Research Topics
Genomes and Genes | Frank M TortiSummaryAffiliation: Wake Forest University School of Medicine Country: USA Publications
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Publications
The transplant iron score as a predictor of stem cell transplant survivalJonathan A Storey
Department of Internal Medicine, Section on Hematology and Oncology, Wake Forest University School of Medicine, Winston Salem, NC, USA
J Hematol Oncol 2:44. 2009..In summary, our results lend further credence to the notion that iron overload prior to transplant is detrimental and suggest iron overload may predispose to a higher rate of lethal infections...- Loss of heterozygosity and SOSTDC1 in adult and pediatric renal tumorsKimberly R Blish
Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
J Exp Clin Cancer Res 29:147. 2010.... 
Ferritin regulation by oxidants and chemopreventive xenobioticsJohn Wilkinson
Departments of Cancer Biology and Biochemistry and the Comprehensive Cancer Center of Wake Forest University, Winston-Salem, NC 27157, USA
Adv Enzyme Regul 43:135-51. 2003- Regulation of ferritin genes and proteinFrank M Torti
Department of Cancer Biology and Biochemistry and the Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
Blood 99:3505-16. 2002 - Tissue-specific expression of ferritin H regulates cellular iron homoeostasis in vivoJohn Wilkinson
Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Biochem J 395:501-7. 2006..These results demonstrate that FerH not only responds to changes in tissue iron (its classic role), but can actively regulate overall tissue iron balance... - Demand for continuing medical education programs on cancer care among primary care physicians in North CarolinaRoger T Anderson
Department of Public Health Sciences, Wake Forest University School of Medicine, USA
N C Med J 65:130-5. 2004..g., pain control lymphedema, tertiary prevention)... - Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse of prostate cancer after definitive local therapyPeter E Clark
Department of Urology and Comprehensive Cancer Center, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
Urology 67:1257-61. 2006..To report a prospective trial of lycopene supplementation in biochemically relapsed prostate cancer... - Serum levels of phytanic acid are associated with prostate cancer riskJianfeng Xu
Center for Human Genomics, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
Prostate 63:209-14. 2005..In this small case-control study, we assessed the association between phytanic acid levels and prostate cancer risk... - Ferritin for the clinicianMary Ann Knovich
Section on Hematology and Oncology, Wake Forest University Health Sciences, Winston Salem, NC 27157 1082, USA
Blood Rev 23:95-104. 2009..Additionally, recent research describes novel functions of ferritin independent of iron storage... - Prostate cancer risk associated loci in African AmericansJianfeng Xu
Center for Cancer Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Cancer Epidemiol Biomarkers Prev 18:2145-9. 2009..However, studies with larger numbers of AA subjects are needed, and this will likely require a major collaborative effort to combine multiple AA study populations... 
Phase I and pharmacokinetic study of angiotensin-(1-7), an endogenous antiangiogenic hormoneW Jeffrey Petty
Department of Medicine, Section on Hematology and Oncology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
Clin Cancer Res 15:7398-404. 2009..Secondary objectives were to assess toxicities, pharmacokinetics, clinical activity, and plasma biomarkers...- Nrf2 mediates the induction of ferritin H in response to xenobiotics and cancer chemopreventive dithiolethionesE Christine Pietsch
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
J Biol Chem 278:2361-9. 2003..Nrf2 may also play a role in basal transcription of both ferritin H and L. These results provide a mechanistic link between regulation of the iron storage protein ferritin and the cancer chemopreventive response... - Phase I/II study of 19-nor-1alpha-25-dihydroxyvitamin D2 (paricalcitol) in advanced, androgen-insensitive prostate cancerGary G Schwartz
Department of Cancer Biology, Wake Forest University, Winston-Salem, NC 27157, and Nortwest Georgia Oncology Centers, Douglasville, USA
Clin Cancer Res 11:8680-5. 2005.... - Post-transcriptional modulation of iron homeostasis during p53-dependent growth arrestFan Zhang
Department of Cancer Biology, Wake Forest University, Winston Salem, NC 27157, USA
J Biol Chem 283:33911-8. 2008.... - Iron chelation in the biological activity of curcuminYan Jiao
Department of Cancer Biology, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA
Free Radic Biol Med 40:1152-60. 2006..These results suggest that iron chelation may be an additional mode of action of curcumin... - Vinorelbine, doxorubicin, and prednisone in androgen-independent prostate cancerLester S Borden
Department of Urology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
