JIANFENG contact XU

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk
    Jielin Sun
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Natl Cancer Inst 97:525-32. 2005
  2. ncbi request reprint Meta-analysis of association of rare mutations and common sequence variants in the MSR1 gene and prostate cancer risk
    Jielin Sun
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Prostate 66:728-37. 2006
  3. pmc Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families
    Joan E Bailey-Wilson
    Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA
    BMC Med Genet 13:46. 2012
  4. pmc MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1alpha/HIF-1beta
    Paul Cao
    Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Mol Cancer 9:108. 2010
  5. pmc Exploring pleiotropy using principal components
    Jeannette T Bensen
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    BMC Genet 4:S53. 2003
  6. ncbi request reprint Interaction effect of PTEN and CDKN1B chromosomal regions on prostate cancer linkage
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Hum Genet 115:255-62. 2004
  7. ncbi request reprint The interaction of four genes in the inflammation pathway significantly predicts prostate cancer risk
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Epidemiol Biomarkers Prev 14:2563-8. 2005
  8. ncbi request reprint Serum levels of phytanic acid are associated with prostate cancer risk
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Prostate 63:209-14. 2005
  9. ncbi request reprint Positive results in association studies are associated with departure from Hardy-Weinberg equilibrium: hint for genotyping error?
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hum Genet 111:573-4. 2002
  10. pmc Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Hum Genet 72:208-12. 2003

Detail Information

Publications82

  1. ncbi request reprint Sequence variants in Toll-like receptor gene cluster (TLR6-TLR1-TLR10) and prostate cancer risk
    Jielin Sun
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Natl Cancer Inst 97:525-32. 2005
    ..In this study, we investigated whether sequence variants in the TLR6-TLR1-TLR10 gene cluster, residing within a 54-kb region on 4p14, were associated with prostate cancer risk...
  2. ncbi request reprint Meta-analysis of association of rare mutations and common sequence variants in the MSR1 gene and prostate cancer risk
    Jielin Sun
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Prostate 66:728-37. 2006
    ..MSR1 has been reported to be associated with increased risk of prostate cancer (PCa)...
  3. pmc Analysis of Xq27-28 linkage in the international consortium for prostate cancer genetics (ICPCG) families
    Joan E Bailey-Wilson
    Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, MD 21224, USA
    BMC Med Genet 13:46. 2012
    ..Current evidence suggests that genetic linkage to prostate cancer has been found on several chromosomes including the X; however, identification of causative genes has been elusive...
  4. pmc MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1alpha/HIF-1beta
    Paul Cao
    Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Mol Cancer 9:108. 2010
    ..In addition, the expression of miR-101 alters upon androgen treatment and HIF-1alpha/HIF-1beta induction...
  5. pmc Exploring pleiotropy using principal components
    Jeannette T Bensen
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    BMC Genet 4:S53. 2003
    ....
  6. ncbi request reprint Interaction effect of PTEN and CDKN1B chromosomal regions on prostate cancer linkage
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Hum Genet 115:255-62. 2004
    ....
  7. ncbi request reprint The interaction of four genes in the inflammation pathway significantly predicts prostate cancer risk
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Epidemiol Biomarkers Prev 14:2563-8. 2005
    ....
  8. ncbi request reprint Serum levels of phytanic acid are associated with prostate cancer risk
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Prostate 63:209-14. 2005
    ..In this small case-control study, we assessed the association between phytanic acid levels and prostate cancer risk...
  9. ncbi request reprint Positive results in association studies are associated with departure from Hardy-Weinberg equilibrium: hint for genotyping error?
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hum Genet 111:573-4. 2002
  10. pmc Common sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Hum Genet 72:208-12. 2003
    ..These results consistently suggest that MSR1 may play an important role in prostate carcinogenesis...
  11. pmc Prostate cancer risk associated loci in African Americans
    Jianfeng Xu
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Cancer Epidemiol Biomarkers Prev 18:2145-9. 2009
    ..However, studies with larger numbers of AA subjects are needed, and this will likely require a major collaborative effort to combine multiple AA study populations...
  12. pmc A genome-wide survey over the ChIP-on-chip identified androgen receptor-binding genomic regions identifies a novel prostate cancer susceptibility locus at 12q13.13
    Junjie Feng
    Center for Cancer Genomics, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Cancer Epidemiol Biomarkers Prev 20:2396-403. 2011
    ..One recent finding that the PCa risk SNPs are enriched in genomic regions containing androgen receptor (AR)-binding sites has suggested altered AR signaling as a potentially important mechanism...
