Edward Shaw

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05
    E Shaw
    Department of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1030, USA
    Int J Radiat Oncol Biol Phys 47:291-8. 2000
  2. ncbi request reprint Phase II study of donepezil in irradiated brain tumor patients: effect on cognitive function, mood, and quality of life
    Edward G Shaw
    Department of Radiation Oncology, Wake Forest University School of Medicine, Brain Tumor Center of Excellence of WFU, Winston Salem, NC 27157 1030, USA
    J Clin Oncol 24:1415-20. 2006
  3. doi request reprint Recurrence following neurosurgeon-determined gross-total resection of adult supratentorial low-grade glioma: results of a prospective clinical trial
    Edward G Shaw
    Department of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurosurg 109:835-41. 2008
  4. ncbi request reprint Current controversies in the radiotherapeutic management of adult low-grade glioma
    Edward G Shaw
    Department of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Semin Oncol 31:653-8. 2004
  5. pmc Presidential symposium on low-grade glioma
    Edward G Shaw
    Department of Radiation Oncology, Comprehensive Cancer Center, WFU Baptist Medical Center, Wake Forest University School of Medicine, Winston Salem, NC 27157 1030, USA
    Neuro Oncol 5:151-2. 2003
  6. pmc Prospective clinical trials of intracranial low-grade glioma in adults and children
    Edward G Shaw
    Department of Radiation Oncology, Comprehensive Cancer Center, WFU Baptist Medical Center, Wake Forest University School of Medicine, Winston Salem, NC 27157 1030, USA
    Neuro Oncol 5:153-60. 2003
  7. ncbi request reprint RSR13 plus cranial radiation therapy in patients with brain metastases: comparison with the Radiation Therapy Oncology Group Recursive Partitioning Analysis Brain Metastases Database
    Edward Shaw
    Department of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1030, USA
    J Clin Oncol 21:2364-71. 2003
  8. ncbi request reprint Prospective randomized trial of low- versus high-dose radiation therapy in adults with supratentorial low-grade glioma: initial report of a North Central Cancer Treatment Group/Radiation Therapy Oncology Group/Eastern Cooperative Oncology Group study
    E Shaw
    North Central Cancer Treatment Group Operations Office, Rochester, MN, USA
    J Clin Oncol 20:2267-76. 2002
  9. ncbi request reprint Whole-brain radiotherapy with or without efaproxiral for the treatment of brain metastases: Determinants of response and its prognostic value for subsequent survival
    Baldassarre Stea
    Department of Radiation Oncology, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    Int J Radiat Oncol Biol Phys 64:1023-30. 2006
  10. ncbi request reprint Phase III study of efaproxiral as an adjunct to whole-brain radiation therapy for brain metastases
    John H Suh
    Cleveland Clinic Foundation, Brain Tumor Institute, Department of Radiation Oncology, Cleveland, OH 44195, USA
    J Clin Oncol 24:106-14. 2006

