Research Topics
Genomes and GenesSpecies | G G SchwartzSummaryAffiliation: Wake Forest University School of Medicine Country: USA Publications
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Publications
Is cadmium a cause of human pancreatic cancer?G G Schwartz
Department of Cancer Biology and Public Health Sciences, Comprehensive Cancer Center of Wake Forest University, Winston Salem, North Carolina 27157, USA
Cancer Epidemiol Biomarkers Prev 9:139-45. 2000..Thus, cadmium is a plausible pancreatic carcinogen. The cadmium hypothesis provides a coherent explanation for much of the descriptive epidemiology of pancreatic cancer and suggests new avenues for analytical research...- UV, latitude, and spatial trends in prostate cancer mortality: all sunlight is not the same (United States)Gary G Schwartz
Department of Cancer Biology, Wake Forest University, Winston Salem, NC, USA
Cancer Causes Control 17:1091-101. 2006..Furthermore, because vitamin D synthesis does not occur during winter months at latitudes higher than 40 degrees N, we examined this relationship above and below 40 degrees N latitude... - Vitamin D status and cancer: new insightsGary G Schwartz
Departments of Cancer Biology and Epidemiology and Prevention, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Curr Opin Clin Nutr Metab Care 10:6-11. 2007..The aim of this article is to describe recent developments in human studies of the role of vitamin D in the etiology and treatment of cancer... - The 'cocaine blues' and other problems in epidemiologic studies of vitamin D and cancerGary G Schwartz
Department of Cancer Biology Wake Forest University, Medical Center Blvd, Winston-Salem, NC 27157, USA
Nutr Rev 65:S75-6. 2007 - 19-nor-1 alpha,25-dihydroxyvitamin D2 (paricalcitol) inhibits the proliferation of human pancreatic cancer cells in vitro and in vivoGary G Schwartz
Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Cancer Biol Ther 7:430-6. 2008..Tumor inhibition was accompanied by in vivo upregulation of p21 and p27 expression. Given the few therapeutic options for patients with pancreatic cancer, further exploration of paricalcitol, an FDA-approved medication, is warranted... 
Prostate cancer, serum parathyroid hormone, and the progression of skeletal metastasesGary G Schwartz
Departments of Cancer Biology and Epidemiology and Prevention, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
Cancer Epidemiol Biomarkers Prev 17:478-83. 2008..In particular, we propose that suppressing serum PTH in advanced prostate cancer may reduce morbidity by decreasing fractures and pain caused by bone resorption and may reduce mortality by retarding the progression of metastatic disease...- Vitamin D and intervention trials in prostate cancer: from theory to therapyGary G Schwartz
Departments of Cancer Biology and Epidemiology and Prevention, Wake Forest University School of Medicine, Winston Salem, NC, USA
Ann Epidemiol 19:96-102. 2009..Once merely a promise, vitamin D-based therapies for prostate cancer may soon be medical practice... - Hypothesis: does ochratoxin A cause testicular cancer?Gary G Schwartz
Department of Cancer Biology, Comprehensive Cancer Center of Wake Forest University, Winston Salem, NC 27157, USA
Cancer Causes Control 13:91-100. 2002..49 and 0.54, p = 0.03 and 0.01). The ochratoxin A hypothesis offers a coherent explanation for much of the descriptive epidemiology of testicular cancer and suggests new avenues for analytic research... - Prostate cancer in African-American men and polymorphism in the calcium-sensing receptorGary G Schwartz
Wake Forest University Health Sciences, Department of Cancer Biology, Winston Salem, NC, USA
Cancer Biol Ther 9:994-9. 2010..This is the first study of CaSR polymorphisms and risk of prostate cancer... - Vitamin D and the epidemiology of prostate cancerGary G Schwartz
Comprehensive Cancer Center, Wake Forest University, Winston Salem, North Carolina 27157, USA
Semin Dial 18:276-89. 2005..In both diseases, ecologic observations about UV radiation preceded experimental observations and were subsequently validated by them... - Urinary cadmium, impaired fasting glucose, and diabetes in the NHANES IIIGary G Schwartz
Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Diabetes Care 26:468-70. 2003.... 