Cancer 107:1093-100. 2006..No patients developed clinical congestive heart failure. CONCLUSIONS: The NAP combination produced substantive palliation and a moderate response rate in men with AIPC... - Ferritin H induction by histone deacetylase inhibitorsWei Wang
Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, United States
Biochem Pharmacol 80:316-24. 2010..These results identify ferritin H as a new target of HDAC inhibitors, and recruitment of NF-Y as a novel mechanism of action of HDAC inhibitors... - Role of zinc and iron chelation in apoptosis mediated by tachpyridine, an anti-cancer iron chelatorRong Zhao
Department of Cancer Biology, Wake Forest University Health Sciences, Wake Forest University, Winston-Salem, NC, USA
Biochem Pharmacol 67:1677-88. 2004..These results demonstrate a link between metal depletion and chelator cytotoxicity, and suggest that intracellular chelation of zinc as well as iron may play a role in the cytotoxicity of tachpyridine... - The role of iron chelation in cancer therapyJoan L Buss
Department of Biochemistry, Comprehensive Cancer Center, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA
Curr Med Chem 10:1021-34. 2003..The development of chelators as anticancer agents is largely an unexplored field, but one with extraordinary potential to impact human cancer... - Curcumin, a cancer chemopreventive and chemotherapeutic agent, is a biologically active iron chelatorYan Jiao
Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Blood 113:462-9. 2009..This may affect the use of curcumin in patients with marginal iron stores or those exhibiting the anemia of cancer and chronic disease... - Radiofrequency ablation of isolated local recurrence of renal cell carcinoma after radical nephrectomyCharles A McLaughlin
Department of Radiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1088, USA
AJR Am J Roentgenol 181:93-4. 2003 - Oxathiolene oxides: a novel family of compounds that induce ferritin, glutathione S-transferase, and other proteins of the phase II responseE Christine Pietsch
Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA
Biochem Pharmacol 65:1261-9. 2003..Consistent with this observation, OTEO-562 failed to induce cytochrome P450 1A1 mRNA. These results suggest that oxathiolene oxides may merit further investigation as candidate chemopreventive agents... - Regulatory effects of ferritin on angiogenesisLan G Coffman
Program in Molecular Medicine, Wake Forest University School of Medicine, Winston Salem NC 27157, USA
Proc Natl Acad Sci U S A 106:570-5. 2009..Ferritin-mediated regulation of angiogenesis represents a new angiogenic regulatory pathway, and identifies a new role for ferritin in cell biology... - A general map of iron metabolism and tissue-specific subnetworksValerie Hower
Department of Cancer Biology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
Mol Biosyst 5:422-43. 2009..The addition of kinetic information to our structural network will permit the simulation of iron metabolism in different tissues as well as in health and disease... - Activation of caspase pathways during iron chelator-mediated apoptosisBryan T Greene
Department of Cancer Biology, and the Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
J Biol Chem 277:25568-75. 2002..These results suggest that activation of a mitochondrial caspase pathway is an important mechanism by which iron chelators induce cell death... - Serum ferritin: Past, present and futureWei Wang
Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Biochim Biophys Acta 1800:760-9. 2010..Serum ferritin was discovered in the 1930s, and was developed as a clinical test in the 1970s. Many diseases are associated with iron overload or iron deficiency. Serum ferritin is widely used in diagnosing and monitoring these diseases... - Use of green fluorescent protein to measure tumor growth in an implanted bladder tumor modelSuzy V Torti
Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
J Urol 167:724-8. 2002..It reduces the time required to measure effects on tumor growth to 2 weeks, while preserving the advantages of this orthotopic tumor model... - A human bone morphogenetic protein antagonist is down-regulated in renal cancerKimberly Rose Blish
Section on Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 0001, USA
Mol Biol Cell 19:457-64. 2008..Because SOSTDC1 suppresses proliferation of renal carcinoma cells, restoration of SOSTDC1 signaling may represent a novel target in treatment of renal clear cell carcinoma... - Iron chelators in cancer chemotherapyJoan L Buss
Department of Biochemistry, Wake Forest University Health Sciences, Medical Center Blvd, Winston-Salem, NC 27157, USA
Curr Top Med Chem 4:1623-35. 2004..While the modest antitumor effects of DFO are encouraging, it is likely that more effective iron chelators may be identified... - Tachpyridine, a metal chelator, induces G2 cell-cycle arrest, activates checkpoint kinases, and sensitizes cells to ionizing radiationJolyn Turner
