C E Wood

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. pmc Soy isoflavones, estrogen therapy, and breast cancer risk: analysis and commentary
    Mark J Messina
    Nutrition Matters, Inc, 439 Calhoun Street, Port Townsend, WA 98368, USA
    Nutr J 7:17. 2008
  2. ncbi Hyperplastic and neoplastic lesions of the mammary gland in macaques
    C E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Vet Pathol 43:471-83. 2006
  3. ncbi Breast and uterine effects of soy isoflavones and conjugated equine estrogens in postmenopausal female monkeys
    Charles E Wood
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    J Clin Endocrinol Metab 89:3462-8. 2004
  4. doi Transcriptional profiles of progestogen effects in the postmenopausal breast
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Breast Cancer Res Treat 114:233-42. 2009
  5. ncbi Soy isoflavonoid effects on endogenous estrogen metabolism in postmenopausal female monkeys
    Charles E Wood
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1040, USA
    Carcinogenesis 28:801-8. 2007
  6. ncbi Mammary gland development in early pubertal female macaques
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Toxicol Pathol 35:795-805. 2007
  7. ncbi Effects of soy on the mammary glands of premenopausal female monkeys
    Charles E Wood
    Section on Comparative Medicine, The Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Fertil Steril 85:1179-86. 2006
  8. ncbi Dietary soy isoflavones inhibit estrogen effects in the postmenopausal breast
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Res 66:1241-9. 2006
  9. ncbi Effects of soybean glyceollins and estradiol in postmenopausal female monkeys
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Nutr Cancer 56:74-81. 2006
  10. pmc Characterization and experimental transmission of an oncogenic papillomavirus in female macaques
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    J Virol 81:6339-45. 2007

Research Grants

Collaborators

Detail Information

Publications59

  1. pmc Soy isoflavones, estrogen therapy, and breast cancer risk: analysis and commentary
    Mark J Messina
    Nutrition Matters, Inc, 439 Calhoun Street, Port Townsend, WA 98368, USA
    Nutr J 7:17. 2008
    ....
  2. ncbi Hyperplastic and neoplastic lesions of the mammary gland in macaques
    C E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Vet Pathol 43:471-83. 2006
    ..These findings suggest that breast cancer is an underreported lesion in macaques and highlight unique morphologic and molecular similarities in breast cancer between human and macaque species...
  3. ncbi Breast and uterine effects of soy isoflavones and conjugated equine estrogens in postmenopausal female monkeys
    Charles E Wood
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    J Clin Endocrinol Metab 89:3462-8. 2004
    ..These findings suggest that high dietary levels of soy isoflavones do not stimulate breast or uterine proliferation in postmenopausal monkeys and may contribute to an estrogen profile associated with reduced breast cancer risk...
  4. doi Transcriptional profiles of progestogen effects in the postmenopausal breast
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Breast Cancer Res Treat 114:233-42. 2009
    ....
  5. ncbi Soy isoflavonoid effects on endogenous estrogen metabolism in postmenopausal female monkeys
    Charles E Wood
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1040, USA
    Carcinogenesis 28:801-8. 2007
    ..01 for all). These findings suggest that long-term exposure to soy isoflavonoids, equol in particular, may facilitate endogenous estrogen clearance and catabolism to more benign 2-hydroxylated metabolites...
  6. ncbi Mammary gland development in early pubertal female macaques
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Toxicol Pathol 35:795-805. 2007
    ..These findings identify dynamic morphologic changes occurring in the primate breast during early puberty and suggest that estradiol (rather than progesterone) is the predominant hormonal stimulus for early ductal and lobular development...
  7. ncbi Effects of soy on the mammary glands of premenopausal female monkeys
    Charles E Wood
    Section on Comparative Medicine, The Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Fertil Steril 85:1179-86. 2006
    ..To evaluate the interactive effects of dietary soy and menstrual cycle phase on breast proliferation, apoptosis, and sex steroid receptor expression in premenopausal female cynomolgus monkeys...
  8. ncbi Dietary soy isoflavones inhibit estrogen effects in the postmenopausal breast
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Res 66:1241-9. 2006
    ..These findings show that in the presence of estrogen higher doses of dietary soy isoflavones may alter ER signaling and induce selective antagonistic effects in the breast...
  9. ncbi Effects of soybean glyceollins and estradiol in postmenopausal female monkeys
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Nutr Cancer 56:74-81. 2006
    ..05 for both) but not in the GLY group. These preliminary findings suggest that soybean glyceollins are natural compounds with potential estrogen-modulating properties in the breast...
