Research Topics
Species | Lynne WagenknechtSummaryAffiliation: Wake Forest University School of Medicine Country: USA Publications
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Publications
Do inflammation and procoagulation biomarkers contribute to the metabolic syndrome cluster?Aldi T Kraja
Division of Statistical Genomics, Washington University School of Medicine, Saint Louis, MO, USA
Nutr Metab (Lond) 4:28. 2007..However, the relationship of inflammatory biomarkers to MetS is not clear...
Familial aggregation of coronary artery calcium in families with type 2 diabetesL E Wagenknecht
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1063, USA
Diabetes 50:861-6. 2001..In these data, CAC seems heritable and may serve as an important feature in designing studies to map genes contributing to both atherosclerosis and type 2 diabetes...- A comparison of risk factors for calcified atherosclerotic plaque in the coronary, carotid, and abdominal aortic arteries: the diabetes heart studyLynne E Wagenknecht
Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Am J Epidemiol 166:340-7. 2007..0001). In summary, CAPs of the coronary, carotid, and abdominal aortic arteries generally share common risk factors, even though several of these factors have a greater impact on CAP in one vascular bed than another... - Insulin sensitivity, insulin secretion, and abdominal fat: the Insulin Resistance Atherosclerosis Study (IRAS) Family StudyLynne E Wagenknecht
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Diabetes 52:2490-6. 2003..The fat measures explained 27% of the model R2 for SI, 16% for AIR, and 16% for DI. Thus, fat distribution is an important determinant of both insulin resistance and insulin secretion... 
Association of PNPLA3 with non-alcoholic fatty liver disease in a minority cohort: the Insulin Resistance Atherosclerosis Family StudyLynne E Wagenknecht
Division of Public Health Sciences, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157, USA
Liver Int 31:412-6. 2011..Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent condition, particularly among Hispanic Americans. A genetic variant in PNPLA3 (rs738409) has been identified as a strong predictor of hepatic fat content...- Association of adipose tissue deposition and beta-2 adrenergic receptor variants: the IRAS family studyL A Lange
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
Int J Obes (Lond) 29:449-57. 2005..We examined whether two common polymorphisms in codons 16 (Arg16Gly) and 27 (Gln27Glu) are associated with measures of fat distribution in participants of the IRAS Family Study... - Diabetes and progression of carotid atherosclerosis: the insulin resistance atherosclerosis studyLynne E Wagenknecht
Department of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1063, USA
Arterioscler Thromb Vasc Biol 23:1035-41. 2003..We sought to determine the rate of progression of carotid atherosclerosis in persons with normal glucose tolerance, impaired glucose tolerance, and undiagnosed and diagnosed type 2 diabetes... - Correlates of carotid plaque presence and composition as measured by MRI: the Atherosclerosis Risk in Communities StudyLynne Wagenknecht
Wake Forest University School of Medicine, Division of Public Health Sciences, Winston Salem, NC 27157, USA
Circ Cardiovasc Imaging 2:314-22. 2009..We hypothesized that traditional risk factors are predictors of carotid wall and plaque characteristics measured 2 decades later... - Correlates of coronary artery calcified plaque in blacks and whites with type 2 diabetesLynne E Wagenknecht
Division of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
Ann Epidemiol 21:34-41. 2011..To examine whether the relationship between cardiovascular disease risk factors and coronary artery calcification (CAC) is modified by race among those with diabetes... - Race-specific relationships between coronary and carotid artery calcification and carotid intimal medial thicknessLynne E Wagenknecht
Department of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1063, USA
Stroke 35:e97-9. 2004..Calcified arterial plaque has been proposed as a subclinical marker of atherosclerosis. We compared it to a well-validated surrogate--carotid intimal medial thickness (IMT)... - Constructing common cohorts from trials with overlapping eligibility criteria: implications for comparing effect sizes between trialsDavid L Mount
Wake Forest University School of Medicine, Winston Salem, NC, USA
Clin Trials 6:416-29. 2009..Comparing findings from separate trials is necessary to choose among treatment options, however differences among study cohorts may impede these comparisons... - Describing patterns of weight changes using principal components analysis: results from the Action for Health in Diabetes (Look AHEAD) research groupMark A Espeland
Department of Biostatistical Sciences, Wake Forest University School of Medicine and Winston Salem, NC 27157, USA
