B K Rubin

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint The effect of a first-generation antihistamine on sputum viscoelasticity in cystic fibrosis
    Douglas N Homnick
    Division of Pediatric Pulmonology, Michigan State University, Kalamazoo Center for Medical Studies, Kalamazoo, Michigan 49008, USA
    J Aerosol Med 20:45-9. 2007
  2. ncbi request reprint An in vitro comparison of the mucoactive properties of guaifenesin, iodinated glycerol, surfactant, and albuterol
    B K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157 1081, USA
    Chest 116:195-200. 1999
  3. ncbi request reprint Immunomodulatory activity and effectiveness of macrolides in chronic airway disease
    Bruce K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1081, USA
    Chest 125:70S-78S. 2004
  4. ncbi request reprint Inhaled corticosteroids: devices and deposition
    Bruce K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1081, USA
    Paediatr Respir Rev 5:S103-6. 2004
  5. ncbi request reprint Optimizing aerosol delivery by pressurized metered-dose inhalers
    Bruce K Rubin
    Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1081, USA
    Respir Care 50:1191-200. 2005
  6. ncbi request reprint Adherence to asthma therapy: the "blocked receptor"
    Bruce K Rubin
    Department of Pediatrics, Pediatric Pulmonary Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Wiston Salem, NC 2757 1081, USA
    Pediatr Pulmonol Suppl 26:36-7. 2004
  7. ncbi request reprint What does it mean when a patient says, "my asthma medication is not working?"
    Bruce K Rubin
    Physiology, and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1081, USA
    Chest 126:972-81. 2004
  8. ncbi request reprint How do patients determine that their metered-dose inhaler is empty?
    Bruce K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Chest 126:1134-7. 2004
  9. ncbi request reprint Mucolytics, expectorants, and mucokinetic medications
    Bruce K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1081, USA
    Respir Care 52:859-65. 2007
  10. ncbi request reprint Mucus, phlegm, and sputum in cystic fibrosis
    Bruce K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem NC 27157 1081, USA
    Respir Care 54:726-32; discussion 732. 2009

Collaborators

Detail Information

Publications75

  1. ncbi request reprint The effect of a first-generation antihistamine on sputum viscoelasticity in cystic fibrosis
    Douglas N Homnick
    Division of Pediatric Pulmonology, Michigan State University, Kalamazoo Center for Medical Studies, Kalamazoo, Michigan 49008, USA
    J Aerosol Med 20:45-9. 2007
    ..From this limited study, CH, a first-generation antihistamine, appears to have no adverse effects in sputum viscoelasticity or cough transportability in CF patients...
  2. ncbi request reprint An in vitro comparison of the mucoactive properties of guaifenesin, iodinated glycerol, surfactant, and albuterol
    B K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157 1081, USA
    Chest 116:195-200. 1999
    ..The purpose of this study was to determine the in vitro effects of several agents on the properties of mucus simulants and sputum collected from 30 adults with stable chronic bronchitis...
  3. ncbi request reprint Immunomodulatory activity and effectiveness of macrolides in chronic airway disease
    Bruce K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1081, USA
    Chest 125:70S-78S. 2004
    ..The immunomodulatory effects of the macrolides also may be beneficial for the treatment of other chronic inflammatory conditions...
  4. ncbi request reprint Inhaled corticosteroids: devices and deposition
    Bruce K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1081, USA
    Paediatr Respir Rev 5:S103-6. 2004
  5. ncbi request reprint Optimizing aerosol delivery by pressurized metered-dose inhalers
    Bruce K Rubin
    Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1081, USA
    Respir Care 50:1191-200. 2005
    ..In this manuscript we discuss ways to optimize the use of medications given via pMDI and examine recent changes in pMDI technology that will make drug delivery more efficient and consistent...
  6. ncbi request reprint Adherence to asthma therapy: the "blocked receptor"
    Bruce K Rubin
    Department of Pediatrics, Pediatric Pulmonary Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Wiston Salem, NC 2757 1081, USA
    Pediatr Pulmonol Suppl 26:36-7. 2004
  7. ncbi request reprint What does it mean when a patient says, "my asthma medication is not working?"