  10. pmc Characterization and experimental transmission of an oncogenic papillomavirus in female macaques
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    J Virol 81:6339-45. 2007
    ..These findings identify key similarities between macaque and human oncogenic PVs which should prove useful in the study of viral persistence, carcinogenesis, and therapeutic development...
  11. doi Comparative effects of oral conjugated equine estrogens and micronized 17beta-estradiol on breast proliferation: a retrospective analysis
    Charles E Wood
    Departments of 1Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 15:890-8. 2008
    ..To evaluate the effects of oral conjugated equine estrogens (CEE) and micronized 17beta-estradiol (E2) on breast proliferation in a postmenopausal primate model...
  12. ncbi Adrenocortical effects of oral estrogens and soy isoflavones in female monkeys
    Charles E Wood
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    J Clin Endocrinol Metab 89:2319-25. 2004
    ..These findings suggest that long-term estrogen treatment may contribute to an androgen-deficient and hypercortisolemic state...
  13. ncbi Cervical and vaginal epithelial neoplasms in cynomolgus monkeys
    C E Wood
    Comparative Medicine Clinical Research Center, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    Vet Pathol 41:108-15. 2004
    ..The unique similarities between the observed lesions and those seen in women suggest that macaques may provide a suitable animal model for study of papillomavirus oncogenesis...
  14. pmc Novel betapapillomavirus associated with hand and foot papillomas in a cynomolgus macaque
    C E Wood
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Vet Pathol 48:731-6. 2011
    ..These findings characterize a new nonhuman beta-PV and provide additional support for the idea that tissue tropism among ancestral primate PVs developed prior to divergence of certain Old World primate lineages...
  15. ncbi Effects of estradiol with micronized progesterone or medroxyprogesterone acetate on risk markers for breast cancer in postmenopausal monkeys
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Breast Cancer Res Treat 101:125-34. 2007
    ..These findings suggest that oral micronized progesterone has a more favorable effect on risk biomarkers for postmenopausal breast cancer than medroxyprogesterone acetate...
  16. pmc Mammary gland and endometrial effects of testosterone in combination with oral estradiol and progesterone
    Charles E Wood
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 16:466-76. 2009
    ..The goal of this pilot study was to evaluate the effects of testosterone (T) cotherapy on mammary gland and endometrial measures in a postmenopausal primate model...
  17. ncbi Effects of estradiol with oral or intravaginal progesterone on risk markers for breast cancer in a postmenopausal monkey model
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 14:639-47. 2007
    ..To evaluate the effects of oral estradiol given with either oral or intravaginal micronized progesterone (P4) on risk biomarkers for breast cancer in a postmenopausal monkey model...
  18. ncbi Effects of high-dose soy isoflavones and equol on reproductive tissues in female cynomolgus monkeys
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Biol Reprod 75:477-86. 2006
    ..1 for all). These findings indicate that high doses of dietary soy isoflavonoids have minimal uterotrophic or mammotrophic effects in an established primate model...
  19. pmc Estrogen effects on epithelial proliferation and benign proliferative lesions in the postmenopausal primate mammary gland
    Charles E Wood
    Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    Lab Invest 88:938-48. 2008
    ....
  20. pmc Effects of prior oral contraceptive use and soy isoflavonoids on estrogen-metabolizing cytochrome P450 enzymes
    L M Scott
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Steroid Biochem Mol Biol 112:179-85. 2008
    ..These results suggest potential mechanisms for prior OC and dietary IF effects on cancer risk in estrogen-responsive tissues...
  21. ncbi Cyclic changes in the mammary gland of cynomolgus macaques
    Petra Stute
    The Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Fertil Steril 82:1160-70. 2004
    ..To evaluate the influence of hormonal changes during the menstrual cycle on the mammary gland of female cynomolgus monkeys...
  22. pmc Endometrial profile of tamoxifen and low-dose estradiol combination therapy
    Charles E Wood
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Clin Cancer Res 16:946-56. 2010
    ..The goal of this study was to evaluate the endometrial profile of low-dose estradiol and the SERM tamoxifen alone and in combination...
  23. ncbi Hormonal effects on the mammary gland of postmenopausal nonhuman primates
    J Mark Cline
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Breast Dis 24:59-70. 2005
    ..Future studies of novel selective estrogens, androgens, and dietary estrogens in the macaque model will further contribute to our understanding of breast cancer risk and prevention...
  24. ncbi Hormone therapy effects on social behavior and activity levels of surgically postmenopausal cynomolgus monkeys
    Carol A Shively
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    Psychoneuroendocrinology 32:981-90. 2007
    ..Further research is needed to explore social context as an important feature of behavioral response to steroid hormone regimens and to verify and extend knowledge of systemic effects of vaginal ring-delivered progestogens...
