Richard Weinberg

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. pmc Distinctive structure and interfacial activity of the human apolipoprotein A-IV 347S isoprotein
    Richard B Weinberg
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Lipid Res 51:2664-71. 2010
  2. ncbi request reprint Apolipoprotein A-IV-2 allele: association of its worldwide distribution with adult persistence of lactase and speculation on its function and origin
    R B Weinberg
    Section of Gastroenterology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Genet Epidemiol 17:285-97. 1999
  3. ncbi request reprint Structure and interfacial properties of human apolipoprotein A-V
    Richard B Weinberg
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 278:34438-44. 2003
  4. ncbi request reprint Bryant
    Richard B Weinberg
    Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Ann Intern Med 137:770-1. 2002
  5. ncbi request reprint Interfacial exclusion pressure determines the ability of apolipoprotein A-IV truncation mutants to activate cholesterol ester transfer protein
    Richard B Weinberg
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 277:21549-53. 2002
  6. ncbi request reprint Apolipoprotein A-IV polymorphisms and diet-gene interactions
    Richard B Weinberg
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Curr Opin Lipidol 13:125-34. 2002
  7. ncbi request reprint apoA-IV tagged with the ER retention signal KDEL perturbs the intracellular trafficking and secretion of apoB
    James W Gallagher
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Lipid Res 45:1826-34. 2004
  8. pmc Structural and dynamic interfacial properties of the lipoprotein initiating domain of apolipoprotein B
    Aubrey S Ledford
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Lipid Res 50:108-15. 2009
  9. ncbi request reprint Self-association and lipid binding properties of the lipoprotein initiating domain of apolipoprotein B
    Aubrey S Ledford
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    J Biol Chem 281:8871-6. 2006
  10. ncbi request reprint Identification of the lipoprotein initiating domain of apolipoprotein B
    Gregory S Shelness
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    J Biol Chem 278:44702-7. 2003

Research Grants

  1. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard Weinberg; Fiscal Year: 2009
  2. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard Weinberg; Fiscal Year: 2007
  3. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard Weinberg; Fiscal Year: 2003
  4. Neonatal Nutrition and the Genetics of Human Lactation
    Richard Weinberg; Fiscal Year: 2003
  5. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard B Weinberg; Fiscal Year: 2010

