Jasmina Varagic

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. doi request reprint ACE2: angiotensin II/angiotensin-(1-7) balance in cardiac and renal injury
    Jasmina Varagic
    Hypertension and Vascular Research Center, Division of Surgical Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC, 27157, USA
    Curr Hypertens Rep 16:420. 2014
  2. pmc Predominance of AT(1) blockade over mas-mediated angiotensin-(1-7) mechanisms in the regulation of blood pressure and renin-angiotensin system in mRen2.Lewis rats
    Jasmina Varagic
    Hypertension and Vascular Research Center, Wake Forest University, Winston Salem, NC, USA
    Am J Hypertens 26:583-90. 2013
  3. ncbi request reprint AT1 receptor antagonism attenuates target organ effects of salt excess in SHRs without affecting pressure
    Jasmina Varagic
    Hypertension Research Laboratory, Ochsner Clinic Foundation, New Orleans, Louisiana, USA
    Am J Physiol Heart Circ Physiol 294:H853-8. 2008
  4. pmc Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction
    Jasmina Varagic
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Ther Adv Cardiovasc Dis 4:17-25. 2010
  5. pmc New angiotensins
    Jasmina Varagic
    The Hypertension and Vascular Research Center, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Mol Med (Berl) 86:663-71. 2008
  6. pmc Salt-induced renal injury in spontaneously hypertensive rats: effects of nebivolol
    Jasmina Varagic
    Hypertension and Vascular Research Center, Wake Forest University, Winston Salem, NC 27157, USA
    Am J Nephrol 32:557-66. 2010
  7. pmc Hemodynamic and hormonal changes to dual renin-angiotensin system inhibition in experimental hypertension
    Norihito Moniwa
    Division of Surgical Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hypertension 61:417-24. 2013
  8. pmc Differential regulation of angiotensin-(1-12) in plasma and cardiac tissue in response to bilateral nephrectomy
    Carlos M Ferrario
    The Hypertension and Vascular Research Center, Wake Forest Univ School of Medicine, Winston Salem, NC 27157, USA
    Am J Physiol Heart Circ Physiol 296:H1184-92. 2009
  9. doi request reprint Cardiovascular effects of inhibition of renin-angiotensin-aldosterone system components in hypertensive rats given salt excess
    Dinko Susic
    Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Am J Physiol Heart Circ Physiol 298:H1177-81. 2010
  10. pmc Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats
    Aaron J Trask
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Hypertens 23:687-93. 2010

Detail Information

Publications39

  1. doi request reprint ACE2: angiotensin II/angiotensin-(1-7) balance in cardiac and renal injury
    Jasmina Varagic
    Hypertension and Vascular Research Center, Division of Surgical Sciences, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC, 27157, USA
    Curr Hypertens Rep 16:420. 2014
    ..We also review recent proceedings on novel therapeutic approaches to enhance ACE2/angiotensin-(1-7) axis. ..
  2. pmc Predominance of AT(1) blockade over mas-mediated angiotensin-(1-7) mechanisms in the regulation of blood pressure and renin-angiotensin system in mRen2.Lewis rats
    Jasmina Varagic
    Hypertension and Vascular Research Center, Wake Forest University, Winston Salem, NC, USA
    Am J Hypertens 26:583-90. 2013
    ..We investigated whether the antihypertensive actions of the angiotensin II (Ang II) receptor (AT(1)-R) blocker, olmesartan medoxomil, may in part be mediated by increased Ang-(1-7) in the absence of significant changes in plasma Ang II...
  3. ncbi request reprint AT1 receptor antagonism attenuates target organ effects of salt excess in SHRs without affecting pressure
    Jasmina Varagic
    Hypertension Research Laboratory, Ochsner Clinic Foundation, New Orleans, Louisiana, USA
    Am J Physiol Heart Circ Physiol 294:H853-8. 2008
    ..These data clearly demonstrated that angiotensin II (via AT(1) receptors), at least in part, participated importantly in the pressure-independent effects of salt excess on target organ damage of hypertension...
  4. pmc Decreased cardiac Ang-(1-7) is associated with salt-induced cardiac remodeling and dysfunction
    Jasmina Varagic
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Ther Adv Cardiovasc Dis 4:17-25. 2010
    ..Therefore, the present study examined the changes in cardiac angiotensin-(1-7), its forming enzyme angiotensin converting enzyme 2 (ACE2) and receptor mas in response to a high salt diet in spontaneously hypertensive rats (SHR)...
