Lynne Wagenknecht

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. pmc Do inflammation and procoagulation biomarkers contribute to the metabolic syndrome cluster?
    Aldi T Kraja
    Division of Statistical Genomics, Washington University School of Medicine, Saint Louis, MO, USA
    Nutr Metab (Lond) 4:28. 2007
  2. ncbi request reprint Familial aggregation of coronary artery calcium in families with type 2 diabetes
    L E Wagenknecht
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1063, USA
    Diabetes 50:861-6. 2001
  3. ncbi request reprint A comparison of risk factors for calcified atherosclerotic plaque in the coronary, carotid, and abdominal aortic arteries: the diabetes heart study
    Lynne E Wagenknecht
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Epidemiol 166:340-7. 2007
  4. ncbi request reprint Insulin sensitivity, insulin secretion, and abdominal fat: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study
    Lynne E Wagenknecht
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Diabetes 52:2490-6. 2003
  5. pmc Association of PNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study
    Lynne E Wagenknecht
    Division of Public Health Sciences, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157, USA
    Liver Int 31:412-6. 2011
  6. ncbi request reprint Association of adipose tissue deposition and beta-2 adrenergic receptor variants: the IRAS family study
    L A Lange
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Int J Obes (Lond) 29:449-57. 2005
  7. ncbi request reprint Diabetes and progression of carotid atherosclerosis: the insulin resistance atherosclerosis study
    Lynne E Wagenknecht
    Department of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1063, USA
    Arterioscler Thromb Vasc Biol 23:1035-41. 2003
  8. pmc Correlates of carotid plaque presence and composition as measured by MRI: the Atherosclerosis Risk in Communities Study
    Lynne Wagenknecht
    Wake Forest University School of Medicine, Division of Public Health Sciences, Winston Salem, NC 27157, USA
    Circ Cardiovasc Imaging 2:314-22. 2009
  9. pmc Correlates of coronary artery calcified plaque in blacks and whites with type 2 diabetes
    Lynne E Wagenknecht
    Division of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Ann Epidemiol 21:34-41. 2011
  10. ncbi request reprint Race-specific relationships between coronary and carotid artery calcification and carotid intimal medial thickness
    Lynne E Wagenknecht
    Department of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1063, USA
    Stroke 35:e97-9. 2004

Research Grants

  1. IRAS FAMILY STUDY--GENETICS OF INSULIN RESISTANCE
    Lynne Wagenknecht; Fiscal Year: 1999
  2. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Lynne Wagenknecht; Fiscal Year: 2009
  3. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Lynne Wagenknecht; Fiscal Year: 2007
  4. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Lynne Wagenknecht; Fiscal Year: 2007
  5. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Lynne Wagenknecht; Fiscal Year: 2007
  6. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Lynne Wagenknecht; Fiscal Year: 2006
  7. GENCAC - North Carolina Field Center
    Lynne Wagenknecht; Fiscal Year: 2004
  8. IRAS FAMILY STUDY--GENETICS OF INSULIN RESISTANCE
    Lynne Wagenknecht; Fiscal Year: 2003
  9. IRAS FAMILY STUDY--GENETICS OF INSULIN RESISTANCE
    Lynne Wagenknecht; Fiscal Year: 2002
  10. IRAS FAMILY STUDY--GENETICS OF INSULIN RESISTANCE
    Lynne Wagenknecht; Fiscal Year: 2001

Detail Information

Publications70

  1. pmc Do inflammation and procoagulation biomarkers contribute to the metabolic syndrome cluster?
    Aldi T Kraja
    Division of Statistical Genomics, Washington University School of Medicine, Saint Louis, MO, USA
    Nutr Metab (Lond) 4:28. 2007
    ..However, the relationship of inflammatory biomarkers to MetS is not clear...
  2. ncbi request reprint Familial aggregation of coronary artery calcium in families with type 2 diabetes
    L E Wagenknecht
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1063, USA
    Diabetes 50:861-6. 2001
    ..In these data, CAC seems heritable and may serve as an important feature in designing studies to map genes contributing to both atherosclerosis and type 2 diabetes...