    Bruce K Rubin
    Physiology, and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1081, USA
    Chest 126:972-81. 2004
  8. ncbi request reprint How do patients determine that their metered-dose inhaler is empty?
    Bruce K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Chest 126:1134-7. 2004
    ..To evaluate how patients determined that pressurized metered-dose inhaler (pMDI) canisters were empty and to measure pMDI depletion under different circumstances in the laboratory...
  9. ncbi request reprint Mucolytics, expectorants, and mucokinetic medications
    Bruce K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1081, USA
    Respir Care 52:859-65. 2007
    ..Aerosol surfactant is one of the most promising of this class of medications...
  10. ncbi request reprint Mucus, phlegm, and sputum in cystic fibrosis
    Bruce K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem NC 27157 1081, USA
    Respir Care 54:726-32; discussion 732. 2009
    ..This paper discusses the scientific basis and potential mechanism of action for many of these interventions and briefly reviews the clinical evidence of their safety and effectiveness...
  11. ncbi request reprint Other medications for aerosol delivery
    Bruce K Rubin
    Department of Pediatrics, Wake Forest University, School of Medicine Medical Center, Boulevard Winston Salem, Winston Salem, NC 27157 1081, USA
    Paediatr Respir Rev 7:S76-9. 2006
    ..Aerosol gene transfer therapy to correct abnormalities associated with cystic fibrosis, primary ciliary dyskinesia and other airway diseases also holds great potential...
  12. ncbi request reprint Novel medications for asthma: a look at the future
    Bruce K Rubin
    Wake Forest University School of Medicine, Winston Salem, NC 27157 1081, USA
    Expert Opin Investig Drugs 16:889-97. 2007
    ....
  13. ncbi request reprint Designing clinical trials to evaluate mucus clearance therapy
    Bruce K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1081, USA
    Respir Care 52:1348-58; discussion 1358-61. 2007
    ..This information is also critically important in identifying an appropriate control group. These challenges can be met to advance our knowledge and to develop truly effective therapy for mucus clearance disorders...
  14. doi request reprint Aerosolized antibiotics for non-cystic fibrosis bronchiectasis
    Bruce K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1081, USA
    J Aerosol Med Pulm Drug Deliv 21:71-6. 2008
    ..Furthermore, the risk of adverse events such as bronchospasm may be more common in adults with non-CF bronchiectasis than reported in the CF population...
  15. ncbi request reprint Thymosin beta4 sequesters actin in cystic fibrosis sputum and decreases sputum cohesivity in vitro
    Bruce K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157 1081, USA
    Chest 130:1433-40. 2006
    ..Thymosin beta4 (Tbeta4) is the major monomeric actin-sequestering peptide in cells and can depolymerize F-actin. Tbeta4 could potentially decrease sputum viscoelasticity and adhesivity and improve sputum clearance...
  16. ncbi request reprint The delivery of inhaled medication to the young child
    Bruce K Rubin
    Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Pediatr Clin North Am 50:717-31. 2003
    ..Regardless of the device chosen, parent and patient education is critical for the appropriate use of the device, and frequent reinforcement of the educational message will often improve adherence and correct use...
  17. ncbi request reprint Experimental macromolecular aerosol therapy
    B K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1081, USA
    Respir Care 45:684-94. 2000
    ..These novel and experimental therapies have the potential of drastically altering our understanding of and approach to airway disease. We indeed live in interesting times...
  18. ncbi request reprint Macrolide antibiotics as biological response modifiers
    B K Rubin
    Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1081, USA
    Curr Opin Investig Drugs 1:169-72. 2000
    ..This review highlights some exciting new data, as well as controversies related to understanding the mechanism of action for these diverse effects...
  19. ncbi request reprint Physiology of airway mucus clearance
    Bruce K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1081, USA
    Respir Care 47:761-8. 2002
    ..When there is extensive ciliary damage and mucus hypersecretion, airflow-dependent mucus clearance such as cough becomes critically important for airway hygiene...
