Research Topics
Species | THOMAS COSTIN REGISTERSummaryAffiliation: Wake Forest University School of Medicine Country: USA Publications
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Publications
Abdominal aortic calcification quantified by the Morphological Atherosclerotic Calcification Distribution (MACD) index is associated with features of the metabolic syndromeNatasha Barascuk
Nordic Bioscience A S, Herlev Hovedgade 207, 2730 Herlev, Denmark
BMC Cardiovasc Disord 11:75. 2011..3 years follow-up, to identify biological parameters that may account for the differential performance of these indices...- Human macrophage foam cells degrade atherosclerotic plaques through cathepsin K mediated processesNatasha Barascuk
Nordic Bioscience A S, Herlev, DK 2730, Denmark
BMC Cardiovasc Disord 10:19. 2010..The aim of the current study was to investigate whether human macrophage foam cells degrade the extracellular matrix (ECM) of atherosclerotic plaques by cathepsin K mediated processes... 
Effects of tibolone and conventional hormone replacement therapies on arterial and hepatic cholesterol accumulation and on circulating endothelin-1, vascular cell adhesion molecule-1, and E-selectin in surgically menopausal monkeysThomas C Register
Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Menopause 9:411-21. 2002....- Soy phytoestrogens do not prevent bone loss in postmenopausal monkeysThomas C Register
Section on Comparative Medicine, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27103 1040, USA
J Clin Endocrinol Metab 88:4362-70. 2003..02). These results suggest that SPE may be poor substitutes for mammalian estrogens in protecting against bone loss resulting from estrogen deficiency... - Effects of soy isoflavones and conjugated equine estrogens on inflammatory markers in atherosclerotic, ovariectomized monkeysThomas C Register
Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1040, USA
J Clin Endocrinol Metab 90:1734-40. 2005..The sites of IF inhibitory effects on sVCAM-1 production are not known, but likely candidates include the liver and/or the cardiovascular system... - Type 2 diabetes is not independently associated with spinal trabecular volumetric bone mineral density measured by QCT in the Diabetes Heart StudyT C Register
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Bone 39:628-33. 2006..05), although the differences disappeared after additional adjustment for BMI. These data suggest that areal BMD measured by DXA and trabecular volumetric BMD measured by QCT are not associated with type 2 diabetes independently from BMI... - Variability of serum soluble intercellular adhesion molecule-1 measurements attributable to a common polymorphismThomas C Register
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA
Clin Chem 50:2185-7. 2004 
Primate models in women's health: inflammation and atherogenesis in female cynomolgus macaques (Macaca fascicularis)Thomas C Register
Wake Forest University Primate Center, Department of Pathology, Section on Comparative Medicine, Winston Salem, North Carolina 27157 1040, USA
Am J Primatol 71:766-75. 2009....- Effects of dietary soy protein on iliac and carotid artery atherosclerosis and gene expression in male monkeysSara E Walker
Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
Atherosclerosis 196:106-13. 2008..The negative associations of arterial ER alpha expression with atherosclerosis lend support to a mechanistic role for estrogen receptors in atherosclerosis susceptibility which merits further study... - Plasma lipid-dependent and -independent effects of dietary soy protein and social status on atherogenesis in premenopausal monkeys: implications for postmenopausal atherosclerosis burdenSara E Walker
Wake Forest University Primate Center, Section on Comparative, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Menopause 15:950-7. 2008..The objective of this study was to determine the effects of dietary soy protein isolate (SPI) and social status on atherogenesis and arterial gene expression in a premenopausal monkey model... - Effects of two novel selective estrogen receptor modulators, raloxifene, tamoxifen, and ethinyl estradiol on the uterus, vagina and breast in ovariectomized cynomolgus monkeys (Macaca fascicularis)Paul Sikoski
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
Am J Obstet Gynecol 196:75.e1-7. 2007..Assess effects of 2 novel selective estrogen receptor modulators on the reproductive system... - Effects of dietary isoflavone aglycones on the reproductive tract of male and female miceJ Mark Cline
The Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
Toxicol Pathol 32:91-9. 2004..We conclude that a diet containing approximately 40 mg/kg soy isoflavone aglycones with a genistein:daidzein ratio of 2:1 or less has marked estrogenic effects on the reproductive system of male and female mice... - The inhibitory effect of soy protein isolate on atherosclerosis in mice does not require the presence of LDL receptors or alteration of plasma lipoproteinsMichael R Adams