Ann Epidemiol 19:701-10. 2009..To demonstrate how principal components analysis can be used to describe patterns of weight changes in response to an intensive lifestyle intervention... - Action for Health in Diabetes (Look AHEAD) trial: baseline evaluation of selected nutrients and food group intakeMara Z Vitolins
Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27104, USA
J Am Diet Assoc 109:1367-75. 2009..Little has been reported regarding food and nutrient intake in individuals diagnosed with type 2 diabetes, and most reports have been based on findings in select groups or individuals who self-reported having diabetes... - A functional polymorphism in the lymphotoxin-alpha gene is associated with carotid artery wall thickness: the Diabetes Heart StudyYongmei Liu
Departments of Public Health Sciences bInternal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Eur J Cardiovasc Prev Rehabil 13:655-7. 2006..We tested for an association between a functional polymorphism, LTA 252A/G, and common carotid artery intima-media thickness in 1088 siblings from 435 Diabetes Heart Study families... - Coincident linkage of type 2 diabetes, metabolic syndrome, and measures of cardiovascular disease in a genome scan of the diabetes heart studyDonald W Bowden
Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Diabetes 55:1985-94. 2006.... - Metabolic syndrome and cardiovascular disease in older people: The cardiovascular health studyAnn Marie McNeill
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27514, USA
J Am Geriatr Soc 54:1317-24. 2006.... - Genome-wide linkage of plasma adiponectin reveals a major locus on chromosome 3q distinct from the adiponectin structural gene: the IRAS family studyXiuqing Guo
Medical Genetics Institutes, Cedars Sinai Medical Center, 8700 Beverly Blvd, 665W, Los Angeles, CA 90048, USA
Diabetes 55:1723-30. 2006..Therefore, a quantitative trait locus at 3q27, likely distinct from the APM1 gene, contributes to the variation of plasma adiponectin levels in the Hispanic-American population... - Progression of plasminogen activator inhibitor-1 and fibrinogen levels in relation to incident type 2 diabetesAndreas Festa
Department of Medicine, University of Texas Health Science Center, San Antonio, Texas, USA
Circulation 113:1753-9. 2006..These findings extend the current knowledge on the relation of fibrinolysis and coagulation abnormalities to the development of type 2 diabetes... - The natural course of beta-cell function in nondiabetic and diabetic individuals: the Insulin Resistance Atherosclerosis StudyAndreas Festa
University of Texas Health Science Center, Department of Medicine, 7703 Floyd Curl Dr, San Antonio, TX 78229-3900, USA
Diabetes 55:1114-20. 2006..Failure to increase insulin secretion led to IGT, and a decrease in insulin secretion led to overt diabetes. This data may have important implications for the prevention and treatment of type 2 diabetes... - Genetic mapping of disposition index and acute insulin response loci on chromosome 11q. The Insulin Resistance Atherosclerosis Study (IRAS) Family StudyNicholette D Palmer
Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
Diabetes 55:911-8. 2006..These detailed genetic analyses provide strong evidence of a DI locus on 11q in African-American pedigrees, with additional suggestive evidence of independent AIR loci in the same region... - Physical activity, insulin sensitivity, and hypertension among US adults: findings from the Insulin Resistance Atherosclerosis StudyCapri Gabrielle Foy
Department of Public Health Sciences, School of Medicine, Wake Forest University, Winston Salem, NC 27104, USA
Am J Epidemiol 163:921-8. 2006..33, 95% CI: 0.26, 0.41). These results suggest that longitudinal studies are warranted to determine whether insulin sensitivity is a mediator of the relation between physical activity and hypertension... - Variants of the CD40 gene but not of the CD40L gene are associated with coronary artery calcification in the Diabetes Heart Study (DHS)Kathryn P Burdon
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Am Heart J 151:706-11. 2006..These processes are implicated in the development and progression of atherosclerosis. Animal models demonstrate that interruption of CD40/CD40L signaling produces a more fibrous and stable atherosclerotic lesion... - Prediction of type 2 diabetes mellitus with alternative definitions of the metabolic syndrome: the Insulin Resistance Atherosclerosis StudyAnthony J G Hanley
Division of Clinical Epidemiology, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA
Circulation 112:3713-21. 2005..Modifications or additions to the NCEP metabolic syndrome definition had limited impact on the prediction of DM... - Haplotypes in the lipoprotein lipase gene influence fasting insulin and discovery of a new risk haplotypeMark O Goodarzi