  3. ncbi request reprint A comparison of risk factors for calcified atherosclerotic plaque in the coronary, carotid, and abdominal aortic arteries: the diabetes heart study
    Lynne E Wagenknecht
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Epidemiol 166:340-7. 2007
    ..0001). In summary, CAPs of the coronary, carotid, and abdominal aortic arteries generally share common risk factors, even though several of these factors have a greater impact on CAP in one vascular bed than another...
  4. ncbi request reprint Insulin sensitivity, insulin secretion, and abdominal fat: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study
    Lynne E Wagenknecht
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Diabetes 52:2490-6. 2003
    ..The fat measures explained 27% of the model R2 for SI, 16% for AIR, and 16% for DI. Thus, fat distribution is an important determinant of both insulin resistance and insulin secretion...
  5. pmc Association of PNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family Study
    Lynne E Wagenknecht
    Division of Public Health Sciences, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157, USA
    Liver Int 31:412-6. 2011
    ..Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent condition, particularly among Hispanic Americans. A genetic variant in PNPLA3 (rs738409) has been identified as a strong predictor of hepatic fat content...
  6. ncbi request reprint Association of adipose tissue deposition and beta-2 adrenergic receptor variants: the IRAS family study
    L A Lange
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Int J Obes (Lond) 29:449-57. 2005
    ..We examined whether two common polymorphisms in codons 16 (Arg16Gly) and 27 (Gln27Glu) are associated with measures of fat distribution in participants of the IRAS Family Study...
  7. ncbi request reprint Diabetes and progression of carotid atherosclerosis: the insulin resistance atherosclerosis study
    Lynne E Wagenknecht
    Department of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1063, USA
    Arterioscler Thromb Vasc Biol 23:1035-41. 2003
    ..We sought to determine the rate of progression of carotid atherosclerosis in persons with normal glucose tolerance, impaired glucose tolerance, and undiagnosed and diagnosed type 2 diabetes...
  8. pmc Correlates of carotid plaque presence and composition as measured by MRI: the Atherosclerosis Risk in Communities Study
    Lynne Wagenknecht
    Wake Forest University School of Medicine, Division of Public Health Sciences, Winston Salem, NC 27157, USA
    Circ Cardiovasc Imaging 2:314-22. 2009
    ..We hypothesized that traditional risk factors are predictors of carotid wall and plaque characteristics measured 2 decades later...
  9. pmc Correlates of coronary artery calcified plaque in blacks and whites with type 2 diabetes
    Lynne E Wagenknecht
    Division of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Ann Epidemiol 21:34-41. 2011
    ..To examine whether the relationship between cardiovascular disease risk factors and coronary artery calcification (CAC) is modified by race among those with diabetes...
  10. ncbi request reprint Race-specific relationships between coronary and carotid artery calcification and carotid intimal medial thickness
    Lynne E Wagenknecht
    Department of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1063, USA
    Stroke 35:e97-9. 2004
    ..Calcified arterial plaque has been proposed as a subclinical marker of atherosclerosis. We compared it to a well-validated surrogate--carotid intimal medial thickness (IMT)...
  11. pmc Constructing common cohorts from trials with overlapping eligibility criteria: implications for comparing effect sizes between trials
    David L Mount
    Wake Forest University School of Medicine, Winston Salem, NC, USA
    Clin Trials 6:416-29. 2009
    ..Comparing findings from separate trials is necessary to choose among treatment options, however differences among study cohorts may impede these comparisons...
  12. pmc Describing patterns of weight changes using principal components analysis: results from the Action for Health in Diabetes (Look AHEAD) research group
    Mark A Espeland
    Department of Biostatistical Sciences, Wake Forest University School of Medicine and Winston Salem, NC 27157, USA
    Ann Epidemiol 19:701-10. 2009
    ..To demonstrate how principal components analysis can be used to describe patterns of weight changes in response to an intensive lifestyle intervention...