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Nutr 132:43-9. 2002..The results represent direct evidence for the existence of LDL receptor- and plasma lipoprotein-independent pathways by which dietary soy protein isolate inhibits atherosclerosis... - Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart StudyBarry I Freedman
Department of Internal Medicine, Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
J Bone Miner Res 24:1719-27. 2009..0143). Polymorphisms in BMP7 are associated with inverse relationships between bone mineralization and VC in the coronary, carotid, and abdominal aorta in a diabetes-enriched cohort of European Americans... - Effects of raloxifene on bone density, biomarkers, and histomorphometric and biomechanical measures in ovariectomized cynomolgus monkeysCynthia J Lees
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Menopause 9:320-8. 2002..The purpose of this study was to determine the effect of raloxifene on bone density, strength, metabolism, and histomorphometric characteristics in ovariectomized cynomolgus monkeys... - Bone mass and soy isoflavones in socially housed, premenopausal macaquesCynthia J Lees
Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 040, USA
Am J Clin Nutr 86:245-50. 2007..It is not known whether premenopausal soy exposure initiated in adulthood can increase bone mass and thereby reduce fracture risk... - Hormone therapy effects on social behavior and activity levels of surgically postmenopausal cynomolgus monkeysCarol A Shively
Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
Psychoneuroendocrinology 32:981-90. 2007..Further research is needed to explore social context as an important feature of behavioral response to steroid hormone regimens and to verify and extend knowledge of systemic effects of vaginal ring-delivered progestogens... - Calcified atherosclerotic plaque and bone mineral density in type 2 diabetes: the diabetes heart studyJ Jeffrey Carr
Department of Radiology, Wake Forest University School of Medicine, Winston Salem, NC, USA
Bone 42:43-52. 2008..QCT determined vBMD was more strongly related to CP than aBMD by DXA. The relation between CP and BMD in diabetes is influenced by age, sex, and ethnicity, with further effect modification by hormone replacement therapy... - Timing of estrogen replacement influences atherosclerosis progression and plaque leukocyte populations in ApoE-/- miceJennifer A Cann
Department of Pathology, Comparative Medicine Clinical Research Center, Wake Forest University Health Sciences, Winston Salem, NC 27157, United States
Atherosclerosis 201:43-52. 2008..These results suggest that a period of estrogen deficiency followed by reintroduction alters the immunologic environment of atherosclerotic lesions as well as plaque progression... - Transcriptional profiles of progestogen effects in the postmenopausal breastCharles E Wood
Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Breast Cancer Res Treat 114:233-42. 2009.... - Comparative effects of tibolone and conjugated equine estrogens with and without medroxyprogesterone acetate on the reproductive tract of female cynomolgus monkeysJ Mark Cline
Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
Menopause 9:242-52. 2002..To measure the effects of 2 years' treatment with tibolone on the reproductive tract of female monkeys (Macaca fascicularis) in comparison with conventional hormone replacement therapy... - Depressive behavior and coronary artery atherogenesis in adult female cynomolgus monkeysCarol A Shively
Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1040, USA
Psychosom Med 70:637-45. 2008..Thus, in prospective studies of depression and CHD, CAA was likely present at baseline in most subjects who experienced cardiac events. Little is known about the relationship between depression and CAA... - Past oral contraceptive use and current dietary soy isoflavones influence estrogen metabolism in postmenopausal monkeys (Macaca fascicularis)Latanya M Scott
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Cancer Epidemiol Biomarkers Prev 17:2594-602. 2008..Premenopausal OCs may have long-term systemic effects on response to estrogen and its metabolism whereas postmenopausal dietary isoflavones may alter endogenous estrogen metabolism in a modest but selective manner... - Hepatic steatosis and subclinical cardiovascular disease in a cohort enriched for type 2 diabetes: the Diabetes Heart StudyRyan L McKimmie
Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Am J Gastroenterol 103:3029-35. 2008.... - Social stress, visceral obesity, and coronary artery atherosclerosis in female primatesCarol A Shively
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Obesity (Silver Spring) 17:1513-20. 2009..Further studies are needed to understand the complex and multifactorial temporal relationship among relative visceral obesity, physiological stress responses, and CAA... - Social stress, visceral obesity, and coronary artery atherosclerosis: product of a primate adaptationCarol A Shively
Wake Forest University Primate Center, Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina NC 27157 1040, USA
