Frank M Torti

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Regulation of ferritin genes and protein
    Frank M Torti
    Department of Cancer Biology and Biochemistry and the Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Blood 99:3505-16. 2002
  2. pmc Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator
    Yan Jiao
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Blood 113:462-9. 2009
  3. doi request reprint Angiotensin-(1-7) attenuates metastatic prostate cancer and reduces osteoclastogenesis
    Bhavani Krishnan
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Prostate 73:71-82. 2013
  4. pmc The resistance of breast cancer stem cells to conventional hyperthermia and their sensitivity to nanoparticle-mediated photothermal therapy
    Andrew R Burke
    Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Biomaterials 33:2961-70. 2012
  5. pmc SOSTDC1 differentially modulates Smad and beta-catenin activation and is down-regulated in breast cancer
    Kathryn A Clausen
    Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Breast Cancer Res Treat 129:737-46. 2011
  6. pmc Post-transcriptional modulation of iron homeostasis during p53-dependent growth arrest
    Fan Zhang
    Department of Cancer Biology, Wake Forest University, Winston Salem, NC 27157, USA
    J Biol Chem 283:33911-8. 2008
  7. pmc Development of iron-containing multiwalled carbon nanotubes for MR-guided laser-induced thermotherapy
    Xuanfeng Ding
    Wake Forest University, Winston Salem, NC 27106, USA
    Nanomedicine (Lond) 6:1341-52. 2011
  8. pmc Tachpyridine, a metal chelator, induces G2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation
    Jolyn Turner
    Department of Biochemistry, Wake Forest University Health Scieces, Winston Salem, NC 27157, USA
    Blood 106:3191-9. 2005
  9. pmc An iron regulatory gene signature predicts outcome in breast cancer
    Lance D Miller
    Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Cancer Res 71:6728-37. 2011
  10. doi request reprint Angiotensin-(1-7) reduces proliferation and angiogenesis of human prostate cancer xenografts with a decrease in angiogenic factors and an increase in sFlt-1
    Bhavani Krishnan
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Prostate 73:60-70. 2013

Research Grants

  1. TRAINING PROGRAM IN CANCER BIOLOGY
    FRANK TORTI; Fiscal Year: 2007
  2. Ferritin, Iron Homeostasis and Cellular Stress
    FRANK TORTI; Fiscal Year: 2007
  3. ADMINISTRATION
    FRANK TORTI; Fiscal Year: 2007

Collaborators

Detail Information

Publications61

  1. ncbi request reprint Regulation of ferritin genes and protein
    Frank M Torti
    Department of Cancer Biology and Biochemistry and the Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Blood 99:3505-16. 2002
  2. pmc Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelator
    Yan Jiao
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Blood 113:462-9. 2009
    ..This may affect the use of curcumin in patients with marginal iron stores or those exhibiting the anemia of cancer and chronic disease...
  3. doi request reprint Angiotensin-(1-7) attenuates metastatic prostate cancer and reduces osteoclastogenesis
    Bhavani Krishnan
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Prostate 73:71-82. 2013
    ..The primary objective of this study was to determine whether Ang-(1-7) effectively reduces prostate cancer metastasis in mice...
  4. pmc The resistance of breast cancer stem cells to conventional hyperthermia and their sensitivity to nanoparticle-mediated photothermal therapy
    Andrew R Burke
    Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Biomaterials 33:2961-70. 2012
    ..These data suggest that nanotube-mediated thermal treatment can simultaneously eliminate both the differentiated cells that constitute the bulk of a tumor and the BCSCs that drive tumor growth and recurrence...
  5. pmc SOSTDC1 differentially modulates Smad and beta-catenin activation and is down-regulated in breast cancer
    Kathryn A Clausen
    Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Breast Cancer Res Treat 129:737-46. 2011
    ..SOSTDC1 differentially affects Wnt3a, BMP-2, and BMP-7 signaling in breast cancer cells. These results identify SOSTDC1 as a clinically important extracellular regulator of multiple signaling pathways in breast cancer...