  13. pmc Action for Health in Diabetes (Look AHEAD) trial: baseline evaluation of selected nutrients and food group intake
    Mara Z Vitolins
    Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27104, USA
    J Am Diet Assoc 109:1367-75. 2009
    ..Little has been reported regarding food and nutrient intake in individuals diagnosed with type 2 diabetes, and most reports have been based on findings in select groups or individuals who self-reported having diabetes...
  14. ncbi request reprint A functional polymorphism in the lymphotoxin-alpha gene is associated with carotid artery wall thickness: the Diabetes Heart Study
    Yongmei Liu
    Departments of Public Health Sciences bInternal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Eur J Cardiovasc Prev Rehabil 13:655-7. 2006
    ..We tested for an association between a functional polymorphism, LTA 252A/G, and common carotid artery intima-media thickness in 1088 siblings from 435 Diabetes Heart Study families...
  15. ncbi request reprint Coincident linkage of type 2 diabetes, metabolic syndrome, and measures of cardiovascular disease in a genome scan of the diabetes heart study
    Donald W Bowden
    Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Diabetes 55:1985-94. 2006
    ....
  16. ncbi request reprint Metabolic syndrome and cardiovascular disease in older people: The cardiovascular health study
    Ann Marie McNeill
    Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA
    J Am Geriatr Soc 54:1317-24. 2006
    ....
  17. ncbi request reprint Genome-wide linkage of plasma adiponectin reveals a major locus on chromosome 3q distinct from the adiponectin structural gene: the IRAS family study
    Xiuqing Guo
    Medical Genetics Institutes, Cedars Sinai Medical Center, 8700 Beverly Blvd, 665W, Los Angeles, CA 90048, USA
    Diabetes 55:1723-30. 2006
    ..Therefore, a quantitative trait locus at 3q27, likely distinct from the APM1 gene, contributes to the variation of plasma adiponectin levels in the Hispanic-American population...
  18. ncbi request reprint Progression of plasminogen activator inhibitor-1 and fibrinogen levels in relation to incident type 2 diabetes
    Andreas Festa
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
    Circulation 113:1753-9. 2006
    ..We studied in the Insulin Resistance Atherosclerosis Study the relation of incident diabetes to dynamic changes of plasminogen activator inhibitor-1 (PAI-1) and fibrinogen...
  19. ncbi request reprint The natural course of beta-cell function in nondiabetic and diabetic individuals: the Insulin Resistance Atherosclerosis Study
    Andreas Festa
    University of Texas Health Science Center, Department of Medicine, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Diabetes 55:1114-20. 2006
    ..Failure to increase insulin secretion led to IGT, and a decrease in insulin secretion led to overt diabetes. This data may have important implications for the prevention and treatment of type 2 diabetes...
  20. ncbi request reprint Genetic mapping of disposition index and acute insulin response loci on chromosome 11q. The Insulin Resistance Atherosclerosis Study (IRAS) Family Study
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabetes 55:911-8. 2006
    ..These detailed genetic analyses provide strong evidence of a DI locus on 11q in African-American pedigrees, with additional suggestive evidence of independent AIR loci in the same region...
  21. ncbi request reprint Physical activity, insulin sensitivity, and hypertension among US adults: findings from the Insulin Resistance Atherosclerosis Study
    Capri Gabrielle Foy
    Department of Public Health Sciences, School of Medicine, Wake Forest University, Winston Salem, NC 27104, USA
    Am J Epidemiol 163:921-8. 2006
    ..33, 95% CI: 0.26, 0.41). These results suggest that longitudinal studies are warranted to determine whether insulin sensitivity is a mediator of the relation between physical activity and hypertension...
  22. ncbi request reprint Variants of the CD40 gene but not of the CD40L gene are associated with coronary artery calcification in the Diabetes Heart Study (DHS)
    Kathryn P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am Heart J 151:706-11. 2006
    ..These processes are implicated in the development and progression of atherosclerosis. Animal models demonstrate that interruption of CD40/CD40L signaling produces a more fibrous and stable atherosclerotic lesion...
  23. ncbi request reprint Prediction of type 2 diabetes mellitus with alternative definitions of the metabolic syndrome: the Insulin Resistance Atherosclerosis Study
    Anthony J G Hanley
    Division of Clinical Epidemiology, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Circulation 112:3713-21. 2005
    ....
