
  47. doi Effect of itch, scratching and mental stress on autonomic nervous system function in atopic dermatitis
    Bryant W Tran
    Department of Dermatology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Acta Derm Venereol 90:354-61. 2010
    ..Atopic subjects exhibited an overactive sympathetic response to itch and scratching, while the parasympathetic tone was persistently and rigidly elevated, showing a lack of adaptability in response to stress...
  48. doi Lower extremity lymphedema update: pathophysiology, diagnosis, and treatment guidelines
    Katherine Kerchner
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Am Acad Dermatol 59:324-31. 2008
    ..This is accomplished through elevation, exercises, compression garments/devices, manual lymph drainage, and treatment is combined with good skin care practices...
  49. ncbi Cutaneous blood flow in dermatomyositis and its association with disease severity
    Aerlyn Dawn
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Skin Res Technol 13:285-92. 2007
    ..Several studies using nailfold capillary microscopes have demonstrated capillary changes in patients with dermatomyositis (DM); however, no previous study has examined cutaneous blood flow in this disease...
  50. doi In vitro and in vivo characterization of a novel liposomal butorphanol formulation for treatment of pruritus
    Grace J Lim
    1Institute for Regenerative Medicine, 2Departments of Dermatology, Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, USA
    Acta Derm Venereol 88:327-30. 2008
    ..This liposomal transdermal delivery formulation could serve as a method to deliver butorphanol for patients with chronic pruritus...
  51. ncbi Butorphanol for treatment of intractable pruritus
    Aerlyn G Dawn
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Am Acad Dermatol 54:527-31. 2006
    ..Because of the small, open-label nature of this study, butorphanol should be investigated further in a larger, randomized controlled trial...
  52. ncbi Cutaneous symptoms of dermatomyositis significantly impact patients' quality of life
    Jennifer L Hundley
    Center for Dermatology Research, Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Acad Dermatol 54:217-20. 2006
    ..Dermatomyositis affects visible skin and causes disease symptoms that can affect patients' quality of life (QOL)...
  53. ncbi It's a wrap: the use of wet pajamas in wet-wrap dressings for atopic dermatitis
    Kelly L Barham
    Wake Forest University School of Medicine, Winston Salem, NC, USA
    Dermatol Nurs 17:365-7. 2005
  54. ncbi Assessment of itch: more to be learned and improvements to be made
    Gil Yosipovitch
    Department of Dermatology and Neuroscience Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Invest Dermatol 121:xiv-xv. 2003
  55. ncbi Lack of efficacy of tacrolimus ointment 0.1% for treatment of hemodialysis-related pruritus: a randomized, double-blind, vehicle-controlled study
    Maria I Duque
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Am Acad Dermatol 52:519-21. 2005
    ..1% for the treatment of hemodialysis-related pruritus. The results of this study do not demonstrate that tacrolimus ointment 0.1% is more effective than vehicle in relieving uremic pruritus...
  56. ncbi An update on pruritus associated with CKD
    Tejesh S Patel
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Kidney Dis 50:11-20. 2007
    ..The purpose of this review is to highlight the importance of this neglected topic by providing an overview of recent epidemiological studies, outcomes data, proposed pathophysiological mechanisms, and emerging treatment options...
  57. ncbi Pruritus in adult dermatomyositis
    Z Shirani
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Clin Exp Dermatol 29:273-6. 2004
    ..Clinicians must be aware of the significant pruritus and provide adequate therapy to improve quality of life...
  58. doi Epidermolysis bullosa pruriginosa masquerading as psychogenic pruritus
    Hong Liang Tey
    Department of Dermatology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1071, USA
    Arch Dermatol 147:956-60. 2011
    ..Epidermolysis bullosa pruriginosa is a rare clinical subtype of dystrophic epidermolysis bullosa characterized by intense pruritus, secondary scratching-induced lesions, and pronounced scarring...
