Lei Shi

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Caloric restricted male rats demonstrate fewer synapses in layer 2 of sensorimotor cortex
    Lei Shi
    Department of Neurobiology and Anatomy, Medical Center Boulevard, Wake Forest University School of Medicine, Winston Salem, NC 27157 1010, USA
    Brain Res 931:32-40. 2002
  2. pmc Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability
    Michelle M Adams
    Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Exp Neurol 211:141-9. 2008
  3. pmc Hippocampal neuron number is unchanged 1 year after fractionated whole-brain irradiation at middle age
    Lei Shi
    Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Winston Salem, NC 27157 1010, USA
    Int J Radiat Oncol Biol Phys 71:526-32. 2008
  4. pmc Caloric restriction eliminates the aging-related decline in NMDA and AMPA receptor subunits in the rat hippocampus and induces homeostasis
    Lei Shi
    Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157 1010, USA
    Exp Neurol 206:70-9. 2007
  5. ncbi request reprint Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampus
    Lei Shi
    Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Radiat Res 166:892-9. 2006
  6. ncbi request reprint Maintenance of inhibitory interneurons and boutons in sensorimotor cortex between middle and old age in Fischer 344 X Brown Norway rats
    Lei Shi
    Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Winston Salem, NC 27157 1010, USA
    J Chem Neuroanat 32:46-53. 2006
  7. ncbi request reprint Differential effects of aging and insulin-like growth factor-1 on synapses in CA1 of rat hippocampus
    Lei Shi
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1010, USA
    Cereb Cortex 15:571-7. 2005
  8. ncbi request reprint Stereological quantification of GAD-67-immunoreactive neurons and boutons in the hippocampus of middle-aged and old Fischer 344 x Brown Norway rats
    Lei Shi
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, North Carolina 27157 1010, USA
    J Comp Neurol 478:282-91. 2004
  9. pmc Aging masks detection of radiation-induced brain injury
    Lei Shi
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Brain Res 1385:307-16. 2011
  10. pmc Maintenance of white matter integrity in a rat model of radiation-induced cognitive impairment
    Lei Shi
    Program in Neuroscience, Wake Forest University School of Medicine, Winston Salem, NC 27157 1010, USA
    J Neurol Sci 285:178-84. 2009

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Caloric restricted male rats demonstrate fewer synapses in layer 2 of sensorimotor cortex
    Lei Shi
    Department of Neurobiology and Anatomy, Medical Center Boulevard, Wake Forest University School of Medicine, Winston Salem, NC 27157 1010, USA
    Brain Res 931:32-40. 2002
    ..These results suggest that not only does caloric restriction fail to prevent the age-related decline in presumptive inhibitory synapses, it results in fewer presumptive excitatory synapses as well...
  2. pmc Caloric restriction and age affect synaptic proteins in hippocampal CA3 and spatial learning ability
    Michelle M Adams
    Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Exp Neurol 211:141-9. 2008
    ..This age-related decrease and CR-induced stabilization are likely to affect CA3 synaptic plasticity and, as a result, hippocampal function...
  3. pmc Hippocampal neuron number is unchanged 1 year after fractionated whole-brain irradiation at middle age
    Lei Shi
    Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Winston Salem, NC 27157 1010, USA
    Int J Radiat Oncol Biol Phys 71:526-32. 2008
    ....
  4. pmc Caloric restriction eliminates the aging-related decline in NMDA and AMPA receptor subunits in the rat hippocampus and induces homeostasis
    Lei Shi
    Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157 1010, USA
    Exp Neurol 206:70-9. 2007
    ..CR eliminates that aging-related decline by inducing stable NMDA and AMPA receptor subunit levels...
  5. ncbi request reprint Spatial learning and memory deficits after whole-brain irradiation are associated with changes in NMDA receptor subunits in the hippocampus
    Lei Shi
    Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Radiat Res 166:892-9. 2006
    ..These findings suggest for the first time that radiation-induced cognitive impairments may be associated with alterations in glutamate receptor composition...