  5. pmc New angiotensins
    Jasmina Varagic
    The Hypertension and Vascular Research Center, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Mol Med (Berl) 86:663-71. 2008
    ..This review focuses on angiotensin-(1-7) and its important contribution to cardiovascular function and growth, while introducing angiotensin-(1-12) as a potential novel angiotensin precursor...
  6. pmc Salt-induced renal injury in spontaneously hypertensive rats: effects of nebivolol
    Jasmina Varagic
    Hypertension and Vascular Research Center, Wake Forest University, Winston Salem, NC 27157, USA
    Am J Nephrol 32:557-66. 2010
    ....
  7. pmc Hemodynamic and hormonal changes to dual renin-angiotensin system inhibition in experimental hypertension
    Norihito Moniwa
    Division of Surgical Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Hypertension 61:417-24. 2013
    ....
  8. pmc Differential regulation of angiotensin-(1-12) in plasma and cardiac tissue in response to bilateral nephrectomy
    Carlos M Ferrario
    The Hypertension and Vascular Research Center, Wake Forest Univ School of Medicine, Winston Salem, NC 27157, USA
    Am J Physiol Heart Circ Physiol 296:H1184-92. 2009
    ..These changes were accompanied by significant increases in p47(phox), Rac1, and Nox4 isoform expression. In conclusion, ANG-(1-12) may be a functional precursor for angiotensin peptide formation in the absence of circulating renin...
  9. doi request reprint Cardiovascular effects of inhibition of renin-angiotensin-aldosterone system components in hypertensive rats given salt excess
    Dinko Susic
    Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Am J Physiol Heart Circ Physiol 298:H1177-81. 2010
    ....
  10. pmc Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats
    Aaron J Trask
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Am J Hypertens 23:687-93. 2010
    ....
  11. pmc Nebivolol reduces cardiac angiotensin II, associated oxidative stress and fibrosis but not arterial pressure in salt-loaded spontaneously hypertensive rats
    Jasmina Varagic
    Hypertension and Vascular Research Center, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Hypertens 30:1766-74. 2012
    ..This study evaluated the hypothesis that nebivolol reduces salt-induced cardiac remodeling and dysfunction in spontaneous hypertensive rats (SHRs) by suppressing cardiac RAS and oxidative stress...
  12. ncbi request reprint Cardiac structural and functional responses to salt loading in SHR
    Jwari Ahn
    Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Am J Physiol Heart Circ Physiol 287:H767-72. 2004
    ..Moreover, the SHR are more susceptible to cardiac damage when high dietary salt is introduced earlier in life...
  13. pmc Chymase mediates angiotensin-(1-12) metabolism in normal human hearts
    Sarfaraz Ahmad
    Division of Surgical Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Am Soc Hypertens 7:128-36. 2013
    ..Chymase accounts for the conversion of Ang-(1-12) and Ang I to Ang II in normal human LV. These novel findings expand knowledge of the alternate mechanism by which Ang-(1-12) contributes to the production of cardiac angiotensin peptides...
  14. doi request reprint Advances in the renin angiotensin system focus on angiotensin-converting enzyme 2 and angiotensin-(1-7)
    Carlos M Ferrario
    Hypertension and Vascular Disease Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Adv Pharmacol 59:197-233. 2010
    ....
  15. ncbi request reprint Long-term mineralocorticoid receptor blockade reduces fibrosis and improves cardiac performance and coronary hemodynamics in elderly SHR
    Dinko Susic
    Division of Research, Ochsner Clinic Foundation, 1520 Jefferson Hwy, New Orleans, LA 70121, USA
    Am J Physiol Heart Circ Physiol 292:H175-9. 2007
    ..Thus reduction in myocardial fibrosis, paralleled by improvements in left ventricular function and coronary hemodynamics, was observed in eplerenone-treated SHR...
  16. pmc Primacy of angiotensin converting enzyme in angiotensin-(1-12) metabolism
    Norihito Moniwa
    Division of Surgical Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina
    Am J Physiol Heart Circ Physiol 305:H644-50. 2013
    ..We conclude that ACE acts as the primary enzyme for the conversion of ANG-(1-12) to smaller angiotensin peptides in the circulation of WKY and SHR and that chymase may be an ANG-(1-7) degrading enzyme. ..