Research Grants

Detail Information

Publications35

  1. ncbi request reprint Single dose radiosurgical treatment of recurrent previously irradiated primary brain tumors and brain metastases: final report of RTOG protocol 90-05
    E Shaw
    Department of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1030, USA
    Int J Radiat Oncol Biol Phys 47:291-8. 2000
    ..To determine the maximum tolerated dose of single fraction radiosurgery in patients with recurrent previously irradiated primary brain tumors and brain metastases...
  2. ncbi request reprint Phase II study of donepezil in irradiated brain tumor patients: effect on cognitive function, mood, and quality of life
    Edward G Shaw
    Department of Radiation Oncology, Wake Forest University School of Medicine, Brain Tumor Center of Excellence of WFU, Winston Salem, NC 27157 1030, USA
    J Clin Oncol 24:1415-20. 2006
    ....
  3. doi request reprint Recurrence following neurosurgeon-determined gross-total resection of adult supratentorial low-grade glioma: results of a prospective clinical trial
    Edward G Shaw
    Department of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurosurg 109:835-41. 2008
    ..In 1998, the Radiation Therapy Oncology Group initiated a Phase II study of observation for adults < 40 years old with cerebral low-grade glioma who underwent a neurosurgeon-determined gross-total resection (GTR)...
  4. ncbi request reprint Current controversies in the radiotherapeutic management of adult low-grade glioma
    Edward G Shaw
    Department of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Semin Oncol 31:653-8. 2004
    ..Further prospective clinical trials are needed to define the optimal management strategy for adults with supratentorial LGG. The schemata from recently completed and ongoing LGG studies will be presented...
  5. pmc Presidential symposium on low-grade glioma
    Edward G Shaw
    Department of Radiation Oncology, Comprehensive Cancer Center, WFU Baptist Medical Center, Wake Forest University School of Medicine, Winston Salem, NC 27157 1030, USA
    Neuro Oncol 5:151-2. 2003
  6. pmc Prospective clinical trials of intracranial low-grade glioma in adults and children
    Edward G Shaw
    Department of Radiation Oncology, Comprehensive Cancer Center, WFU Baptist Medical Center, Wake Forest University School of Medicine, Winston Salem, NC 27157 1030, USA
    Neuro Oncol 5:153-60. 2003
    ..The schemata from recently completed and ongoing studies in both adult and pediatric intracranial LGG are reviewed...
  7. ncbi request reprint RSR13 plus cranial radiation therapy in patients with brain metastases: comparison with the Radiation Therapy Oncology Group Recursive Partitioning Analysis Brain Metastases Database
    Edward Shaw
    Department of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1030, USA
    J Clin Oncol 21:2364-71. 2003
    ..The primary end point was patient survival in comparison with the Radiation Therapy Oncology Group Recursive Partitioning Analysis Brain Metastases Database (RTOG RPA BMD)...
  8. ncbi request reprint Prospective randomized trial of low- versus high-dose radiation therapy in adults with supratentorial low-grade glioma: initial report of a North Central Cancer Treatment Group/Radiation Therapy Oncology Group/Eastern Cooperative Oncology Group study
    E Shaw
    North Central Cancer Treatment Group Operations Office, Rochester, MN, USA
    J Clin Oncol 20:2267-76. 2002
    ..4 Gy/28 fractions) versus high-dose (64.8 Gy/36 fractions) localized radiation therapy (RT) for supratentorial low-grade astrocytoma, oligodendroglioma, and mixed oligoastrocytoma...
  9. ncbi request reprint Whole-brain radiotherapy with or without efaproxiral for the treatment of brain metastases: Determinants of response and its prognostic value for subsequent survival
    Baldassarre Stea
    Department of Radiation Oncology, University of Arizona Health Sciences Center, Tucson, AZ 85724, USA
    Int J Radiat Oncol Biol Phys 64:1023-30. 2006
    ..To determine the prognostic factors for radiographic response and its prognostic value for subsequent survival in patients undergoing whole-brain radiotherapy (WBRT) for brain metastases...
  10. ncbi request reprint Phase III study of efaproxiral as an adjunct to whole-brain radiation therapy for brain metastases
    John H Suh
    Cleveland Clinic Foundation, Brain Tumor Institute, Department of Radiation Oncology, Cleveland, OH 44195, USA
    J Clin Oncol 24:106-14. 2006
    ..To determine whether efaproxiral, an allosteric modifier of hemoglobin, improves survival in patients with brain metastases when used as an adjunct to whole-brain radiation therapy (WBRT)...
  11. ncbi request reprint Spinal cord gliomas: A multi-institutional retrospective analysis
    May Abdel-Wahab
    Department of Radiation Oncology, University of Miami, Miami, FL, USA
    Int J Radiat Oncol Biol Phys 64:1060-71. 2006
    ..To determine the impact of postoperative radiation therapy (POXRT) on outcome in spinal cord gliomas...
  12. doi request reprint A phase I-B trial of the radiosensitizer: etanidazole (SR-2508) with radiosurgery for the treatment of recurrent previously irradiated primary brain tumors or brain metastases (RTOG Study 95-02)
