Research Topics
Species | J D WagnerSummaryAffiliation: Wake Forest University School of Medicine Country: USA Publications
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Publications
Effects of soy protein and isoflavones on insulin resistance and adiponectin in male monkeysJanice D Wagner
Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Metabolism 57:S24-31. 2008..Further studies are needed to determine the mechanisms involved in these effects of a high-soy isoflavone diet and to optimize dietary isoflavone content for maximal health benefits in male subjects...
A selective cannabinoid-1 receptor antagonist, PF-95453, reduces body weight and body fat to a greater extent than pair-fed controls in obese monkeysJanice D Wagner
Department of Pathology, Wake Forest University, Winston Salem, NC 27157, USA
J Pharmacol Exp Ther 335:103-13. 2010..Similar to humans, monkeys treated with the CB(1) receptor antagonist exhibited decreased body weight and body fat, a substantial portion of which seemed to be independent of the effects on food intake...
Reproductive hormones and cardiovascular disease mechanism of action and clinical implicationsJanice D Wagner
Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Obstet Gynecol Clin North Am 29:475-93. 2002..The remainder of the study groups including an estrogen-only arm, are expected to continue until 2005...- A selective peroxisome proliferator-activated receptor alpha agonist, CP-900691, improves plasma lipids, lipoproteins, and glycemic control in diabetic monkeysJanice D Wagner
Department of Pathology, Wake Forest University, Winston Salem, North Carolina 27157, USA
J Pharmacol Exp Ther 333:844-53. 2010.... - The applicability of hormonal effects on atherosclerosis in animals to heart disease in postmenopausal womenJanice D Wagner
Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Semin Reprod Med 23:149-56. 2005..Future studies should be directed at studying hormone therapy in relevant ages of women (perimenopausal women) using the lowest effective doses of hormones and comparing oral and parenteral forms of delivery... - Effects of soy vs. casein protein on body weight and glycemic control in female monkeys and their offspringJanice D Wagner
Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
Am J Primatol 71:802-11. 2009.... - Soy protein with isoflavones, but not an isoflavone-rich supplement, improves arterial low-density lipoprotein metabolism and atherogenesisJanice D Wagner
Wake Forest University Medical Center, Winston Salem, NC, USA
Arterioscler Thromb Vasc Biol 23:2241-6. 2003..We sought to determine if arterial LDL metabolism contributes to the decreased atherosclerosis seen with soy and if isolated isoflavones would have similar effects... - Effects of tibolone and conjugated equine estrogens with or without medroxyprogesterone acetate on body composition and fasting carbohydrate measures in surgically postmenopausal monkeysMelanie K Shadoan
Wake Forest University School of Medicine, Winston-Salem, NC 27157-1032, USA
Metabolism 52:1085-91. 2003..03), except CEE (P =.12). In conclusion, HRT with CEE + MPA or tibolone results in greater BW, abdominal soft tissue, and insulin resistance (CEE + MPA and HiTib) compared to control-treated monkeys... - Rosiglitazone treatment improves insulin regulation and dyslipidemia in type 2 diabetic cynomolgus monkeysMelaney K Gee
Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
Metabolism 53:1121-5. 2004..Body weights remained steady in both groups during the study. These results suggest overall improvement in insulin regulation and lipid profiles during treatment with rosiglitazone... - Esterified estrogens with and without methyltestosterone decrease arterial LDL metabolism in cynomolgus monkeysJ D Wagner
Comparative Medicine Clinical Research Center, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, NC, USA
Arterioscler Thromb Vasc Biol 16:1473-80. 1996.... - Effects of short-term hormone replacement therapies on low-density lipoprotein metabolism in cynomologus monkeysJ D Wagner
Comparative Medicine Clinical Research Center, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, NC 27157 1040, USA
Arterioscler Thromb Vasc Biol 17:1128-34. 1997..The decrease in hepatic cholesterol content in hypothesized to be due to increased biliary secretion of cholesterol... - Medroxyprogesterone acetate antagonizes inhibitory effects of conjugated equine estrogens on coronary artery atherosclerosisM R Adams
Comparative Medicine Clinical Research Center, Bowman Gray School of Medicine, Wake Forest University, Winston Salem, NC 27157 1040, USA
Arterioscler Thromb Vasc Biol 17:217-21. 1997..Although the mechanism(s) remains unclear, we conclude that oral CEE inhibits the initiation and progression of coronary artery atherosclerosis and that continuously administered oral MPA antagonizes this atheroprotective effect... - Effects of 17 alpha-dihydroequilenin sulfate on atherosclerotic male and female rhesus monkeysS A Washburn
Comparative Medicine Clinical Research Center, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, USA