  20. ncbi request reprint The pharmacologic approach to airway clearance: mucoactive agents
    Bruce K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1081, USA
    Respir Care 47:818-22. 2002
    ..Classifying mucoactive agents should help us to develop and evaluate new types of therapy and to better direct therapy toward the patients who are most likely to benefit...
  21. ncbi request reprint Nebulizer therapy for children: the device-patient interface
    Bruce K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem NC 27157 1081, USA
    Respir Care 47:1314-9; discussion 1319-20. 2002
    ..Education is critically important, but unfortunately it is often a misunderstood or neglected part of aerosol administration...
  22. ncbi request reprint The pharmacologic approach to airway clearance: mucoactive agents
    Bruce K Rubin
    Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1081, USA
    Paediatr Respir Rev 7:S215-9. 2006
    ..I review here the many classes of mucoactive agents and identify a number of medications with great promise for the treatment of chronic airway disease...
  23. ncbi request reprint Cystic fibrosis: bench to bedside 2003
    Bruce K Rubin
    Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Can Respir J 10:161-4. 2003
  24. ncbi request reprint Respiratory controversies in the critical care setting. When caring for critically ill patients, do clinicians have a responsibility to be innovative and try unproven approaches when accepted approaches are failing?
    Bruce K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1082, USA
    Respir Care 52:408-15. 2007
    ..In such cases, it is to be hoped that this can be done in such a way that data are formally and prospectively collected to increase our knowledge...
  25. ncbi request reprint Mucus structure and properties in cystic fibrosis
    Bruce K Rubin
    Pediatrics and Biomedical Engineering, Wake Forest University School of Medicine, Winston Salem, NC 27157 1081, USA
    Paediatr Respir Rev 8:4-7. 2007
    ..In this mini-Symposium on Airway Clearance in Cystic Fibrosis, the physiology of CF secretion structure and rheology is discussed in the context of medications and physical maneuvers for enhancing sputum clearance...
  26. ncbi request reprint The role of DNA and actin polymers on the polymer structure and rheology of cystic fibrosis sputum and depolymerization by gelsolin or thymosin beta 4
    Arnon Kater
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157 1081, USA
    Ann N Y Acad Sci 1112:140-53. 2007
    ....
  27. ncbi request reprint Aerosol therapy for children
    B K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
    Respir Care Clin N Am 7:175-213, v. 2001
    ..This article focuses on the care of smaller infants and children in whom anatomic differences present substantial challenges for aerosol delivery...
  28. ncbi request reprint Sputum processing for evaluation of inflammatory mediators
    J S Kim
    Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
    Pediatr Pulmonol 32:152-8. 2001
    ..There is a significant relationship among these inflammatory markers in sputum. DNA polymers bind myeloperoxidase in the sputum, and we speculate that treatment with dornase alfa may remove a source of MPO inhibition...
  29. ncbi request reprint Force-dependent static dead space of face masks used with holding chambers
    Samir A Shah
    Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1081, USA
    Respir Care 51:140-4. 2006
    ..Drug delivery can decrease when the dead-space volume (DSV) of the valved holding chamber is increased, but there are no published data evaluating force-dependent DSV among different masks...
  30. ncbi request reprint Acute renal failure in cystic fibrosis: association with inhaled tobramycin therapy
    Ingrid M Hoffmann
    Department of Pediatrics, Wake Forest University School of Medicine Baptist Medical Center, Winston Salem, North Carolina 27157 1081, USA
    Pediatr Pulmonol 34:375-7. 2002
    ..Measurable tobramycin levels due to inhalational therapy with conventional dosing in the reported patient indicate that the drug can be systemically absorbed, and renal tubular toxicity may occur...
  31. ncbi request reprint Macrolide antibiotics, bacterial populations and inflammatory airway disease
    W E Swords
    Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Centre Boulevard, Winston Salem, NC 27157, USA
    Neth J Med 61:242-8. 2003
    ..The current data clearly suggest that activities beyond antimicrobial effects contribute significantly to the beneficial effect of macrolide therapy on inflammatory conditions...