Am J Primatol 71:742-51. 2009..Social stress may be engaging these same physiological systems, increasing the visceral deposition of fat and its sequelae, which increase CHD risk... - A diet rich in green and yellow vegetables inhibits atherosclerosis in miceMichael R Adams
Bell Institute of Health and Nutrition, General Mills Company, Minneapolis, MN 55440, USA
J Nutr 136:1886-9. 2006.... - Estrogen decreases atherosclerosis in part by reducing hepatic acyl-CoA:cholesterol acyltransferase 2 (ACAT2) in monkeysKylie Kavanagh
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
Arterioscler Thromb Vasc Biol 29:1471-7. 2009..This study aimed to determine estrogen-induced changes in hepatic cholesterol metabolism, plasma lipoproteins, and the relationship of these changes to atherosclerosis extent... - A comparison of tibolone and hormone replacement therapy on coronary artery and myocardial function in ovariectomized atherosclerotic monkeysJ Koudy Williams
The Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
Menopause 9:41-51. 2002.... - Ethnic differences in the relationship between pericardial adipose tissue and coronary artery calcified plaque: African-American-diabetes heart studyJasmin Divers
Department of Public Health Sciences, Center for Diabetes Research, Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1053, USA
J Clin Endocrinol Metab 95:5382-9. 2010..Because pericardial adipose tissue (PAT) is associated with CP in the neighboring coronary arteries, we explored ethnic-specific relationships between PAT and CP... - The atheroprotective effect of dietary soy isoflavones in apolipoprotein E-/- mice requires the presence of estrogen receptor-alphaMichael R Adams
Department of Pathology Comparative Medicine, Wake Forest University Medical Center, Winston Salem, NC 27157 1040, USA
Arterioscler Thromb Vasc Biol 22:1859-64. 2002..We sought to determine whether soy isoflavones exert atheroprotective effects through estrogen receptor-dependent processes and, if so, which estrogen receptor subtype (ie, alpha or beta) is involved... - Effects of estradiol with oral or intravaginal progesterone on risk markers for breast cancer in a postmenopausal monkey modelCharles E Wood
Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Menopause 14:639-47. 2007..To evaluate the effects of oral estradiol given with either oral or intravaginal micronized progesterone (P4) on risk biomarkers for breast cancer in a postmenopausal monkey model... - Measurement of trabecular bone mineral density in the thoracic spine using cardiac gated quantitative computed tomographyLeon Lenchik
Department of Radiology, Wake Forest University School of Medicine, University Health Sciences, Winston Salem, NC 27157, USA
J Comput Assist Tomogr 28:134-9. 2004..To develop a method and evaluate the performance of thoracic bone mineral density (BMD) measurement using cardiac gated quantitative computed tomography (QCT)... - Adrenocortical effects of oral estrogens and soy isoflavones in female monkeysCharles E Wood
Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
J Clin Endocrinol Metab 89:2319-25. 2004..These findings suggest that long-term estrogen treatment may contribute to an androgen-deficient and hypercortisolemic state... - Breast and uterine effects of soy isoflavones and conjugated equine estrogens in postmenopausal female monkeysCharles E Wood
Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
J Clin Endocrinol Metab 89:3462-8. 2004..These findings suggest that high dietary levels of soy isoflavones do not stimulate breast or uterine proliferation in postmenopausal monkeys and may contribute to an estrogen profile associated with reduced breast cancer risk... - Effects of social status and moderate alcohol consumption on mammary gland and endometrium of surgically postmenopausal monkeysCarol A Shively
Comparative Medicine Section, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Menopause 11:389-99. 2004..To evaluate the effects of social subordination stress and chronic moderate alcohol consumption on indices of breast and endometrial cancer risk... - Social stress-associated depression in adult female cynomolgus monkeys (Macaca fascicularis)Carol A Shively
Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1040, USA
Biol Psychol 69:67-84. 2005..These monkeys may be a useful model of reproductive system-associated mood disorders in females... - Heritability of body composition measured by DXA in the diabetes heart studyFang Chi Hsu
Department of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
Obes Res 13:312-9. 2005..The purpose of this study was to investigate the heritability of body composition measured by DXA in the Diabetes Heart Study (DHS)... - Soy protein containing isoflavones reduces the size of atherosclerotic plaques without affecting coronary artery reactivity in adult male monkeysMichael R Adams
Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Nutr 135:2852-6. 2005.... - Dietary soy isoflavones inhibit estrogen effects in the postmenopausal breastCharles E Wood
Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Cancer Res 66:1241-9. 2006..These findings show that in the presence of estrogen higher doses of dietary soy isoflavones may alter ER signaling and induce selective antagonistic effects in the breast... - Soy isoflavonoid effects on endogenous estrogen metabolism in postmenopausal female monkeysCharles E Wood
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1040, USA
Carcinogenesis 28:801-8. 2007..01 for all). These findings suggest that long-term exposure to soy isoflavonoids, equol in particular, may facilitate endogenous estrogen clearance and catabolism to more benign 2-hydroxylated metabolites... - Effects of estradiol with micronized progesterone or medroxyprogesterone acetate on risk markers for breast cancer in postmenopausal monkeysCharles E Wood
Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
Breast Cancer Res Treat 101:125-34. 2007..These findings suggest that oral micronized progesterone has a more favorable effect on risk biomarkers for postmenopausal breast cancer than medroxyprogesterone acetate... - Effects of tibolone and hormone replacement therapy on the breast of cynomolgus monkeysJ Mark Cline
Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Menopause 9:422-9. 2002..To measure the effects of 2 years of treatment with tibolone on the breasts of cynomolgus macaques (Macaca fascicularis) in comparison with conventional hormone replacement therapy... - Effects of long-term moderate alcohol consumption on agonistic and affiliative behavior of socially housed female cynomolgus monkeys (Macaca fascicularis)Carol A Shively
Department of Pathology, Comparative Medicine Section, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
Psychopharmacology (Berl) 165:1-8. 2002..However, little is known about the chronic effects of moderate alcohol consumption. Alcohol, even in moderate doses, has immediate and robust effects on behavior... - The effects of moderate ethanol consumption on the liver of the monkey, Macaca fascicularisPriscilla Ivester
Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1016, USA
Alcohol Clin Exp Res 27:1831-7. 2003..This is still a concern because some human studies suggest that levels of ethanol considered to be cardioprotective cause liver injury when consumed over a lifetime... - Health issues in postmenopausal women who drinkThomas C Register
Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA
Alcohol Res Health 26:299-307. 2002..The effects of alcohol consumption on these three diseases in postmenopausal women are reviewed, along with limitations in interpreting results of studies of alcohol's effects on postmenopausal women's health... - Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart studyKathryn P Burdon
Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Mediators Inflamm 2010:170153. 2010..Genes of the 5-lipoxygenase pathway are compelling candidates for atherosclerosis. We hypothesize that polymorphisms in ALOX12, ALOX15, ALOX5, and ALOX5AP genes are associated with subclinical atherosclerosis in multiple vascular beds... - Association of alpha2-Heremans-Schmid glycoprotein polymorphisms with subclinical atherosclerosisAllison B Lehtinen
Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
J Clin Endocrinol Metab 92:345-52. 2007.... - Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylationKonduru S R Sastry
Department of Cancer Biology, Section on Comparative Medicine, and Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Biol Chem 282:14094-100. 2007..Antiapoptotic signaling by epinephrine could be one of the mechanisms by which stress promotes tumorigenesis and decreases the efficacy of anti-cancer therapies... - Estrogen replacement therapy induces telomerase RNA expression in the macaque endometriumJustin D Vidal
Virginia-Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia, USA
Fertil Steril 77:601-8. 2002..CONCLUSION(S): These results show for the first time a cell-specific hormonal regulation of TRNA in the primate endometrium, with up-regulation of TRNA by treatments associated with increased risk of endometrial cancer in women... - Effects of tibolone on estrogen biosynthesis in the mammary tissue of postmenopausal monkeysPetra Stute
Department of Obstetrics and Gynecology, , , Germany
Menopause 13:232-40. 2006..Therefore, breast tissue composition affects the steroidogenic response to hormonal treatment... - Increased aggressive behavior and decreased affiliative behavior in adult male monkeys after long-term consumption of diets rich in soy protein and isoflavonesNeal G Simon
Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
Horm Behav 45:278-84. 2004..The results indicate that long-term consumption of a diet rich in soy isoflavones can have marked influences on patterns of aggressive and social behavior...
Research Grants
- Atherosclerosis Stage, Estrogen Receptors, and Vascular Responses to EstrogenTHOMAS REGISTER; Fiscal Year: 2007....
- Atherosclerosis Stage, Estrogen Receptors, and Vascular Responses to EstrogenTHOMAS COSTIN REGISTER; Fiscal Year: 2010....