L E Wagenknecht

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Impaired glucose tolerance, type 2 diabetes, and carotid wall thickness: the Insulin Resistance Atherosclerosis Study
    L E Wagenknecht
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Diabetes Care 21:1812-8. 1998
  2. pmc Implication of European-derived adiposity loci in African Americans
    J M Hester
    Center for Diabetes Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Int J Obes (Lond) 36:465-73. 2012
  3. doi request reprint Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort
    M R Wing
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Int J Obes (Lond) 35:1173-82. 2011
  4. doi request reprint Genetic epidemiology of subclinical cardiovascular disease in the diabetes heart study
    D W Bowden
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, 27157, USA
    Ann Hum Genet 72:598-610. 2008
  5. ncbi request reprint Duration of diabetes and carotid wall thickness. The Insulin Resistance Atherosclerosis Study (IRAS)
    L E Wagenknecht
    Department of Public Health Sciences, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, NC 27157, USA
    Stroke 28:999-1005. 1997
  6. ncbi request reprint Familial aggregation of coronary artery calcium in families with type 2 diabetes
    L E Wagenknecht
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1063, USA
    Diabetes 50:861-6. 2001
  7. ncbi request reprint Cigarette smoking and progression of atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Study
    G Howard
    Department of Public Health Sciences of Wake Forest University, Winston Salem, NC 27157 1063, USA
    JAMA 279:119-24. 1998
  8. ncbi request reprint Association analysis of genes in the renin-angiotensin system with subclinical cardiovascular disease in families with Type 2 diabetes mellitus: the Diabetes Heart Study
    K P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabet Med 23:228-34. 2006
  9. ncbi request reprint Hormone replacement therapy is associated with increased C-reactive protein in women with Type 2 diabetes in the Diabetes Heart Study
    D W Bowden
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabet Med 23:763-7. 2006
  10. ncbi request reprint Ability of alternative indices of insulin sensitivity to predict cardiovascular risk: comparison with the "minimal model". Insulin Resistance Atherosclerosis Study (IRAS) Investigators
    G Howard
    Department of Public Health Sciences, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, NC, USA
    Ann Epidemiol 8:358-69. 1998