  24. ncbi request reprint Haplotypes in the lipoprotein lipase gene influence fasting insulin and discovery of a new risk haplotype
    Mark O Goodarzi
    Cedars Sinai Medical Center, Division of Endocrinology, Diabetes, and Metabolism, 8700 Beverly Boulevard, Becker B 131, Los Angeles, California 90048, USA
    J Clin Endocrinol Metab 92:293-6. 2007
    ..The most common haplotype (haplotype 1) was protective, whereas the fourth most common haplotype (haplotype 4) conferred risk for insulin resistance and atherosclerosis...
  25. ncbi request reprint Heritability and expression of C-reactive protein in type 2 diabetes in the Diabetes Heart Study
    Leslie A Lange
    Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Ann Hum Genet 70:717-25. 2006
    ..While the APOE locus shows evidence of contributing to CRP levels, no evidence of CRP gene polymorphism association with CRP levels was observed...
  26. ncbi request reprint Associations of adiponectin with body fat distribution and insulin sensitivity in nondiabetic Hispanics and African-Americans
    Anthony J G Hanley
    Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada M5S 3E2
    J Clin Endocrinol Metab 92:2665-71. 2007
    ....
  27. pmc Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetes
    Yongmei Liu
    Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, UAS
    Am J Kidney Dis 52:242-50. 2008
    ..These products can induce cell hypertrophy, cell proliferation, and extracellular matrix deposition, potentially leading to diabetic nephropathy...
  28. pmc Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African Americans
    Corinne D Engelman
    Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, 610 Walnut Street, 1007A WARF, Madison, Wisconsin 53726 2397, USA
    J Clin Endocrinol Metab 93:3381-8. 2008
    ..Vitamin D deficiency is associated with many adverse health outcomes, yet little is known about the genetic epidemiology of vitamin D or its metabolites...
  29. doi request reprint Abdominal adiposity and diabetes risk: the importance of precise measures and longitudinal studies
    Anthony J G Hanley
    University of Toronto, Department of Nutritional Sciences, Toronto, Ontario, Canada
    Diabetes 57:1153-5. 2008
  30. doi request reprint Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family Study
    Nicholette D Palmer
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabetes 57:1093-100. 2008
    ....
  31. doi request reprint Genome-wide admixture mapping for coronary artery calcification in African Americans: the NHLBI Family Heart Study
    Qunyuan Zhang
    Division of Statistical Genomics, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Genet Epidemiol 32:264-72. 2008
    ..On the basis of the results from this and other independent studies, the location of D6S1053 at 80cM on chromosome 6 (6q12) seems to harbor a highly promising quantitative trait loci for atherosclerosis...
  32. pmc Kidney volume associations with subclinical renal and cardiovascular disease: the Diabetes Heart Study
    Anita M Saran
    Department of Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Am J Nephrol 28:366-71. 2008
    ..The prognostic significance of total kidney volume (TKV) in subjects with type 2 diabetes mellitus (T2DM) is unknown...
  33. pmc Calcified atherosclerotic plaque and bone mineral density in type 2 diabetes: the diabetes heart study
    J Jeffrey Carr
    Department of Radiology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Bone 42:43-52. 2008
    ..QCT determined vBMD was more strongly related to CP than aBMD by DXA. The relation between CP and BMD in diabetes is influenced by age, sex, and ethnicity, with further effect modification by hormone replacement therapy...
  34. ncbi request reprint Whole-grain intake and carotid artery atherosclerosis in a multiethnic cohort: the Insulin Resistance Atherosclerosis Study
    Philip B Mellen
    Department of Internal Medicine, Section of General Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Clin Nutr 85:1495-502. 2007
    ..Whole-grain intake has been shown to be inversely associated with cardiovascular events, but an association with atherosclerosis is less well established...
  35. pmc Baseline characteristics of the randomised cohort from the Look AHEAD (Action for Health in Diabetes) study
    George Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Diab Vasc Dis Res 3:202-15. 2006
    ..5 years) of intensive weight loss intervention on the time to incidence of major cardiovascular events...