    R E Drzymala
    Department of Radiation Oncology, Washington University Medical Center, St Louis, MO 63110, USA
    Radiother Oncol 87:89-92. 2008
    ..The toxicity is reported in three groups of patients according to the tumor size. Etanidazole doses of 12g/m2 combined with radiosurgery were well tolerated...
  13. ncbi request reprint Radiation safety issues with high activities of liquid I-125: techniques and experience
    A F deGuzman
    Department of Radiation Oncology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    J Appl Clin Med Phys 4:143-8. 2003
    ..To date we have treated 22 patients with infused activities ranging up to 26.8 GBq (724 mCi). The careful manipulation of such solutions is important to maintain a safe environment for the patients and the involved medical staff...
  14. ncbi request reprint Determination of a clinical value for the repair half-time (T1/2) of the trigeminal nerve based on outcome data from gamma knife radiosurgery for facial pain
    Volker Stieber
    Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1030, USA
    Radiat Res 168:143-8. 2007
    ..28-1.77 h for T(1/2). The biological model appeared to accurately predict that, given the doses and treatment times used in general clinical practice, there would be no significant difference in clinical outcome...
  15. pmc Efaproxiral red blood cell concentration predicts efficacy in patients with brain metastases
    B Stea
    Department of Radiation Oncology, The University of Arizona Health Sciences Center, Tucson, 85724, USA
    Br J Cancer 94:1777-84. 2006
    ..This analysis defined the efaproxiral concentration-dependence in survival and response rate improvement, and provided a clearer understanding of efaproxiral dosing requirements...
  16. ncbi request reprint Nothing ventured, nothing gained: Treatment of glioblastoma multiforme in the elderly
    Edward G Shaw
    J Clin Oncol 22:1540-1. 2004
  17. ncbi request reprint Results of a phase II trial of the GliaSite radiation therapy system for the treatment of newly diagnosed, resected single brain metastases
    Lisa R Rogers
    Department of Neurology and Neurosurgery, Henry Ford Hospital, Detroit, Michigan 48109 0316, USA
    J Neurosurg 105:375-84. 2006
    ..The primary end point of the study was local tumor control. The secondary end points included patient survival, distant brain recurrence, quality of life, and treatment toxicity...
  18. ncbi request reprint Managing the cognitive effects of brain tumor radiation therapy
    Jerome M Butler
    Department of Radiation Oncology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Curr Treat Options Oncol 7:517-23. 2006
    ..Given the prevalence of brain neoplasms and the high incidence of the radiation-induced symptom cluster and brain injury, clinical research to address these important clinical problems is critical...
  19. ncbi request reprint Prognostic factors for survival in adult patients with recurrent glioma enrolled onto the new approaches to brain tumor therapy CNS consortium phase I and II clinical trials
    Kathryn A Carson
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health and The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA
    J Clin Oncol 25:2601-6. 2007
    ..Prognostic factor analyses have proven useful in predicting outcome in patients with newly diagnosed malignant glioma. Similar analyses in patients with recurrent glioma could affect the design and conduct of clinical trials substantially...
  20. ncbi request reprint A phase III, double-blind, placebo-controlled prospective randomized clinical trial of d-threo-methylphenidate HCl in brain tumor patients receiving radiation therapy
    Jerome M Butler
    Department of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Int J Radiat Oncol Biol Phys 69:1496-501. 2007
    ..We assessed the effect of prophylactic d-threo-methylphenidate HCl (d-MPH), a central nervous system (CNS) stimulant on QOL and cognitive function in patients undergoing RT...
  21. ncbi request reprint Symptom clusters in patients with newly-diagnosed brain tumors
    John F Gleason
    Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    J Support Oncol 5:427-33, 436. 2007
    ..Our results suggest that interventions that target both cognitive function and mood should be considered in this patient population. Further research on symptom clusters in brain tumor patients is needed...
  22. pmc The neurocognitive effects of radiation in adult low-grade glioma patients
    Paul D Brown
    Division of Radiation Oncology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA
    Neuro Oncol 5:161-7. 2003
    ..The weight of evidence suggests only sporadic, limited neurocognitive damage from focal radiotherapy at the doses usually prescribed for low-grade gliomas...
  23. ncbi request reprint Supportive use of megestrol acetate (Megace) with head/neck and lung cancer patients receiving radiation therapy
    Richard P McQuellon
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1082, USA
    Int J Radiat Oncol Biol Phys 52:1180-5. 2002
    ..The purpose of this study was to measure the effect of megestrol acetate (MA) on weight loss and quality of life (QOL) in patients with cancer of the lung or head and neck undergoing curative radiation therapy...