Cedars Sinai Medical Center, Division of Endocrinology, Diabetes, and Metabolism, 8700 Beverly Boulevard, Becker B 131, Los Angeles, California 90048, USA
J Clin Endocrinol Metab 92:293-6. 2007..The most common haplotype (haplotype 1) was protective, whereas the fourth most common haplotype (haplotype 4) conferred risk for insulin resistance and atherosclerosis... - Heritability and expression of C-reactive protein in type 2 diabetes in the Diabetes Heart StudyLeslie A Lange
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Ann Hum Genet 70:717-25. 2006..While the APOE locus shows evidence of contributing to CRP levels, no evidence of CRP gene polymorphism association with CRP levels was observed... - Associations of adiponectin with body fat distribution and insulin sensitivity in nondiabetic Hispanics and African-AmericansAnthony J G Hanley
Department of Nutritional Sciences, University of Toronto, Toronto, Ontario, Canada M5S 3E2
J Clin Endocrinol Metab 92:2665-71. 2007.... - Association of arachidonate 12-lipoxygenase genotype variation and glycemic control with albuminuria in type 2 diabetesYongmei Liu
Division of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, UAS
Am J Kidney Dis 52:242-50. 2008..These products can induce cell hypertrophy, cell proliferation, and extracellular matrix deposition, potentially leading to diabetic nephropathy... - Genetic and environmental determinants of 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D levels in Hispanic and African AmericansCorinne D Engelman
Department of Population Health Sciences, University of Wisconsin School of Medicine and Public Health, 610 Walnut Street, 1007A WARF, Madison, Wisconsin 53726 2397, USA
J Clin Endocrinol Metab 93:3381-8. 2008..Vitamin D deficiency is associated with many adverse health outcomes, yet little is known about the genetic epidemiology of vitamin D or its metabolites... - Abdominal adiposity and diabetes risk: the importance of precise measures and longitudinal studiesAnthony J G Hanley
University of Toronto, Department of Nutritional Sciences, Toronto, Ontario, Canada
Diabetes 57:1153-5. 2008 - Quantitative trait analysis of type 2 diabetes susceptibility loci identified from whole genome association studies in the Insulin Resistance Atherosclerosis Family StudyNicholette D Palmer
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Diabetes 57:1093-100. 2008.... - Genome-wide admixture mapping for coronary artery calcification in African Americans: the NHLBI Family Heart StudyQunyuan Zhang
Division of Statistical Genomics, Washington University School of Medicine, St Louis, Missouri 63108, USA
Genet Epidemiol 32:264-72. 2008..On the basis of the results from this and other independent studies, the location of D6S1053 at 80cM on chromosome 6 (6q12) seems to harbor a highly promising quantitative trait loci for atherosclerosis... - Kidney volume associations with subclinical renal and cardiovascular disease: the Diabetes Heart StudyAnita M Saran
Department of Internal Medicine Nephrology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
Am J Nephrol 28:366-71. 2008..The prognostic significance of total kidney volume (TKV) in subjects with type 2 diabetes mellitus (T2DM) is unknown... - Calcified atherosclerotic plaque and bone mineral density in type 2 diabetes: the diabetes heart studyJ Jeffrey Carr
Department of Radiology, Wake Forest University School of Medicine, Winston Salem, NC, USA
Bone 42:43-52. 2008..QCT determined vBMD was more strongly related to CP than aBMD by DXA. The relation between CP and BMD in diabetes is influenced by age, sex, and ethnicity, with further effect modification by hormone replacement therapy... - Whole-grain intake and carotid artery atherosclerosis in a multiethnic cohort: the Insulin Resistance Atherosclerosis StudyPhilip B Mellen
Department of Internal Medicine, Section of General Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Am J Clin Nutr 85:1495-502. 2007..Whole-grain intake has been shown to be inversely associated with cardiovascular events, but an association with atherosclerosis is less well established... - Baseline characteristics of the randomised cohort from the Look AHEAD (Action for Health in Diabetes) studyGeorge Bray
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Diab Vasc Dis Res 3:202-15. 2006..5 years) of intensive weight loss intervention on the time to incidence of major cardiovascular events... - Serum uric acid predicts incident hypertension in a biethnic cohort: the atherosclerosis risk in communities studyPhilip B Mellen
Section of General Medicine, Department of Internal Medicine, Division of Public Health Sciences, Wake Forest University, Winston Salem, NC 27157, USA
Hypertension 48:1037-42. 2006..More research is warranted concerning the physiological and clinical consequences of hyperuricemia, especially in blacks... - The relationship between C-reactive protein and subclinical cardiovascular disease in the Diabetes Heart Study (DHS)Donald W Bowden
