Research Topics
| B K RubinSummaryAffiliation: Wake Forest University School of Medicine Country: USA Publications
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Detail Information
Publications
The effect of a first-generation antihistamine on sputum viscoelasticity in cystic fibrosisDouglas N Homnick
Division of Pediatric Pulmonology, Michigan State University, Kalamazoo Center for Medical Studies, Kalamazoo, Michigan 49008, USA
J Aerosol Med 20:45-9. 2007..From this limited study, CH, a first-generation antihistamine, appears to have no adverse effects in sputum viscoelasticity or cough transportability in CF patients...- An in vitro comparison of the mucoactive properties of guaifenesin, iodinated glycerol, surfactant, and albuterolB K Rubin
Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157 1081, USA
Chest 116:195-200. 1999..The purpose of this study was to determine the in vitro effects of several agents on the properties of mucus simulants and sputum collected from 30 adults with stable chronic bronchitis... - Immunomodulatory activity and effectiveness of macrolides in chronic airway diseaseBruce K Rubin
Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1081, USA
Chest 125:70S-78S. 2004..The immunomodulatory effects of the macrolides also may be beneficial for the treatment of other chronic inflammatory conditions... - Inhaled corticosteroids: devices and depositionBruce K Rubin
Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1081, USA
Paediatr Respir Rev 5:S103-6. 2004 - Optimizing aerosol delivery by pressurized metered-dose inhalersBruce K Rubin
Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1081, USA
Respir Care 50:1191-200. 2005..In this manuscript we discuss ways to optimize the use of medications given via pMDI and examine recent changes in pMDI technology that will make drug delivery more efficient and consistent... - Adherence to asthma therapy: the "blocked receptor"Bruce K Rubin
Department of Pediatrics, Pediatric Pulmonary Medicine, Wake Forest University Health Sciences, Medical Center Boulevard, Wiston-Salem, NC 2757-1081, USA
Pediatr Pulmonol Suppl 26:36-7. 2004 - What does it mean when a patient says, "my asthma medication is not working?"Bruce K Rubin
Physiology, and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1081, USA
Chest 126:972-81. 2004 - How do patients determine that their metered-dose inhaler is empty?Bruce K Rubin
Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
Chest 126:1134-7. 2004..To evaluate how patients determined that pressurized metered-dose inhaler (pMDI) canisters were empty and to measure pMDI depletion under different circumstances in the laboratory... - Mucolytics, expectorants, and mucokinetic medicationsBruce K Rubin
Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1081, USA
Respir Care 52:859-65. 2007..Aerosol surfactant is one of the most promising of this class of medications... - Mucus, phlegm, and sputum in cystic fibrosisBruce K Rubin
Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem NC 27157 1081, USA
Respir Care 54:726-32; discussion 732. 2009..This paper discusses the scientific basis and potential mechanism of action for many of these interventions and briefly reviews the clinical evidence of their safety and effectiveness... - Other medications for aerosol deliveryBruce K Rubin
Department of Pediatrics, Wake Forest University, School of Medicine Medical Center, Boulevard Winston Salem, Winston Salem, NC 27157 1081, USA
Paediatr Respir Rev 7:S76-9. 2006..Aerosol gene transfer therapy to correct abnormalities associated with cystic fibrosis, primary ciliary dyskinesia and other airway diseases also holds great potential... - Novel medications for asthma: a look at the futureBruce K Rubin
Wake Forest University School of Medicine, Winston Salem, NC 27157 1081, USA
Expert Opin Investig Drugs 16:889-97. 2007.... - Designing clinical trials to evaluate mucus clearance therapyBruce K Rubin
Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1081, USA
Respir Care 52:1348-58; discussion 1358-61. 2007..This information is also critically important in identifying an appropriate control group. These challenges can be met to advance our knowledge and to develop truly effective therapy for mucus clearance disorders... 