Detail Information

Publications23

  1. ncbi request reprint Impaired glucose tolerance, type 2 diabetes, and carotid wall thickness: the Insulin Resistance Atherosclerosis Study
    L E Wagenknecht
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Diabetes Care 21:1812-8. 1998
    ..To assess whether people with impaired glucose tolerance (IGT) exhibit an increased risk of atherosclerosis as measured by the thickness of the carotid artery...
  2. pmc Implication of European-derived adiposity loci in African Americans
    J M Hester
    Center for Diabetes Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Int J Obes (Lond) 36:465-73. 2012
    ..Limited study of these loci has been reported in African Americans. Here we examined the effects of these previously identified adiposity loci in African Americans...
  3. doi request reprint Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort
    M R Wing
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Int J Obes (Lond) 35:1173-82. 2011
    ..This cohort provides the unique ability to evaluate how variation within FTO influences measures of adiposity and glucose homeostasis in three different ethnicities, which were ascertained and examined using a common protocol...
  4. doi request reprint Genetic epidemiology of subclinical cardiovascular disease in the diabetes heart study
    D W Bowden
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, 27157, USA
    Ann Hum Genet 72:598-610. 2008
    ..Additional loci on chromosomes 1, 2, 7, 10, 13, and 21 had LODs > 2.0. The identification of trait-determining polymorphisms underlying these linkages will help delineate risk factors for CVD in T2DM and the general population...
  5. ncbi request reprint Duration of diabetes and carotid wall thickness. The Insulin Resistance Atherosclerosis Study (IRAS)
    L E Wagenknecht
    Department of Public Health Sciences, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, NC 27157, USA
    Stroke 28:999-1005. 1997
    ..Diabetes is a major risk factor for morbidity and mortality from cardiovascular disease. However, the role of the primary metabolic abnormality of diabetes (chronic hyperglycemia) in this disease process has not been fully elucidated...
  6. ncbi request reprint Familial aggregation of coronary artery calcium in families with type 2 diabetes
    L E Wagenknecht
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1063, USA
    Diabetes 50:861-6. 2001
    ..In these data, CAC seems heritable and may serve as an important feature in designing studies to map genes contributing to both atherosclerosis and type 2 diabetes...
  7. ncbi request reprint Cigarette smoking and progression of atherosclerosis: The Atherosclerosis Risk in Communities (ARIC) Study
    G Howard
    Department of Public Health Sciences of Wake Forest University, Winston Salem, NC 27157 1063, USA
    JAMA 279:119-24. 1998
    ..Cigarette smoking is a powerful risk factor for incident heart disease and stroke, but the relationship of active and passive smoking with the progression of atherosclerosis has not been described...
  8. ncbi request reprint Association analysis of genes in the renin-angiotensin system with subclinical cardiovascular disease in families with Type 2 diabetes mellitus: the Diabetes Heart Study
    K P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabet Med 23:228-34. 2006
    ....
  9. ncbi request reprint Hormone replacement therapy is associated with increased C-reactive protein in women with Type 2 diabetes in the Diabetes Heart Study
    D W Bowden
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Diabet Med 23:763-7. 2006
    ..The aim of this study was to determine the influence of HRT on women with diabetes in a large cross-sectional study...
  10. ncbi request reprint Ability of alternative indices of insulin sensitivity to predict cardiovascular risk: comparison with the "minimal model". Insulin Resistance Atherosclerosis Study (IRAS) Investigators
    G Howard
    Department of Public Health Sciences, Bowman Gray School of Medicine of Wake Forest University, Winston Salem, NC, USA
    Ann Epidemiol 8:358-69. 1998
    ..This report evaluates previously described alternative indices of insulin sensitivity with the goal of identifying a reliable, but logistically simpler, alternative...
  11. ncbi request reprint The impact of ethnicity and sex on subclinical cardiovascular disease: the Diabetes Heart Study
    B I Freedman
    Wake Forest University School of Medicine, Department of Internal Medicine Section on Nephrology, Medical Center Boulevard, 27157 1053, Winston Salem, NC 27157 1053, USA
    Diabetologia 48:2511-8. 2005
    ..We evaluated whether ethnic differences in subclinical cardiovascular disease, coronary and carotid artery calcified plaque and carotid artery intima-medial thickness (IMT) were present in members of The Diabetes Heart Study families...
  12. ncbi request reprint Genetic mapping of a 17q chromosomal region linked to obesity phenotypes in the IRAS family study
    B S Sutton
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Int J Obes (Lond) 30:1433-41. 2006
    ..In the IRAS Family Study a genomewide scan was performed on 1425 individuals of Hispanic descent (90 extended pedigree families) to identify regions of the genome linked to obesity phenotypes...
  13. pmc Association of PNPLA3 SNP rs738409 with liver density in African Americans with type 2 diabetes mellitus
    A J Cox
    Center for Human Genomics, Wake Forest School of Medicine, Winston Salem, NC, USA
    Diabetes Metab 37:452-5. 2011
    ..This association remains to be investigated in African Americans with T2DM, a group at lower risk for hepatic steatosis relative to European Americans with T2DM...
  14. doi request reprint Genome-wide linkage scans for renal function and albuminuria in Type 2 diabetes mellitus: the Diabetes Heart Study
    B I Freedman
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1053, USA
    Diabet Med 25:268-76. 2008
    ..We performed a genome-wide linkage scan in 416 Diabetes Heart Study (DHS) families to detect loci that contributed to renal function and albuminuria...
  15. ncbi request reprint Cigarette smoking and other risk factors for silent cerebral infarction in the general population
    G Howard
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Stroke 29:913-7. 1998
    ..This report focuses on the role of cigarette smoking and other risk factors for SCI in the general population...
  16. ncbi request reprint Lipoprotein concentrations and carotid atherosclerosis by diabetes status: results from the Insulin Resistance Atherosclerosis Study
    D C Goff
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Diabetes Care 23:1006-11. 2000
    ..The relative strength of these associations could differ by diabetes status as a result of diabetes-related lipoprotein modifications...
  17. ncbi request reprint Association of adipose tissue deposition and beta-2 adrenergic receptor variants: the IRAS family study
    L A Lange
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Int J Obes (Lond) 29:449-57. 2005
    ..We examined whether two common polymorphisms in codons 16 (Arg16Gly) and 27 (Gln27Glu) are associated with measures of fat distribution in participants of the IRAS Family Study...
  18. ncbi request reprint Ten-year trends in cigarette smoking among young adults, 1986-1996: the CARDIA study. Coronary Artery Risk Development In Young Adults
    L E Wagenknecht
    Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Ann Epidemiol 8:301-7. 1998
    ..To calculate ten-year smoking trends in a longitudinal cohort of young adults, and to characterize trends by race, sex, education, and birth cohort...
  19. ncbi request reprint Cross-sectional correlates of fasting hyperinsulinaemia in post-menopausal women of different ethnic origin
    A D Pradhan
    Division of Preventive Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Diabet Med 23:77-85. 2006
    ..In a large ethnically diverse nationwide sample of post-menopausal women we explored the relationship between fasting insulin levels, ethnicity, and a wide range of anthropometric, socio-economic, and lifestyle factors...
  20. pmc Association of genes of lipid metabolism with measures of subclinical cardiovascular disease in the Diabetes Heart Study
    K P Burdon
    J Med Genet 42:720-4. 2005
    ..Dyslipidaemia is a well known risk factor for cardiovascular disease (CVD). Lipid metabolism is affected by a range of genes and proteins. This study investigated whether some of these genes are associated with measures of subclinical CVD...
  21. ncbi request reprint Quantitative trait loci for abdominal fat and BMI in Hispanic-Americans and African-Americans: the IRAS Family study
    J M Norris
    Department of Preventive Medicine and Biometrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Int J Obes (Lond) 29:67-77. 2005
    ..To conduct linkage analysis for body mass index (BMI, kg/m2), waist-to-hip ratio (WHR), visceral adipose tissue mass (VAT, cm2) and subcutaneous adipose tissue mass (SAT, cm2) using a whole genome scan...
  22. ncbi request reprint Abdominal obesity predicts declining insulin sensitivity in non-obese normoglycaemics: the Insulin Resistance Atherosclerosis Study (IRAS)
    A J Karter
    Kaiser Permanente, Division of Research, Northern California Region, Oakland, CA, USA
    Diabetes Obes Metab 7:230-8. 2005
    ..Cross-sectional studies have demonstrated a relationship between obesity and insulin sensitivity (S(I)); however, there is a lack of evidence from longitudinal studies...
  23. ncbi request reprint Insulin resistance and weight gain in postmenopausal women of diverse ethnic groups
    B V Howard
    MedStar Research Institute, Washington, DC 20783, USA
    Int J Obes Relat Metab Disord 28:1039-47. 2004
    ..This study was conducted to examine the influence of insulin resistance on weight change in postmenopausal women of various ethnic groups...