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Am Heart J 150:1032-8. 2005..Epidemiological studies suggest that levels of C-reactive protein (CRP) predict cardiovascular disease (CVD). We have evaluated the relationship between CRP and subclinical CVD in a study cohort at high risk of CVD... - Trends in racial disparities in careBarry I Freedman
N Engl J Med 353:2081-5; author reply 2081-5. 2005 - Liver markers and development of the metabolic syndrome: the insulin resistance atherosclerosis studyAnthony J G Hanley
Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
Diabetes 54:3140-7. 2005..In conclusion, NAFLD markers ALT and the AST-to-ALT ratio predict metabolic syndrome independently of potential confounding variables, including directly measured Si and AIR... - Excess mortality related to diabetes mellitus in elderly Medicare beneficiariesAlain G Bertoni
Department of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, NC, USA
Ann Epidemiol 14:362-7. 2004..To determine whether diabetes remains an important contributor to mortality among the elderly... - Insulin sensitivity, body fat distribution, and family diabetes history: the IRAS Family StudyBraxton D Mitchell
University of Maryland School of Medicine, Division of Endocrinology, Diabetes, and Nutrition, 660 W Redwood Street, Room 492, Baltimore, MD 21201, USA
Obes Res 12:831-9. 2004..Whether diabetes family history (FH) also predicts visceral fat accumulation and, if so, whether the increased insulin resistance in relatives of diabetic subjects occurs independently of visceral fat accumulation are not known... - Heritability of GFR and albuminuria in Caucasians with type 2 diabetes mellitusCarl D Langefeld
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1053, USA
Am J Kidney Dis 43:796-800. 2004..Given their biological and clinical importance and the similarity of these estimates with other cardiovascular disease- and DM-related traits, efforts to map genes that influence GFR and urine ACR levels should have increased importance... - Linkage of the metabolic syndrome to 1q23-q31 in Hispanic families: the Insulin Resistance Atherosclerosis Study Family StudyCarl D Langefeld
Department of Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157 1063, USA
Diabetes 53:1170-4. 2004..These results contribute to the growing evidence that chromosome 1q harbors at least one locus related to the metabolic precursors of diabetes... - Site-specific progression of carotid artery intimal-medial thicknessMark A Espeland
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Atherosclerosis 171:137-43. 2003..To characterize the intercorrelation of changes in intimal-medial thickness (IMT) among carotid artery sites and examine the influence of diabetes and sex on these correlations... - Comparison of the associations of apolipoprotein B and low-density lipoprotein cholesterol with other cardiovascular risk factors in the Insulin Resistance Atherosclerosis Study (IRAS)Ken Williams
Department of Medicine, University of Texas Health Science Center, San Antonio, USA
Circulation 108:2312-6. 2003..This may provide new insight into why apoB is a better predictor of vascular risk than LDLC... - Identification of subjects with insulin resistance and beta-cell dysfunction using alternative definitions of the metabolic syndromeAnthony J G Hanley
Division of Clinical Epidemiology, University of Texas Health Sciences Center, San Antonio, Texas 78229-3900, USA
Diabetes 52:2740-7. 2003..The definitions are generally less useful for identifying those with low AIR or DI, although NCEP-MetS seems to differentiate black subjects with insulin secretion defects... - Low insulin sensitivity (S(i) = 0) in diabetic and nondiabetic subjects in the insulin resistance atherosclerosis study: is it associated with components of the metabolic syndrome and nontraditional risk factors?Steven M Haffner
Department of Medicine, University of Texas Health Science Center, San Antonio, Texas 78229 3900, USA
Diabetes Care 26:2796-803. 2003..To determine the meaning of S(i) = 0 derived from the frequently sampled intravenous glucose tolerance test... - Minimal model-based insulin sensitivity has greater heritability and a different genetic basis than homeostasis model assessment or fasting insulinRichard N Bergman
Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Diabetes 52:2168-74. 2003..Thus S(I), a direct measure of insulin sensitivity, is determined more by genetic factors rather than measures such as HOMA, which reflect fasting insulin... - Differences in LDL oxidizability by glycemic status: the insulin resistance atherosclerosis studyDawn C Schwenke
Carl T Hayden Veterans Affairs Medical Center, Phoenix, Arizona 85012, USA