  13. pmc Major recessive gene(s) with considerable residual polygenic effect regulating adult height: confirmation of genomewide scan results for chromosomes 6, 9, and 12
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, 27157, USA
    Am J Hum Genet 71:646-50. 2002
    ..06, D6S2436), 9p1 (LOD = 2.09, D9S301), and 12q1 (LOD = 1.86, D12S375). Our results provide evidence that a combination of segregation and linkage approaches is valuable in understanding genetic determination of common complex traits...
  14. pmc Inherited genetic variant predisposes to aggressive but not indolent prostate cancer
    Jianfeng Xu
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 107:2136-40. 2010
    ....
  15. pmc Estimation of absolute risk for prostate cancer using genetic markers and family history
    Jianfeng Xu
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Prostate 69:1565-72. 2009
    ..Multiple DNA sequence variants in the form of single-nucleotide polymorphisms (SNPs) have been found to be reproducibly associated with prostate cancer (PCa) risk...
  16. pmc Association of prostate cancer risk variants with clinicopathologic characteristics of the disease
    Jianfeng Xu
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Clin Cancer Res 14:5819-24. 2008
    ..Fifteen independent genetic variants have been implicated in prostate cancer risk by recent genome-wide association studies. However, their association with clinicopathologic features of prostate cancer is uncertain...
  17. ncbi request reprint Association between two unlinked loci at 8q24 and prostate cancer risk among European Americans
    S Lilly Zheng
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Natl Cancer Inst 99:1525-33. 2007
    ..We examined whether multiple independent risk variants exist in this region and whether the strength of observed associations differs as a function of disease aggressiveness...
  18. pmc Individual and cumulative effect of prostate cancer risk-associated variants on clinicopathologic variables in 5,895 prostate cancer patients
    A Karim Kader
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Prostate 69:1195-205. 2009
    ..Their association with PCa aggressiveness and clinicopathologic variables is inconclusive...
  19. pmc Promoter polymorphisms in the nitric oxide synthase 3 gene are associated with ischemic stroke susceptibility in young black women
    Timothy D Howard
    The Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Stroke 36:1848-51. 2005
    ..Endothelial nitric oxide exerts a variety of protective effects on endothelial cells and blood vessels, and therefore the nitric oxide synthase 3 gene (NOS3) is a logical candidate gene for stroke susceptibility...
  20. ncbi request reprint Interactions of sequence variants in interleukin-1 receptor-associated kinase4 and the toll-like receptor 6-1-10 gene cluster increase prostate cancer risk
    Jielin Sun
    Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Epidemiol Biomarkers Prev 15:480-5. 2006
    ..Although this study was based on a priori hypothesis and was designed to address many common issues facing this type of study, our results need confirmation in even larger studies...
  21. pmc Association of 17 prostate cancer susceptibility loci with prostate cancer risk in Chinese men
    Siqun Lilly Zheng
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Prostate 70:425-32. 2010
    ..Several genome-wide association studies (GWAS) in populations of European descent have identified more than a dozen common genetic variants that are associated with prostate cancer risk...
  22. pmc A combined genomewide linkage scan of 1,233 families for prostate cancer-susceptibility genes conducted by the international consortium for prostate cancer genetics
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Hum Genet 77:219-29. 2005
    ....
  23. ncbi request reprint Association of a disintegrin and metalloprotease 33 (ADAM33) gene with asthma in ethnically diverse populations
    Timothy D Howard
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 112:717-22. 2003
    ..Recently, a gene potentially involved in airway remodeling, a disintegrin and metalloprotease 33 (ADAM33), was implicated in asthma susceptibility...
  24. pmc Association between sequence variants at 17q12 and 17q24.3 and prostate cancer risk in European and African Americans
    Jielin Sun
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Prostate 68:691-7. 2008
    ..Three SNPs at 17q12 and four SNPs at 17q24.3 were recently identified to be associated with prostate cancer risk using a genome-wide association study...
  25. pmc Assembly of inflammation-related genes for pathway-focused genetic analysis
    Matthew J Loza
    Center for Human Genomics, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 2:e1035. 2007
    ..For existing genome-wide association data, this list of key inflammation-related genes and associated subpathways can facilitate comprehensive inflammation pathway- focused association analyses...