  6. pmc Post-transcriptional modulation of iron homeostasis during p53-dependent growth arrest
    Fan Zhang
    Department of Cancer Biology, Wake Forest University, Winston Salem, NC 27157, USA
    J Biol Chem 283:33911-8. 2008
    ....
  7. pmc Development of iron-containing multiwalled carbon nanotubes for MR-guided laser-induced thermotherapy
    Xuanfeng Ding
    Wake Forest University, Winston Salem, NC 27106, USA
    Nanomedicine (Lond) 6:1341-52. 2011
    ..To test iron-containing multiwalled carbon nanotubes (MWCNTs) as bifunctional nanomaterials for imaging and thermal ablation of tumors...
  8. pmc Tachpyridine, a metal chelator, induces G2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiation
    Jolyn Turner
    Department of Biochemistry, Wake Forest University Health Scieces, Winston Salem, NC 27157, USA
    Blood 106:3191-9. 2005
    ..Collectively, our results suggest that iron chelators may function as antitumor and radioenhancing agents and uncover a previously unexplored activity of iron chelators in activation of ATR and checkpoint kinases...
  9. pmc An iron regulatory gene signature predicts outcome in breast cancer
    Lance D Miller
    Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Cancer Res 71:6728-37. 2011
    ....
  10. doi request reprint Angiotensin-(1-7) reduces proliferation and angiogenesis of human prostate cancer xenografts with a decrease in angiogenic factors and an increase in sFlt-1
    Bhavani Krishnan
    Hypertension and Vascular Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Prostate 73:60-70. 2013
    ..The purpose of this study was to determine the anti-proliferative and anti-angiogenic efficacy of angiotensin-(1-7) [Ang-(1-7)], an endogenous peptide hormone, in human prostate cancer xenografts...
  11. ncbi request reprint Vinorelbine, doxorubicin, and prednisone in androgen-independent prostate cancer
    Lester S Borden
    Department of Urology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cancer 107:1093-100. 2006
    ..The authors conducted a Phase II trial with vinorelbine, doxorubicin, and daily prednisone (NAP) to investigate the antitumor activity and palliative response of this regimen in patients with AIPC...
  12. ncbi request reprint Ferritin regulation by oxidants and chemopreventive xenobiotics
    John Wilkinson
    Departments of Cancer Biology and Biochemistry and the Comprehensive Cancer Center of Wake Forest University, Winston Salem, NC 27157, USA
    Adv Enzyme Regul 43:135-51. 2003
  13. ncbi request reprint Excess capacity of the iron regulatory protein system
    Wei Wang
    Department of Cancer Biology, Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    J Biol Chem 282:24650-9. 2007
    ....
  14. pmc Loss of heterozygosity and SOSTDC1 in adult and pediatric renal tumors
    Kimberly R Blish
    Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Exp Clin Cancer Res 29:147. 2010
    ....
  15. pmc Tissue-specific expression of ferritin H regulates cellular iron homoeostasis in vivo
    John Wilkinson
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Biochem J 395:501-7. 2006
    ..These results demonstrate that FerH not only responds to changes in tissue iron (its classic role), but can actively regulate overall tissue iron balance...
  16. pmc Regulatory effects of ferritin on angiogenesis
    Lan G Coffman
    Program in Molecular Medicine, Wake Forest University School of Medicine, Winston Salem NC 27157, USA
    Proc Natl Acad Sci U S A 106:570-5. 2009
    ..Ferritin-mediated regulation of angiogenesis represents a new angiogenic regulatory pathway, and identifies a new role for ferritin in cell biology...
  17. ncbi request reprint Preliminary evaluation of the cytotoxicity of a series of tris-2-aminoethylamine (Tren) based hexadentate heterocyclic donor agents
    Suzy V Torti
    Department of Biochemistry, The Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Bioorg Med Chem 13:5961-7. 2005
    ..These results suggest that analogous derivatives with substitution at the 3-position of the pyridyl ring deserve further exploration...