Aerosolized antibiotics for non-cystic fibrosis bronchiectasisBruce K Rubin
Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1081, USA
J Aerosol Med Pulm Drug Deliv 21:71-6. 2008..Furthermore, the risk of adverse events such as bronchospasm may be more common in adults with non-CF bronchiectasis than reported in the CF population...- Thymosin beta4 sequesters actin in cystic fibrosis sputum and decreases sputum cohesivity in vitroBruce K Rubin
Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157 1081, USA
Chest 130:1433-40. 2006..Thymosin beta4 (Tbeta4) is the major monomeric actin-sequestering peptide in cells and can depolymerize F-actin. Tbeta4 could potentially decrease sputum viscoelasticity and adhesivity and improve sputum clearance... - The delivery of inhaled medication to the young childBruce K Rubin
Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Pediatr Clin North Am 50:717-31. 2003..Regardless of the device chosen, parent and patient education is critical for the appropriate use of the device, and frequent reinforcement of the educational message will often improve adherence and correct use... - Experimental macromolecular aerosol therapyB K Rubin
Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1081, USA
Respir Care 45:684-94. 2000..These novel and experimental therapies have the potential of drastically altering our understanding of and approach to airway disease. We indeed live in interesting times... - Macrolide antibiotics as biological response modifiersB K Rubin
Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1081, USA
Curr Opin Investig Drugs 1:169-72. 2000..This review highlights some exciting new data, as well as controversies related to understanding the mechanism of action for these diverse effects... - Physiology of airway mucus clearanceBruce K Rubin
Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1081, USA
Respir Care 47:761-8. 2002..When there is extensive ciliary damage and mucus hypersecretion, airflow-dependent mucus clearance such as cough becomes critically important for airway hygiene... - The pharmacologic approach to airway clearance: mucoactive agentsBruce K Rubin
Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1081, USA
Respir Care 47:818-22. 2002..Classifying mucoactive agents should help us to develop and evaluate new types of therapy and to better direct therapy toward the patients who are most likely to benefit... - Nebulizer therapy for children: the device-patient interfaceBruce K Rubin
Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem NC 27157 1081, USA
Respir Care 47:1314-9; discussion 1319-20. 2002..Education is critically important, but unfortunately it is often a misunderstood or neglected part of aerosol administration... - The pharmacologic approach to airway clearance: mucoactive agentsBruce K Rubin
Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1081, USA
Paediatr Respir Rev 7:S215-9. 2006..I review here the many classes of mucoactive agents and identify a number of medications with great promise for the treatment of chronic airway disease... - Cystic fibrosis: bench to bedside 2003Bruce K Rubin
Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA
Can Respir J 10:161-4. 2003 - Respiratory controversies in the critical care setting. When caring for critically ill patients, do clinicians have a responsibility to be innovative and try unproven approaches when accepted approaches are failing?Bruce K Rubin
Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1082, USA
Respir Care 52:408-15. 2007..In such cases, it is to be hoped that this can be done in such a way that data are formally and prospectively collected to increase our knowledge... - Mucus structure and properties in cystic fibrosisBruce K Rubin
Pediatrics and Biomedical Engineering, Wake Forest University School of Medicine, Winston Salem, NC 27157 1081, USA
Paediatr Respir Rev 8:4-7. 2007..In this mini-Symposium on Airway Clearance in Cystic Fibrosis, the physiology of CF secretion structure and rheology is discussed in the context of medications and physical maneuvers for enhancing sputum clearance... - The role of DNA and actin polymers on the polymer structure and rheology of cystic fibrosis sputum and depolymerization by gelsolin or thymosin beta 4Arnon Kater
Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157 1081, USA
