Research Topics
| Clara R ThoreSummaryAffiliation: Wake Forest University School of Medicine Country: USA Publications
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Detail Information
Publications
Morphometric analysis of arteriolar tortuosity in human cerebral white matter of preterm, young, and aged subjectsClara R Thore
Department of Radiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
J Neuropathol Exp Neurol 66:337-45. 2007....
Vascular dementia in leukoaraiosis may be a consequence of capillary loss not only in the lesions, but in normal-appearing white matter and cortex as wellWilliam R Brown
Department of Radiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
J Neurol Sci 257:62-6. 2007..In the four irradiated brains, we found very low vessel densities, similar to those found in LA, without an additional age-related decline...- Microvascular changes in the white mater in dementiaWilliam R Brown
Department of Radiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
J Neurol Sci 283:28-31. 2009..Once the capillaries stop dying, no more string vessels are formed, and the string vessels gradually disappear... - Morphometric assessment of collagen accumulation in germinal matrix vessels of premature human neonatesJohn A Anstrom
Department of Radiology, Wake Forest University School of Medicine Winston Salem, NC 27157, USA
Neuropathol Appl Neurobiol 31:181-90. 2005..The high incidence of GM haemorrhage in premature neonates may be related to factors other than a deficiency in accumulated collagen... - Quantification of afferent vessels shows reduced brain vascular density in subjects with leukoaraiosisDixon M Moody
Department of Radiology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
Radiology 233:883-90. 2004..To investigate vessel density changes with increasing age in three areas of the brain and to correlate these changes with leukoaraiosis (LA) on the basis of magnetic resonance (MR) images and location in deep white matter (WM)... - Germinal matrix cells associate with veins and a glial scaffold in the human fetal brainJohn A Anstrom
Department of Radiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Brain Res Dev Brain Res 160:96-100. 2005..We suggest that the GM cuff cells may represent a distinct subset of GM cells that migrate away from the GM on a pathway consisting of a vein and its associated astrocytic scaffold... - Immunolocalization of tight junction proteins in blood vessels in human germinal matrix and cortexJohn A Anstrom
Department of Radiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Histochem Cell Biol 127:205-13. 2007..This maturation could relate to the pathogenesis of germinal matrix hemorrhage-intraventricular hemorrhage... - Venous collagenosis and arteriolar tortuosity in leukoaraiosisWilliam R Brown
Department of Radiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
J Neurol Sci 203:159-63. 2002..In conclusion, our studies support the concept that LA results from chronic ischemia due to age-related vascular pathology... - Anatomical analysis of the developing cerebral vasculature in premature neonates: absence of precapillary arteriole-to-venous shuntsJohn A Anstrom
Department of Radiology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Pediatr Res 52:554-60. 2002..We conclude that precapillary arteriole-to-venous shunts are not a significant factor leading to GMH... - Capillary loss precedes the cognitive impairment induced by fractionated whole-brain irradiation: a potential rat model of vascular dementiaWilliam R Brown
Department of Radiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
J Neurol Sci 257:67-71. 2007..Capillary loss may play an important role in radiation-induced dementia and this may be a model of vascular dementia... - Vascular damage after fractionated whole-brain irradiation in ratsWilliam R Brown
Department of Radiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Radiat Res 164:662-8. 2005..We suggest that the early (10-week) and persistent vascular damage that occurs after a prolonged whole-brain irradiation fractionation scheme may play an important role in the development of late delayed radiation-induced brain injury... - Reduced ratio of afferent to total vascular density in mesial temporal sclerosisRyan T Mott
From the Department of Pathology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
J Neuropathol Exp Neurol 68:1147-54. 2009..e. remnants of regressing vasculature) were also observed in Ammon's horn, suggesting vascular degeneration in the MTS hippocampus. These findings may help further our understanding of the pathophysiology of MTS... - Increase of white matter string vessels in Alzheimer's diseaseVenkat R Challa
Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Alzheimers Dis 6:379-83; discussion 443-9. 2004..88 +/- 0.38) compared to controls (1.36 +/- 0.27) (p = 0.0057). This increase in string vessels in the white matter of AD subjects suggests a decrease in vascular supply in this disease... - Subependymal veins in premature neonates: implications for hemorrhageJohn A Anstrom
Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 2715.7, USA
Pediatr Neurol 30:46-53. 2004..These data support our suggestion that the structural immaturity of these veins in premature neonates is causally related to the high incidence of germinal matrix hemorrhage in these patients... - Apoptosis in leukoaraiosis lesionsWilliam R Brown
Department of Radiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
J Neurol Sci 203:169-71. 2002..The apoptosis in the white matter adjacent to the LA lesions suggests progressive cell loss and expansion of the LA lesions... - Temporal expression pattern of cerebrovascular endothelial cell alkaline phosphatase during human gestationJohn A Anstrom
Department of Radiology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
J Neuropathol Exp Neurol 61:76-84. 2002..Our measurements indicate that neonates born prior to 28 wk gestation are characterized by immature cerebral white matter afferent vessels and raise the possibility that the immaturity compromises vascular function...