G G Schwartz

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Is cadmium a cause of human pancreatic cancer?
    G G Schwartz
    Department of Cancer Biology and Public Health Sciences, Comprehensive Cancer Center of Wake Forest University, Winston Salem, North Carolina 27157, USA
    Cancer Epidemiol Biomarkers Prev 9:139-45. 2000
  2. ncbi request reprint UV, latitude, and spatial trends in prostate cancer mortality: all sunlight is not the same (United States)
    Gary G Schwartz
    Department of Cancer Biology, Wake Forest University, Winston Salem, NC, USA
    Cancer Causes Control 17:1091-101. 2006
  3. ncbi request reprint Vitamin D status and cancer: new insights
    Gary G Schwartz
    Departments of Cancer Biology and Epidemiology and Prevention, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Curr Opin Clin Nutr Metab Care 10:6-11. 2007
  4. ncbi request reprint The 'cocaine blues' and other problems in epidemiologic studies of vitamin D and cancer
    Gary G Schwartz
    Department of Cancer Biology Wake Forest University, Medical Center Blvd, Winston Salem, NC 27157, USA
    Nutr Rev 65:S75-6. 2007
  5. ncbi request reprint 19-nor-1 alpha,25-dihydroxyvitamin D2 (paricalcitol) inhibits the proliferation of human pancreatic cancer cells in vitro and in vivo
    Gary G Schwartz
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cancer Biol Ther 7:430-6. 2008
  6. doi request reprint Prostate cancer, serum parathyroid hormone, and the progression of skeletal metastases
    Gary G Schwartz
    Departments of Cancer Biology and Epidemiology and Prevention, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Cancer Epidemiol Biomarkers Prev 17:478-83. 2008
  7. doi request reprint Vitamin D and intervention trials in prostate cancer: from theory to therapy
    Gary G Schwartz
    Departments of Cancer Biology and Epidemiology and Prevention, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Ann Epidemiol 19:96-102. 2009
  8. ncbi request reprint Hypothesis: does ochratoxin A cause testicular cancer?
    Gary G Schwartz
    Department of Cancer Biology, Comprehensive Cancer Center of Wake Forest University, Winston Salem, NC 27157, USA
    Cancer Causes Control 13:91-100. 2002
  9. ncbi request reprint Prostate cancer in African-American men and polymorphism in the calcium-sensing receptor
    Gary G Schwartz
    Wake Forest University Health Sciences, Department of Cancer Biology, Winston Salem, NC, USA
    Cancer Biol Ther 9:994-9. 2010
  10. ncbi request reprint Vitamin D and the epidemiology of prostate cancer
    Gary G Schwartz
    Comprehensive Cancer Center, Wake Forest University, Winston Salem, North Carolina 27157, USA
    Semin Dial 18:276-89. 2005

