J D Wagner

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. pmc Effects of soy protein and isoflavones on insulin resistance and adiponectin in male monkeys
    Janice D Wagner
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Metabolism 57:S24-31. 2008
  2. doi request reprint A selective cannabinoid-1 receptor antagonist, PF-95453, reduces body weight and body fat to a greater extent than pair-fed controls in obese monkeys
    Janice D Wagner
    Department of Pathology, Wake Forest University, Winston Salem, NC 27157, USA
    J Pharmacol Exp Ther 335:103-13. 2010
  3. ncbi request reprint Reproductive hormones and cardiovascular disease mechanism of action and clinical implications
    Janice D Wagner
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Obstet Gynecol Clin North Am 29:475-93. 2002
  4. doi request reprint A selective peroxisome proliferator-activated receptor alpha agonist, CP-900691, improves plasma lipids, lipoproteins, and glycemic control in diabetic monkeys
    Janice D Wagner
    Department of Pathology, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Pharmacol Exp Ther 333:844-53. 2010
  5. ncbi request reprint The applicability of hormonal effects on atherosclerosis in animals to heart disease in postmenopausal women
    Janice D Wagner
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Semin Reprod Med 23:149-56. 2005
  6. doi request reprint Effects of soy vs. casein protein on body weight and glycemic control in female monkeys and their offspring
    Janice D Wagner
    Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Am J Primatol 71:802-11. 2009
  7. ncbi request reprint Soy protein with isoflavones, but not an isoflavone-rich supplement, improves arterial low-density lipoprotein metabolism and atherogenesis
    Janice D Wagner
    Wake Forest University Medical Center, Winston Salem, NC, USA
    Arterioscler Thromb Vasc Biol 23:2241-6. 2003
  8. ncbi request reprint Effects of tibolone and conjugated equine estrogens with or without medroxyprogesterone acetate on body composition and fasting carbohydrate measures in surgically postmenopausal monkeys
    Melanie K Shadoan
    Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Metabolism 52:1085-91. 2003
  9. ncbi request reprint Rosiglitazone treatment improves insulin regulation and dyslipidemia in type 2 diabetic cynomolgus monkeys
    Melaney K Gee
    Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Metabolism 53:1121-5. 2004
  10. ncbi request reprint Esterified estrogens with and without methyltestosterone decrease arterial LDL metabolism in cynomolgus monkeys
    J D Wagner
    Comparative Medicine Clinical Research Center, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, NC, USA
    Arterioscler Thromb Vasc Biol 16:1473-80. 1996