  18. pmc Ferritin H induction by histone deacetylase inhibitors
    Wei Wang
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States
    Biochem Pharmacol 80:316-24. 2010
    ..These results identify ferritin H as a new target of HDAC inhibitors, and recruitment of NF-Y as a novel mechanism of action of HDAC inhibitors...
  19. pmc Ferritin for the clinician
    Mary Ann Knovich
    Section on Hematology and Oncology, Wake Forest University Health Sciences, Winston Salem, NC 27157 1082, USA
    Blood Rev 23:95-104. 2009
    ..Additionally, recent research describes novel functions of ferritin independent of iron storage...
  20. pmc Serum ferritin: Past, present and future
    Wei Wang
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Biochim Biophys Acta 1800:760-9. 2010
    ..Serum ferritin was discovered in the 1930s, and was developed as a clinical test in the 1970s. Many diseases are associated with iron overload or iron deficiency. Serum ferritin is widely used in diagnosing and monitoring these diseases...
  21. pmc Weekly doxorubicin increases coronary arteriolar wall and adventitial thickness
    Delrae M Eckman
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 8:e57554. 2013
    ..This study was performed to determine if the weekly administration of DOX influenced coronary arteriolar medial and/or adventitial wall thickening...
  22. pmc Potential impact of adding genetic markers to clinical parameters in predicting prostate biopsy outcomes in men following an initial negative biopsy: findings from the REDUCE trial
    A Karim Kader
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Eur Urol 62:953-61. 2012
    ..Several germline single nucleotide polymorphisms (SNPs) have been consistently associated with prostate cancer (PCa) risk...
  23. ncbi request reprint Iron chelators in cancer chemotherapy
    Joan L Buss
    Department of Biochemistry, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157, USA
    Curr Top Med Chem 4:1623-35. 2004
    ..While the modest antitumor effects of DFO are encouraging, it is likely that more effective iron chelators may be identified...
  24. ncbi request reprint Iron chelation in the biological activity of curcumin
    Yan Jiao
    Department of Cancer Biology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Free Radic Biol Med 40:1152-60. 2006
    ..These results suggest that iron chelation may be an additional mode of action of curcumin...
  25. pmc The transplant iron score as a predictor of stem cell transplant survival
    Jonathan A Storey
    Department of Internal Medicine, Section on Hematology and Oncology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Hematol Oncol 2:44. 2009
    ..In summary, our results lend further credence to the notion that iron overload prior to transplant is detrimental and suggest iron overload may predispose to a higher rate of lethal infections...
  26. pmc Long-term survival following a single treatment of kidney tumors with multiwalled carbon nanotubes and near-infrared radiation
    Andrew Burke
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Proc Natl Acad Sci U S A 106:12897-902. 2009
    ..These treatment parameters resulted in complete ablation of tumors and a >3.5-month durable remission in 80% of mice treated with 100 microg of MWCNT. Use of MWCNTs with NIR may be effective in anticancer therapy...
  27. ncbi request reprint Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse of prostate cancer after definitive local therapy
    Peter E Clark
    Department of Urology and Comprehensive Cancer Center, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Urology 67:1257-61. 2006
    ..To report a prospective trial of lycopene supplementation in biochemically relapsed prostate cancer...
  28. pmc Ferroportin and iron regulation in breast cancer progression and prognosis
    Zandra K Pinnix
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Sci Transl Med 2:43ra56. 2010
    ..Ferroportin is a pivotal protein in breast biology and a strong and independent predictor of prognosis in breast cancer...
  29. pmc Ironing out cancer
    Suzy V Torti
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Cancer Res 71:1511-4. 2011
    ..A number of studies directly support a role of these proteins in modifying bioavailable iron, whereas other studies suggest that at least some of their effects are independent of their role in iron biology...
  30. doi request reprint Cleavage of high-molecular-weight kininogen by elastase and tryptase is inhibited by ferritin
    Lan G Coffman
    Program in Molecular Medicine, Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Physiol Lung Cell Mol Physiol 294:L505-15. 2008
    ..Furthermore, ferritin, HK, and elastase are all present in or on alveolar macrophages in a mouse model of pulmonary inflammation. Collectively, these results implicate ferritin in the modulation of HK cleavage at sites of inflammation...