Research Grants

Detail Information

Publications34

  1. ncbi request reprint Is cadmium a cause of human pancreatic cancer?
    G G Schwartz
    Department of Cancer Biology and Public Health Sciences, Comprehensive Cancer Center of Wake Forest University, Winston Salem, North Carolina 27157, USA
    Cancer Epidemiol Biomarkers Prev 9:139-45. 2000
    ..Thus, cadmium is a plausible pancreatic carcinogen. The cadmium hypothesis provides a coherent explanation for much of the descriptive epidemiology of pancreatic cancer and suggests new avenues for analytical research...
  2. ncbi request reprint UV, latitude, and spatial trends in prostate cancer mortality: all sunlight is not the same (United States)
    Gary G Schwartz
    Department of Cancer Biology, Wake Forest University, Winston Salem, NC, USA
    Cancer Causes Control 17:1091-101. 2006
    ..Furthermore, because vitamin D synthesis does not occur during winter months at latitudes higher than 40 degrees N, we examined this relationship above and below 40 degrees N latitude...
  3. ncbi request reprint Vitamin D status and cancer: new insights
    Gary G Schwartz
    Departments of Cancer Biology and Epidemiology and Prevention, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Curr Opin Clin Nutr Metab Care 10:6-11. 2007
    ..The aim of this article is to describe recent developments in human studies of the role of vitamin D in the etiology and treatment of cancer...
  4. ncbi request reprint The 'cocaine blues' and other problems in epidemiologic studies of vitamin D and cancer
    Gary G Schwartz
    Department of Cancer Biology Wake Forest University, Medical Center Blvd, Winston Salem, NC 27157, USA
    Nutr Rev 65:S75-6. 2007
  5. ncbi request reprint 19-nor-1 alpha,25-dihydroxyvitamin D2 (paricalcitol) inhibits the proliferation of human pancreatic cancer cells in vitro and in vivo
    Gary G Schwartz
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Cancer Biol Ther 7:430-6. 2008
    ..Tumor inhibition was accompanied by in vivo upregulation of p21 and p27 expression. Given the few therapeutic options for patients with pancreatic cancer, further exploration of paricalcitol, an FDA-approved medication, is warranted...
  6. doi request reprint Prostate cancer, serum parathyroid hormone, and the progression of skeletal metastases
    Gary G Schwartz
    Departments of Cancer Biology and Epidemiology and Prevention, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Cancer Epidemiol Biomarkers Prev 17:478-83. 2008
    ..In particular, we propose that suppressing serum PTH in advanced prostate cancer may reduce morbidity by decreasing fractures and pain caused by bone resorption and may reduce mortality by retarding the progression of metastatic disease...
  7. doi request reprint Vitamin D and intervention trials in prostate cancer: from theory to therapy
    Gary G Schwartz
    Departments of Cancer Biology and Epidemiology and Prevention, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Ann Epidemiol 19:96-102. 2009
    ..Once merely a promise, vitamin D-based therapies for prostate cancer may soon be medical practice...
  8. ncbi request reprint Hypothesis: does ochratoxin A cause testicular cancer?
    Gary G Schwartz
    Department of Cancer Biology, Comprehensive Cancer Center of Wake Forest University, Winston Salem, NC 27157, USA
    Cancer Causes Control 13:91-100. 2002
    ..49 and 0.54, p = 0.03 and 0.01). The ochratoxin A hypothesis offers a coherent explanation for much of the descriptive epidemiology of testicular cancer and suggests new avenues for analytic research...
  9. ncbi request reprint Prostate cancer in African-American men and polymorphism in the calcium-sensing receptor
    Gary G Schwartz
    Wake Forest University Health Sciences, Department of Cancer Biology, Winston Salem, NC, USA
    Cancer Biol Ther 9:994-9. 2010
    ..This is the first study of CaSR polymorphisms and risk of prostate cancer...
  10. ncbi request reprint Vitamin D and the epidemiology of prostate cancer
    Gary G Schwartz
    Comprehensive Cancer Center, Wake Forest University, Winston Salem, North Carolina 27157, USA
    Semin Dial 18:276-89. 2005
    ..In both diseases, ecologic observations about UV radiation preceded experimental observations and were subsequently validated by them...
  11. ncbi request reprint Urinary cadmium, impaired fasting glucose, and diabetes in the NHANES III
    Gary G Schwartz
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Diabetes Care 26:468-70. 2003
    ....
  12. pmc Serum parathyroid hormone levels predict falls in older adults with diabetes mellitus
    Denise K Houston
    Sticht Center on Aging, Wake Forest University, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 56:2027-32. 2008