Ann N Y Acad Sci 1112:140-53. 2007.... - Aerosol therapy for childrenB K Rubin
Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
Respir Care Clin N Am 7:175-213, v. 2001..This article focuses on the care of smaller infants and children in whom anatomic differences present substantial challenges for aerosol delivery... - Sputum processing for evaluation of inflammatory mediatorsJ S Kim
Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
Pediatr Pulmonol 32:152-8. 2001..There is a significant relationship among these inflammatory markers in sputum. DNA polymers bind myeloperoxidase in the sputum, and we speculate that treatment with dornase alfa may remove a source of MPO inhibition... - Force-dependent static dead space of face masks used with holding chambersSamir A Shah
Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1081, USA
Respir Care 51:140-4. 2006..CONCLUSION: Rigid masks with large DSV might not be not suitable for use in children, especially if discomfort from the stiff mask makes its use less acceptable to the child... - Acute renal failure in cystic fibrosis: association with inhaled tobramycin therapyIngrid M Hoffmann
Department of Pediatrics, Wake Forest University School of Medicine Baptist Medical Center, Winston-Salem, North Carolina 27157-1081, USA
Pediatr Pulmonol 34:375-7. 2002..Measurable tobramycin levels due to inhalational therapy with conventional dosing in the reported patient indicate that the drug can be systemically absorbed, and renal tubular toxicity may occur... - Macrolide antibiotics, bacterial populations and inflammatory airway diseaseW E Swords
Department of Microbiology and Immunology, Wake Forest University School of Medicine, Medical Centre Boulevard, Winston Salem, NC 27157, USA
Neth J Med 61:242-8. 2003..The current data clearly suggest that activities beyond antimicrobial effects contribute significantly to the beneficial effect of macrolide therapy on inflammatory conditions... - Macrolides and airway inflammation in childrenMasaharu Shinkai
Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1081 USA
Paediatr Respir Rev 6:227-35. 2005..Long-term macrolides have also proven clinically beneficial in some patients with plastic bronchitis. Adverse reactions are few and generally self-limited when used at the recommended dosage for immunomodulation... - Mucins, mucus, and sputumJudith A Voynow
Department of Pediatrics, Duke University School of Medicine, Durham, NC 27710, USA
Chest 135:505-12. 2009..This review will highlight the most recent insights on mucus biology in health and disease... - Quantification of biopolymer filament structureSamir A Shah
Departments of Biomedical Engineering, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1081, USA
Ultramicroscopy 104:244-54. 2005..These quantitative descriptions of the network can be correlated to material, mechanical, diffusion, or flow properties, physiological processes, or therapy... - The role of mucus in cough researchBruce K Rubin
Department of Pediatrics, Virginia Commonwealth University School of Medicine, 1001 East Marshall Street, P O Box 980646, Richmond, VA 23298, USA
Lung 188:S69-72. 2010..The biophysical properties of mucus and phlegm determine how readily these secretions can be cleared by coughing... - The future in paediatric respirologyH Joel Schmidt
Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298, USA
Respirology 15:733-41. 2010..The authors hope that these visionary articles will generate comments, arguments, inspiration, and perhaps even motivate funding agencies... - A randomized controlled trial of inhaled flunisolide in the management of acute asthma in childrenAlbert K Nakanishi
Department of Pediatrics, St Louis University School of Medicine, Cardinal Glennon Children s Hospital, 1465 S Grand Boulevard, St Louis, MO 63119, USA
Chest 124:790-4. 2003..Inhaled corticosteroids (ICS) may provide benefit in the therapy of acute asthma. The purpose of this study was to test the hypothesis that ICS are as effective as oral corticosteroids (OCS) in the management of acute childhood asthma... - Pulmonary function is negatively correlated with sputum inflammatory markers and cough clearability in subjects with cystic fibrosis but not those with chronic bronchitisJung-Soo Kim
Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157-1081, USA
Chest 129:1148-54. 2006..CONCLUSIONS: The sputum concentrations of IL-8, MPO, and DNA appear to be closely associated with pulmonary function in subjects with CF but not in subjects with CB... - Clarithromycin has an immunomodulatory effect on ERK-mediated inflammation induced by Pseudomonas aeruginosa flagellinMasaharu Shinkai
Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1081, USA
J Antimicrob Chemother 59:1096-101. 2007..This polyphasic immune response is referred to as immunomodulation... - Mucus and mucinsBruce K Rubin
Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
Otolaryngol Clin North Am 43:27-34, vii-viii. 2010..This article discusses the composition of mucus and phlegm, the process of mucin secretion and mucus clearance, and reviews current therapy and mucolytics in use or being studied for mucus clearance disorders... - Effect of macrolides on in vivo ion transport across cystic fibrosis nasal epitheliumPierre M Barker
Department of Pediatrics, University of North Carolina at Chapel Hill, 200 Mason Farm Road, Chapel Hill, NC 27599 7220, USA
Am J Respir Crit Care Med 171:868-71. 2005..We conclude that the apparent beneficial effects of macrolides on pulmonary outcome in CF are not mediated by their modulation of ion transport... - Immunomodulatory properties of macrolides: overview and historical perspectiveBruce K Rubin
Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1081, USA
Am J Med 117:2S-4S. 2004 - Vicks VapoRub induces mucin secretion, decreases ciliary beat frequency, and increases tracheal mucus transport in the ferret tracheaJuan Carlos Abanses
Department of Pediatrics, Wake Forest University School of Medicine, Winston Salem, NC 27157 1081, USA
Chest 135:143-8. 2009..We hypothesized that VVR induced inflammation and adversely affected mucociliary function, and tested this hypothesis in an animal model of airway inflammation... - IL-13-induced MUC5AC production and goblet cell differentiation is steroid resistant in human airway cellsS Kanoh
Department of Pediatrics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA
Clin Exp Allergy 41:1747-56. 2011..The effect of GCS on IL-13-induced mucin production is not well characterized... - Secretory phospholipases A2 stimulate mucus secretion, induce airway inflammation, and produce secretory hyperresponsiveness to neutrophil elastase in ferret tracheaKosuke Okamoto
Department of Pediatrics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1081, USA
Am J Physiol Lung Cell Mol Physiol 292:L62-7. 2007..sPLA(2) increased tracheal inflammation, MG secretion, and secretory hyperresponsiveness to HNE probably through enzymatic action rather than by activation of its receptor... - In vitro evaluation of endotracheal tubes with intrinsic suctionKarla I Mujica-Lopez
Department of Pediatrics, Virginia Commonwealth University, Richmond, VA, USA
Chest 138:863-9. 2010..Endotracheal tube (ETT) intubation impairs mucus clearance, which can lead to respiratory compromise. We compared three ETTs that have intrinsic capacity to aspirate secretions pooling above the cuff... - An in vitro evaluation of the effectiveness of endotracheal suction cathetersSamir Shah
Department of Biomedical Engineering, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
Chest 128:3699-704. 2005..The distance between side holes, end hole size, suction force, and duration of suctioning were not tested but could also have an effect on TSC performance... 
Clarithromycin delays progression of bronchial epithelial cells from G1 phase to S phase and delays cell growth via extracellular signal-regulated protein kinase suppressionMasaharu Shinkai
Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1081, USA
Antimicrob Agents Chemother 50:1738-44. 2006..These results suggest that macrolide antibiotics can delay the progression of NHBE cells from G(1) phase to S phase and can slow cell growth, probably through the suppression of ERK1/2...- Macrolide antibiotics modulate ERK phosphorylation and IL-8 and GM-CSF production by human bronchial epithelial cellsMasaharu Shinkai
Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1081, USA