  32. ncbi request reprint Macrolides and airway inflammation in children
    Masaharu Shinkai
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157 1081 USA
    Paediatr Respir Rev 6:227-35. 2005
    ..Long-term macrolides have also proven clinically beneficial in some patients with plastic bronchitis. Adverse reactions are few and generally self-limited when used at the recommended dosage for immunomodulation...
  33. doi request reprint Mucins, mucus, and sputum
    Judith A Voynow
    Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA
    Chest 135:505-12. 2009
    ..This review will highlight the most recent insights on mucus biology in health and disease...
  34. ncbi request reprint Quantification of biopolymer filament structure
    Samir A Shah
    Departments of Biomedical Engineering, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1081, USA
    Ultramicroscopy 104:244-54. 2005
    ..These quantitative descriptions of the network can be correlated to material, mechanical, diffusion, or flow properties, physiological processes, or therapy...
  35. doi request reprint The role of mucus in cough research
    Bruce K Rubin
    Department of Pediatrics, Virginia Commonwealth University School of Medicine, 1001 East Marshall Street, P O Box 980646, Richmond, VA 23298, USA
    Lung 188:S69-72. 2010
    ..The biophysical properties of mucus and phlegm determine how readily these secretions can be cleared by coughing...
  36. doi request reprint The future in paediatric respirology
    H Joel Schmidt
    Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
    Respirology 15:733-41. 2010
    ..The authors hope that these visionary articles will generate comments, arguments, inspiration, and perhaps even motivate funding agencies...
  37. ncbi request reprint A randomized controlled trial of inhaled flunisolide in the management of acute asthma in children
    Albert K Nakanishi
    Department of Pediatrics, St Louis University School of Medicine, Cardinal Glennon Children s Hospital, 1465 S Grand Boulevard, St Louis, MO 63119, USA
    Chest 124:790-4. 2003
    ..Inhaled corticosteroids (ICS) may provide benefit in the therapy of acute asthma. The purpose of this study was to test the hypothesis that ICS are as effective as oral corticosteroids (OCS) in the management of acute childhood asthma...
  38. ncbi request reprint Pulmonary function is negatively correlated with sputum inflammatory markers and cough clearability in subjects with cystic fibrosis but not those with chronic bronchitis
    Jung Soo Kim
    Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1081, USA
    Chest 129:1148-54. 2006
    ..Interleukin (IL)-8, myeloperoxidase (MPO), and DNA are markers of neutrophilic inflammation. We hypothesized that sputum MPO, DNA, and IL-8 concentrations would negatively correlate with pulmonary function and sputum transportability...
  39. ncbi request reprint Clarithromycin has an immunomodulatory effect on ERK-mediated inflammation induced by Pseudomonas aeruginosa flagellin
    Masaharu Shinkai
    Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1081, USA
    J Antimicrob Chemother 59:1096-101. 2007
    ..This polyphasic immune response is referred to as immunomodulation...
  40. doi request reprint Mucus and mucins
    Bruce K Rubin
    Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Otolaryngol Clin North Am 43:27-34, vii-viii. 2010
    ..This article discusses the composition of mucus and phlegm, the process of mucin secretion and mucus clearance, and reviews current therapy and mucolytics in use or being studied for mucus clearance disorders...
  41. ncbi request reprint Effect of macrolides on in vivo ion transport across cystic fibrosis nasal epithelium
    Pierre M Barker
    Department of Pediatrics, University of North Carolina at Chapel Hill, 200 Mason Farm Road, Chapel Hill, NC 27599 7220, USA
    Am J Respir Crit Care Med 171:868-71. 2005
    ..We conclude that the apparent beneficial effects of macrolides on pulmonary outcome in CF are not mediated by their modulation of ion transport...