  6. ncbi request reprint Maintenance of inhibitory interneurons and boutons in sensorimotor cortex between middle and old age in Fischer 344 X Brown Norway rats
    Lei Shi
    Department of Neurobiology and Anatomy, Wake Forest University Health Sciences, Winston Salem, NC 27157 1010, USA
    J Chem Neuroanat 32:46-53. 2006
    ....
  7. ncbi request reprint Differential effects of aging and insulin-like growth factor-1 on synapses in CA1 of rat hippocampus
    Lei Shi
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1010, USA
    Cereb Cortex 15:571-7. 2005
    ..These changes in synaptic configurations are morphological correlates of enhanced synaptic efficacy. Thus, aging and IGF-1 affect different, but complementary, aspects of synapses in hippocampal CA1...
  8. ncbi request reprint Stereological quantification of GAD-67-immunoreactive neurons and boutons in the hippocampus of middle-aged and old Fischer 344 x Brown Norway rats
    Lei Shi
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, North Carolina 27157 1010, USA
    J Comp Neurol 478:282-91. 2004
    ..It is possible that loss of CA1 inhibitory interneurons in the dorsal hippocampus contributes to the learning and memory impairments reported in old rats...
  9. pmc Aging masks detection of radiation-induced brain injury
    Lei Shi
    Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Brain Res 1385:307-16. 2011
    ....
  10. pmc Maintenance of white matter integrity in a rat model of radiation-induced cognitive impairment
    Lei Shi
    Program in Neuroscience, Wake Forest University School of Medicine, Winston Salem, NC 27157 1010, USA
    J Neurol Sci 285:178-84. 2009
    ..Imaging studies with advanced techniques including diffusion tensor imaging may be required to elucidate the neurobiological changes associated with the cognitive impairment in this model...
  11. pmc Differential effects of radiation and age on diffusion tensor imaging in rats
    Ann M Peiffer
    Department of Radiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Brain Res 1351:23-31. 2010
    ..These findings suggest that targets of the fWBI-induced change in this model may be the less myelinated or unmyelinated axons, extracellular matrix, or synaptic fields rather than heavily myelinated tracts...
  12. ncbi request reprint Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism
    Wing Yu Fu
    Department of Biochemistry, Biotechnology Research Institute and Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Nat Neurosci 10:67-76. 2007
    ..These findings suggest that ephrin-A1 promotes EphA4-dependent spine retraction through the activation of Cdk5 and ephexin1, which in turn modulates actin cytoskeletal dynamics...
  13. doi request reprint Porcine circovirus type 2 induces the activation of nuclear factor kappa B by IkappaBalpha degradation
    Li Wei
    Institute of Animal Husbandry and Veterinary Medicine, Beijing Municipal Academy of Agriculture and Forestry Sciences, No 9 Shuguang Garden Central Road, Haidian District, Beijing 100097, People s Republic of China
    Virology 378:177-84. 2008
    ..The results presented here provide a basis for understanding molecular mechanism of PCV2 infection...
  14. ncbi request reprint Roles of Drosophila Kruppel-homolog 1 in neuronal morphogenesis
    Lei Shi
    Department of Neurobiology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Dev Neurobiol 67:1614-26. 2007
    ..Thus, although KR-H1 has a potential for modulating neuronal morphogenesis, it appears physiologically involved in coordinating general ecdysone signaling...
  15. ncbi request reprint Human adenovirus modulates surfactant phospholipid trafficking
    Olga L Miakotina
    Department of Internal Medicine, University of Iowa, Roy J and Lucille A Carver College of Medicine, Iowa City, IA 52242, USA
    Traffic 8:1765-77. 2007
    ..The results support a novel pathway, whereby a viral pathogen disrupts surfactant trafficking...
  16. pmc Alpha2-chimaerin interacts with EphA4 and regulates EphA4-dependent growth cone collapse
    Lei Shi
    Department of Biochemistry, Biotechnology Research Institute, and Molecular Neuroscience Center, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China
    Proc Natl Acad Sci U S A 104:16347-52. 2007
    ..Our findings have therefore identified a new alpha2-chimaerin-dependent signaling mechanism through which EphA4 transduces its signals to the actin cytoskeleton and modulates growth cone morphology...