Am J Physiol Lung Cell Mol Physiol 290:L75-85. 2006..The p38 MAP kinase inhibitor, SB-203580 increased ERK phosphorylation and IL-8 secretion. These results suggest that macrolide antibiotics can differentially modulate proinflammatory cytokine secretion in NHBE cells, in part through ERK... - Nasal and sinus disease in cystic fibrosisJohn M Robertson
Department of Pediatrics, Texas Children s Hospital, Houston, Texas 77030, USA
Paediatr Respir Rev 9:213-9. 2008..Complications of sinonasal disease in CF are rare and include mucoceles and periorbital abscesses... - Effect of meconium on the surface properties of perflubronMamta Fuloria
Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC, USA
Pediatr Crit Care Med 5:167-71. 2004..In addition to these clinical implications, the novel interfacial tension technique described here could prove useful for assessing the interfacial properties of other poorly miscible biological fluids... - Mechanisms of action and clinical application of macrolides as immunomodulatory medicationsSoichiro Kanoh
Department of Pediatrics, Virginia Commonwealth University School of Medicine, 1001 E Marshall St, Richmond, VA 23298, USA
Clin Microbiol Rev 23:590-615. 2010..A concern is that long-term use of macrolides increases the emergence of antimicrobial resistance. Nonantimicrobial macrolides are now in development as potential immunomodulatory therapies... - Vasoactive intestinal peptide stimulates mucus secretion, but nitric oxide has no effect on mucus secretion in the ferret tracheaJung-Soo Kim
Dept. of Pediatrics, Wake Forest Univ. School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA
J Appl Physiol 101:486-91. 2006..We conclude that VIP-stimulated mucin and lysozyme secretion was both time dependent and dose dependent and that NO neither stimulates nor inhibits mucus secretion in the ferret trachea... - Macrolides as immunomodulatory medications for the therapy of chronic lung diseasesYolanda S López-Boado
GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pa 19406 0939, United States
Curr Opin Pharmacol 8:286-91. 2008..In this paper, we review recent findings on novel effects of macrolides on epithelial barrier function and resolution of inflammation, which may shed light on the mechanisms underlying the beneficial effects of macrolides in the clinic... - Editorial overview: the value of FeNO measurement in asthma management Fire sticks and burning bushes--maybe NO, but perhaps yesBruce K Rubin
Paediatr Respir Rev 9:132-3. 2008 - Mucus properties in children with primary ciliary dyskinesia: comparison with cystic fibrosisAndrew Bush
Pediatric Pulmonology, Imperial School of Medicine at National Heart and Lung Institute, London, UK
Chest 129:118-23. 2006.... - Problems with inhaler use: a call for improved clinician and patient educationJames B Fink
Aerogen, Mountain View, California 94943, USA
Respir Care 50:1360-74; discussion 1374-5. 2005..Problems with inhaler use, the cost of inhalers, and myths associated with inhalers are reviewed, with recommendations for strategies and techniques to better educate patients in inhaler use... - Inhaled mannitol for the treatment of mucociliary dysfunction in patients with bronchiectasis: effect on lung function, health status and sputumEvangelia Daviskas
Department of Respiratory Medicine, Royal Prince Alfred Hospital, Sydney, NSW, Australia
Respirology 10:46-56. 2005..Inhaled mannitol increases mucus clearance in patients with bronchiectasis by an unclear mechanism. The effect of mannitol on lung function, health status and sputum properties was investigated... - MUC5AC and MUC5B Mucins Are Decreased in Cystic Fibrosis Airway SecretionsMarkus O Henke
Department of Pulmonary Medicine, Philipps University Marburg, Germany
Am J Respir Cell Mol Biol 31:86-91. 2004..This may be due to a relative increase in other components of sputum in the CF airway or to a primary defect in mucin secretion in CF... - Pharmacological approaches to discovery and development of new mucolytic agentsMalcolm King
University of Alberta Pulmonary Research Group, 173 Heritage Medical Research Center, Edmonton, Alberta T6G 2S2, Canada
Adv Drug Deliv Rev 54:1475-90. 2002..Further studies are required to confirm these findings, to perform direct assessments of mucus clearability, and to extend the observations to patients with various types of pulmonary diseases where mucoactive treatments are required... - Bye-bye, blow-byBruce K Rubin