Department of Biochemistry, Wake Forest University Health Scieces, Winston-Salem, NC 27157, USA
Blood 106:3191-9. 2005..Collectively, our results suggest that iron chelators may function as antitumor and radioenhancing agents and uncover a previously unexplored activity of iron chelators in activation of ATR and checkpoint kinases... - Preliminary evaluation of the cytotoxicity of a series of tris-2-aminoethylamine (Tren) based hexadentate heterocyclic donor agentsSuzy V Torti
Department of Biochemistry, The Comprehensive Cancer Center, Wake Forest University School of Medicine, Winston-Salem, NC, USA
Bioorg Med Chem 13:5961-7. 2005..These results suggest that analogous derivatives with substitution at the 3-position of the pyridyl ring deserve further exploration... - Antiandrogen withdrawal alone or in combination with ketoconazole in androgen-independent prostate cancer patients: a phase III trial (CALGB 9583)Eric J Small
UCSF Comprehensive Cancer Center, University of California San Francisco, 1600 Divisadero St, Room A 718, San Francisco, CA 94115, USA
J Clin Oncol 22:1025-33. 2004..Thereafter, adrenal androgen ablation with agents such as ketoconazole (K) is commonly utilized. The therapeutic effect of AAWD alone was compared with simultaneous AAWD and K therapy... - Ferritin heavy chain upregulation by NF-kappaB inhibits TNFalpha-induced apoptosis by suppressing reactive oxygen speciesCan G Pham
The Ben May Institute for Cancer Research and The University of Chicago, 924 East 57th Street, Chicago, IL 60637, USA
Cell 119:529-42. 2004..Our results suggest modulation of FHC or, more broadly, of iron metabolism as a potential approach for anti-inflammatory therapy... - Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stressKhristy Thompson
Department of Neuroscience and Anatomy, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
J Neurosci Res 71:46-63. 2003..These results suggest that this mouse may be a model to determine the role of iron mismanagement in neurodegenerative disorders and for testing antioxidant therapeutic strategies... - TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosisThomas T Chen
Veterans Administration Medical Center, San Francisco, CA 94121, USA
J Exp Med 202:955-65. 2005..This is the first identification of a receptor for ferritin and reveals a new role for TIM-2... - Synthesis of 1,3,5-cis,cis-triaminocyclohexane N-pyridyl derivatives as potential antitumor agentsHyun Soon Chong
Chemistry Section, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
J Org Chem 67:8072-8. 2002..Bifunctional agent 24 possessing a maleimide linker that is functional for conjugation to thiolated monoclonal antibodies is a promising lead compound for development of antitumor conjugates for antibody-targeted therapies... - Excess capacity of the iron regulatory protein systemWei Wang
Department of Cancer Biology, Public Health Sciences, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
J Biol Chem 282:24650-9. 2007.... - Synthesis and potent antitumor activities of novel 1,3,5-cis,cis-triaminocyclohexane N-pyridyl derivativesHyun Soon Chong
Chemistry Section, National Cancer Institute NIH, Bethesda, MD 20892, USA
J Med Chem 47:5230-4. 2004..Tachpyr derivative 14 was further converted into bifunctional tachpyr 17 possessing a maleimide linker for conjugation with thiolated monoclonal antibodies (mAbs)... - N-picolyl derivatives of Kemp's triamine as potential antitumor agents: a preliminary investigationCeleste Aida S Regino
Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, 10 Center Drive, Bethesda, Maryland 20892, USA
J Med Chem 48:7993-9. 2005.... - Thermal ablation therapeutics based on CN(x) multi-walled nanotubesSuzy V Torti
Department of Biochemistry, Wake Forest University Health Sciences, Winston Salem, NC 27109 7507, USA
Int J Nanomedicine 2:707-14. 2007..This cell death was attributed directly to photothermal effect generated within the culture, since neither the infrared irradiation itself nor the CN(x)-MWNT were toxic to the cells... - Bone metastases in prostate cancer: a targeted approachJonathan A Storey
Wake Forest University Comprehensive Cancer Center, Winston Salem, NC 27106, USA
Curr Opin Oncol 19:254-8. 2007..In this article, we review current and developing clinical strategies designed to control prostate-cancer bone metastases... - Questions without answersFrank M Torti
Curr Opin Oncol 17:254-6. 2005
Research Grants
- TRAINING PROGRAM IN CANCER BIOLOGYFRANK TORTI; Fiscal Year: 2007..abstract_text> ..
- Ferritin, Iron Homeostasis and Cellular StressFRANK TORTI; Fiscal Year: 2007..In our third Specific Aim, we develop in vivo mouse models to test the relevance of our findings in the context of whole animals. ..
- ADMINISTRATIONFRANK TORTI; Fiscal Year: 2007..The blueprint for our next five years is embodied in this application, which provides the Center's vision of how it can reduce the burden of cancer in our region and in the nation. ..