  42. ncbi request reprint Immunomodulatory properties of macrolides: overview and historical perspective
    Bruce K Rubin
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1081, USA
    Am J Med 117:2S-4S. 2004
  43. doi request reprint Vicks VapoRub induces mucin secretion, decreases ciliary beat frequency, and increases tracheal mucus transport in the ferret trachea
    Juan Carlos Abanses
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157 1081, USA
    Chest 135:143-8. 2009
    ..We hypothesized that VVR induced inflammation and adversely affected mucociliary function, and tested this hypothesis in an animal model of airway inflammation...
  44. doi request reprint IL-13-induced MUC5AC production and goblet cell differentiation is steroid resistant in human airway cells
    S Kanoh
    Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
    Clin Exp Allergy 41:1747-56. 2011
    ..The effect of GCS on IL-13-induced mucin production is not well characterized...
  45. ncbi request reprint Secretory phospholipases A2 stimulate mucus secretion, induce airway inflammation, and produce secretory hyperresponsiveness to neutrophil elastase in ferret trachea
    Kosuke Okamoto
    Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1081, USA
    Am J Physiol Lung Cell Mol Physiol 292:L62-7. 2007
    ..sPLA(2) increased tracheal inflammation, MG secretion, and secretory hyperresponsiveness to HNE probably through enzymatic action rather than by activation of its receptor...
  46. doi request reprint In vitro evaluation of endotracheal tubes with intrinsic suction
    Karla I Mujica-Lopez
    Department of Pediatrics, Virginia Commonwealth University, Richmond, VA, USA
    Chest 138:863-9. 2010
    ..Endotracheal tube (ETT) intubation impairs mucus clearance, which can lead to respiratory compromise. We compared three ETTs that have intrinsic capacity to aspirate secretions pooling above the cuff...
  47. ncbi request reprint An in vitro evaluation of the effectiveness of endotracheal suction catheters
    Samir Shah
    Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Chest 128:3699-704. 2005
    ..In this study, different adult TSCs were evaluated for their ability to suction mucus simulants that had properties similar to airway mucus...
  48. pmc Clarithromycin delays progression of bronchial epithelial cells from G1 phase to S phase and delays cell growth via extracellular signal-regulated protein kinase suppression
    Masaharu Shinkai
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157 1081, USA
    Antimicrob Agents Chemother 50:1738-44. 2006
    ..These results suggest that macrolide antibiotics can delay the progression of NHBE cells from G(1) phase to S phase and can slow cell growth, probably through the suppression of ERK1/2...
  49. ncbi request reprint Macrolide antibiotics modulate ERK phosphorylation and IL-8 and GM-CSF production by human bronchial epithelial cells
    Masaharu Shinkai
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157 1081, USA
    Am J Physiol Lung Cell Mol Physiol 290:L75-85. 2006
    ..The p38 MAP kinase inhibitor, SB-203580 increased ERK phosphorylation and IL-8 secretion. These results suggest that macrolide antibiotics can differentially modulate proinflammatory cytokine secretion in NHBE cells, in part through ERK...
  50. doi request reprint Nasal and sinus disease in cystic fibrosis
    John M Robertson
    Department of Pediatrics, Texas Children s Hospital, Houston, Texas 77030, USA
    Paediatr Respir Rev 9:213-9. 2008
    ..Complications of sinonasal disease in CF are rare and include mucoceles and periorbital abscesses...
  51. ncbi request reprint Effect of meconium on the surface properties of perflubron
    Mamta Fuloria
    Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Pediatr Crit Care Med 5:167-71. 2004
    ..Exogenously administered surfactant is inactivated by meconium. We wished to determine whether meconium would alter the surface properties of perfluorooctyl bromide (perflubron)...
  52. pmc Mechanisms of action and clinical application of macrolides as immunomodulatory medications
    Soichiro Kanoh
    Department of Pediatrics, Virginia Commonwealth University School of Medicine, 1001 E Marshall St, Richmond, VA 23298, USA
    Clin Microbiol Rev 23:590-615. 2010
    ..A concern is that long-term use of macrolides increases the emergence of antimicrobial resistance. Nonantimicrobial macrolides are now in development as potential immunomodulatory therapies...