  24. ncbi request reprint Effects of radiotherapy on cognitive function in patients with low-grade glioma measured by the folstein mini-mental state examination
    Paul D Brown
    Mayo Clinic, Division of Radiation Oncology, Rochester, MN 55905, USA
    J Clin Oncol 21:2519-24. 2003
    ..To assess the neurocognitive effects of cranial radiotherapy on patients with low-grade gliomas, we analyzed cognitive performance data collected in a prospective, intergroup clinical trial...
  25. ncbi request reprint Importance of baseline mini-mental state examination as a prognostic factor for patients with low-grade glioma
    Paul D Brown
    Division of Radiation Ocology, Mayo Clinic, Rochester, MN 55905, USA
    Int J Radiat Oncol Biol Phys 59:117-25. 2004
    ....
  26. ncbi request reprint Lessons learned from randomised clinical trials in adult low grade glioma
    Michael A Papagikos
    Department of Radiation Oncology, Comprehensive Cancer Center, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157, USA
    Lancet Oncol 6:240-4. 2005
    ..The goal is to show that the lessons learned are not necessarily literal or dogmatic but can be much more allegorical in nature...
  27. ncbi request reprint Cognitive function after radiotherapy for supratentorial low-grade glioma: a North Central Cancer Treatment Group prospective study
    Nadia N Laack
    Division of Radiation Oncology, Mayo Clinic, Rochester, MN 55905, USA
    Int J Radiat Oncol Biol Phys 63:1175-83. 2005
    ..To evaluate the effects of cranial radiotherapy (RT) on cognitive function in patients with supratentorial low-grade glioma...
  28. ncbi request reprint The evolving role of biological imaging in stereotactic radiosurgery
    J Daniel Bourland
    Department of Radiation Oncology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Technol Cancer Res Treat 2:135-9. 2003
    ..These aspects are reviewed to explore the potential uses and impact these images may have on radiosurgery treatment...
  29. ncbi request reprint Does dose rate affect efficacy? The outcomes of 256 gamma knife surgery procedures for trigeminal neuralgia and other types of facial pain as they relate to the half-life of cobalt
    Christopher J Balamucki
    Department of Neurosurgery, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1030, USA
    J Neurosurg 105:730-5. 2006
    ..26 years. The authors examined whether the decrease in dose rate over 4.6 years between Co source replacements affected the control rates of facial pain in patients undergoing GKS...
  30. ncbi request reprint Low-grade glioma: current management and controversies
    Glenn Bauman
    University of Western Ontario, London, Ontario N6A 4L6, Canada
    Clin Adv Hematol Oncol 1:546-53. 2003
    ..Other advances include the molecular characterization of these tumors that should assist in selection of existing and development of future therapies...
  31. ncbi request reprint An inflatable balloon catheter and liquid 125I radiation source (GliaSite Radiation Therapy System) for treatment of recurrent malignant glioma: multicenter safety and feasibility trial
    Stephen B Tatter
    Department of Neurosurgery, Wake Forest University, Winston Salem, North Carolina, USA
    J Neurosurg 99:297-303. 2003
    ..In this study the authors evaluated the safety and performance of the GliaSite Radiation Therapy System (RTS) in patients with recurrent malignant brain tumors who were undergoing tumor resection...
  32. ncbi request reprint The management of radiation-induced brain injury
    Edward G Shaw
    Department of Radiation Oncology, Comprehensive Cancer Center of Wake Forest University School of Medicine, Winston Salem, NC, USA
    Cancer Treat Res 128:7-22. 2006
  33. ncbi request reprint Integrating patient-reported outcomes into cancer symptom management clinical trials supported by the National Cancer Institute-sponsored clinical trials networks
    Jeff A Sloan
    Department of Health Sciences Research, Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    J Clin Oncol 25:5070-7. 2007
    ..There remains a need for more research in several methodologic aspects of design, analysis, and interpretation of symptom management trials...
  34. ncbi request reprint Phase II trial of procarbazine, lomustine, and vincristine as initial therapy for patients with low-grade oligodendroglioma or oligoastrocytoma: efficacy and associations with chromosomal abnormalities
    Jan C Buckner
    Mayo Clinic and Mayo Foundation, Rochester, MN 55905, USA
    J Clin Oncol 21:251-5. 2003
    ....
  35. ncbi request reprint Adult patients with supratentorial pilocytic astrocytomas: a prospective multicenter clinical trial
    Paul D Brown
    Department of Oncology, Mayo Clinic, Rochester, MN 55905, USA
    Int J Radiat Oncol Biol Phys 58:1153-60. 2004
    ..Supratentorial pilocytic astrocytomas in adults are uncommon. A prospective clinical trial was conducted to obtain clinical and outcome data in these patients...

Research Grants4

  1. CCCWFU RESEARCH BASE GRANT
    Edward Shaw; Fiscal Year: 2006
    ..abstract_text> ..
  2. Comprehensive Cancer Center of Wake Forest University CCOP Research Base
    Edward Shaw; Fiscal Year: 2007
    ....