Affiliation: Wake Forest University School of Medicine
- Caloric restricted male rats demonstrate fewer synapses in layer 2 of sensorimotor cortexLei Shi
Department of Neurobiology and Anatomy, Medical Center Boulevard, Wake Forest University School of Medicine, Winston Salem, NC 27157 1010, USA
Brain Res 931:32-40. 2002..These results suggest that not only does caloric restriction fail to prevent the age-related decline in presumptive inhibitory synapses, it results in fewer presumptive excitatory synapses as well...
- Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning abilityMichelle M Adams
Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
Exp Neurol 211:141-9. 2008..This age-related decrease and CR-induced stabilization are likely to affect CA3 synaptic plasticity and, as a result, hippocampal function...
- Hippocampal neuron number is unchanged 1 year after fractionated whole-brain irradiation at middle ageLei Shi
Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Winston Salem, NC 27157 1010, USA
Int J Radiat Oncol Biol Phys 71:526-32. 2008....
- Caloric restriction eliminates the aging-related decline in NMDA and AMPA receptor subunits in the rat hippocampus and induces homeostasisLei Shi
Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157 1010, USA
Exp Neurol 206:70-9. 2007..CR eliminates that aging-related decline by inducing stable NMDA and AMPA receptor subunit levels...
- Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampusLei Shi
Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
Radiat Res 166:892-9. 2006..These findings suggest for the first time that radiation-induced cognitive impairments may be associated with alterations in glutamate receptor composition...
- Maintenance of inhibitory interneurons and boutons in sensorimotor cortex between middle and old age in Fischer 344 X Brown Norway ratsLei Shi
Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Winston Salem, NC 27157 1010, USA
J Chem Neuroanat 32:46-53. 2006....
- Differential effects of aging and insulin-like growth factor-1 on synapses in CA1 of rat hippocampusLei Shi
Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1010, USA
Cereb Cortex 15:571-7. 2005..These changes in synaptic configurations are morphological correlates of enhanced synaptic efficacy. Thus, aging and IGF-1 affect different, but complementary, aspects of synapses in hippocampal CA1...
- Stereological quantification of GAD-67-immunoreactive neurons and boutons in the hippocampus of middle-aged and old Fischer 344 x Brown Norway ratsLei Shi
Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, North Carolina 27157 1010, USA
J Comp Neurol 478:282-91. 2004..It is possible that loss of CA1 inhibitory interneurons in the dorsal hippocampus contributes to the learning and memory impairments reported in old rats...
- Aging masks detection of radiation-induced brain injuryLei Shi
Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Brain Res 1385:307-16. 2011....
- Maintenance of white matter integrity in a rat model of radiation-induced cognitive impairmentLei Shi
Program in Neuroscience, Wake Forest University School of Medicine, Winston Salem, NC 27157 1010, USA
J Neurol Sci 285:178-84. 2009..Imaging studies with advanced techniques including diffusion tensor imaging may be required to elucidate the neurobiological changes associated with the cognitive impairment in this model...
- Differential effects of radiation and age on diffusion tensor imaging in ratsAnn M Peiffer
Department of Radiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Brain Res 1351:23-31. 2010..These findings suggest that targets of the fWBI-induced change in this model may be the less myelinated or unmyelinated axons, extracellular matrix, or synaptic fields rather than heavily myelinated tracts...
- Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanismWing Yu Fu
Department of Biochemistry, Biotechnology Research Institute and Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
Nat Neurosci 10:67-76. 2007..These findings suggest that ephrin-A1 promotes EphA4-dependent spine retraction through the activation of Cdk5 and ephexin1, which in turn modulates actin cytoskeletal dynamics...
- Porcine circovirus type 2 induces the activation of nuclear factor kappa B by IkappaBalpha degradationLi Wei
Institute of Animal Husbandry and Veterinary Medicine, Beijing Municipal Academy of Agriculture and Forestry Sciences, No 9 Shuguang Garden Central Road, Haidian District, Beijing 100097, People s Republic of China
Virology 378:177-84. 2008..The results presented here provide a basis for understanding molecular mechanism of PCV2 infection...
- Roles of Drosophila Kruppel-homolog 1 in neuronal morphogenesisLei Shi
Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
Dev Neurobiol 67:1614-26. 2007..Thus, although KR-H1 has a potential for modulating neuronal morphogenesis, it appears physiologically involved in coordinating general ecdysone signaling...
- Human adenovirus modulates surfactant phospholipid traffickingOlga L Miakotina
Department of Internal Medicine, University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
Traffic 8:1765-77. 2007..The results support a novel pathway, whereby a viral pathogen disrupts surfactant trafficking...
- Alpha2-chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapseLei Shi
Department of Biochemistry, Biotechnology Research Institute, and Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
Proc Natl Acad Sci U S A 104:16347-52. 2007..Our findings have therefore identified a new alpha2-chimaerin-dependent signaling mechanism through which EphA4 transduces its signals to the actin cytoskeleton and modulates growth cone morphology...
- Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory painMichael E Kort
Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6100, USA
J Med Chem 51:407-16. 2008..2, Nav1.5, Nav1.7) and human ether-a-go-go (hERG) channels. Following systemic administration, compounds 7 and 27 dose-dependently reduced neuropathic and inflammatory pain in experimental rodent models...
- [Phenols in seedling cortex of Magnolia officinalis from Enshi]Hong bing Yang
School of Pharmacy, Hubei College of Traditional Chinese Medicine, Wuhan 430061, China
Zhong Yao Cai 31:181-3. 2008..To study the phenols in Cortex of Magnolia officinalis of biernial seedings produced in Enshi, Hubei...