    ..To examine the association between serum parathyroid hormone (PTH) levels and incident falls in older adults with diabetes mellitus...
  13. pmc Association between vitamin D status and physical performance: the InCHIANTI study
    Denise K Houston
    Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 62:440-6. 2007
    ..Vitamin D status has been hypothesized to play a role in musculoskeletal function. Using data from the InCHIANTI study, we examined the association between vitamin D status and physical performance...
  14. ncbi request reprint Phase I/II study of 19-nor-1alpha-25-dihydroxyvitamin D2 (paricalcitol) in advanced, androgen-insensitive prostate cancer
    Gary G Schwartz
    Department of Cancer Biology, Wake Forest University, Winston Salem, NC 27157, and Nortwest Georgia Oncology Centers, Douglasville, USA
    Clin Cancer Res 11:8680-5. 2005
    ..We assessed the safety and efficacy of the vitamin D analogue, 19-nor-1alpha-25-dihydroxyvitamin D2 (paricalcitol), in patients with androgen-independent prostate cancer...
  15. pmc 1alpha,25-dihydroxyvitamin D(3) (calcitriol) and its analogue, 19-nor-1alpha,25(OH)(2)D(2), potentiate the effects of ionising radiation on human prostate cancer cells
    N Dunlap
    Department of Radiation Oncology, Comprehensive Cancer Center of Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Br J Cancer 89:746-53. 2003
    ....
  16. ncbi request reprint Pancreatic cancer cells express 25-hydroxyvitamin D-1 alpha-hydroxylase and their proliferation is inhibited by the prohormone 25-hydroxyvitamin D3
    Gary G Schwartz
    Department of Cancer Biology, Comprehensive Cancer Center of Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Carcinogenesis 25:1015-26. 2004
    ....
  17. ncbi request reprint Cadmium and renal cancer
    Dora Il'yasova
    Department of Cancer Biology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Toxicol Appl Pharmacol 207:179-86. 2005
    ..Cadmium, a widespread environmental pollutant, is a carcinogen that accumulates in the kidney cortex and is a cause of end-stage renal disease. Several observations suggest that cadmium may be a cause of renal cancer...
  18. ncbi request reprint 19-Nor-1alpha,25-dihydroxyvitamin D2 (paricalcitol) exerts anticancer activity against HL-60 cells in vitro at clinically achievable concentrations
    Istvan Molnar
    Section on Hematology and Oncology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Steroid Biochem Mol Biol 89:539-43. 2004
    ..The concentration required to achieve inhibition of growth of HL-60 cells is comparable to clinically achievable levels. These findings support the clinical evaluation of paricalcitol as an antileukemia agent...
  19. ncbi request reprint 19-nor-1alpha,25-dihydroxyvitamin D(2) (paricalcitol): effects on clonal proliferation, differentiation, and apoptosis in human leukemic cell lines
    Istvan Molnar
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Cancer Res Clin Oncol 129:35-42. 2003
    ..Paricalcitol has recently been reported to have anticancer activity in prostate cancer. In order to explore paricalcitol as a potential agent against leukemia, we tested its effects on HL-60 and U937 leukemia cell lines...
  20. ncbi request reprint Recent clinical trials of vitamin D3 supplementation and serum calcium levels in humans: Implications for vitamin D-based chemoprevention
    Halcyon G Skinner
    1University of Wisconsin Madison, Department of Population Health Sciences, 610 Walnut Street, Madison, WI 53726, USA
    Curr Opin Investig Drugs 11:678-87. 2010
    ..Therefore, efforts to chemoprevent diseases with vitamin D must consider the potential health risks associated with high normocalcemia...
  21. ncbi request reprint The prostate 25-hydroxyvitamin D-1 alpha-hydroxylase is not influenced by parathyroid hormone and calcium: implications for prostate cancer chemoprevention by vitamin D
    Michael V Young
    Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, MA 02118, USA
    Carcinogenesis 25:967-71. 2004
    ..These findings support the hypothesis that vitamin D or 25(OH)D may be useful as chemopreventive agents for prostate cancer because their administration should cause an increased synthesis of 1 alpha,25(OH)(2)D within prostate cells...
  22. pmc Serum calcium and incident and fatal prostate cancer in the National Health and Nutrition Examination Survey
    Halcyon G Skinner
    Department of Population Health Sciences, University of Wisconsin Madison, Madison, Wisconsin, USA
    Cancer Epidemiol Biomarkers Prev 17:2302-5. 2008
    ....
  23. ncbi request reprint Sun exposure and prostate cancer risk: evidence for a protective effect of early-life exposure