Research Grants

Detail Information

Publications38

  1. pmc Effects of soy protein and isoflavones on insulin resistance and adiponectin in male monkeys
    Janice D Wagner
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Metabolism 57:S24-31. 2008
    ..Further studies are needed to determine the mechanisms involved in these effects of a high-soy isoflavone diet and to optimize dietary isoflavone content for maximal health benefits in male subjects...
  2. doi request reprint A selective cannabinoid-1 receptor antagonist, PF-95453, reduces body weight and body fat to a greater extent than pair-fed controls in obese monkeys
    Janice D Wagner
    Department of Pathology, Wake Forest University, Winston Salem, NC 27157, USA
    J Pharmacol Exp Ther 335:103-13. 2010
    ..Similar to humans, monkeys treated with the CB(1) receptor antagonist exhibited decreased body weight and body fat, a substantial portion of which seemed to be independent of the effects on food intake...
  3. ncbi request reprint Reproductive hormones and cardiovascular disease mechanism of action and clinical implications
    Janice D Wagner
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Obstet Gynecol Clin North Am 29:475-93. 2002
    ..The remainder of the study groups including an estrogen-only arm, are expected to continue until 2005...
  4. doi request reprint A selective peroxisome proliferator-activated receptor alpha agonist, CP-900691, improves plasma lipids, lipoproteins, and glycemic control in diabetic monkeys
    Janice D Wagner
    Department of Pathology, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Pharmacol Exp Ther 333:844-53. 2010
    ....
  5. ncbi request reprint The applicability of hormonal effects on atherosclerosis in animals to heart disease in postmenopausal women
    Janice D Wagner
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Semin Reprod Med 23:149-56. 2005
    ..Future studies should be directed at studying hormone therapy in relevant ages of women (perimenopausal women) using the lowest effective doses of hormones and comparing oral and parenteral forms of delivery...
  6. doi request reprint Effects of soy vs. casein protein on body weight and glycemic control in female monkeys and their offspring
    Janice D Wagner
    Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Am J Primatol 71:802-11. 2009
    ....
  7. ncbi request reprint Soy protein with isoflavones, but not an isoflavone-rich supplement, improves arterial low-density lipoprotein metabolism and atherogenesis
    Janice D Wagner
    Wake Forest University Medical Center, Winston Salem, NC, USA
    Arterioscler Thromb Vasc Biol 23:2241-6. 2003
    ..We sought to determine if arterial LDL metabolism contributes to the decreased atherosclerosis seen with soy and if isolated isoflavones would have similar effects...
  8. ncbi request reprint Effects of tibolone and conjugated equine estrogens with or without medroxyprogesterone acetate on body composition and fasting carbohydrate measures in surgically postmenopausal monkeys
    Melanie K Shadoan
    Wake Forest University School of Medicine, Winston Salem, NC 27157 1032, USA
    Metabolism 52:1085-91. 2003
    ..03), except CEE (P =.12). In conclusion, HRT with CEE + MPA or tibolone results in greater BW, abdominal soft tissue, and insulin resistance (CEE + MPA and HiTib) compared to control-treated monkeys...
  9. ncbi request reprint Rosiglitazone treatment improves insulin regulation and dyslipidemia in type 2 diabetic cynomolgus monkeys
    Melaney K Gee
    Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Metabolism 53:1121-5. 2004
    ..Body weights remained steady in both groups during the study. These results suggest overall improvement in insulin regulation and lipid profiles during treatment with rosiglitazone...
  10. ncbi request reprint Esterified estrogens with and without methyltestosterone decrease arterial LDL metabolism in cynomolgus monkeys
    J D Wagner
    Comparative Medicine Clinical Research Center, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, NC, USA
    Arterioscler Thromb Vasc Biol 16:1473-80. 1996
    ....
  11. ncbi request reprint Effects of short-term hormone replacement therapies on low-density lipoprotein metabolism in cynomologus monkeys
    J D Wagner
    Comparative Medicine Clinical Research Center, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, NC 27157 1040, USA
    Arterioscler Thromb Vasc Biol 17:1128-34. 1997
    ..The decrease in hepatic cholesterol content in hypothesized to be due to increased biliary secretion of cholesterol...
  12. ncbi request reprint Medroxyprogesterone acetate antagonizes inhibitory effects of conjugated equine estrogens on coronary artery atherosclerosis
    M R Adams
    Comparative Medicine Clinical Research Center, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, NC 27157 1040, USA
    Arterioscler Thromb Vasc Biol 17:217-21. 1997
    ..Although the mechanism(s) remains unclear, we conclude that oral CEE inhibits the initiation and progression of coronary artery atherosclerosis and that continuously administered oral MPA antagonizes this atheroprotective effect...
  13. ncbi request reprint Effects of 17 alpha-dihydroequilenin sulfate on atherosclerotic male and female rhesus monkeys
    S A Washburn
    Comparative Medicine Clinical Research Center, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, USA
    Am J Obstet Gynecol 175:341-9; discussion 349-51. 1996
    ....