  17. doi request reprint Discovery and biological evaluation of 5-aryl-2-furfuramides, potent and selective blockers of the Nav1.8 sodium channel with efficacy in models of neuropathic and inflammatory pain
    Michael E Kort
    Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, IL 60064 6100, USA
    J Med Chem 51:407-16. 2008
    ..2, Nav1.5, Nav1.7) and human ether-a-go-go (hERG) channels. Following systemic administration, compounds 7 and 27 dose-dependently reduced neuropathic and inflammatory pain in experimental rodent models...
  18. ncbi request reprint [Phenols in seedling cortex of Magnolia officinalis from Enshi]
    Hong bing Yang
    School of Pharmacy, Hubei College of Traditional Chinese Medicine, Wuhan 430061, China
    Zhong Yao Cai 31:181-3. 2008
    ..To study the phenols in Cortex of Magnolia officinalis of biernial seedings produced in Enshi, Hubei...
  19. pmc An intracellular interaction network regulates conformational transitions in the dopamine transporter
    Julie Kniazeff
    Molecular Neuropharmacology Group and Center for Pharmacogenomics, Department of Neuroscience and Pharmacology, The Panum Institute, University of Copenhagen, DK 2200 Copenhagen, Denmark
    J Biol Chem 283:17691-701. 2008
    ..The mechanism that emerges from these findings may be unique to the NSS family, where the local disruption of ionic interactions modulates the transition of the transporter between the outward- and inward-facing conformations...
  20. pmc Structural effects of quinacrine binding in the open channel of the acetylcholine receptor
    Yong Yu
    Center for Molecular Recognition, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    Proc Natl Acad Sci U S A 100:3907-12. 2003
    ..Blocker binding in the open channel causes a further change in structure...
  21. pmc Two genes encoding protein kinases of the HstK family are involved in synthesis of the minor heterocyst-specific glycolipid in the cyanobacterium Anabaena sp. strain PCC 7120
    Lei Shi
    National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, People s Republic of China
    J Bacteriol 189:5075-81. 2007
    ....
  22. ncbi request reprint Specific inhibition of type I interferon signal transduction by respiratory syncytial virus
    Murali Ramaswamy
    University of Iowa Roy J and Lucille A Carver College of Medicine, Department of Internal Medicine, 200 Hawkins Drive, C33 GH, Iowa City, IA 52242, USA
    Am J Respir Cell Mol Biol 30:893-900. 2004
    ..Decreased antiviral gene expression in RSV-infected airway epithelial cells may allow RSV replication and establishment of a productive viral infection through subversion of IFN-dependent immunity...
  23. ncbi request reprint Characterization of the oligomer structure of recombinant human mannan-binding lectin
    Pia H Jensen
    Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark
    J Biol Chem 280:11043-51. 2005
    ..The oligomerization patterns of these mutants support the proposed model. The model indicates that the polypeptide dimer is the basic unit in the oligomerization...
  24. ncbi request reprint A pincer-like configuration of TM2 in the human dopamine transporter is responsible for indirect effects on cocaine binding
    Namita Sen
    Center for Molecular Recognition and Departments of Psychiatry and Pharmacology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Neuropharmacology 49:780-90. 2005
    ..We have taken advantage of this structure to explore further and interpret our experimental results in a rigorous structural context...
  25. ncbi request reprint Respiratory syncytial virus nonstructural protein 2 specifically inhibits type I interferon signal transduction
    Murali Ramaswamy
    Department of Internal Medicine, University of Iowa Carver College of Medicine, 200 Hawkins Drive, Iowa City, IA 52242, USA
    Virology 344:328-39. 2006
    ..Taken together, our results indicate that NS2 regulates Stat2 levels during RSV infection, thereby modulating viral effects on interferon-dependent gene expression...