  25. ncbi Lessons to be learned from animal studies on hormones and the breast
    Thomas B Clarkson
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1040, USA
    Maturitas 49:79-89. 2004
    ....
  26. pmc Past oral contraceptive use and current dietary soy isoflavones influence estrogen metabolism in postmenopausal monkeys (Macaca fascicularis)
    Latanya M Scott
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Epidemiol Biomarkers Prev 17:2594-602. 2008
    ..Premenopausal OCs may have long-term systemic effects on response to estrogen and its metabolism whereas postmenopausal dietary isoflavones may alter endogenous estrogen metabolism in a modest but selective manner...
  27. doi Estrogen/isoflavone interactions in cynomolgus macaques (Macaca fascicularis)
    J Mark Cline
    Wake Forest University Primate Center, Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Am J Primatol 71:722-31. 2009
    ..Because soy isoflavones are both abundant in standard monkey chow diets and widely available as dietary supplements for human beings, these findings have broad relevance to the health of human and nonhuman primates...
  28. pmc Effect of ovarian aging on androgen biosynthesis in a cynomolgus macaque model
    K F Ethun
    Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Climacteric 15:82-92. 2012
    ....
  29. ncbi Adrenalectomy alters regulation of blood pressure and endothelial nitric oxide synthase in sheep: modulation by estradiol
    Feng Li
    Department of Pharmacodynamics, University of Florida, Gainesville, FL 32610 0487, USA
    Am J Physiol Regul Integr Comp Physiol 293:R257-66. 2007
    ..However, the study reveals an important effect of corticosteroid withdrawal on blood pressure, consistent with corticosteroid modulation of baroreflex responsiveness...
  30. ncbi Antiestrogenic glyceollins suppress human breast and ovarian carcinoma tumorigenesis
    Virgilo A Salvo
    Section of Hematology and Medical Oncology, Department of Medicine, Tulane Cancer Center, New Orleans, LA 70112, USA
    Clin Cancer Res 12:7159-64. 2006
    ....
  31. pmc Blockade of estrogen receptors decreases CNS and pituitary prostaglandin synthase expression in fetal sheep
    Christine E Schaub
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL 32610 0274, USA
    Neuroendocrinology 87:121-8. 2008
    ..The present study was designed to test the hypothesis that blockade of estrogen receptors in the fetal brain decrease PGHS-2 expression and reduces fetal HPA axis activity...
  32. pmc Cerebral hypoperfusion increases estrogen receptor abundance in the ovine fetal brain and pituitary
    Charles E Wood
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Fla 32610 0274, USA
    Neuroendocrinology 87:216-22. 2008
    ....
  33. pmc Central nervous system prostaglandin endoperoxide synthase-1 and -2 responses to oestradiol and cerebral hypoperfusion in late-gestation fetal sheep
    Charles E Wood
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL 32610, USA
    J Physiol 549:573-81. 2003
    ..We speculate that at least a part of the effect of oestradiol on fetal HPA axis function is mediated by an interaction between oestradiol and prostaglandin biosynthesis in the fetal brain...
  34. ncbi Resuscitation of hemorrhagic shock attenuates intrapulmonary nitric oxide formation
    Chun Jen Huang
    Department of Anesthesiology at Mackay Memorial Hospital, Taipei, Taiwan, ROC
    Resuscitation 55:201-9. 2002
    ..We believe that exhaled NO concentrations provide a useful, non-invasive method of monitoring the intrapulmonary inflammatory sequelae of hemorrhagic shock...
  35. ncbi Dexamethasone suppresses iNOS yet induces GTPCH and CAT-2 mRNA expression in rat lungs
    Jeffrey W Skimming
    Department of Child Health, University of Missouri, Columbia, MO 65212, USA
    Am J Physiol Lung Cell Mol Physiol 285:L484-91. 2003
    ..Our results support the idea that dexamethasone inhibits nitric oxide formation in a manner that is independent of tetrahydrobiopterin and arginine transport yet dependent on downregulation of iNOS mRNA expression...
  36. ncbi Expression of nitric oxide synthase isoforms in the ovine fetal brain: alteration by hormonal and hemodynamic stimuli
    Charles E Wood
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Florida 32610 0274, USA
    J Soc Gynecol Investig 13:329-37. 2006
    ..We propose that, in the fetal brain, cerebral hypoperfusion alters the expression of NOS isoforms, and that estrogen administration modulates the NOS response to hypoperfusion...