  36. ncbi request reprint Serum uric acid predicts incident hypertension in a biethnic cohort: the atherosclerosis risk in communities study
    Philip B Mellen
    Section of General Medicine, Department of Internal Medicine, Division of Public Health Sciences, Wake Forest University, Winston Salem, NC 27157, USA
    Hypertension 48:1037-42. 2006
    ..More research is warranted concerning the physiological and clinical consequences of hyperuricemia, especially in blacks...
  37. ncbi request reprint The relationship between C-reactive protein and subclinical cardiovascular disease in the Diabetes Heart Study (DHS)
    Donald W Bowden
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am Heart J 150:1032-8. 2005
    ..Epidemiological studies suggest that levels of C-reactive protein (CRP) predict cardiovascular disease (CVD). We have evaluated the relationship between CRP and subclinical CVD in a study cohort at high risk of CVD...
  38. ncbi request reprint Trends in racial disparities in care
    Barry I Freedman
    N Engl J Med 353:2081-5; author reply 2081-5. 2005
  39. ncbi request reprint Liver markers and development of the metabolic syndrome: the insulin resistance atherosclerosis study
    Anthony J G Hanley
    Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    Diabetes 54:3140-7. 2005
    ..In conclusion, NAFLD markers ALT and the AST-to-ALT ratio predict metabolic syndrome independently of potential confounding variables, including directly measured Si and AIR...
  40. ncbi request reprint Excess mortality related to diabetes mellitus in elderly Medicare beneficiaries
    Alain G Bertoni
    Department of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, NC, USA
    Ann Epidemiol 14:362-7. 2004
    ..To determine whether diabetes remains an important contributor to mortality among the elderly...
  41. ncbi request reprint Insulin sensitivity, body fat distribution, and family diabetes history: the IRAS Family Study
    Braxton D Mitchell
    University of Maryland School of Medicine, Division of Endocrinology, Diabetes, and Nutrition, 660 W Redwood Street, Room 492, Baltimore, MD 21201, USA
    Obes Res 12:831-9. 2004
    ..Whether diabetes family history (FH) also predicts visceral fat accumulation and, if so, whether the increased insulin resistance in relatives of diabetic subjects occurs independently of visceral fat accumulation are not known...
  42. ncbi request reprint Heritability of GFR and albuminuria in Caucasians with type 2 diabetes mellitus
    Carl D Langefeld
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Am J Kidney Dis 43:796-800. 2004
    ..Elevated urinary albumin excretion and decreased glomerular filtration rate (GFR) are risk factors for cardiovascular death and end-stage renal disease in individuals with type 2 diabetes mellitus (DM)...
  43. ncbi request reprint Linkage of the metabolic syndrome to 1q23-q31 in Hispanic families: the Insulin Resistance Atherosclerosis Study Family Study
    Carl D Langefeld
    Department of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157 1063, USA
    Diabetes 53:1170-4. 2004
    ..These results contribute to the growing evidence that chromosome 1q harbors at least one locus related to the metabolic precursors of diabetes...
  44. ncbi request reprint Site-specific progression of carotid artery intimal-medial thickness
    Mark A Espeland
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Atherosclerosis 171:137-43. 2003
    ..To characterize the intercorrelation of changes in intimal-medial thickness (IMT) among carotid artery sites and examine the influence of diabetes and sex on these correlations...
  45. ncbi request reprint Comparison of the associations of apolipoprotein B and low-density lipoprotein cholesterol with other cardiovascular risk factors in the Insulin Resistance Atherosclerosis Study (IRAS)
    Ken Williams
    Department of Medicine, University of Texas Health Science Center, San Antonio, USA
    Circulation 108:2312-6. 2003
    ..This study compares the associations of apolipoprotein B (apoB) and LDL cholesterol (LDLC) with a wide array of measures of these risk factors...
  46. ncbi request reprint Identification of subjects with insulin resistance and beta-cell dysfunction using alternative definitions of the metabolic syndrome
    Anthony J G Hanley
    Division of Clinical Epidemiology, University of Texas Health Sciences Center, San Antonio, Texas 78229 3900, USA
    Diabetes 52:2740-7. 2003
    ..The definitions are generally less useful for identifying those with low AIR or DI, although NCEP-MetS seems to differentiate black subjects with insulin secretion defects...