  14. ncbi request reprint Insulin sensitivity and cardiovascular risk factors in ovariectomized monkeys with estradiol alone or combined with nomegestrol acetate
    J D Wagner
    Department of Comparative Medicine, Bowman Gray School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    J Clin Endocrinol Metab 83:896-901. 1998
    ..In conclusion, NA, a progestin without androgenic activity, may still affect some cardiovascular risk factors differently than estrogen-only therapy. However, it seems to be less detrimental than MPA...
  15. ncbi request reprint A comparison of tibolone and conjugated equine estrogens effects on coronary artery atherosclerosis and bone density of postmenopausal monkeys
    T B Clarkson
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    J Clin Endocrinol Metab 86:5396-404. 2001
    ..01). Despite adverse effects of tibolone on plasma lipoprotein concentrations, there was no increase in CAA, suggesting that tibolone is a cardiovascular-safe treatment for climacteric symptoms and the prevention of osteoporosis...
  16. doi request reprint Clinicopathologic characterization of naturally occurring diabetes mellitus in vervet monkeys
    J A Cann
    Department of Pathology, Section on Comparative Medicine, Winston Salem, NC 27157, USA
    Vet Pathol 47:713-8. 2010
    ..The authors thus hypothesize that a naturally occurring monogenic form of diabetes may occur in vervet monkeys, making them a potential animal model for future studies...
  17. ncbi request reprint Glycation of plasma low density lipoproteins increases interaction with arterial proteoglycans
    I J Edwards
    Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1047, USA
    Diabetes Res Clin Pract 46:9-18. 1999
    ....
  18. ncbi request reprint Naturally occurring and experimental diabetes in cynomolgus monkeys: a comparison of carbohydrate and lipid metabolism and islet pathology
    J D Wagner
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Toxicol Pathol 29:142-8. 2001
    ..Studies are ongoing to determine the pathogenic changes associated with the progression of diabetes and to find novel drug treatments for diabetics...
  19. pmc Dual radiotracer analysis of cholinergic neuronal changes in prediabetic mouse pancreas
    Paige B Clark
    Department of Radiology Nuclear Medicine, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Diabetes Technol Ther 11:107-11. 2009
    ..In this study, we investigate the feasibility of dual radiotracer analysis in identifying neurofunctional changes that may signify type 1 diabetes mellitus in its early preclinical state...
  20. pmc Comparative analyses of single-nucleotide polymorphisms in the TNF promoter region provide further validation for the vervet monkey model of obesity
    Stanton B Gray
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Comp Med 59:580-8. 2009
    ..More broadly, the sequence data and comparative analyses reported herein facilitates study of the evolution of regulatory sequences of inflammatory and immune-related genes...
  21. pmc Enhanced cholinergic response in pancreata of nonhuman primates with impaired glucose tolerance shown on [18F]fluorobenzyltrozamicol positron emission tomography
    Paige B Clark
    Department of Radiology Nuclear Medicine, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Diabetes Technol Ther 11:451-5. 2009
    ..In this study, we utilize [18F]FBT PET to demonstrate pancreatic cholinergic activity before and after dextrose infusion in nonhuman primates with normal (NGT) and impaired (IGT) glucose tolerance...
  22. doi request reprint Fluid compartmental shifts with efficacious pioglitazone therapy in overweight monkeys: implications for peroxisome proliferator-activated receptor-gamma agonist use in prediabetes
    Kylie Kavanagh
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27127, USA
    Metabolism 59:914-20. 2010
    ..We conclude that thiazolidinedione-related plasma volume expansion occurs in nondiabetic primates and that fluid retention is detectable when compartments are directly measured...
  23. doi request reprint High isoflavone soy diet increases insulin secretion without decreasing insulin sensitivity in premenopausal nonhuman primates
    Kylie Kavanagh
    Department of Pathology, Section on Comparative Medicine, Wake Forest University, Winston Salem, NC 27107, USA
    Nutr Res 28:368-76. 2008
    ..These study results demonstrate that consumption of soy containing high isoflavone levels is not associated with changes in insulin sensitivity in the high estrogen milieu of the premenopausal female...
  24. pmc Tissue-specific regulation and expression of heat shock proteins in type 2 diabetic monkeys
    K Kavanagh
    Department of Pathology, Wake Forest University, Winston Salem, NC 27157, USA
    Cell Stress Chaperones 14:291-9. 2009
    ..Pancreas maintains HSP levels despite hyperglycemia, likely in an attempt to protect vulnerable beta cells from exocrine pancreatic damage and from stress associated with insulin hypersecretion...
  25. pmc Estrogen decreases atherosclerosis in part by reducing hepatic acyl-CoA:cholesterol acyltransferase 2 (ACAT2) in monkeys
    Kylie Kavanagh
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Arterioscler Thromb Vasc Biol 29:1471-7. 2009
    ..This study aimed to determine estrogen-induced changes in hepatic cholesterol metabolism, plasma lipoproteins, and the relationship of these changes to atherosclerosis extent...
  26. ncbi request reprint Trans fat diet induces abdominal obesity and changes in insulin sensitivity in monkeys