Collaborators

Detail Information

Publications15

  1. pmc Distinctive structure and interfacial activity of the human apolipoprotein A-IV 347S isoprotein
    Richard B Weinberg
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Lipid Res 51:2664-71. 2010
    ..Together, these observations establish that the T347S substitution alters the conformation of apo A-IV and lowers its interfacial activity-changes that could account for the effect of this polymorphism on postprandial lipid metabolism...
  2. ncbi request reprint Apolipoprotein A-IV-2 allele: association of its worldwide distribution with adult persistence of lactase and speculation on its function and origin
    R B Weinberg
    Section of Gastroenterology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Genet Epidemiol 17:285-97. 1999
    ....
  3. ncbi request reprint Structure and interfacial properties of human apolipoprotein A-V
    Richard B Weinberg
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 278:34438-44. 2003
    ..Given that overexpression of the apoA-V gene lowers plasma triglycerides in mice, these data together suggest that apoA-V may function intracellularly to modulate hepatic VLDL synthesis and/or secretion...
  4. ncbi request reprint Bryant
    Richard B Weinberg
    Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Ann Intern Med 137:770-1. 2002
  5. ncbi request reprint Interfacial exclusion pressure determines the ability of apolipoprotein A-IV truncation mutants to activate cholesterol ester transfer protein
    Richard B Weinberg
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 277:21549-53. 2002
    ....
  6. ncbi request reprint Apolipoprotein A-IV polymorphisms and diet-gene interactions
    Richard B Weinberg
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Curr Opin Lipidol 13:125-34. 2002
    ..Studies on the diet-gene interactions of other apolipoprotein A-IV alleles are needed, as are studies on the interactions between apolipoprotein A-IV alleles and other apolipoprotein polymorphisms...
  7. ncbi request reprint apoA-IV tagged with the ER retention signal KDEL perturbs the intracellular trafficking and secretion of apoB
    James W Gallagher
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Lipid Res 45:1826-34. 2004
    ..These data suggest that apoA-IV may physically interact with apoB in the secretory pathway, perhaps reflecting a role in modulating the process of triglyceride-rich lipoprotein assembly and secretion...
  8. pmc Structural and dynamic interfacial properties of the lipoprotein initiating domain of apolipoprotein B
    Aubrey S Ledford
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Lipid Res 50:108-15. 2009
    ..9 +/- 0.8 mN/m vs. 22.9 +/- 0.8 mN/m). These data establish that the transition of apoB to assembly competence is accompanied by increases in surface activity and elasticity, but not by significant changes in global structure...
  9. ncbi request reprint Self-association and lipid binding properties of the lipoprotein initiating domain of apolipoprotein B
    Aubrey S Ledford
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    J Biol Chem 281:8871-6. 2006
    ..The high affinity of apoB20.1H for neutral lipid is consistent with the membrane binding and desorption model of apoB-containing lipoprotein assembly...
  10. ncbi request reprint Identification of the lipoprotein initiating domain of apolipoprotein B
    Gregory S Shelness
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    J Biol Chem 278:44702-7. 2003
    ..The composition of lipids recruited into lipoproteins by this initiating domain is consistent with formation of small emulsion particles, perhaps by simultaneous desorption of both polar and neutral lipids from a saturated bilayer...
  11. ncbi request reprint Apolipoprotein A-I helix 6 negatively charged residues attenuate lecithin-cholesterol acyltransferase (LCAT) reactivity
    Eric T Alexander
    Department of Pathology, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Biochemistry 44:5409-19. 2005
    ..These results support the concept that highly conserved negatively charged residues in apoA-I helix 6 interact directly and attenuate LCAT activation, independent of the overall particle charge...
  12. ncbi request reprint The C terminus of apolipoprotein A-V modulates lipid-binding activity
    Jennifer A Beckstead
    Center for Prevention of Obesity, Diabetes, and Cardiovascular Disease, Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    J Biol Chem 282:15484-9. 2007
    ....
  13. ncbi request reprint Specific sequences in the N and C termini of apolipoprotein A-IV modulate its conformation and lipid association
    Kevin Pearson
    Department of Pathology and Laboratory Medicine, The University of Cincinnati, Cincinnati, Ohio 45237 0507, USA
    J Biol Chem 280:38576-82. 2005
    ..We propose a structural model in which these sequences can modulate the conformation and lipid affinity of apoA-IV...
  14. ncbi request reprint Overexpression of apolipoprotein A-IV enhances lipid secretion in IPEC-1 cells by increasing chylomicron size
    Song Lu
    Children s Foundation Research Center at Le Bonheur Children s Medical Center and Department of Pediatrics, University of Tennessee Health Science Center, Memphis, Tennessee 38103, USA
    J Biol Chem 281:3473-83. 2006
    ..The EQQQ-rich region may play an inhibitory or modulatory role in chylomicron packaging in humans...
  15. ncbi request reprint Common variants of apolipoprotein A-IV differ in their ability to inhibit low density lipoprotein oxidation
    Wai Man R Wong
    Centre for Cardiovascular Genetics, British Heart Foundation Laboratories, Royal Free and University College London Medical School, London, UK
    Atherosclerosis 192:266-74. 2007
    ..The reduced inhibition of LDL oxidation by apoA-IV-S347 compared to wild type apoA-IV may account for the previous association of the APOA4 S347 variant with increased CHD risk and oxidative stress...

Research Grants11

  1. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard Weinberg; Fiscal Year: 2009
    ..We believe that these studies will provide new knowledge on the function of apo A-IV in the complex process of lipoprotein assembly relevant to the dietary control of atherosclerotic cardiovascular disease and obesity. ..
  2. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard Weinberg; Fiscal Year: 2007
    ..We believe that these studies will provide new knowledge on the function of apo A-IV in the complex process of lipoprotein assembly relevant to the dietary control of atherosclerotic cardiovascular disease and obesity. ..
  3. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard Weinberg; Fiscal Year: 2003
    ....
  4. Neonatal Nutrition and the Genetics of Human Lactation
    Richard Weinberg; Fiscal Year: 2003
    ..This knowledge could eventually enable the identification of women who require specific fatty acid or vitamin supplementation to assure optimal infant nutrition. ..
  5. STRUCTURE AND FUNCTION OF APOLIPOPROTEIN A-IV
    Richard B Weinberg; Fiscal Year: 2010
    ..We believe that these studies will provide new knowledge on the function of apo A-IV in the complex process of lipoprotein assembly relevant to the dietary control of atherosclerotic cardiovascular disease and obesity. ..