  53. ncbi request reprint Vasoactive intestinal peptide stimulates mucus secretion, but nitric oxide has no effect on mucus secretion in the ferret trachea
    Jung Soo Kim
    Dept of Pediatrics, Wake Forest Univ School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    J Appl Physiol 101:486-91. 2006
    ..We conclude that VIP-stimulated mucin and lysozyme secretion was both time dependent and dose dependent and that NO neither stimulates nor inhibits mucus secretion in the ferret trachea...
  54. doi request reprint Macrolides as immunomodulatory medications for the therapy of chronic lung diseases
    Yolanda S López-Boado
    GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pa 19406 0939, United States
    Curr Opin Pharmacol 8:286-91. 2008
    ..In this paper, we review recent findings on novel effects of macrolides on epithelial barrier function and resolution of inflammation, which may shed light on the mechanisms underlying the beneficial effects of macrolides in the clinic...
  55. doi request reprint Editorial overview: the value of FeNO measurement in asthma management Fire sticks and burning bushes--maybe NO, but perhaps yes
    Bruce K Rubin
    Paediatr Respir Rev 9:132-3. 2008
  56. ncbi request reprint Mucus properties in children with primary ciliary dyskinesia: comparison with cystic fibrosis
    Andrew Bush
    Pediatric Pulmonology, Imperial School of Medicine at National Heart and Lung Institute, London, UK
    Chest 129:118-23. 2006
    ..Our objective was to compare the biophysical and transport properties of CF and PCD sputa in subjects matched for age and degree of lung function impairment...
  57. ncbi request reprint Problems with inhaler use: a call for improved clinician and patient education
    James B Fink
    Aerogen, Mountain View, California 94943, USA
    Respir Care 50:1360-74; discussion 1374-5. 2005
    ..Problems with inhaler use, the cost of inhalers, and myths associated with inhalers are reviewed, with recommendations for strategies and techniques to better educate patients in inhaler use...
  58. ncbi request reprint Inhaled mannitol for the treatment of mucociliary dysfunction in patients with bronchiectasis: effect on lung function, health status and sputum
    Evangelia Daviskas
    Department of Respiratory Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia
    Respirology 10:46-56. 2005
    ..Inhaled mannitol increases mucus clearance in patients with bronchiectasis by an unclear mechanism. The effect of mannitol on lung function, health status and sputum properties was investigated...
  59. ncbi request reprint MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway Secretions
    Markus O Henke
    Department of Pulmonary Medicine, Philipps University Marburg, Germany
    Am J Respir Cell Mol Biol 31:86-91. 2004
    ..This may be due to a relative increase in other components of sputum in the CF airway or to a primary defect in mucin secretion in CF...
  60. ncbi request reprint Pharmacological approaches to discovery and development of new mucolytic agents
    Malcolm King
    University of Alberta Pulmonary Research Group, 173 Heritage Medical Research Center, Edmonton, Alberta T6G 2S2, Canada
    Adv Drug Deliv Rev 54:1475-90. 2002
    ..Further studies are required to confirm these findings, to perform direct assessments of mucus clearability, and to extend the observations to patients with various types of pulmonary diseases where mucoactive treatments are required...
  61. ncbi request reprint Bye-bye, blow-by
    Bruce K Rubin
    Respir Care 52:981. 2007
  62. doi request reprint Macrolide antibiotics as immunomodulatory medications: proposed mechanisms of action
    Masaharu Shinkai
    Ministry of Defense and National Defense Medical College, Japan
    Pharmacol Ther 117:393-405. 2008
    ..Consistent with this, macrolide antibiotics possibly reduce mucin production as well as neutrophil migration by interfering with ERK signal transduction...
  63. ncbi request reprint Comparison of high-frequency chest wall oscillation with differing waveforms for airway clearance in cystic fibrosis
    Robert R Kempainen
    Minnesota Cystic Fibrosis Center, Department of Medicine, University of Minnesota School of Medicine, Minneapolis, MN, USA
    Chest 132:1227-32. 2007
    ....