  37. ncbi Increased maternal cortisol in late-gestation ewes decreases fetal cardiac expression of 11beta-HSD2 mRNA and the ratio of AT1 to AT2 receptor mRNA
    Seth A Reini
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610 0487, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1708-16. 2006
    ..These results indicate that cortisol could indeed act in the fetal heart to induce enlargement and suggest that the renin-angiotensin system may play a role...
  38. ncbi Chronic alterations in ovine maternal corticosteroid levels influence uterine blood flow and placental and fetal growth
    Ellen Jensen
    Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610 0487, USA
    Am J Physiol Regul Integr Comp Physiol 288:R54-61. 2005
    ..The results of this study demonstrate that maternal plasma cortisol during pregnancy is an important contributor to the maternal environment supporting optimal conditions for fetal homeostasis and somatic growth...
  39. ncbi Fetal brain regional responses to cerebral hypoperfusion: modulation by estrogen
    Charles E Wood
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, P O Box 100274, Gainesville, FL 32610 0274, USA
    Brain Res 993:84-9. 2003
    ..The measurement of regional Fos responses using Western blot reveals a negative interaction between estrogen and BCO which might result from alterations in cerebral blood flow or metabolism...
  40. ncbi Ontogeny of expression of organic anion transporters 1 and 3 in ovine fetal and neonatal kidney
    Charles E Wood
    Department of Physiology and Functional Genomics, P O Box 100274, University of Florida College of Medicine, Gainesville, FL 32610 0274, USA
    Exp Biol Med (Maywood) 230:668-73. 2005
    ....
  41. ncbi Cellular localization of thromboxane synthase in ovine spinal cord and hindbrain
    David Husted
    Department of Physiology and Functional Genomics, PO Box 100274, University of Florida College of Medicine, Gainesville, FL 32610 0274, USA
    Brain Res 971:107-15. 2003
    ..We conclude that, consistent with physiological evidence, thromboxane synthase is present in brain regions which are important for afferent and efferent cardiovascular signaling...
  42. ncbi High-dose angiotensin-converting enzyme inhibition restores body fluid homeostasis in heart-transplant recipients
    Randy W Braith
    Center for Exercise Science, College of Health and Human Performance, PO Box 118206, University of Florida, Gainesville, FL 32611, USA
    J Am Coll Cardiol 41:426-32. 2003
    ..We tested the hypothesis that salt and fluid retention in heart-transplant recipients (HTRs) is caused by a failure to reflexively suppress the renin-angiotensin-aldosterone system (RAAS)...
  43. ncbi Biological activity of 17beta-estradiol-3-sulfate in ovine fetal plasma and uptake in fetal brain
    Charles E Wood
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Florida 32610 0274, USA
    Endocrinology 144:599-604. 2003
    ..We propose that in late gestation the large circulating pool of sulfoconjugated estrogen is a biologically important source of active hormone that might play a role in the timing of parturition in sheep...
  44. ncbi Induction of immunoreactive prostaglandin H synthases 1 and 2 and fos in response to cerebral hypoperfusion in late-gestation fetal sheep
    Haiyan Tong
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Florida 32610, USA
    J Soc Gynecol Investig 9:342-50. 2002
    ....
  45. pmc Oestrogen augments the fetal ovine hypothalamus- pituitary-adrenal axis in response to hypotension
    Scott C Purinton
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville 32610, USA
    J Physiol 544:919-29. 2002
    ..We conclude that oestradiol augments the activity of the central baroreceptor and chemoreceptor reflex pathways, and that it may influence fetal ACTH secretion via this site of action...
  46. pmc The ovine fetal endocrine reflex responses to haemorrhage are not mediated by cardiac nerves
    Charles E Wood
    Department of Physiology, University of Florida College of Medicine, Gainesville, FL 32610 0274, USA
    J Physiol 541:613-22. 2002
    ....
  47. ncbi Genetic AT1A receptor deficiency attenuates cold-induced hypertension
    Zhongjie Sun
    Department of Medicine, College of Medicine, University of Florida, Gainesville, FL 32610 0274, USA
    Am J Physiol Regul Integr Comp Physiol 288:R433-9. 2005
    ....
  48. ncbi The association of low birth weight and physiological risk factors of hypertension in African American adolescents
    Maureen McCormick Covelli
    College of Nursing Orlando, University of Central Florida, FL, USA
    J Cardiovasc Nurs 22:440-7; quiz 448-9. 2007
    ..We examined the association of blood pressure and cortisol levels during induced physiologic stress with LBW in an African American adolescent population (n = 106)...