  31. pmc Ferritin blocks inhibitory effects of two-chain high molecular weight kininogen (HKa) on adhesion and survival signaling in endothelial cells
    Lia Tesfay
    Department of Cancer Biology, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    PLoS ONE 7:e40030. 2012
    ..We propose that ferritin blocks the anti-angiogenic activity of HKa by reducing binding of HKa to UPAR and interfering with anti-adhesive and anti-proliferative signaling of HKa...
  32. pmc Novel approach to early detection of doxorubicin cardiotoxicity by gadolinium-enhanced cardiovascular magnetic resonance imaging in an experimental model
    James C Lightfoot
    Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Circ Cardiovasc Imaging 3:550-8. 2010
    ....
  33. pmc Thermal ablation therapeutics based on CN(x) multi-walled nanotubes
    Suzy V Torti
    Department of Biochemistry, Wake Forest University Health Sciences, Winston Salem, NC 27109 7507, USA
    Int J Nanomedicine 2:707-14. 2007
    ..This cell death was attributed directly to photothermal effect generated within the culture, since neither the infrared irradiation itself nor the CN(x)-MWNT were toxic to the cells...
  34. pmc A human bone morphogenetic protein antagonist is down-regulated in renal cancer
    Kimberly Rose Blish
    Section on Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 0001, USA
    Mol Biol Cell 19:457-64. 2008
    ..Because SOSTDC1 suppresses proliferation of renal carcinoma cells, restoration of SOSTDC1 signaling may represent a novel target in treatment of renal clear cell carcinoma...
  35. ncbi request reprint Role of zinc and iron chelation in apoptosis mediated by tachpyridine, an anti-cancer iron chelator
    Rong Zhao
    Department of Cancer Biology, Wake Forest University Health Sciences, Wake Forest University, Winston Salem, NC, USA
    Biochem Pharmacol 67:1677-88. 2004
    ..These results demonstrate a link between metal depletion and chelator cytotoxicity, and suggest that intracellular chelation of zinc as well as iron may play a role in the cytotoxicity of tachpyridine...
  36. doi request reprint Synthetic and natural iron chelators: therapeutic potential and clinical use
    Heather C Hatcher
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Future Med Chem 1:1643-70. 2009
    ..Established and novel iron chelators will be discussed, as well as the emerging role of dietary plant polyphenols that effectively modulate iron biochemistry...
  37. pmc Determinants of the thrombogenic potential of multiwalled carbon nanotubes
    Andrew R Burke
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Biomaterials 32:5970-8. 2011
    ..Further, functionalization can markedly attenuate the procoagulant activity of MWCNTs in vivo. This work will inform the rational development of biocompatible MWCNTs for systemic delivery...
  38. ncbi request reprint The role of iron chelation in cancer therapy
    Joan L Buss
    Department of Biochemistry, Comprehensive Cancer Center, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Curr Med Chem 10:1021-34. 2003
    ..The development of chelators as anticancer agents is largely an unexplored field, but one with extraordinary potential to impact human cancer...
  39. ncbi request reprint Coordinate inhibition of cytokine-mediated induction of ferritin H, manganese superoxide dismutase, and interleukin-6 by the adenovirus E1A oncogene
    Jamie E Jennings-Gee
    Department of Biochemistry, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Biol Chem 281:16428-35. 2006
    ..These results suggest that p300/CBP is a critical control point in NF-kappaB-dependent transcriptional regulation of cytoprotective genes by cytokines...
  40. ncbi request reprint Oxathiolene oxides: a novel family of compounds that induce ferritin, glutathione S-transferase, and other proteins of the phase II response
    E Christine Pietsch
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Biochem Pharmacol 65:1261-9. 2003
    ..Consistent with this observation, OTEO-562 failed to induce cytochrome P450 1A1 mRNA. These results suggest that oxathiolene oxides may merit further investigation as candidate chemopreventive agents...