Am J Obstet Gynecol 175:341-9; discussion 349-51. 1996.... - Insulin sensitivity and cardiovascular risk factors in ovariectomized monkeys with estradiol alone or combined with nomegestrol acetateJ D Wagner
Department of Comparative Medicine, Bowman Gray School of Medicine, Winston Salem, North Carolina 27157 1040, USA
J Clin Endocrinol Metab 83:896-901. 1998..In conclusion, NA, a progestin without androgenic activity, may still affect some cardiovascular risk factors differently than estrogen-only therapy. However, it seems to be less detrimental than MPA... - A comparison of tibolone and conjugated equine estrogens effects on coronary artery atherosclerosis and bone density of postmenopausal monkeysT B Clarkson
Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
J Clin Endocrinol Metab 86:5396-404. 2001..01). Despite adverse effects of tibolone on plasma lipoprotein concentrations, there was no increase in CAA, suggesting that tibolone is a cardiovascular-safe treatment for climacteric symptoms and the prevention of osteoporosis... - Clinicopathologic characterization of naturally occurring diabetes mellitus in vervet monkeysJ A Cann
Department of Pathology, Section on Comparative Medicine, Winston Salem, NC 27157, USA
Vet Pathol 47:713-8. 2010..The authors thus hypothesize that a naturally occurring monogenic form of diabetes may occur in vervet monkeys, making them a potential animal model for future studies... - Glycation of plasma low density lipoproteins increases interaction with arterial proteoglycansI J Edwards
Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1047, USA
Diabetes Res Clin Pract 46:9-18. 1999.... - Naturally occurring and experimental diabetes in cynomolgus monkeys: a comparison of carbohydrate and lipid metabolism and islet pathologyJ D Wagner
Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
Toxicol Pathol 29:142-8. 2001..Studies are ongoing to determine the pathogenic changes associated with the progression of diabetes and to find novel drug treatments for diabetics... - Dual radiotracer analysis of cholinergic neuronal changes in prediabetic mouse pancreasPaige B Clark
Department of Radiology Nuclear Medicine, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
Diabetes Technol Ther 11:107-11. 2009..In this study, we investigate the feasibility of dual radiotracer analysis in identifying neurofunctional changes that may signify type 1 diabetes mellitus in its early preclinical state... - Comparative analyses of single-nucleotide polymorphisms in the TNF promoter region provide further validation for the vervet monkey model of obesityStanton B Gray
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Comp Med 59:580-8. 2009..More broadly, the sequence data and comparative analyses reported herein facilitates study of the evolution of regulatory sequences of inflammatory and immune-related genes... - Enhanced cholinergic response in pancreata of nonhuman primates with impaired glucose tolerance shown on [18F]fluorobenzyltrozamicol positron emission tomographyPaige B Clark
Department of Radiology Nuclear Medicine, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
Diabetes Technol Ther 11:451-5. 2009..In this study, we utilize [18F]FBT PET to demonstrate pancreatic cholinergic activity before and after dextrose infusion in nonhuman primates with normal (NGT) and impaired (IGT) glucose tolerance... - Fluid compartmental shifts with efficacious pioglitazone therapy in overweight monkeys: implications for peroxisome proliferator-activated receptor-gamma agonist use in prediabetesKylie Kavanagh
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27127, USA
Metabolism 59:914-20. 2010..We conclude that thiazolidinedione-related plasma volume expansion occurs in nondiabetic primates and that fluid retention is detectable when compartments are directly measured... - High isoflavone soy diet increases insulin secretion without decreasing insulin sensitivity in premenopausal nonhuman primatesKylie Kavanagh
Department of Pathology, Section on Comparative Medicine, Wake Forest University, Winston Salem, NC 27107, USA
Nutr Res 28:368-76. 2008..These study results demonstrate that consumption of soy containing high isoflavone levels is not associated with changes in insulin sensitivity in the high estrogen milieu of the premenopausal female... - Tissue-specific regulation and expression of heat shock proteins in type 2 diabetic monkeysK Kavanagh
Department of Pathology, Wake Forest University, Winston Salem, NC 27157, USA
Cell Stress Chaperones 14:291-9. 2009..Pancreas maintains HSP levels despite hyperglycemia, likely in an attempt to protect vulnerable beta cells from exocrine pancreatic damage and from stress associated with insulin hypersecretion... - Estrogen decreases atherosclerosis in part by reducing hepatic acyl-CoA:cholesterol acyltransferase 2 (ACAT2) in monkeysKylie Kavanagh
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
Arterioscler Thromb Vasc Biol 29:1471-7. 2009..This study aimed to determine estrogen-induced changes in hepatic cholesterol metabolism, plasma lipoproteins, and the relationship of these changes to atherosclerosis extent... - Trans fat diet induces abdominal obesity and changes in insulin sensitivity in monkeysKylie Kavanagh
Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Obesity (Silver Spring) 15:1675-84. 2007..The effect of moderately high intake of dietary monounsaturated TFAs on body composition and indices of glucose metabolism was evaluated to determine any pro-diabetic effect in the absence of weight gain... - Effects of tibolone and conventional hormone replacement therapies on arterial and hepatic cholesterol accumulation and on circulating endothelin-1, vascular cell adhesion molecule-1, and E-selectin in surgically menopausal monkeysThomas C Register
Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Menopause 9:411-21. 2002.... - Effects of hormone therapy on insulin signaling proteins in skeletal muscle of cynomolgus monkeysMelanie K Shadoan
Department of Pathology, Comparative Medicine Clinical Research Center, Medical Center Boulevard, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Steroids 69:313-8. 2004..14). These deficiencies in skeletal muscle insulin signaling likely contribute to the unfavorable changes in whole body insulin sensitivity associated with CEE + MPA treatment... - Toxicology and pharmacokinetics of DT388IL3, a fusion toxin consisting of a truncated diphtheria toxin (DT388) linked to human interleukin 3 (IL3), in cynomolgus monkeysKimberley A Cohen
Department of Comparative Medicine and Cancer Biology, Wake Forest Health Sciences, Winston-Salem, NC 27157, USA
Leuk Lymphoma 45:1647-56. 2004..Thus, we propose this agent is a promising drug for AML patients... - Effects of soy isoflavones and conjugated equine estrogens on inflammatory markers in atherosclerotic, ovariectomized monkeysThomas C Register
Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1040, USA
J Clin Endocrinol Metab 90:1734-40. 2005..The sites of IF inhibitory effects on sVCAM-1 production are not known, but likely candidates include the liver and/or the cardiovascular system... - Safety evaluation of DT388IL3, a diphtheria toxin/interleukin 3 fusion protein, in the cynomolgus monkeyKimberley A Cohen
Department of Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
Cancer Immunol Immunother 54:799-806. 2005..Based on these findings a phase I clinical trial has recently been initiated with DT388IL3 for the treatment of AML... - Mice heterozygous for a defect in mitochondrial trifunctional protein develop hepatic steatosis and insulin resistanceJamal A Ibdah
Division of Gastroenterology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Gastroenterology 128:1381-90. 2005..In this study, we investigated effects of heterozygosity for the MTP defect on hepatic oxidative stress, insulin resistance, and development of NAFLD in mice... - Naturally occurring menopause in cynomolgus monkeys: changes in hormone, lipid, and carbohydrate measures with hormonal statusKylie Kavanagh
Department of Pathology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
J Med Primatol 34:171-7. 2005..E(2) treatment restored estrogen levels and induced improvements in the lipid profile of PM females... - Characterization and heritability of obesity and associated risk factors in vervet monkeysKylie Kavanagh
Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
Obesity (Silver Spring) 15:1666-74. 2007..The objective was to determine the prevalence and heritability of obesity and risk factors associated with metabolic syndrome (MS) in a pedigreed colony of vervet monkeys... - Neonatal and fetal exposure to trans-fatty acids retards early growth and adiposity while adversely affecting glucose in miceKylie Kavanagh
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Nutr Res 30:418-26. 2010..Trans-fatty acid surprisingly retarded growth and adiposity while still adversely affecting glucose metabolism... - Type 2 diabetes-an introduction to the development and use of animal modelsJay R Kaplan
Department of Pathology (Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC, USA
ILAR J 47:181-5. 2006..The individual contributions comprising this issue of ILAR Journal review the research that has been conducted on many of these animals... - Caloric restriction and cardiovascular aging in cynomolgus monkeys (Macaca fascicularis): metabolic, physiologic, and atherosclerotic measures from a 4-year intervention trialWilliam T Cefalu
Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
J Gerontol A Biol Sci Med Sci 59:1007-14. 2004..Thus, further studies are needed to determine if improved insulin sensitivity might decrease arterial inflammation and improve endothelial function, despite no changes in atherosclerosis extent... - Addition of medroxyprogesterone acetate to conjugated equine estrogens results in insulin resistance in adipose tissueMelanie K Shadoan
Department of Endocrinology, Lexicon Pharmaceuticals, The Woodlands, TX 77381, USA
Metabolism 56:830-7. 2007....
Research Grants
- DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCESJANICE WAGNER; Fiscal Year: 2006....
- WFUSM Macaca fascicularis SPF Breeding ColonyJANICE WAGNER; Fiscal Year: 2007..These conditions will provide a unique resource of both SPF and diet-defined Macaca fascicularis available for NIH-sponsored biomedical research. ..