  26. ncbi request reprint A polymorphism in the CDKN1B gene is associated with increased risk of hereditary prostate cancer
    Bao Li Chang
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Res 64:1997-9. 2004
    ..Together with the previous association study in a sporadic prostate cancer population, our new findings additionally suggest that germ-line variants of this gene play a role in prostate cancer susceptibility...
  27. pmc Association of a germ-line copy number variation at 2p24.3 and risk for aggressive prostate cancer
    Wennuan Liu
    Center for Cancer Genomics and Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Cancer Res 69:2176-9. 2009
    ..Additional confirmation of this association and functional studies are warranted...
  28. ncbi request reprint Estrogen-receptor polymorphisms and effects of estrogen replacement on high-density lipoprotein cholesterol in women with coronary disease
    David M Herrington
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    N Engl J Med 346:967-74. 2002
    ....
  29. ncbi request reprint Association studies of serum prostate-specific antigen levels and the genetic polymorphisms at the androgen receptor and prostate-specific antigen genes
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cancer Epidemiol Biomarkers Prev 11:664-9. 2002
    ..A systematic approach is required to identify sequence variants in these genes and other related genes, and to test for an association between these variants and PSA levels in large samples...
  30. ncbi request reprint Polymorphisms in the CYP1A1 gene are associated with prostate cancer risk
    Bao Li Chang
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 USA
    Int J Cancer 106:375-8. 2003
    ..These findings suggest that genetic polymorphisms in CYP1A1 may modify the risk for CaP...
  31. ncbi request reprint Germline mutations and sequence variants of the macrophage scavenger receptor 1 gene are associated with prostate cancer risk
    Jianfeng Xu
    Center for Human Genomics and the Department of Public Health, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Nat Genet 32:321-5. 2002
    ..009). Among African American men, these values were 12.5% and 1.8%, respectively (P = 0.01). These results show that MSR1 may be important in susceptibility to prostate cancer in men of both African American and European descent...
  32. pmc Gene-gene interaction in asthma: IL4RA and IL13 in a Dutch population with asthma
    Timothy D Howard
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Hum Genet 70:230-6. 2002
    ..0004). These data suggest that variations in IL4RA contribute to elevated total serum IgE levels, and interaction between IL4RA and IL13 markedly increases an individual's susceptibility to asthma...
  33. ncbi request reprint Racial differences in selected cytokine allelic and genotypic frequencies among healthy, pregnant women in North Carolina
    Mohamed I Hassan
    Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1081, USA
    Cytokine 21:10-6. 2003
    ..The value of SNPs for linkage and association mapping studies may depend on the distribution of SNP allele frequencies across populations...
  34. doi request reprint Cumulative association of five genetic variants with prostate cancer
    S Lilly Zheng
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    N Engl J Med 358:910-9. 2008
    ..3--have been associated with prostate cancer. Each SNP has only a moderate association, but when SNPs are combined, the association may be stronger...
  35. pmc A multigenic approach to evaluating prostate cancer risk in a systematic replication study
    Fang Chi Hsu
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Cancer Genet Cytogenet 183:94-8. 2008
    ..99, P = 0.0014). A significant trend relationship was observed (P < 0.0001). In the present study, additive effects but not multiplicative effects among these six polymorphisms with significant main effects were observed...
  36. pmc Family-based samples can play an important role in genetic association studies
    Ethan M Lange
    Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Cancer Epidemiol Biomarkers Prev 17:2208-14. 2008
    ....
  37. pmc Sequence variants at 22q13 are associated with prostate cancer risk
    Jielin Sun
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Cancer Res 69:10-5. 2009
    ..11 (95% CI, 1.04-1.19; P = 0.004). The risk-associated variants are located within the genomic region of TNRC6B, a gene involved in miRNA-mediated mRNA degradation. Additional studies are warranted to further confirm the association...
  38. pmc Genetic variants and family history predict prostate cancer similar to prostate-specific antigen
    S Lilly Zheng
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Clin Cancer Res 15:1105-11. 2009
    ..68. The goal of the present study is to assess the ability of genetic variants as a PSA-independent method to predict prostate cancer risk...