  41. ncbi request reprint Serum levels of phytanic acid are associated with prostate cancer risk
    Jianfeng Xu
    Center for Human Genomics, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Prostate 63:209-14. 2005
    ..In this small case-control study, we assessed the association between phytanic acid levels and prostate cancer risk...
  42. pmc A general map of iron metabolism and tissue-specific subnetworks
    Valerie Hower
    Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Mol Biosyst 5:422-43. 2009
    ..The addition of kinetic information to our structural network will permit the simulation of iron metabolism in different tissues as well as in health and disease...
  43. doi request reprint Ferritin H is a novel marker of early erythroid precursors and macrophages
    Wei Wang
    Department of Pathology, Wake Forest Baptist Health, Winston Salem, NC 27157, USA
    Histopathology 62:931-40. 2013
    ..In this study, we aimed to determine whether ferritin is highly expressed in macrophages and erythroid precursors, and whether it can be used as a marker for these two cell types...
  44. pmc Phase I and pharmacokinetic study of angiotensin-(1-7), an endogenous antiangiogenic hormone
    W Jeffrey Petty
    Department of Medicine, Section on Hematology and Oncology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Clin Cancer Res 15:7398-404. 2009
    ..Secondary objectives were to assess toxicities, pharmacokinetics, clinical activity, and plasma biomarkers...
  45. pmc Aortic stiffness increases upon receipt of anthracycline chemotherapy
    Narumol Chaosuwannakit
    Wake Forest University Health Sciences, Bowman Gray Campus, Medical Center Blvd, Winston Salem, North Carolina 27157 1045, USA
    J Clin Oncol 28:166-72. 2010
    ..These results indicate that previously regarded cardiotoxic cancer therapy adversely increases thoracic aortic stiffness, a known independent predictor of adverse cardiovascular events...
  46. pmc Prostate cancer risk associated loci in African Americans
    Jianfeng Xu
    Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Cancer Epidemiol Biomarkers Prev 18:2145-9. 2009
    ..However, studies with larger numbers of AA subjects are needed, and this will likely require a major collaborative effort to combine multiple AA study populations...
  47. ncbi request reprint Bone metastases in prostate cancer: a targeted approach
    Jonathan A Storey
    Wake Forest University Comprehensive Cancer Center, Winston Salem, NC 27106, USA
    Curr Opin Oncol 19:254-8. 2007
    ..In this article, we review current and developing clinical strategies designed to control prostate-cancer bone metastases...
  48. ncbi request reprint Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethiones
    E Christine Pietsch
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 278:2361-9. 2003
    ..Nrf2 may also play a role in basal transcription of both ferritin H and L. These results provide a mechanistic link between regulation of the iron storage protein ferritin and the cancer chemopreventive response...
  49. ncbi request reprint Phase I/II study of 19-nor-1alpha-25-dihydroxyvitamin D2 (paricalcitol) in advanced, androgen-insensitive prostate cancer
    Gary G Schwartz
    Department of Cancer Biology, Wake Forest University, Winston Salem, NC 27157, and Nortwest Georgia Oncology Centers, Douglasville, USA
    Clin Cancer Res 11:8680-5. 2005
    ..We assessed the safety and efficacy of the vitamin D analogue, 19-nor-1alpha-25-dihydroxyvitamin D2 (paricalcitol), in patients with androgen-independent prostate cancer...
  50. ncbi request reprint Demand for continuing medical education programs on cancer care among primary care physicians in North Carolina
    Roger T Anderson
    Department of Public Health Sciences, Wake Forest University School of Medicine, USA
    N C Med J 65:130-5. 2004
    ..g., pain control lymphedema, tertiary prevention)...