Diabetes Care 26:1449-55. 2003..To investigate differences in LDL oxidizability by glycemic status within the Insulin Resistance Atherosclerosis Study cohort... - Genetic epidemiology of insulin resistance and visceral adiposity. The IRAS Family Study design and methodsLeora Henkin
Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Ann Epidemiol 13:211-7. 2003..In this report, we describe the methods of the IRAS Family Study, which was designed to identify the genetic and environmental risk factors for insulin resistance and visceral adiposity... - Prediction of type 2 diabetes using simple measures of insulin resistance: combined results from the San Antonio Heart Study, the Mexico City Diabetes Study, and the Insulin Resistance Atherosclerosis StudyAnthony J G Hanley
Division of Clinical Epidemiology, University of Texas Health Sciences Center, San Antonio 78229, USA
Diabetes 52:463-9. 2003..This index may reflect other aspects of diabetes pathogenesis in addition to IR, which might explain its strong predictive abilities despite its moderate correlation with direct measures of IR... - Factor analysis of metabolic syndrome using directly measured insulin sensitivity: The Insulin Resistance Atherosclerosis StudyAnthony J G Hanley
Division of Clinical Epidemiology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas 78229-3900, USA
Diabetes 51:2642-7. 2002..Additional clarification of the physiologic characteristics of metabolic syndrome is required as individuals with this condition are increasingly being considered candidates for behavioral and pharmacologic intervention... - Heritability of carotid artery intima-medial thickness in type 2 diabetesLeslie A Lange
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
Stroke 33:1876-81. 2002..CONCLUSIONS: These data provide empirical evidence that subclinical cardiovascular disease has a significant genetic component and merits a search for the genes involved in susceptibility to the atherosclerotic complications of diabetes... - Metabolic and inflammation variable clusters and prediction of type 2 diabetes: factor analysis using directly measured insulin sensitivityAnthony J G Hanley
Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, Mail Code 7873, 7703 Floyd Curl Dr, San Antonio, TX 78229-3900, USA
Diabetes 53:1773-81. 2004..The findings support the emerging hypothesis that chronic subclinical inflammation is associated with insulin resistance and comprises a component of the metabolic syndrome... - Identification of quantitative trait loci for glucose homeostasis: the Insulin Resistance Atherosclerosis Study (IRAS) Family StudyStephen S Rich
Department of Public Health Sciences, Wake Forest University School of Medicine, 3rd Floor, MRI Center, Winston Salem, NC 27157, USA
Diabetes 53:1866-75. 2004.... - Smoking and incidence of diabetes among U.S. adults: findings from the Insulin Resistance Atherosclerosis StudyCapri Gabrielle Foy
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Diabetes Care 28:2501-7. 2005..The objective of this study was to determine the association between smoking and incident diabetes among U.S. adults... - The impact of pedigree structure on heritability estimates for pulse pressure in three studiesFang Chi Hsu
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Hum Hered 60:63-72. 2005.... - P-selectin gene haplotype associations with albuminuria in the Diabetes Heart StudyYongmei Liu
Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Kidney Int 68:741-6. 2005..We investigated the relationship between P-selectin gene polymorphisms and albuminuria in 565 European American siblings (84% with type 2 diabetes) from 227 families participating in the Diabetes Heart Study (DHS)... - Nuclear magnetic resonance lipoprotein abnormalities in prediabetic subjects in the Insulin Resistance Atherosclerosis StudyAndreas Festa
Department of Medicine, University of Texas Health Science Center, San Antonio, TX 78229-3900, USA
Circulation 111:3465-72. 2005..These findings extend previous work indicating a proatherogenic state in healthy, nondiabetic subjects who subsequently develop diabetes... - The relationship between albuminuria and hormone therapy in postmenopausal womenMamta Agarwal
Department of Internal Medicine Nephrology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
Am J Kidney Dis 45:1019-25. 2005..Elevated urinary albumin excretion and hormone therapy (HT) are associated with increased risk for cardiovascular events. We assessed the relationship between albuminuria and the use of hormonal preparations in postmenopausal women... - Cosegregation of albuminuria and blood pressure: the Insulin Resistance Atherosclerosis (IRAS) family studyXiuqing Guo
Cedars Sinai Medical Center, Los Angeles, California 90048, USA
Am J Hypertens 18:823-7. 2005..Our aim in this study was to examine the familial aggregation of albuminuria and its phenotypic, genetic, and environmental correlations with BP in nondiabetic individuals of Hispanic (HA) and African American (AA) ethnicity... - Relation of the metabolic syndrome to calcified atherosclerotic plaque in the coronary arteries and aortaR Curtis Ellison
Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts 02118, USA
Am J Cardiol 95:1180-6. 2005..We conclude that the metabolic syndrome and most of its components are associated with a higher prevalence of calcified atherosclerotic plaque in the coronary arteries and abdominal aorta in white and African-American men and women... - Relationship between albuminuria and cardiovascular disease in Type 2 diabetesBarry I Freedman
Department of Internal Medicine Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
J Am Soc Nephrol 16:2156-61. 2005..004) and carotid artery calcium (P = 0.0004). Albuminuria is strongly associated with calcified plaque in the coronary and carotid arteries in white individuals with type 2 diabetes and relatively preserved renal function... - T-786C polymorphism of the endothelial nitric oxide synthase gene is associated with albuminuria in the diabetes heart studyYongmei Liu
Wake Forest University School of Medicine, Department of Public Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
J Am Soc Nephrol 16:1085-90. 2005..The -786C eNOS variant was positively correlated with a higher prevalence and a greater degree of albuminuria in European American families in both diabetic and nondiabetic family members... - Pericardial and visceral adipose tissues measured volumetrically with computed tomography are highly associated in type 2 diabetic familiesGuy L Wheeler
Department of Radiology, University of Missouri Health Care, Columbia, Missouri, USA
Invest Radiol 40:97-101. 2005.... - A genome scan for fasting insulin and fasting glucose identifies a quantitative trait locus on chromosome 17p: the insulin resistance atherosclerosis study (IRAS) family studyStephen S Rich
Department of Public Health Sciences, Wake Forest University School of Medicine, 3rd Floor MRI Center, Winston Salem, NC 27157, USA
Diabetes 54:290-5. 2005..Identifying genes in these regions should provide insight into the nature of genetic factors regulating plasma glucose and insulin concentrations... - Epidemiological marker for oxidant status: comparison of the ELISA and the gas chromatography/mass spectrometry assay for urine 2,3-dinor-5,6-dihydro-15-F2t-isoprostaneDora Il'yasova
Wake Forest University School of Medicine, Departments of Cancer Biology and Public Health Sciences, Winston Salem, NC 27157, USA
Ann Epidemiol 14:793-7. 2004..However, this method is laborious and costly, which prohibits its use in large epidemiological studies... - Elevations in markers of liver injury and risk of type 2 diabetes: the insulin resistance atherosclerosis studyAnthony J G Hanley
Division of Clinical Epidemiology, University of Texas Health Science Center at San Antonio, Mail Code 7873, 7703 Floyd Curl Dr, San Antonio, TX 78229-3900, USA
Diabetes 53:2623-32. 2004..In conclusion, AST and ALT independently predict type 2 diabetes. Baseline elevations of these markers may reflect NAFLD or related pathologies... - Cardiovascular disease risk factors predict the development of type 2 diabetes: the insulin resistance atherosclerosis studyRALPH B D'AGOSTINO
Department of Public Health Science, Biostatistics Section, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Diabetes Care 27:2234-40. 2004..Our objective was to determine whether the presence of CVD RFs predict the eventual development of diabetes after controlling for known RFs, such as directly measured insulin resistance and obesity... - Increased proinsulin levels and decreased acute insulin response independently predict the incidence of type 2 diabetes in the insulin resistance atherosclerosis studyAnthony J G Hanley
Division of Clinical Epidemiology, University of Texas Health Sciences Center at San Antonio, San Antonio, Texas 78229-3900, USA
Diabetes 51:1263-70. 2002....
Research Grants
- GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASISLynne Wagenknecht; Fiscal Year: 2009..abstract_text> ..
- GENETICS OF ADIPOSITY AND GLUCOSE HOMEOSTASISLynne Wagenknecht; Fiscal Year: 2007..abstract_text> ..
- GENCAC - North Carolina Field CenterLynne Wagenknecht; Fiscal Year: 2004..This application corresponds to the GENCAC clinic submitted by the Wake Forest University School of Medicine as part of the GENCAC genetic epidemiology network. ..
- IRAS FAMILY STUDY--GENETICS OF INSULIN RESISTANCELynne Wagenknecht; Fiscal Year: 2003..This project will contribute substantially to our understanding of the genetic determinants of insulin resistance, visceral adiposity, and, consequently to risk of atherosclerosis. ..
- Genetic & Epidemiologic Predictors of Glucose Homeostasis Measures in HispanicsRichard M Watanabe; Fiscal Year: 2010..The public health significance of this project is its contribution toward an improved understanding of type 2 diabetes, a highly prevalent condition. ..