Serum parathyroid hormone levels predict falls in older adults with diabetes mellitusDenise K Houston
Sticht Center on Aging, Wake Forest University, Winston Salem, North Carolina, USA
J Am Geriatr Soc 56:2027-32. 2008..To examine the association between serum parathyroid hormone (PTH) levels and incident falls in older adults with diabetes mellitus...- Association between vitamin D status and physical performance: the InCHIANTI studyDenise K Houston
Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Gerontol A Biol Sci Med Sci 62:440-6. 2007..Vitamin D status has been hypothesized to play a role in musculoskeletal function. Using data from the InCHIANTI study, we examined the association between vitamin D status and physical performance... - Phase I/II study of 19-nor-1alpha-25-dihydroxyvitamin D2 (paricalcitol) in advanced, androgen-insensitive prostate cancerGary G Schwartz
Department of Cancer Biology, Wake Forest University, Winston-Salem, NC 27157, and Nortwest Georgia Oncology Centers, Douglasville, USA
Clin Cancer Res 11:8680-5. 2005.... - 1alpha,25-dihydroxyvitamin D(3) (calcitriol) and its analogue, 19-nor-1alpha,25(OH)(2)D(2), potentiate the effects of ionising radiation on human prostate cancer cellsN Dunlap
Department of Radiation Oncology, Comprehensive Cancer Center of Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Br J Cancer 89:746-53. 2003.... - Pancreatic cancer cells express 25-hydroxyvitamin D-1 alpha-hydroxylase and their proliferation is inhibited by the prohormone 25-hydroxyvitamin D3Gary G Schwartz
Department of Cancer Biology, Comprehensive Cancer Center of Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
Carcinogenesis 25:1015-26. 2004.... - Cadmium and renal cancerGary G Schwartz
Department of Cancer Biology, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA
Toxicol Appl Pharmacol 207:179-86. 2005..Whether cadmium is a cause of renal cancer may be answered more definitively by future studies that employ biomarkers of cadmium exposure, such as cadmium levels in blood and urine... - 19-Nor-1alpha,25-dihydroxyvitamin D2 (paricalcitol) exerts anticancer activity against HL-60 cells in vitro at clinically achievable concentrationsIstvan Molnar
Section on Hematology and Oncology, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Steroid Biochem Mol Biol 89:539-43. 2004..The concentration required to achieve inhibition of growth of HL-60 cells is comparable to clinically achievable levels. These findings support the clinical evaluation of paricalcitol as an antileukemia agent... - 19-nor-1alpha,25-dihydroxyvitamin D(2) (paricalcitol): effects on clonal proliferation, differentiation, and apoptosis in human leukemic cell linesIstvan Molnar
Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Cancer Res Clin Oncol 129:35-42. 2003..Paricalcitol has recently been reported to have anticancer activity in prostate cancer. In order to explore paricalcitol as a potential agent against leukemia, we tested its effects on HL-60 and U937 leukemia cell lines... - Recent clinical trials of vitamin D3 supplementation and serum calcium levels in humans: Implications for vitamin D-based chemopreventionHalcyon G Skinner
1University of Wisconsin Madison, Department of Population Health Sciences, 610 Walnut Street, Madison, WI 53726, USA
Curr Opin Investig Drugs 11:678-87. 2010..Therefore, efforts to chemoprevent diseases with vitamin D must consider the potential health risks associated with high normocalcemia... - The prostate 25-hydroxyvitamin D-1 alpha-hydroxylase is not influenced by parathyroid hormone and calcium: implications for prostate cancer chemoprevention by vitamin DMichael V Young
Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, MA 02118, USA
Carcinogenesis 25:967-71. 2004..These findings support the hypothesis that vitamin D or 25(OH)D may be useful as chemopreventive agents for prostate cancer because their administration should cause an increased synthesis of 1 alpha,25(OH)(2)D within prostate cells... - Serum calcium and incident and fatal prostate cancer in the National Health and Nutrition Examination SurveyHalcyon G Skinner
Department of Population Health Sciences, University of Wisconsin Madison, Madison, Wisconsin, USA
Cancer Epidemiol Biomarkers Prev 17:2302-5. 2008.... - Sun exposure and prostate cancer risk: evidence for a protective effect of early-life exposureEsther M John