  17. ncbi request reprint Local cardiac renin-angiotensin system: hypertension and cardiac failure
    Jasmina Varagic
    Hypertension Research Laboratory, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    J Mol Cell Cardiol 34:1435-42. 2002
    ..This paper reviews evidence that supports the concept that the cardiac RAS participate importantly in the development and risk of HHD...
  18. ncbi request reprint Myocardial fibrosis, impaired coronary hemodynamics, and biventricular dysfunction in salt-loaded SHR
    Jasmina Varagic
    Hypertension Research Laboratory, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Am J Physiol Heart Circ Physiol 290:H1503-9. 2006
    ..These findings point to the conclusion that the concept of "salt sensitivity" in hypertension is far more complex than simply its effects on arterial pressure or the LV...
  19. ncbi request reprint Cardiovascular and renal effects of a collagen cross-link breaker (ALT 711) in adult and aged spontaneously hypertensive rats
    Dinko Susic
    Hypertension Research Laboratory, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Am J Hypertens 17:328-33. 2004
    ..This study reports our initial inquires into the cardiovascular and renal effects of a cross-link breaker (ALT-711) in aged spontaneously hypertensive rats (SHR)...
  20. ncbi request reprint Salt loading produces severe renal hemodynamic dysfunction independent of arterial pressure in spontaneously hypertensive rats
    Luis C Matavelli
    Hypertension Research Laboratory, Division of Research, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Am J Physiol Heart Circ Physiol 292:H814-9. 2007
    ..These findings support the concept of a strong independent causal relationship between salt excess and cardiovascular and renal injury...
  21. pmc Restoration of the blood pressure circadian rhythm by direct renin inhibition and blockade of angiotensin II receptors in mRen2.Lewis hypertensive rats
    Norihito Moniwa
    Division of Surgical Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Ther Adv Cardiovasc Dis 6:15-29. 2012
    ..Lewis hypertensive rats, a renin-dependent model of hypertension derived from the backcross of transgenic hypertensive [mRen-2]27 rats with Lewis normotensive ones...
  22. ncbi request reprint Omapatrilat induces profound renal vasodilation but does not affect coronary hemodynamics
    Jasmina Varagic
    Hypertension Research Laboratory, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    J Cardiovasc Pharmacol Ther 8:167-74. 2003
    ..The contribution of endogenous bradykinin on the cardiovascular actions of omapatrilat in this genetic model of hypertension was also investigated...
  23. ncbi request reprint Crosslink breakers: a new approach to cardiovascular therapy
    Dinko Susic
    Hypertension Research Laboratory, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Curr Opin Cardiol 19:336-40. 2004
    ..This review summarizes the latest evidence that breaking collagen crosslinks may be an efficient new therapeutic approach to the adverse cardiovascular and renal consequences of aging and diabetes...
  24. pmc The ANG-(1-7)/ACE2/mas axis in the regulation of nephron function
    Carlos M Ferrario
    Hypertension and Vascular Disease Research Center and Department of Surgery, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am J Physiol Renal Physiol 298:F1297-305. 2010
    ..This review summarizes the evolving knowledge of the counterregulatory arm of the renin-angiotensin system in the control of nephron function and renal disease...
  25. ncbi request reprint Sodium directly impairs target organ function in hypertension
    Edward D Frohlich
    Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Curr Opin Cardiol 20:424-9. 2005
    ....
  26. ncbi request reprint Beneficial cardiovascular actions of eplerenone in the spontaneously hypertensive rat
    Dinko Susic
    Hypertension Research Laboratory, Division of Research, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    J Cardiovasc Pharmacol Ther 10:197-203. 2005
    ....
  27. pmc Uptake and metabolism of the novel peptide angiotensin-(1-12) by neonatal cardiac myocytes
    Sarfaraz Ahmad
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 6:e15759. 2011
    ..This study evaluated whether Ang-(1-12) is incorporated by neonatal cardiac myocytes and the enzymatic pathways of ¹²⁵I-Ang-(1-12) metabolism in the cardiac myocyte medium from WKY and SHR rats...
  28. pmc Amelioration of renal injury and oxidative stress by the nNOS inhibitor L-VNIO in the salt-sensitive mRen2.Lewis congenic rat
    Liliya M Yamaleyeva
    The Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157 1095, USA
    J Cardiovasc Pharmacol 59:529-38. 2012
    ..We conclude that an increase in nNOS expression in conjunction with reduced levels of cortical tetrahydrobiopterin may stimulate oxidative stress and renal injury in the salt-sensitive female mRen2.Lewis rat...