- An intracellular interaction network regulates conformational transitions in the dopamine transporterJulie Kniazeff
Molecular Neuropharmacology Group and Center for Pharmacogenomics, Department of Neuroscience and Pharmacology, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen, Denmark
J Biol Chem 283:17691-701. 2008..The mechanism that emerges from these findings may be unique to the NSS family, where the local disruption of ionic interactions modulates the transition of the transporter between the outward- and inward-facing conformations...
- Structural effects of quinacrine binding in the open channel of the acetylcholine receptorYong Yu
Center for Molecular Recognition, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
Proc Natl Acad Sci U S A 100:3907-12. 2003..Blocker binding in the open channel causes a further change in structure...
- Two genes encoding protein kinases of the HstK family are involved in synthesis of the minor heterocyst-specific glycolipid in the cyanobacterium Anabaena sp. strain PCC 7120Lei Shi
National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, People s Republic of China
J Bacteriol 189:5075-81. 2007....
- Specific inhibition of type I interferon signal transduction by respiratory syncytial virusMurali Ramaswamy
University of Iowa Roy J. and Lucille A. Carver College of Medicine, Department of Internal Medicine, 200 Hawkins Drive, C33-GH, Iowa City, IA 52242, USA
Am J Respir Cell Mol Biol 30:893-900. 2004..Decreased antiviral gene expression in RSV-infected airway epithelial cells may allow RSV replication and establishment of a productive viral infection through subversion of IFN-dependent immunity...
- Characterization of the oligomer structure of recombinant human mannan-binding lectinPia H Jensen
Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark
J Biol Chem 280:11043-51. 2005..The oligomerization patterns of these mutants support the proposed model. The model indicates that the polypeptide dimer is the basic unit in the oligomerization...
- A pincer-like configuration of TM2 in the human dopamine transporter is responsible for indirect effects on cocaine bindingNamita Sen
Center for Molecular Recognition and Departments of Psychiatry and Pharmacology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Neuropharmacology 49:780-90. 2005..We have taken advantage of this structure to explore further and interpret our experimental results in a rigorous structural context...
- Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transductionMurali Ramaswamy
Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
Virology 344:328-39. 2006..Taken together, our results indicate that NS2 regulates Stat2 levels during RSV infection, thereby modulating viral effects on interferon-dependent gene expression...
- Deficiency of mannose-binding lectin greatly increases susceptibility to postburn infection with Pseudomonas aeruginosaMette Møller-Kristensen
Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Immunol 176:1769-75. 2006..aeruginosa infection following burn injury and suggests that MBL deficiency in humans maybe a premorbid variable in the predisposition to infection in burn victims...
- Baboon/dSmad2 TGF-beta signaling is required during late larval stage for development of adult-specific neuronsXiaoyan Zheng
Department of Cell and Developmental Biology, School of Molecular and Cellular Biology, University of Illinois, Urbana, IL, USA
EMBO J 25:615-27. 2006..Our results suggest that Babo/dSmad2 signaling prior to metamorphosis may be widely required to prepare neurons for the dynamic environment present during metamorphosis...
- Propagation of photon noise and information transfer in visual motion detectionLei Shi
Department of Systems and Computational Neuroscience, Max-Planck-Institute of Neurobiology, Martinsried, Germany
J Comput Neurosci 20:167-78. 2006..Most notably, due to inherent adaptive properties, the transmitted information about stimulus velocity remains nearly constant over a large range of velocity entropies...
- Expression of macrophage inflammatory protein-1alpha in Kupffer cells following liver ischemia or reperfusion injury in ratsWei Ma
Department of Hepatobiliary Surgery, First Hospital of Xi an Jiaotong University, Shaanxi Province, China
World J Gastroenterol 12:3854-8. 2006..To explore the expression of macrophage inflammatory protein-1alpha (MIP-1alpha) in Kupffer cells (KCs) following liver ischemia/reperfusion injury IRI in rats...
- [Effect of prostaglandin E1 on monocyte chemotactic protein-1 expression in Kupffer cells of rats with hepatic ischemia-reperfusion injury]Wei Ma
Department of Hepatobiliary Surgery, First Hospital of Xi an Jiaotong University, Xi an 710061, China
Nan Fang Yi Ke Da Xue Xue Bao 26:1180-3. 2006..To observe the effect of prostaglandin E(1) (PGE(1)) on the expression of monocyte chemotactic protein-1 (MCP-1) in Kupffer cells (KCs) of rats with hepatic ischemia-reperfusion injury (IRI)...
- Infection of human airway epithelia by SARS coronavirus is associated with ACE2 expression and localizationHong Peng Jia
University of Iowa, Iowa City 52242, USA
Adv Exp Med Biol 581:479-84. 2006
- Rapid learning in cortical coding of visual scenesHaishan Yao
Division of Neurobiology, Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA
Nat Neurosci 10:772-8. 2007..Thus, repeated exposure to natural stimuli not only induces a rapid improvement in cortical response reliability, but also leaves a 'memory trace' in subsequent spontaneous activity...
- A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the ratMichael F Jarvis
Neuroscience Research, Abbott Laboratories, Abbott Park, IL 60064, USA
Proc Natl Acad Sci U S A 104:8520-5. 2007..These data demonstrate that acute and selective pharmacological blockade of Na(v)1.8 sodium channels in vivo produces significant antinociception in animal models of neuropathic and inflammatory pain...
- NSPc1, a mainly nuclear localized protein of novel PcG family members, has a transcription repression activity related to its PKC phosphorylation site at S183Yanhua Gong
Institute of Basic Medical Sciences, National Laboratory of Medical Molecular Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, National Human Genome Center, Beijing 100005, China
FEBS Lett 579:115-21. 2005..Taken together, results from our study suggest that NSPc1, as a typical PcG family member, has powerful transcriptional repression ability, which may be related to the PKC signaling pathway...