  49. ncbi Differential modulation of ovine fetal ACTH secretion by PGHS-1 and PGHS-2
    Sharon Reimsnider
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Fla 32610 0274, USA
    Neuroendocrinology 83:4-11. 2006
    ..The present study was performed to test the relative roles of prostaglandin endoperoxide synthases-1 and -2 (PGHS-1 and 2, or COX-1 and 2) as potential mediators of this interaction...
  50. ncbi Genomic analysis of neuroendocrine development of fetal brain-pituitary-adrenal axis in late gestation
    Maureen Keller-Wood
    Department of Pharmacodynamics, University of Florida, Gainesville, Florida, USA
    Physiol Genomics 24:218-24. 2006
    ..Decreases in expression of GR in pituitary at the end of gestation might contribute to the decreased corticosteroid negative feedback sensitivity at term in this species...
  51. pmc Ketamine inhibits fetal ACTH responses to cerebral hypoperfusion
    Melanie J Powers
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gaineseville, Florida, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1542-9. 2007
    ....
  52. ncbi Neuronal prostaglandin endoperoxide synthase 2 responses to oxygen and glucose deprivation are mediated by mitogen-activated protein kinase ERK1/2
    Daying Zhang
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, FL 32610 0264, USA
    Brain Res 1060:100-7. 2005
    ..These results indicate that PGHS-2 gene expression is induced by oxygen and glucose deprivation synergistically in neurons, and this induction is mediated by one or more members of the MAPK family...
  53. ncbi Expression of nitric oxide synthase isoforms is reduced in late-gestation ovine fetal brainstem
    Charles E Wood
    Dept of Physiology and Functional Genomics, University of Florida College of Medicine, P O Box 100274, Gainesville, FL 32610 0274, USA
    Am J Physiol Regul Integr Comp Physiol 289:R613-R619. 2005
    ..We speculate that the reduced expression of NOS in this brain region plays a role in the increased fetal baroreflex activity in late gestation...
  54. ncbi Does reduction of circulating prostaglandin E2 reduce fetal hypothalamic-pituitary-adrenal axis activity?
    Sharon K Reimsnider
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Florida 32610 0274, USA
    J Soc Gynecol Investig 12:e13-9. 2005
    ..We performed the present experiments to test the hypothesis that the elevated concentrations of PGE2 in fetal plasma do not tonically stimulate fetal ACTH secretion...
  55. ncbi Psychosocial and physiological stress among women leaving welfare
    Shawn M Kneipp
    University of Florida, USA
    West J Nurs Res 29:864-83; discussion 884-95. 2007
    ..Psychosocial stress was not associated with changes in physiologic indicators of stress...
  56. ncbi Mineralocorticoid receptor expression in late-gestation ovine fetal lung
    Maureen Keller-Wood
    Department of Pharmacodynamics, College of Pharmacy, and Department of Physiology and Functional Genomics, College of Medicine, University of Florida, Gainesville, Florida 32610 0487, USA
    J Soc Gynecol Investig 12:84-91. 2005
    ..These results indicate that the molecular apparatus for mineralocorticoid-stimulated lung liquid reabsorption is present in epithelium by 120 days' gestation...
  57. ncbi Estrogen/hypothalamus-pituitary-adrenal axis interactions in the fetus: The interplay between placenta and fetal brain
    Charles E Wood
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, Gainesville, Florida 32610 0274, USA
    J Soc Gynecol Investig 12:67-76. 2005
    ..The hormonal interactions between the placenta and the fetal hypothalamus-pituitary-adrenal (HPA) axis are reviewed...
  58. ncbi Ontogenetic changes in the extra-pituitary expression of pro-opiomelanocortin in the developing ovine fetus
    Nyima S Ali
    Department of Physiology and Functional Genomics, University of Florida College of Medicine, P O Box 100274, Gainesville, FL 32610 0274, USA
    Peptides 26:301-6. 2005
    ..We speculate that the decreasing abundance of POMC mRNA and protein reflects decreased release of POMC and POMC-related peptides into the fetal bloodstream...
  59. doi Regulation of maternal ACTH in ovine pregnancy: does progesterone play a role?
    Maureen Keller-Wood
    Department of Pharmacodynamics, University of Florida, Gainesville, Florida 32605, USA
    Am J Physiol Endocrinol Metab 295:E913-20. 2008
    ..We conclude that increased progesterone does not alter the feedback relation of cortisol to ACTH, but may modulate ACTH indirectly through plasma volume...

Research Grants2

  1. Progestin Actions in the Primate Breast and Uterus
    Charles Wood; Fiscal Year: 2007
    ..This work will have immediate public health relevance to postmenopausal women seeking the safest form of hormone therapy. ..