  29. pmc Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue
    Sarfaraz Ahmad
    Division of Surgical Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 6:e28501. 2011
    ..In conclusion, we demonstrate for the first time in human cardiac tissue a dominant role of cardiac chymase in the formation of Ang II from Ang-(1-12)...
  30. ncbi request reprint Beneficial pleiotropic vascular effects of rosuvastatin in two hypertensive models
    Dinko Susic
    Hypertension Research Laboratory, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    J Am Coll Cardiol 42:1091-7. 2003
    ..The goal of this research was to study the effects of rosuvastatin on systemic and regional hemodynamics in two hypertensive rat models, one genetic, the other induced with inhibition of nitric oxide synthesis...
  31. ncbi request reprint The role of sodium in hypertension is more complex than simply elevating arterial pressure
    Edward D Frohlich
    Oschner Clinic Foundation, New Orleans, LA 70121, USA
    Nat Clin Pract Cardiovasc Med 1:24-30. 2004
    ....
  32. ncbi request reprint High rate of ventricular septal defects in WKY rats
    Michel Slama
    Hypertension Research Laboratories, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Hypertension 40:175-8. 2002
    ....
  33. doi request reprint Angiotensin-(1-12): A Chymase-Mediated Cellular Angiotensin II Substrate
    Sarfaraz Ahmad
    Division of Surgical Sciences, Wake Forest School of Medicine, Winston Salem, NC, USA
    Curr Hypertens Rep 16:429. 2014
    ..This new information provides a renewed argument for exploring the role of chymase inhibitors in the correction of cardiac arrhythmias and left ventricular systolic and diastolic dysfunction. ..
  34. ncbi request reprint Collagen cross-link breakers: a beginning of a new era in the treatment of cardiovascular changes associated with aging, diabetes, and hypertension
    Dinko Susic
    Hypertension Research Laboratory, Ochsner Clinic Foundation, New Orleans, LA 70121, USA
    Curr Drug Targets Cardiovasc Haematol Disord 4:97-101. 2004
    ..This report briefly summarizes age related changes in cardiovascular structure and function and describes results of experimental and clinical studies involving collagen cross-link breakers...
  35. ncbi request reprint Diastolic dysfunction in hypertension
    Michel Slama
    Hypertension Research Laboratories, Division of Research, Ochsner Clinic Foundation, New Orleans, Louisiana 70121, USA
    Curr Opin Cardiol 17:368-73. 2002
    ..Furthermore, it has been made clear recently that myocardial ischemia and fibrosis are two important factors associated with diastolic dysfunction in hypertension...
  36. pmc Coronary circulation in hypertension and aging: an experimental study
    Dinko Susic
    Division of Research, Ochsner Clinic Foundation, New Orleans, Louisiana
    Ochsner J 8:5-10. 2008
    ..Perivascular fibrosis within myocardium may significantly contribute to the coronary vascular impairment...
  37. ncbi request reprint Cilnidipine improves spontaneously hypertensive rat coronary hemodynamics without altering cardiovascular mass and collagen
    Jasmina Varagic
    Hypertension Research Laboratory, Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121, USA
    J Hypertens 20:317-22. 2002
    ....
  38. ncbi request reprint Validation of echocardiographic and Doppler indexes of left ventricular relaxation in adult hypertensive and normotensive rats
    Michel Slama
    Unite de Reanimation, Service de Nephrologie, CHU Sud Amiens 80054 Cedex 1, France
    Am J Physiol Heart Circ Physiol 289:H1131-6. 2005
    ..In conclusion, LV relaxation can be assessed reliably using echocardiographic and Doppler techniques, and, using these indexes, impaired relaxation was demonstrated in SHR...
  39. ncbi request reprint Long-term left ventricular echocardiographic follow-up of SHR and WKY rats: effects of hypertension and age
    Michel Slama
    Unite de Reanimation, Service de Nephrologie, CHU, Sud Amiens 80054 cedex 1, France
    Am J Physiol Heart Circ Physiol 286:H181-5. 2004
    ..In contrast, relaxation and SF were only slightly altered in old WKY rats, suggesting that pressure-related changes in LV function were the dominant features in the SHR...