  47. ncbi request reprint Low insulin sensitivity (S(i) = 0) in diabetic and nondiabetic subjects in the insulin resistance atherosclerosis study: is it associated with components of the metabolic syndrome and nontraditional risk factors?
    Steven M Haffner
    Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
    Diabetes Care 26:2796-803. 2003
    ..To determine the meaning of S(i) = 0 derived from the frequently sampled intravenous glucose tolerance test...
  48. ncbi request reprint Minimal model-based insulin sensitivity has greater heritability and a different genetic basis than homeostasis model assessment or fasting insulin
    Richard N Bergman
    Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Diabetes 52:2168-74. 2003
    ..Thus S(I), a direct measure of insulin sensitivity, is determined more by genetic factors rather than measures such as HOMA, which reflect fasting insulin...
  49. ncbi request reprint Differences in LDL oxidizability by glycemic status: the insulin resistance atherosclerosis study
    Dawn C Schwenke
    Carl T Hayden Veterans Affairs Medical Center, Phoenix, Arizona 85012, USA
    Diabetes Care 26:1449-55. 2003
    ..To investigate differences in LDL oxidizability by glycemic status within the Insulin Resistance Atherosclerosis Study cohort...
  50. ncbi request reprint Genetic epidemiology of insulin resistance and visceral adiposity. The IRAS Family Study design and methods
    Leora Henkin
    Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Ann Epidemiol 13:211-7. 2003
    ..In this report, we describe the methods of the IRAS Family Study, which was designed to identify the genetic and environmental risk factors for insulin resistance and visceral adiposity...
  51. ncbi request reprint Prediction of type 2 diabetes using simple measures of insulin resistance: combined results from the San Antonio Heart Study, the Mexico City Diabetes Study, and the Insulin Resistance Atherosclerosis Study
    Anthony J G Hanley
    Division of Clinical Epidemiology, University of Texas Health Sciences Center, San Antonio 78229, USA
    Diabetes 52:463-9. 2003
    ..This index may reflect other aspects of diabetes pathogenesis in addition to IR, which might explain its strong predictive abilities despite its moderate correlation with direct measures of IR...
  52. ncbi request reprint Factor analysis of metabolic syndrome using directly measured insulin sensitivity: The Insulin Resistance Atherosclerosis Study
    Anthony J G Hanley
    Division of Clinical Epidemiology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Diabetes 51:2642-7. 2002
    ..Additional clarification of the physiologic characteristics of metabolic syndrome is required as individuals with this condition are increasingly being considered candidates for behavioral and pharmacologic intervention...
  53. ncbi request reprint Heritability of carotid artery intima-medial thickness in type 2 diabetes
    Leslie A Lange
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Stroke 33:1876-81. 2002
    ..We hypothesize that in families with multiple members having diabetes, carotid IMT is likely to be associated with both inherited and environmental factors...
  54. ncbi request reprint Metabolic and inflammation variable clusters and prediction of type 2 diabetes: factor analysis using directly measured insulin sensitivity
    Anthony J G Hanley
    Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, Mail Code 7873, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Diabetes 53:1773-81. 2004
    ..The findings support the emerging hypothesis that chronic subclinical inflammation is associated with insulin resistance and comprises a component of the metabolic syndrome...
  55. ncbi request reprint Identification of quantitative trait loci for glucose homeostasis: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study
    Stephen S Rich
    Department of Public Health Sciences, Wake Forest University School of Medicine, 3rd Floor, MRI Center, Winston Salem, NC 27157, USA
    Diabetes 53:1866-75. 2004
    ....
  56. ncbi request reprint Smoking and incidence of diabetes among U.S. adults: findings from the Insulin Resistance Atherosclerosis Study
    Capri Gabrielle Foy
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes Care 28:2501-7. 2005
    ..The objective of this study was to determine the association between smoking and incident diabetes among U.S. adults...
  57. ncbi request reprint The impact of pedigree structure on heritability estimates for pulse pressure in three studies
    Fang Chi Hsu
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hum Hered 60:63-72. 2005
    ....