  39. ncbi request reprint Genome-wide scan for prostate cancer susceptibility genes in the Johns Hopkins hereditary prostate cancer families
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Prostate 57:320-5. 2003
    ..Genome-wide scans for linkage in prostate cancer families can be used to systematically search for genes capable of affecting risk for the disease...
  40. ncbi request reprint Sequence variants in the human 25-hydroxyvitamin D3 1-alpha-hydroxylase (CYP27B1) gene are not associated with prostate cancer risk
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Prostate 53:175-8. 2002
    ..25-hydroxyvitamin D(3) 1-alpha-hydroxylase, the enzyme that catalyzes the final step of vitamin D synthesis, converting 25-hydroxyvitamin D(3) to 1,25-dihydroxyvitamin D(3), is expressed in the prostate...
  41. pmc Fine-mapping and family-based association analyses of prostate cancer risk variants at Xp11
    Lingyi Lu
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Cancer Epidemiol Biomarkers Prev 18:2132-6. 2009
    ..05. Additional studies are warranted to test independent prostate cancer associations at these two regions...
  42. doi request reprint Chromosome 8q24 risk variants in hereditary and non-hereditary prostate cancer patients
    Jielin Sun
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Prostate 68:489-97. 2008
    ..The role that these variants may play in familial prostate cancer risk has not been extensively investigated...
  43. pmc Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer
    Wennuan Liu
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Neoplasia 10:897-907. 2008
    ..The genomic alterations revealed in this study provide an important catalog of positional information relevant to efforts aimed at deciphering the molecular genetic basis of prostate cancer...
  44. pmc Cumulative effect of five genetic variants on prostate cancer risk in multiple study populations
    Jielin Sun
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Prostate 68:1257-62. 2008
    ..We carried out this study to confirm the finding in two U.S. study populations and perform a combined analysis to obtain a more stable estimate of the odds ratio (OR) for prostate cancer...
  45. ncbi request reprint Germline sequence variants of the LZTS1 gene are associated with prostate cancer risk
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Cancer Genet Cytogenet 137:1-7. 2002
    ..Four of these SNP were statistically significant for association with prostate cancer (P < or = 0.04). These results add evidence supporting a role of LZTS1 in prostate cancer risk...
  46. ncbi request reprint Analysis of G/A polymorphism in the androgen response element I of the PSA gene and its interactions with the androgen receptor polymorphisms
    Anuradha Rao
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Urology 61:864-9. 2003
    ..Data are conflicting regarding the association of PSA promoter alleles with serum PSA in men...
  47. ncbi request reprint Two-locus genome-wide linkage scan for prostate cancer susceptibility genes with an interaction effect
    Bao Li Chang
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Hum Genet 118:716-24. 2006
    ....
  48. pmc Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12
    Jielin Sun
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Nat Genet 40:1153-5. 2008
    ..7 x 10(-9) for an allelic test of the seven studies combined. The association at each SNP remained significant after adjustment for the other SNP...
  49. ncbi request reprint Associations between hOGG1 sequence variants and prostate cancer susceptibility
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Cancer Res 62:2253-7. 2002
    ..These results suggest that sequence variants in this gene are associated with prostate cancer risk, presumably through defective DNA repair function of hOGG1...
  50. ncbi request reprint Association between genetic polymorphisms in the prostate-specific antigen gene promoter and serum prostate-specific antigen levels
    Scott D Cramer
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Natl Cancer Inst 95:1044-53. 2003
    ..However, polymorphisms associated with variations in PSA levels have not been identified...
  51. pmc The association between innate immunity gene (IRAK1) and C-reactive protein in the Diabetes Heart Study
    Susan G Lakoski
    Department of Internal Medicine Cardiology, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Exp Mol Pathol 82:280-3. 2007
    ..Evidence suggests that interleukin-1 receptor-associated kinase-1 (IRAK1), fundamental in the toll-like receptor pathway (TLR), may play a more specific role in atherosclerosis...
  52. ncbi request reprint Sequence variants of toll-like receptor 4 are associated with prostate cancer risk: results from the CAncer Prostate in Sweden Study
    S Lilly Zheng
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Cancer Res 64:2918-22. 2004
    ..9%. Although the biological mechanism of the observed association remains to be elucidated, our finding supports a role for a bacteria-associated response pathway, possibly acting via inflammation, in the development of prostate cancer...