  59. ncbi Granular parakeratosis: a case report and literature review
    Christopher A Wallace
    Department of Dermatology, Wake Forest University Baptist Medical Center, Winston Salem, NC, USA
    J Cutan Pathol 30:332-5. 2003
    ..Characteristic histopathologic features include a thickened stratum corneum, compact parakeratosis with retention of keratohyalin granules, vascular proliferation, and ectasia. The pathogenesis of this entity is uncertain...
  60. ncbi Hemorrhagic bullae after cryosurgery in a patient with hemophilia A
    John G Hancox
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Dermatol Surg 29:1084-6. 2003
    ..A case of hemorrhagic bullae and blisters on the hand of a patient with hemophilia A after cryosurgery for verruca vulgaris is reported...
  61. ncbi Nephrogenic fibrosing dermopathy after five days of hemodialysis
    John G Hancox
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Drugs Dermatol 2:550-3. 2003
  62. ncbi Mirtazapine for reducing nocturnal itch in patients with chronic pruritus: a pilot study
    Jennifer L Hundley
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Am Acad Dermatol 50:889-91. 2004
    ..Mirtazapine is a safe medication without serious side effects and may be an effective alternative for the treatment of nocturnal pruritus...
  63. ncbi Glucocorticoid-induced bone loss in dermatologic patients: an update
    Brett T Summey
    Department of Dermatology, Drexel University College of Medicine, Philadelphia, USA
    Arch Dermatol 142:82-90. 2006
    ..To raise awareness of the new treatment options and current recommendations among dermatologists treating patients with systemic corticosteroids...
  64. ncbi Exogenous factors in itch response
    Christopher B Yelverton
    Department of Dermatology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Curr Probl Dermatol 35:146-53. 2007
    ..These factors were classified into mechanical, chemical, and environmental components. A better understanding of the various mechanisms of pruritus is critical to effective research into the treatment of itch...
  65. ncbi Clinical classification of itch: a position paper of the International Forum for the Study of Itch
    Sonja Ständer
    Clinical Neurodermatology, Department of Dermatology, University of Munster, Von Esmarch Strasse 58, Munster, Germany
    Acta Derm Venereol 87:291-4. 2007
    ..It is intended to serve as a diagnostic route for better evaluation of patients with chronic pruritus and aims to improve patients' care...
  66. ncbi Are itch and chronic pain associated in adults? Results of a large population survey in Norway
    Florence Dalgard
    Department of Dermatology, Ullevål University Hospital and Institute of General Practice and Community Medicine, University of Oslo, Oslo, Norway
    Dermatology 214:305-9. 2007
    ..Itch and pain are common and complex symptoms which contribute to the burden of disease. Although there is antagonistic interaction between itch and pain, there are also many similarities in their pathophysiology...
  67. ncbi Itch characteristics in Chinese patients with atopic dermatitis using a new questionnaire for the assessment of pruritus
    Gil Yosipovitch
    National Skin Center, National Medical Research Council, Ministry of Health, 1 Mandalay Road, Singapore 308205
    Int J Dermatol 41:212-6. 2002
    ..Although pruritus is the predominant and commonest feature of atopic dermatitis, its clinical characteristics have not been explored...
  68. ncbi Barrier repair in chronic plaque-type psoriasis
    Anthony Teik Jin Goon
    National Skin Centre, Singapore, Singapore
    Skin Res Technol 10:10-3. 2004
    ..To investigate barrier repair after mild trauma in lesional skin of psoriasis patients with chronic plaque-type disease and to compare this with non-involved psoriatic skin and normal controls...
  69. ncbi Pruritus, pain, and small nerve fiber function in keloids: a controlled study
    Siong See Lee
    National Skin Center, Singapore
    J Am Acad Dermatol 51:1002-6. 2004
    ..Because itch and pain are carried by small nerve fibers, abnormal function of these fibers could be an explanation for such phenomena...