  58. ncbi request reprint P-selectin gene haplotype associations with albuminuria in the Diabetes Heart Study
    Yongmei Liu
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Kidney Int 68:741-6. 2005
    ..We investigated the relationship between P-selectin gene polymorphisms and albuminuria in 565 European American siblings (84% with type 2 diabetes) from 227 families participating in the Diabetes Heart Study (DHS)...
  59. ncbi request reprint Nuclear magnetic resonance lipoprotein abnormalities in prediabetic subjects in the Insulin Resistance Atherosclerosis Study
    Andreas Festa
    Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229 3900, USA
    Circulation 111:3465-72. 2005
    ....
  60. ncbi request reprint The relationship between albuminuria and hormone therapy in postmenopausal women
    Mamta Agarwal
    Department of Internal Medicine Nephrology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Am J Kidney Dis 45:1019-25. 2005
    ..Elevated urinary albumin excretion and hormone therapy (HT) are associated with increased risk for cardiovascular events. We assessed the relationship between albuminuria and the use of hormonal preparations in postmenopausal women...
  61. ncbi request reprint Cosegregation of albuminuria and blood pressure: the Insulin Resistance Atherosclerosis (IRAS) family study
    Xiuqing Guo
    Cedars Sinai Medical Center, Los Angeles, California 90048, USA
    Am J Hypertens 18:823-7. 2005
    ..Our aim in this study was to examine the familial aggregation of albuminuria and its phenotypic, genetic, and environmental correlations with BP in nondiabetic individuals of Hispanic (HA) and African American (AA) ethnicity...
  62. ncbi request reprint Relation of the metabolic syndrome to calcified atherosclerotic plaque in the coronary arteries and aorta
    R Curtis Ellison
    Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    Am J Cardiol 95:1180-6. 2005
    ..We conclude that the metabolic syndrome and most of its components are associated with a higher prevalence of calcified atherosclerotic plaque in the coronary arteries and abdominal aorta in white and African-American men and women...
  63. ncbi request reprint Relationship between albuminuria and cardiovascular disease in Type 2 diabetes
    Barry I Freedman
    Department of Internal Medicine Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    J Am Soc Nephrol 16:2156-61. 2005
    ..004) and carotid artery calcium (P = 0.0004). Albuminuria is strongly associated with calcified plaque in the coronary and carotid arteries in white individuals with type 2 diabetes and relatively preserved renal function...
  64. ncbi request reprint T-786C polymorphism of the endothelial nitric oxide synthase gene is associated with albuminuria in the diabetes heart study
    Yongmei Liu
    Wake Forest University School of Medicine, Department of Public Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Am Soc Nephrol 16:1085-90. 2005
    ..The -786C eNOS variant was positively correlated with a higher prevalence and a greater degree of albuminuria in European American families in both diabetic and nondiabetic family members...
  65. ncbi request reprint Pericardial and visceral adipose tissues measured volumetrically with computed tomography are highly associated in type 2 diabetic families
    Guy L Wheeler
    Department of Radiology, University of Missouri Health Care, Columbia, Missouri, USA
    Invest Radiol 40:97-101. 2005
    ..We describe a new method for quantifying pericardial adipose tissue volumes with computed tomography (CT), and present its precision and relation to established measures of adiposity...
  66. ncbi request reprint A genome scan for fasting insulin and fasting glucose identifies a quantitative trait locus on chromosome 17p: the insulin resistance atherosclerosis study (IRAS) family study
    Stephen S Rich
    Department of Public Health Sciences, Wake Forest University School of Medicine, 3rd Floor MRI Center, Winston Salem, NC 27157, USA
    Diabetes 54:290-5. 2005
    ..Identifying genes in these regions should provide insight into the nature of genetic factors regulating plasma glucose and insulin concentrations...