  51. ncbi request reprint Radiofrequency ablation of isolated local recurrence of renal cell carcinoma after radical nephrectomy
    Charles A McLaughlin
    Department of Radiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1088, USA
    AJR Am J Roentgenol 181:93-4. 2003
  52. ncbi request reprint Use of green fluorescent protein to measure tumor growth in an implanted bladder tumor model
    Suzy V Torti
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Urol 167:724-8. 2002
    ..This model offers the opportunity to test the efficacy of therapies administered systemically or intravesically. However, quantitation of tumor growth has been difficult...
  53. ncbi request reprint Activation of caspase pathways during iron chelator-mediated apoptosis
    Bryan T Greene
    Department of Cancer Biology, and the Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 277:25568-75. 2002
    ..These results suggest that activation of a mitochondrial caspase pathway is an important mechanism by which iron chelators induce cell death...
  54. ncbi request reprint Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress
    Khristy Thompson
    Department of Neuroscience and Anatomy, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    J Neurosci Res 71:46-63. 2003
    ..These results suggest that this mouse may be a model to determine the role of iron mismanagement in neurodegenerative disorders and for testing antioxidant therapeutic strategies...
  55. ncbi request reprint Antiandrogen withdrawal alone or in combination with ketoconazole in androgen-independent prostate cancer patients: a phase III trial (CALGB 9583)
    Eric J Small
    UCSF Comprehensive Cancer Center, University of California San Francisco, 1600 Divisadero St, Room A 718, San Francisco, CA 94115, USA
    J Clin Oncol 22:1025-33. 2004
    ..Thereafter, adrenal androgen ablation with agents such as ketoconazole (K) is commonly utilized. The therapeutic effect of AAWD alone was compared with simultaneous AAWD and K therapy...
  56. ncbi request reprint Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen species
    Can G Pham
    The Ben May Institute for Cancer Research and The University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA
    Cell 119:529-42. 2004
    ..Our results suggest modulation of FHC or, more broadly, of iron metabolism as a potential approach for anti-inflammatory therapy...
  57. ncbi request reprint Synthesis of 1,3,5-cis,cis-triaminocyclohexane N-pyridyl derivatives as potential antitumor agents
    Hyun Soon Chong
    Chemistry Section, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    J Org Chem 67:8072-8. 2002
    ..Bifunctional agent 24 possessing a maleimide linker that is functional for conjugation to thiolated monoclonal antibodies is a promising lead compound for development of antitumor conjugates for antibody-targeted therapies...
  58. ncbi request reprint Synthesis and potent antitumor activities of novel 1,3,5-cis,cis-triaminocyclohexane N-pyridyl derivatives
    Hyun Soon Chong
    Chemistry Section, National Cancer Institute NIH, Bethesda, MD 20892, USA
    J Med Chem 47:5230-4. 2004
    ..Tachpyr derivative 14 was further converted into bifunctional tachpyr 17 possessing a maleimide linker for conjugation with thiolated monoclonal antibodies (mAbs)...
  59. pmc N-picolyl derivatives of Kemp's triamine as potential antitumor agents: a preliminary investigation
    Celeste Aida S Regino
    Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA
    J Med Chem 48:7993-9. 2005
    ....
  60. pmc TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis
    Thomas T Chen
    Veterans Administration Medical Center, San Francisco, CA 94121, USA
    J Exp Med 202:955-65. 2005
    ..This is the first identification of a receptor for ferritin and reveals a new role for TIM-2...
  61. ncbi request reprint Questions without answers
    Frank M Torti
    Curr Opin Oncol 17:254-6. 2005

Research Grants4

  1. TRAINING PROGRAM IN CANCER BIOLOGY
    FRANK TORTI; Fiscal Year: 2007
    ..abstract_text> ..
  2. Ferritin, Iron Homeostasis and Cellular Stress
    FRANK TORTI; Fiscal Year: 2007
    ..In our third Specific Aim, we develop in vivo mouse models to test the relevance of our findings in the context of whole animals. ..
  3. ADMINISTRATION
    FRANK TORTI; Fiscal Year: 2007
    ..The blueprint for our next five years is embodied in this application, which provides the Center's vision of how it can reduce the burden of cancer in our region and in the nation. ..