  53. doi request reprint Association of prostate-specific antigen promoter genotype with clinical and histopathologic features of prostate cancer
    Scott D Cramer
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Cancer Epidemiol Biomarkers Prev 17:2451-7. 2008
    ..15-36.49], presence of any Gleason grade 4/5 cancer (OR, 4.26; 95% CI, 1.30-14.00), presence of any intraductal cancer (OR, 1.03; 95% CI, 1.00-1.04), and serum PSA at diagnosis (OR, 2.04; 95% CI, 1.50-2.77)...
  54. ncbi request reprint Common estrogen receptor polymorphism augments effects of hormone replacement therapy on E-selectin but not C-reactive protein
    David M Herrington
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1045, USA
    Circulation 105:1879-82. 2002
    ..This study sought to determine if this augmentation extends to HRT regulation of E-selectin and C-reactive protein (CRP) and to explore possible mechanisms by which this polymorphism might influence estrogen action...
  55. pmc A novel prostate cancer susceptibility locus at 19q13
    Fang Chi Hsu
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Cancer Res 69:2720-3. 2009
    ..A fine-mapping study in a 110-kb region at 19q13 among CAPS and JHH study populations revealed that rs887391 was the most strongly associated SNP in the region. Additional confirmation studies of this region are warranted...
  56. pmc Fine mapping association study and functional analysis implicate a SNP in MSMB at 10q11 as a causal variant for prostate cancer risk
    Bao Li Chang
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hum Mol Genet 18:1368-75. 2009
    ....
  57. ncbi request reprint Fine mapping of an IgE-controlling gene on chromosome 2q: Analysis of CTLA4 and CD28
    Timothy D Howard
    Center for Human Genomics, Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Allergy Clin Immunol 110:743-51. 2002
    ..Two candidate genes, CTLA4 and CD28, important homeostatic regulators of T-cell activation and subsequent IgE production, map within this candidate region...
  58. ncbi request reprint Joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk in Chinese women
    S Lilly Zheng
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Res 63:7624-9. 2003
    ..Our results are consistent with the hypothesis of a joint effect of estrogen receptor beta sequence variants and endogenous estrogen exposure on breast cancer risk...
  59. pmc Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation
    Seong Tae Kim
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Prostate 70:1729-38. 2010
    ..These SNPs may potentially be used for risk prediction. To date, there is not a stable estimate of their effect on PCa risk and their contribution to the genetic variation both of which are important for future risk prediction...
  60. ncbi request reprint DNA-repair genetic polymorphisms and breast cancer risk
    Tasha R Smith
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cancer Epidemiol Biomarkers Prev 12:1200-4. 2003
    ..We provide evidence that variants of XRCC1, XRCC3, and ERCC4/XPF genes, particularly in combination, contribute to breast cancer susceptibility...
  61. ncbi request reprint Mutational analysis of PINX1 in hereditary prostate cancer
    Gregory A Hawkins
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Prostate 60:298-302. 2004
    ..The PinX1 gene is located within chromosomal region 8p22-23, a region associated with LOH and potentially linked to increased prostate cancer risk...
  62. pmc Comparison of two methods for estimating absolute risk of prostate cancer based on single nucleotide polymorphisms and family history
    Fang Chi Hsu
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cancer Epidemiol Biomarkers Prev 19:1083-8. 2010
    ..These results suggest that method 2 is superior to method 1 in estimating absolute risk if the purpose of risk prediction is to identify high-risk individuals...
  63. ncbi request reprint Evaluation of SRD5A2 sequence variants in susceptibility to hereditary and sporadic prostate cancer
    Bao Li Chang
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Prostate 56:37-44. 2003
    ..However, the role of SRD5A2 sequence variants in the susceptibility to hereditary prostate cancer (HPC) has not been evaluated to date...
  64. pmc COPD is associated with a macrophage scavenger receptor-1 gene sequence variation
    Jill A Ohar
    Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Chest 137:1098-107. 2010
    ....
  65. ncbi request reprint Polymorphic GGC repeats in the androgen receptor gene are associated with hereditary and sporadic prostate cancer risk
    Bao Li Chang
    Center for Human Genomics, Wake Forest University School of Medicine, Winton Salem, NC 27157, USA
    Hum Genet 110:122-9. 2002
    ..Further studies on this polymorphism in other independent data sets and functional analysis of the GGC repeat length on AR activity are warranted...