    Esther M John
    Northern California Cancer Center, Fremont, CA 94538, USA
    Cancer Epidemiol Biomarkers Prev 16:1283-6. 2007
    ..47; 95% confidence interval, 0.23-0.99). These findings suggest that, in addition to sun exposure in adulthood, sun exposure in early life protects against prostate cancer...
  24. ncbi request reprint Vitamin D status and cancer incidence and mortality: something new under the sun
    Gary G Schwartz
    J Natl Cancer Inst 98:428-30. 2006
  25. ncbi request reprint Cadmium and prostate cancer: a critical epidemiologic analysis
    Abe E Sahmoun
    Department of Internal Medicine, University of North Dakota School of Medicine, Fargo, North Dakota, USA
    Cancer Invest 23:256-63. 2005
    ..Future epidemiological studies that attempt to resolve the discrepancy between laboratory and epidemiological studies of cadmium carcinogenesis may benefit from incorporating biological measures of cadmium exposure...
  26. ncbi request reprint The G gamma / T-15 transgenic mouse model of androgen-independent prostate cancer: target cells of carcinogenesis and the effect of the vitamin D analogue EB 1089
    Carlos M Perez-Stable
    Geriatric Research, Education, and Clinical Center and Research Service, Veterans Affairs Medical Center, Miami, Florida 33125, USA
    Cancer Epidemiol Biomarkers Prev 11:555-63. 2002
    ..The superiority of EB 1089 over 1,25(OH)(2)D(3) in the growth suppression of androgen-insensitive prostate cancer cells supports the use of EB 1089 in androgen-insensitive prostate cancer...
  27. ncbi request reprint 25-Hydroxyvitamin D-1alpha-hydroxylase activity is diminished in human prostate cancer cells and is enhanced by gene transfer
    Lyman W Whitlatch
    Department of Medicine, Vitamin D, Skin and Bone Research Laboratory, Endocrine Section, Boston University School of Medicine, Boston, MA 02118, USA
    J Steroid Biochem Mol Biol 81:135-40. 2002
    ....
  28. ncbi request reprint Evaluation of vitamin D analogs as therapeutic agents for prostate cancer
    Tai C Chen
    Department of Medicine, Endocrine Section, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
    Recent Results Cancer Res 164:273-88. 2003
    ..These compounds may be good candidates for human clinical trials in prostate cancer...
  29. ncbi request reprint Anatomical distribution of small cell lung cancer: effects of lobe and gender on brain metastasis and survival
    Abe E Sahmoun
    University of North Dakota School of Medicine, Fargo, ND 58102, USA
    Anticancer Res 25:1101-8. 2005
    ..The aim of this study was to examine the association between gender and pulmonary location and to examine the effects of these variables on the incidence of brain metastasis and the survival rate of patients with SCLC...
  30. ncbi request reprint Sun exposure, vitamin D receptor gene polymorphisms, and breast cancer risk in a multiethnic population
    Esther M John
    Northern California Cancer Center, Fremont, CA 94538, USA
    Am J Epidemiol 166:1409-19. 2007
    ..Localized breast cancer was not associated with sun exposure or VDR genotype. This study supports the hypothesis that sunlight exposure reduces risk of advanced breast cancer among women with light skin pigmentation...
  31. ncbi request reprint Vitamin D, ecologic studies and endometrial cancer
    Gary G Schwartz
    Prev Med 45:323-4. 2007
  32. ncbi request reprint Residential sunlight exposure is associated with a decreased risk of prostate cancer
    Esther M John
    Northern California Cancer Center, Union City, CA 94587, USA
    J Steroid Biochem Mol Biol 89:549-52. 2004
    ..These data support the hypothesis that sunlight exposure reduces the risk of prostate cancer and have important implications for prostate cancer prevention...
  33. ncbi request reprint Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
    Scott M Lippman
    The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
    J Natl Cancer Inst 97:94-102. 2005
    ....
  34. ncbi request reprint Sun exposure, vitamin D receptor gene polymorphisms, and risk of advanced prostate cancer
    Esther M John
    Northern California Cancer Center, Fremont, California 94538, USA
    Cancer Res 65:5470-9. 2005
    ..46 to 0.67. Our findings support the hypothesis that sun exposure and VDR polymorphisms together play important roles in the etiology of prostate cancer...

Research Grants1

  1. Cadmium & Pancreatic Cancer: A Pilot Case-Control Study
    Gary Schwartz; Fiscal Year: 2002
    ..5. Secondarily, analyze urine specimens for zinc and copper and compare tile patient groups with respect to the zinc:cadmium ratio, and to the concentrations of copper. ..