  64. ncbi request reprint CFTR is a modulator of airway inflammation
    Bruce K Rubin
    Am J Physiol Lung Cell Mol Physiol 292:L381-2. 2007
  65. ncbi request reprint Did Lady Windermere have cystic fibrosis?
    Bruce K Rubin
    Chest 130:937-8. 2006
  66. ncbi request reprint Respiratory therapies in the critical care setting. Should aerosolized antibiotics be administered to prevent or treat ventilator-associated pneumonia in patients who do not have cystic fibrosis?
    Neil R MacIntyre
    Respiratory Care Services, Duke University Medical Center, Durham, NC 27710, USA
    Respir Care 52:416-21; discussion 421-2. 2007
    ..Importantly, the clinical evidence that aerosolized antibiotics can treat established VAP is negative, and multiple consensus groups recommend against treating established VAP with aerosolized antibiotics...
  67. ncbi request reprint The role of airway secretions in COPD--clinical applications
    Markus O Henke
    Department of Pulmonary Medicine, Philipps University Marburg, Marburg 35043, Germany
    COPD 2:377-90. 2005
    ..Carefully conducted studies of interventions to improve airway clearance, similar to those done in cystic fibrosis (CF), may help us to identify effective therapies and possibly novel diagnostic tests for the management of COPD...
  68. ncbi request reprint MUC5AC and MUC5B mucins increase in cystic fibrosis airway secretions during pulmonary exacerbation
    Markus O Henke
    Philipps University Marburg, Department of Pulmonary Medicine, Baldingerstrasse 1, 35043 Marburg, Germany
    Am J Respir Crit Care Med 175:816-21. 2007
    ..However, we have shown that these mucins are decreased during stable CF disease...
  69. ncbi request reprint A scientific koan: what is the cause of cystic fibrosis?
    Bruce K Rubin
    Chest 123:1792-3. 2003
  70. ncbi request reprint Hyperosmolar solutions stimulate mucus secretion in the ferret trachea
    Chikako Kishioka
    Department of Otolaryngology, Mie University School of Medicine, Tsu, Mie, Japan
    Chest 124:306-13. 2003
    ..The ratio of mucin to lysozyme secretion was approximately 2. This ratio appeared to be independent of the osmotic concentration of the stimulus and therefore of secretory rate...
  71. ncbi request reprint Up-regulation of S100A8 and S100A9 protein in bronchial epithelial cells by lipopolysaccharide
    Markus O Henke
    Department of Pulmonary Medicine, Philipps University Marburg, Marburg, Germany
    Exp Lung Res 32:331-47. 2006
    ..This finding suggests that S100A8 and S100A9 are involved in the innate defense of the bronchial epithelium...
  72. ncbi request reprint Nasal and sinus inflammation in chronic obstructive pulmonary disease
    Jung Soo Kim
    Department of Otolaryngology, Kyungpook National University, Daegu, Korea
    COPD 4:163-6. 2007
    ..Postnasal drainage of nasal inflammatory mediators during sleep also may increase lower airway responsiveness. Therapy of nasal and sinus disease is associated with improved pulmonary function in patients with COPD...
  73. ncbi request reprint Emerging and unusual gram-negative infections in cystic fibrosis
    Jane C Davies
    Department of Pediatric Respiratory Medicine, Royal Brompton Hospital, and Department of Gene Therapy, Imperial College, London, United Kingdom
    Semin Respir Crit Care Med 28:312-21. 2007
    ..cepacia complex, are clearly linked to an adverse prognosis, and both treatment and infection control issues can pose a real challenge...
  74. ncbi request reprint High-frequency external chest wall compression for secretion clearance: shake it, but don't break it
    Bruce K Rubin
    Respir Care 52:982-3. 2007
  75. doi request reprint Nasal and sinus involvement in chronic obstructive pulmonary disease
    Jung Soo Kim
    Department of Otolaryngology, Kyungpook National University, Daegu, Korea
    Curr Opin Pulm Med 14:101-4. 2008
    ..We review the current understanding of the relationship between upper and lower airway disease, particularly in chronic obstructive pulmonary disease, including therapeutic implications...