Respir Care 52:981. 2007 - Macrolide antibiotics as immunomodulatory medications: proposed mechanisms of actionMasaharu Shinkai
Ministry of Defense and National Defense Medical College, Japan
Pharmacol Ther 117:393-405. 2008..Consistent with this, macrolide antibiotics possibly reduce mucin production as well as neutrophil migration by interfering with ERK signal transduction... - Comparison of high-frequency chest wall oscillation with differing waveforms for airway clearance in cystic fibrosisRobert R Kempainen
Minnesota Cystic Fibrosis Center, Department of Medicine, University of Minnesota School of Medicine, Minneapolis, MN, USA
Chest 132:1227-32. 2007.... - CFTR is a modulator of airway inflammationBruce K Rubin
Am J Physiol Lung Cell Mol Physiol 292:L381-2. 2007 - Did Lady Windermere have cystic fibrosis?Bruce K Rubin
Chest 130:937-8. 2006 - Respiratory therapies in the critical care setting. Should aerosolized antibiotics be administered to prevent or treat ventilator-associated pneumonia in patients who do not have cystic fibrosis?Neil R MacIntyre
Respiratory Care Services, Duke University Medical Center, Durham, NC 27710, USA
Respir Care 52:416-21; discussion 421-2. 2007..Importantly, the clinical evidence that aerosolized antibiotics can treat established VAP is negative, and multiple consensus groups recommend against treating established VAP with aerosolized antibiotics... - The role of airway secretions in COPD--clinical applicationsMarkus O Henke
Department of Pulmonary Medicine, Philipps-University Marburg, Marburg 35043, Germany
COPD 2:377-90. 2005..Carefully conducted studies of interventions to improve airway clearance, similar to those done in cystic fibrosis (CF), may help us to identify effective therapies and possibly novel diagnostic tests for the management of COPD... - MUC5AC and MUC5B mucins increase in cystic fibrosis airway secretions during pulmonary exacerbationMarkus O Henke
Philipps University Marburg, Department of Pulmonary Medicine, Baldingerstrasse 1, 35043 Marburg, Germany
Am J Respir Crit Care Med 175:816-21. 2007..However, we have shown that these mucins are decreased during stable CF disease... - A scientific koan: what is the cause of cystic fibrosis?Bruce K Rubin
Chest 123:1792-3. 2003 - Hyperosmolar solutions stimulate mucus secretion in the ferret tracheaChikako Kishioka
Department of Otolaryngology, Mie University School of Medicine, Tsu, Mie, Japan
Chest 124:306-13. 2003..This may be a protective response. These results also suggest that the therapeutic use of hyperosmolar aerosols should be evaluated with care when used for patients with mucus hypersecretion and impaired mucus clearance... - Up-regulation of S100A8 and S100A9 protein in bronchial epithelial cells by lipopolysaccharideMarkus O Henke
Department of Pulmonary Medicine, Philipps University Marburg, Marburg, Germany
Exp Lung Res 32:331-47. 2006..This finding suggests that S100A8 and S100A9 are involved in the innate defense of the bronchial epithelium... - Nasal and sinus inflammation in chronic obstructive pulmonary diseaseJung Soo Kim
Department of Otolaryngology, Kyungpook National University, Daegu, Korea
COPD 4:163-6. 2007..Postnasal drainage of nasal inflammatory mediators during sleep also may increase lower airway responsiveness. Therapy of nasal and sinus disease is associated with improved pulmonary function in patients with COPD... - Emerging and unusual gram-negative infections in cystic fibrosisJane C Davies
Department of Pediatric Respiratory Medicine, Royal Brompton Hospital, and Department of Gene Therapy, Imperial College, London, United Kingdom
Semin Respir Crit Care Med 28:312-21. 2007..cepacia complex, are clearly linked to an adverse prognosis, and both treatment and infection control issues can pose a real challenge... - High-frequency external chest wall compression for secretion clearance: shake it, but don't break itBruce K Rubin
Respir Care 52:982-3. 2007 - Nasal and sinus involvement in chronic obstructive pulmonary diseaseJung Soo Kim
Department of Otolaryngology, Kyungpook National University, Daegu, Korea
Curr Opin Pulm Med 14:101-4. 2008..We review the current understanding of the relationship between upper and lower airway disease, particularly in chronic obstructive pulmonary disease, including therapeutic implications...