FREDDIE SALSBURY

Summary

Affiliation: Wake Forest University
Country: USA

Publications

  1. ncbi Molecular dynamic simulations of the metallo-beta-lactamase from Bacteroides fragilis in the presence and absence of a tight-binding inhibitor
    Freddie R Salsbury
    Department of Physics, Wake Forest University, Winston Salem, NC 27109, USA
    J Mol Model 15:133-45. 2009
  2. ncbi Effects of Cisplatin binding to DNA on the dynamics of the E. Coli MutS dimer
    F R Salsbury
    Wake Forest University, Department of Physics, Winston Salem, NC 27106 USA
    Protein Pept Lett 17:744-50. 2010
  3. ncbi Molecular dynamics simulations of protein dynamics and their relevance to drug discovery
    Freddie R Salsbury
    Department of Physics, Wake Forest University, 1834 Wake Forest Road, Winston Salem, NC 27106, USA
    Curr Opin Pharmacol 10:738-44. 2010
  4. ncbi Insights into protein - DNA interactions, stability and allosteric communications: a computational study of mutSĪ±-DNA recognition complexes
    Lacramioara Negureanu
    Department of Physics, Wake Forest University, Winston Salem, NC, USA
    J Biomol Struct Dyn 29:757-76. 2012
  5. ncbi Synthesis and characterization of a novel prostate cancer-targeted phosphatidylinositol-3-kinase inhibitor prodrug
    Daniele Baiz
    Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    J Med Chem 55:8038-46. 2012
  6. ncbi Mutations in the nucleotide-binding domain of MutS homologs uncouple cell death from cell survival
    Karin Drotschmann
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    DNA Repair (Amst) 3:729-42. 2004
  7. ncbi Insights into correlated motions and long-range interactions in CheY derived from molecular dynamics simulations
    Michael H Knaggs
    Department of Physics, Wake Forest University, Winston Salem, North Carolina 27109, USA
    Biophys J 92:2062-79. 2007
  8. ncbi Conformational and oligomeric effects on the cysteine pK(a) of tryparedoxin peroxidase
    Ye Yuan
    Departments of Physics and Wake Forest University, 1834 Reynold Road, Winston Salem, North Carolina 27106, USA
    J Biomol Struct Dyn 28:51-70. 2010

Research Grants

  1. Targeting the MSH2-dependent Apoptotic Pathway
    FREDDIE SALSBURY; Fiscal Year: 2009
  2. Targeting the MSH2-dependent Apoptotic Pathway
    Freddie R Salsbury; Fiscal Year: 2010

Collaborators

  • M W Crowder
  • Michael H Knaggs
  • Lacramioara Negureanu
  • Daniele Baiz
  • Ye Yuan
  • Jacquelyn S Fetrow
  • Karin Drotschmann
  • Sazzad Hassan
  • George Kulik
  • Mark E Welker
  • Tanya A Pinder
  • Yelena Karpova
  • Leslie B Poole
  • Marshall Hall Edgell
  • Ryan P Topping
  • Jill E Clodfelter

Detail Information

Publications8

  1. ncbi Molecular dynamic simulations of the metallo-beta-lactamase from Bacteroides fragilis in the presence and absence of a tight-binding inhibitor
    Freddie R Salsbury
    Department of Physics, Wake Forest University, Winston Salem, NC 27109, USA
    J Mol Model 15:133-45. 2009
    ..These dynamic perturbations radiate outward from the active site and their existence suggests that long-range communication and dynamics may be important in the activity of this enzyme...
  2. ncbi Effects of Cisplatin binding to DNA on the dynamics of the E. Coli MutS dimer
    F R Salsbury
    Wake Forest University, Department of Physics, Winston Salem, NC 27106 USA
    Protein Pept Lett 17:744-50. 2010
    ....
  3. ncbi Molecular dynamics simulations of protein dynamics and their relevance to drug discovery
    Freddie R Salsbury
    Department of Physics, Wake Forest University, 1834 Wake Forest Road, Winston Salem, NC 27106, USA
    Curr Opin Pharmacol 10:738-44. 2010
    ..In this article, the methods and principles of all-atom molecular dynamics will be elucidated with several examples provided of their utility to investigators interested on drug discovery...
  4. ncbi Insights into protein - DNA interactions, stability and allosteric communications: a computational study of mutSĪ±-DNA recognition complexes
    Lacramioara Negureanu
    Department of Physics, Wake Forest University, Winston Salem, NC, USA
    J Biomol Struct Dyn 29:757-76. 2012
    ..Due to extended number of known MMR cancer causing mutations among the residues proved to make specific contacts with ADP molecules, recommendations for further studies on similar mutagenic effects were made...
  5. ncbi Synthesis and characterization of a novel prostate cancer-targeted phosphatidylinositol-3-kinase inhibitor prodrug
    Daniele Baiz
    Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    J Med Chem 55:8038-46. 2012
    ..Once activated, the L-O-CH(2)-LY294002 (compound 10) can specifically inhibit PI3K in PSA-secreting prostate cancer cells and induce apoptosis with a potency comparable to that of the original LY294002 compound...
  6. ncbi Mutations in the nucleotide-binding domain of MutS homologs uncouple cell death from cell survival
    Karin Drotschmann
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    DNA Repair (Amst) 3:729-42. 2004
    ..These data present evidence for a mechanism of MMR-dependent damage response that differs from MMR; these results have strong implications for the chemotherapeutic treatment of MMR-defective tumors...
  7. ncbi Insights into correlated motions and long-range interactions in CheY derived from molecular dynamics simulations
    Michael H Knaggs
    Department of Physics, Wake Forest University, Winston Salem, North Carolina 27109, USA
    Biophys J 92:2062-79. 2007
    ..Potential biological consequences of differential flexibility and long-range correlated motion are discussed...
  8. ncbi Conformational and oligomeric effects on the cysteine pK(a) of tryparedoxin peroxidase
    Ye Yuan
    Departments of Physics and Wake Forest University, 1834 Reynold Road, Winston Salem, North Carolina 27106, USA
    J Biomol Struct Dyn 28:51-70. 2010
    ..These side chain and backbone interactions which contribute to pK(a) modulation indicate the importance of oligomerization to the function of the typical 2-Cys Prxs...

Research Grants2

  1. Targeting the MSH2-dependent Apoptotic Pathway
    FREDDIE SALSBURY; Fiscal Year: 2009
    ..PUBLIC HEALTH REVELANCE:The eventual goal of this research is the discovery and design of improved chemotherapeutics, ones that are both safer and more effective, based on a MSH2-dependent apoptotic pathway. ..
  2. Targeting the MSH2-dependent Apoptotic Pathway
    Freddie R Salsbury; Fiscal Year: 2010
    ..PUBLIC HEALTH REVELANCE:The eventual goal of this research is the discovery and design of improved chemotherapeutics, ones that are both safer and more effective, based on a MSH2-dependent apoptotic pathway. ..