  66. ncbi request reprint Analysis of the macrophage scavenger receptor 1 gene in Swedish hereditary and sporadic prostate cancer
    Fredrik Lindmark
    Department of Radiation Sciences, Oncology, University of Umea, Umea, Sweden
    Prostate 59:132-40. 2004
    ..Here, we further elucidate the role of MSR1 in both Swedish families with HPC and in a cohort of unselected prostate cancer...
  67. ncbi request reprint H6D polymorphism in macrophage-inhibitory cytokine-1 gene associated with prostate cancer
    Fredrik Lindmark
    Department of Radiation Sciences Oncology, Umea University, Umea, Sweden
    J Natl Cancer Inst 96:1248-54. 2004
    ..We examined whether sequence variants in the MIC-1 gene are associated with the risk of prostate cancer...
  68. pmc Identification of a prostate cancer susceptibility locus on chromosome 7q11-21 in Jewish families
    Danielle M Friedrichsen
    Divisions of Clinical Research and Human Biology and Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Proc Natl Acad Sci U S A 101:1939-44. 2004
    ..12 (P = 0.00007). These studies highlight the utility of analyzing defined sets of families with a common origin for reducing locus heterogeneity problems associated with studying complex traits...
  69. ncbi request reprint Combined genome-wide scan for prostate cancer susceptibility genes
    Elizabeth M Gillanders
    National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA
    J Natl Cancer Inst 96:1240-7. 2004
    ....
  70. ncbi request reprint Fine-mapping the putative chromosome 17q21-22 prostate cancer susceptibility gene to a 10 cM region based on linkage analysis
    Ethan M Lange
    Department of Genetics, University of North Carolina, Chapel Hill, NC, USA
    Hum Genet 121:49-55. 2007
    ..This large set of pedigrees with four more prostate cancer cases characterized by early-onset disease will serve as a useful resource for identifying the putative 17q21-22 prostate cancer susceptibility gene...
  71. ncbi request reprint Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24
    Julius Gudmundsson
    deCODE Genetics, Sturlugata 8, 101 Reykjavik, Iceland
    Nat Genet 39:631-7. 2007
    ..The newly identified variant shows a stronger association with affected individuals who have an earlier age at diagnosis...
  72. ncbi request reprint MSR1 variants and the risks of prostate cancer and benign prostatic hyperplasia: a population-based study in China
    Ann W Hsing
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    Carcinogenesis 28:2530-6. 2007
    ..The role of MSR1 warrants further investigation in larger studies and other populations...
  73. ncbi request reprint Two genome-wide association studies of aggressive prostate cancer implicate putative prostate tumor suppressor gene DAB2IP
    David Duggan
    Division of Genetic Basis of Human Disease, Translational Genomics Research Institute, Phoenix, AZ, USA
    J Natl Cancer Inst 99:1836-44. 2007
    ..The consistent finding of a genetic susceptibility to prostate cancer suggests that there are germline sequence variants predisposing individuals to this disease. These variants could be useful in screening and treatment...
  74. ncbi request reprint Comprehensive genetic evaluation of common E-cadherin sequence variants and prostate cancer risk: strong confirmation of functional promoter SNP
    Sara Lindstrom
    Department of Radiation Sciences, Oncology, University of Umea, 901 87, Umea, Sweden
    Hum Genet 118:339-47. 2005
    ..Due to the difficulties in replication of genetic association studies, this finding is unusual and novel...
  75. pmc Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer
    Julius Gudmundsson
    deCODE Genetics, 101 Reykjavik, Iceland
    Nat Genet 40:281-3. 2008
    ..23 and 1.15; P = 3.9 x 10(-13) and 7.7 x 10(-9), respectively). The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease...
  76. doi request reprint Polymorphisms in angiogenesis-related genes and prostate cancer
    Eric J Jacobs
    Epidemiology and Surveillance Research, American Cancer Society, National Home Office, Atlanta, GA 30303 1002, USA
    Cancer Epidemiol Biomarkers Prev 17:972-7. 2008
    ..Potentially functional single nucleotide polymorphisms (SNP) in genes important in prostate angiogenesis (VEGF, HIF1A, and NOS3) have previously been associated with risk or severity of prostate cancer...