  67. ncbi request reprint Epidemiological marker for oxidant status: comparison of the ELISA and the gas chromatography/mass spectrometry assay for urine 2,3-dinor-5,6-dihydro-15-F2t-isoprostane
    Dora Il'yasova
    Wake Forest University School of Medicine, Departments of Cancer Biology and Public Health Sciences, Winston Salem, NC 27157, USA
    Ann Epidemiol 14:793-7. 2004
    ..However, this method is laborious and costly, which prohibits its use in large epidemiological studies...
  68. ncbi request reprint Elevations in markers of liver injury and risk of type 2 diabetes: the insulin resistance atherosclerosis study
    Anthony J G Hanley
    Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, Mail Code 7873, 7703 Floyd Curl Dr, San Antonio, TX 78229 3900, USA
    Diabetes 53:2623-32. 2004
    ..In conclusion, AST and ALT independently predict type 2 diabetes. Baseline elevations of these markers may reflect NAFLD or related pathologies...
  69. ncbi request reprint Cardiovascular disease risk factors predict the development of type 2 diabetes: the insulin resistance atherosclerosis study
    RALPH B D'AGOSTINO
    Department of Public Health Science, Biostatistics Section, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Diabetes Care 27:2234-40. 2004
    ..Our objective was to determine whether the presence of CVD RFs predict the eventual development of diabetes after controlling for known RFs, such as directly measured insulin resistance and obesity...
  70. ncbi request reprint Increased proinsulin levels and decreased acute insulin response independently predict the incidence of type 2 diabetes in the insulin resistance atherosclerosis study
    Anthony J G Hanley
    Division of Clinical Epidemiology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas 78229 3900, USA
    Diabetes 51:1263-70. 2002
    ....

Research Grants13

  1. IRAS FAMILY STUDY--GENETICS OF INSULIN RESISTANCE
    Lynne Wagenknecht; Fiscal Year: 1999
    ..This project will contribute substantially to our understanding of the genetic determinants of insulin resistance, visceral adiposity, and, consequently to risk of atherosclerosis. ..
  2. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Lynne Wagenknecht; Fiscal Year: 2009
    ..abstract_text> ..
  3. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Lynne Wagenknecht; Fiscal Year: 2007
    ..abstract_text> ..
  4. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Lynne Wagenknecht; Fiscal Year: 2007
    ..abstract_text> ..
  5. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Lynne Wagenknecht; Fiscal Year: 2007
    ..abstract_text> ..
  6. GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASIS
    Lynne Wagenknecht; Fiscal Year: 2006
    ..abstract_text> ..
  7. GENCAC - North Carolina Field Center
    Lynne Wagenknecht; Fiscal Year: 2004
    ..This application corresponds to the GENCAC clinic submitted by the Wake Forest University School of Medicine as part of the GENCAC genetic epidemiology network. ..
  8. IRAS FAMILY STUDY--GENETICS OF INSULIN RESISTANCE
    Lynne Wagenknecht; Fiscal Year: 2003
    ..This project will contribute substantially to our understanding of the genetic determinants of insulin resistance, visceral adiposity, and, consequently to risk of atherosclerosis. ..
  9. IRAS FAMILY STUDY--GENETICS OF INSULIN RESISTANCE
    Lynne Wagenknecht; Fiscal Year: 2002
    ..This project will contribute substantially to our understanding of the genetic determinants of insulin resistance, visceral adiposity, and, consequently to risk of atherosclerosis. ..
  10. IRAS FAMILY STUDY--GENETICS OF INSULIN RESISTANCE
    Lynne Wagenknecht; Fiscal Year: 2001
    ..This project will contribute substantially to our understanding of the genetic determinants of insulin resistance, visceral adiposity, and, consequently to risk of atherosclerosis. ..
  11. IRAS FAMILY STUDY--GENETICS OF INSULIN RESISTANCE
    Lynne Wagenknecht; Fiscal Year: 2000
    ..This project will contribute substantially to our understanding of the genetic determinants of insulin resistance, visceral adiposity, and, consequently to risk of atherosclerosis. ..
  12. Genetic & Epidemiologic Predictors of Glucose Homeostasis Measures in Hispanics
    Richard M Watanabe; Fiscal Year: 2010
    ..The public health significance of this project is its contribution toward an improved understanding of type 2 diabetes, a highly prevalent condition. ..