    Kylie Kavanagh
    Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Obesity (Silver Spring) 15:1675-84. 2007
    ..The effect of moderately high intake of dietary monounsaturated TFAs on body composition and indices of glucose metabolism was evaluated to determine any pro-diabetic effect in the absence of weight gain...
  27. ncbi request reprint Effects of tibolone and conventional hormone replacement therapies on arterial and hepatic cholesterol accumulation and on circulating endothelin-1, vascular cell adhesion molecule-1, and E-selectin in surgically menopausal monkeys
    Thomas C Register
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Menopause 9:411-21. 2002
    ....
  28. ncbi request reprint Effects of hormone therapy on insulin signaling proteins in skeletal muscle of cynomolgus monkeys
    Melanie K Shadoan
    Department of Pathology, Comparative Medicine Clinical Research Center, Medical Center Boulevard, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Steroids 69:313-8. 2004
    ..14). These deficiencies in skeletal muscle insulin signaling likely contribute to the unfavorable changes in whole body insulin sensitivity associated with CEE + MPA treatment...
  29. ncbi request reprint Toxicology and pharmacokinetics of DT388IL3, a fusion toxin consisting of a truncated diphtheria toxin (DT388) linked to human interleukin 3 (IL3), in cynomolgus monkeys
    Kimberley A Cohen
    Department of Comparative Medicine and Cancer Biology, Wake Forest Health Sciences, Winston Salem, NC 27157, USA
    Leuk Lymphoma 45:1647-56. 2004
    ..Thus, we propose this agent is a promising drug for AML patients...
  30. ncbi request reprint Effects of soy isoflavones and conjugated equine estrogens on inflammatory markers in atherosclerotic, ovariectomized monkeys
    Thomas C Register
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1040, USA
    J Clin Endocrinol Metab 90:1734-40. 2005
    ..The sites of IF inhibitory effects on sVCAM-1 production are not known, but likely candidates include the liver and/or the cardiovascular system...
  31. ncbi request reprint Safety evaluation of DT388IL3, a diphtheria toxin/interleukin 3 fusion protein, in the cynomolgus monkey
    Kimberley A Cohen
    Department of Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Cancer Immunol Immunother 54:799-806. 2005
    ..Based on these findings a phase I clinical trial has recently been initiated with DT388IL3 for the treatment of AML...
  32. ncbi request reprint Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistance
    Jamal A Ibdah
    Division of Gastroenterology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Gastroenterology 128:1381-90. 2005
    ..In this study, we investigated effects of heterozygosity for the MTP defect on hepatic oxidative stress, insulin resistance, and development of NAFLD in mice...
  33. ncbi request reprint Naturally occurring menopause in cynomolgus monkeys: changes in hormone, lipid, and carbohydrate measures with hormonal status
    Kylie Kavanagh
    Department of Pathology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    J Med Primatol 34:171-7. 2005
    ..E(2) treatment restored estrogen levels and induced improvements in the lipid profile of PM females...
  34. ncbi request reprint Characterization and heritability of obesity and associated risk factors in vervet monkeys
    Kylie Kavanagh
    Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Obesity (Silver Spring) 15:1666-74. 2007
    ..The objective was to determine the prevalence and heritability of obesity and risk factors associated with metabolic syndrome (MS) in a pedigreed colony of vervet monkeys...
  35. pmc Neonatal and fetal exposure to trans-fatty acids retards early growth and adiposity while adversely affecting glucose in mice
    Kylie Kavanagh
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Nutr Res 30:418-26. 2010
    ..Trans-fatty acid surprisingly retarded growth and adiposity while still adversely affecting glucose metabolism...
  36. ncbi request reprint Type 2 diabetes-an introduction to the development and use of animal models
    Jay R Kaplan
    Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    ILAR J 47:181-5. 2006
    ..The individual contributions comprising this issue of ILAR Journal review the research that has been conducted on many of these animals...
  37. ncbi request reprint Caloric restriction and cardiovascular aging in cynomolgus monkeys (Macaca fascicularis): metabolic, physiologic, and atherosclerotic measures from a 4-year intervention trial
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    J Gerontol A Biol Sci Med Sci 59:1007-14. 2004
    ..Thus, further studies are needed to determine if improved insulin sensitivity might decrease arterial inflammation and improve endothelial function, despite no changes in atherosclerosis extent...
  38. ncbi request reprint Addition of medroxyprogesterone acetate to conjugated equine estrogens results in insulin resistance in adipose tissue
    Melanie K Shadoan
    Department of Endocrinology, Lexicon Pharmaceuticals, The Woodlands, TX 77381, USA
    Metabolism 56:830-7. 2007
    ....

Research Grants3

  1. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    JANICE WAGNER; Fiscal Year: 2006
    ....
  2. WFUSM Macaca fascicularis SPF Breeding Colony
    JANICE WAGNER; Fiscal Year: 2007
    ..These conditions will provide a unique resource of both SPF and diet-defined Macaca fascicularis available for NIH-sponsored biomedical research. ..