Northern California Cancer Center, Fremont, CA 94538, USA
Cancer Epidemiol Biomarkers Prev 16:1283-6. 2007..47; 95% confidence interval, 0.23-0.99). These findings suggest that, in addition to sun exposure in adulthood, sun exposure in early life protects against prostate cancer... - Vitamin D status and cancer incidence and mortality: something new under the sunGary G Schwartz
J Natl Cancer Inst 98:428-30. 2006 - Cadmium and prostate cancer: a critical epidemiologic analysisAbe E Sahmoun
Department of Internal Medicine, University of North Dakota School of Medicine, Fargo, North Dakota, USA
Cancer Invest 23:256-63. 2005..Future epidemiological studies that attempt to resolve the discrepancy between laboratory and epidemiological studies of cadmium carcinogenesis may benefit from incorporating biological measures of cadmium exposure... - The G gamma / T-15 transgenic mouse model of androgen-independent prostate cancer: target cells of carcinogenesis and the effect of the vitamin D analogue EB 1089Carlos M Perez-Stable
Geriatric Research, Education, and Clinical Center and Research Service, Veterans Affairs Medical Center, Miami, Florida 33125, USA
Cancer Epidemiol Biomarkers Prev 11:555-63. 2002..The superiority of EB 1089 over 1,25(OH)(2)D(3) in the growth suppression of androgen-insensitive prostate cancer cells supports the use of EB 1089 in androgen-insensitive prostate cancer... - 25-Hydroxyvitamin D-1alpha-hydroxylase activity is diminished in human prostate cancer cells and is enhanced by gene transferLyman W Whitlatch
Department of Medicine, Vitamin D, Skin and Bone Research Laboratory, Endocrine Section, Boston University School of Medicine, Boston, MA 02118, USA
J Steroid Biochem Mol Biol 81:135-40. 2002.... - Evaluation of vitamin D analogs as therapeutic agents for prostate cancerTai C Chen
Department of Medicine, Endocrine Section, Boston University School of Medicine, 715 Albany Street, Boston, MA 02118, USA
Recent Results Cancer Res 164:273-88. 2003..These compounds may be good candidates for human clinical trials in prostate cancer... - Anatomical distribution of small cell lung cancer: effects of lobe and gender on brain metastasis and survivalAbe E Sahmoun
University of North Dakota School of Medicine, Fargo, ND 58102, USA
Anticancer Res 25:1101-8. 2005..The aim of this study was to examine the association between gender and pulmonary location and to examine the effects of these variables on the incidence of brain metastasis and the survival rate of patients with SCLC... - Sun exposure, vitamin D receptor gene polymorphisms, and breast cancer risk in a multiethnic populationEsther M John
Northern California Cancer Center, Fremont, CA 94538, USA
Am J Epidemiol 166:1409-19. 2007..Localized breast cancer was not associated with sun exposure or VDR genotype. This study supports the hypothesis that sunlight exposure reduces risk of advanced breast cancer among women with light skin pigmentation... - Vitamin D, ecologic studies and endometrial cancerGary G Schwartz
Prev Med 45:323-4. 2007 - Residential sunlight exposure is associated with a decreased risk of prostate cancerEsther M John
Northern California Cancer Center, Union City, CA 94587, USA
J Steroid Biochem Mol Biol 89:549-52. 2004..These data support the hypothesis that sunlight exposure reduces the risk of prostate cancer and have important implications for prostate cancer prevention... - Designing the Selenium and Vitamin E Cancer Prevention Trial (SELECT)Scott M Lippman
The University of Texas M D Anderson Cancer Center, Houston, TX 77030 4009, USA
J Natl Cancer Inst 97:94-102. 2005.... - Sun exposure, vitamin D receptor gene polymorphisms, and risk of advanced prostate cancerEsther M John
Northern California Cancer Center, Fremont, California 94538, USA
Cancer Res 65:5470-9. 2005..46 to 0.67. Our findings support the hypothesis that sun exposure and VDR polymorphisms together play important roles in the etiology of prostate cancer...
Research Grants
- Cadmium & Pancreatic Cancer: A Pilot Case-Control StudyGary Schwartz; Fiscal Year: 2002..5. Secondarily, analyze urine specimens for zinc and copper and compare tile patient groups with respect to the zinc:cadmium ratio, and to the concentrations of copper. ..