  26. pmc Deficiency of mannose-binding lectin greatly increases susceptibility to postburn infection with Pseudomonas aeruginosa
    Mette Møller-Kristensen
    Laboratory of Developmental Immunology, Department of Pediatrics, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 176:1769-75. 2006
    ..aeruginosa infection following burn injury and suggests that MBL deficiency in humans maybe a premorbid variable in the predisposition to infection in burn victims...
  27. pmc Baboon/dSmad2 TGF-beta signaling is required during late larval stage for development of adult-specific neurons
    Xiaoyan Zheng
    Department of Cell and Developmental Biology, School of Molecular and Cellular Biology, University of Illinois, Urbana, IL, USA
    EMBO J 25:615-27. 2006
    ..Our results suggest that Babo/dSmad2 signaling prior to metamorphosis may be widely required to prepare neurons for the dynamic environment present during metamorphosis...
  28. ncbi request reprint Propagation of photon noise and information transfer in visual motion detection
    Lei Shi
    Department of Systems and Computational Neuroscience, Max Planck Institute of Neurobiology, Martinsried, Germany
    J Comput Neurosci 20:167-78. 2006
    ..Most notably, due to inherent adaptive properties, the transmitted information about stimulus velocity remains nearly constant over a large range of velocity entropies...
  29. ncbi request reprint Expression of macrophage inflammatory protein-1alpha in Kupffer cells following liver ischemia or reperfusion injury in rats
    Wei Ma
    Department of Hepatobiliary Surgery, First Hospital of Xi an Jiaotong University, Shaanxi Province, China
    World J Gastroenterol 12:3854-8. 2006
    ..To explore the expression of macrophage inflammatory protein-1alpha (MIP-1alpha) in Kupffer cells (KCs) following liver ischemia/reperfusion injury IRI in rats...
  30. ncbi request reprint [Effect of prostaglandin E1 on monocyte chemotactic protein-1 expression in Kupffer cells of rats with hepatic ischemia-reperfusion injury]
    Wei Ma
    Department of Hepatobiliary Surgery, First Hospital of Xi an Jiaotong University, Xi an 710061, China
    Nan Fang Yi Ke Da Xue Xue Bao 26:1180-3. 2006
    ..To observe the effect of prostaglandin E(1) (PGE(1)) on the expression of monocyte chemotactic protein-1 (MCP-1) in Kupffer cells (KCs) of rats with hepatic ischemia-reperfusion injury (IRI)...
  31. ncbi request reprint Infection of human airway epithelia by SARS coronavirus is associated with ACE2 expression and localization
    Hong Peng Jia
    University of Iowa, Iowa City 52242, USA
    Adv Exp Med Biol 581:479-84. 2006
  32. ncbi request reprint Rapid learning in cortical coding of visual scenes
    Haishan Yao
    Division of Neurobiology, Department of Molecular and Cell Biology, University of California at Berkeley, Berkeley, California 94720, USA
    Nat Neurosci 10:772-8. 2007
    ..Thus, repeated exposure to natural stimuli not only induces a rapid improvement in cortical response reliability, but also leaves a 'memory trace' in subsequent spontaneous activity...
  33. pmc A-803467, a potent and selective Nav1.8 sodium channel blocker, attenuates neuropathic and inflammatory pain in the rat
    Michael F Jarvis
    Neuroscience Research, Abbott Laboratories, Abbott Park, IL 60064, USA
    Proc Natl Acad Sci U S A 104:8520-5. 2007
    ..These data demonstrate that acute and selective pharmacological blockade of Na(v)1.8 sodium channels in vivo produces significant antinociception in animal models of neuropathic and inflammatory pain...
  34. ncbi request reprint NSPc1, a mainly nuclear localized protein of novel PcG family members, has a transcription repression activity related to its PKC phosphorylation site at S183
    Yanhua Gong
    Institute of Basic Medical Sciences, National Laboratory of Medical Molecular Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, National Human Genome Center, Beijing 100005, China
    FEBS Lett 579:115-21. 2005
    ..Taken together, results from our study suggest that NSPc1, as a typical PcG family member, has powerful transcriptional repression ability, which may be related to the PKC signaling pathway...