  77. ncbi request reprint Germ-line mutations of the macrophage scavenger receptor 1 gene: association with prostate cancer risk in African-American men
    David C Miller
    Department of Urology, University of Michigan, Medical School, Ann Arbor, Michigan 48109 0946, USA
    Cancer Res 63:3486-9. 2003
    ..02). Taken together, our results provide some additional support for the hypothesis that selected, rare MSR1 mutations are associated with increased prostate cancer susceptibility among African-American men...
  78. ncbi request reprint A major locus for hereditary prostate cancer in Finland: localization by linkage disequilibrium of a haplotype in the HPCX region
    Agnes B Baffoe-Bonnie
    Division of Population Science, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA 19111, USA
    Hum Genet 117:307-16. 2005
    ..Fine mapping efforts included the genotyping of four additional markers D3S2390, bG82i1.9, bG82i1.1, bG82i1.0 and four single nucleotide polymorphisms (SNPs) to augment the original markers around DXS1205...
  79. ncbi request reprint A germline DNA polymorphism enhances alternative splicing of the KLF6 tumor suppressor gene and is associated with increased prostate cancer risk
    Goutham Narla
    Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    Cancer Res 65:1213-22. 2005
    ....
  80. ncbi request reprint Pooled genome linkage scan of aggressive prostate cancer: results from the International Consortium for Prostate Cancer Genetics
    Daniel J Schaid
    Harwick 7, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    Hum Genet 120:471-85. 2006
    ..This provides a basis for attempts to identify these genes, with potential clinical utility for men with aggressive prostate cancer and their relatives...
  81. ncbi request reprint CYP17 polymorphisms in relation to risks of prostate cancer and benign prostatic hyperplasia: a population-based study in China
    M Patricia Madigan
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20852 7234, USA
    Int J Cancer 107:271-5. 2003
    ..Large population-based studies are needed to clarify whether CYP17 plays a role in prostate cancer risk and whether genotype effects vary in different racial/ethnic and other subgroups...
  82. ncbi request reprint Transmission/disequilibrium tests of androgen receptor and glutathione S-transferase pi variants in prostate cancer families
    Gloria Y F Ho
    Department of Epidemiology and Social Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Int J Cancer 98:938-42. 2002
    ..Our findings do not support the hypothesis that familial clustering of prostate cancer in high-risk families is attributable to these genetic variants...

Research Grants22

  1. Mapping Prostate Cancer Susceptibility Genes at 8p22-23
    Jianfeng Xu; Fiscal Year: 2007
    ..Successful identification of prostate cancer genes will have a significant impact on understanding the etiology, prevention, diagnosis, and treatment of prostate cancer. ..
  2. Confirmation of SNPs Associated with Aggressive PCa in a GWA Study
    Jianfeng Xu; Fiscal Year: 2009
    ..The focus on aggressive PCa is particularly important because this is the most clinically relevant form of PCa. ..
  3. QTL mapping for genes regulating apoptosis capacity
    Jianfeng Xu; Fiscal Year: 2009
    ..Our proposal describes a novel and efficient approach to identify apoptosis genes that are critical in cancer susceptibility. ..
  4. Confirmation of SNPs Associated with Aggressive PCa in a GWA Study
    Jianfeng Xu; Fiscal Year: 2010
    ..The identification of PCa risk variants may impact the understanding, prevention, diagnosis, and treatment of this disease. ..
  5. Genetic profiling in PCPT: prostate cancer risk, PSA levels, and chemoprevention
    JIANFENG contact XU; Fiscal Year: 2010
    ..Prostate cancer risk associated variants could also be used in combination with PSA and other existing clinical variables to considerably improve their predictive accuracy for positive prostate biopsy. 1 ..
  6. Interaction of PTEN and CDKN1B in Pca susceptibility
    Jianfeng Xu; Fiscal Year: 2007
    ..The results from this study are likely to significant advance our knowledge of prostate cancer risk and begin to explore the underlying biological mechanisms for any observed differences. ..
  7. Association of inflammatory genes and prostate cancer
    Jianfeng Xu; Fiscal Year: 2007
    ..Answers to these questions will significantly improve our knowledge of the role of inflammation in prostate cancer and will guide our efforts in identifying additional prostate cancer genes. ..
  8. QTL mapping for genes regulating apoptosis capacity
    Jianfeng Xu; Fiscal Year: 2010
    ..Our proposal describes a novel and efficient approach to identify apoptosis genes that are critical in cancer susceptibility. ..