  70. ncbi HIV and leprosy in the Eastern United States
    Phoebe D Lu
    J Infect Dis 192:1673-4; author reply 1674-5. 2005
  71. ncbi The neurobiology of itch
    Akihiko Ikoma
    Department of Dermatology, Kyoto University, Shogin Kawahara cho 54, Sakyo ku, Kyoto 606 8507, Japan
    Nat Rev Neurosci 7:535-47. 2006
    ..The antagonistic interaction between pain and itch is already exploited in pruritus therapy, and current research concentrates on the identification of common targets for future analgesic and antipruritic therapy...
  72. ncbi Recurrent, pruritic dermal plaques and bullae. Diagnosis: eosinophilic cellulitis (Wells syndrome)
    W Harris Green
    East Tennessee State University, Johnson City, USA
    Arch Dermatol 143:791-6. 2007
  73. ncbi Palmar-plantar keratoderma of Unna Thost associated with atopic dermatitis: an underrecognized entity?
    Teck Hiong Loh
    National Skin Center, Singapore
    Pediatr Dermatol 20:195-8. 2003
    ..We believe that the association between the two disorders is not coincidental but an underrecognized entity that may shed light on the underlying pathogenesis of these two conditions...
  74. ncbi Acute Churg-Strauss syndrome in an asthmatic patient receiving montelukast therapy
    Mark B Y Tang
    National Skin Centre, Singapore
    Arch Dermatol 139:715-8. 2003
  75. ncbi A case of nonfatal cutaneous melioidosis
    T G Thng
    National Skin Centre, Singapore
    Cutis 72:310-2. 2003
    ..It is endemic in many parts of the world, including Southeast Asia, and has a mortality rate of about 45%. We report a case of localized nonfatal cutaneous melioidosis presenting as a persistent ulcer in an otherwise healthy young woman...
  76. ncbi Clinical characteristics of generalized idiopathic pruritus in patients from a tertiary referral center in Singapore
    Anthony T-J Goon
    National Skin Centre and National University of Singapore, Singapore
    Int J Dermatol 46:1023-6. 2007
    ..Generalized idiopathic pruritus is a rarely studied heterogeneous condition, where patients with non-inflamed, non-pathologic skin complain of widespread pruritus...
  77. ncbi Suggested guidelines for screening and management of tuberculosis in patients taking oral glucocorticoids--an important but often neglected issue
    Yuin Chew Chan
    National Skin Center, Singapore
    J Am Acad Dermatol 49:91-5. 2003
    ....
  78. ncbi Medical pearl: Scleroderma-like skin changes in patients with diabetes mellitus
    Gil Yosipovitch
    National Skin Center and Department of General Medicine, Tan Tock Seng Hospital, Singapore
    J Am Acad Dermatol 49:109-11. 2003
  79. ncbi Photo recall phenomenon: an adverse reaction to taxanes
    Hock Leong Ee
    National Skin Center, Singapore, Republic of Singapore
    Dermatology 207:196-8. 2003
    ..We report a case of photo recall phenomenon in a 55-year-old Chinese woman with metastatic breast cancer who was undergoing chemotherapy with taxanes...
  80. doi Itching in the psychiatric ward
    Doron Mazeh
    Abarbanel Mental Health Center, Bat Yam, Tel Aviv University Tel Aviv, Israel
    Acta Derm Venereol 88:128-31. 2008
    ..Thirty-six patients (32% of those screened) reported itching. Few sought help or used anti-pruritic therapy. Itching should be addressed during psychiatric assessments, in order to provide appropriate treatment...
  81. ncbi Prevalence and characterization of uremic pruritus in patients undergoing hemodialysis: uremic pruritus is still a major problem for patients with end-stage renal disease
    Inbar Zucker
    Department of Dermatology, Rabin Medical Center, Petach Tikva
    J Am Acad Dermatol 49:842-6. 2003
    ..Pruritus is a common disabling problem in patients with advanced end-stage renal disease. Few studies have evaluated the clinical characteristics of uremic itch...
  82. doi [4th International Workshop for the Study of Itch vom 9.-11.9.2007 in San Francisco]
    Uwe Gieler
    J Dtsch Dermatol Ges 6:252-4. 2008