THOMAS COSTIN REGISTER

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. pmc Abdominal aortic calcification quantified by the Morphological Atherosclerotic Calcification Distribution (MACD) index is associated with features of the metabolic syndrome
    Natasha Barascuk
    Nordic Bioscience A S, Herlev Hovedgade 207, 2730 Herlev, Denmark
    BMC Cardiovasc Disord 11:75. 2011
  2. pmc Human macrophage foam cells degrade atherosclerotic plaques through cathepsin K mediated processes
    Natasha Barascuk
    Nordic Bioscience A S, Herlev, DK 2730, Denmark
    BMC Cardiovasc Disord 10:19. 2010
  3. ncbi request reprint Effects of tibolone and conventional hormone replacement therapies on arterial and hepatic cholesterol accumulation and on circulating endothelin-1, vascular cell adhesion molecule-1, and E-selectin in surgically menopausal monkeys
    Thomas C Register
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Menopause 9:411-21. 2002
  4. ncbi request reprint Soy phytoestrogens do not prevent bone loss in postmenopausal monkeys
    Thomas C Register
    Section on Comparative Medicine, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27103 1040, USA
    J Clin Endocrinol Metab 88:4362-70. 2003
  5. ncbi request reprint Effects of soy isoflavones and conjugated equine estrogens on inflammatory markers in atherosclerotic, ovariectomized monkeys
    Thomas C Register
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1040, USA
    J Clin Endocrinol Metab 90:1734-40. 2005
  6. ncbi request reprint Type 2 diabetes is not independently associated with spinal trabecular volumetric bone mineral density measured by QCT in the Diabetes Heart Study
    T C Register
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Bone 39:628-33. 2006
  7. ncbi request reprint Variability of serum soluble intercellular adhesion molecule-1 measurements attributable to a common polymorphism
    Thomas C Register
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Clin Chem 50:2185-7. 2004
  8. pmc Primate models in women's health: inflammation and atherogenesis in female cynomolgus macaques (Macaca fascicularis)
    Thomas C Register
    Wake Forest University Primate Center, Department of Pathology, Section on Comparative Medicine, Winston Salem, North Carolina 27157 1040, USA
    Am J Primatol 71:766-75. 2009
  9. pmc Effects of dietary soy protein on iliac and carotid artery atherosclerosis and gene expression in male monkeys
    Sara E Walker
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    Atherosclerosis 196:106-13. 2008
  10. pmc Plasma lipid-dependent and -independent effects of dietary soy protein and social status on atherogenesis in premenopausal monkeys: implications for postmenopausal atherosclerosis burden
    Sara E Walker
    Wake Forest University Primate Center, Section on Comparative, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 15:950-7. 2008

Detail Information

Publications52

  1. pmc Abdominal aortic calcification quantified by the Morphological Atherosclerotic Calcification Distribution (MACD) index is associated with features of the metabolic syndrome
    Natasha Barascuk
    Nordic Bioscience A S, Herlev Hovedgade 207, 2730 Herlev, Denmark
    BMC Cardiovasc Disord 11:75. 2011
    ..3 years follow-up, to identify biological parameters that may account for the differential performance of these indices...
  2. pmc Human macrophage foam cells degrade atherosclerotic plaques through cathepsin K mediated processes
    Natasha Barascuk
    Nordic Bioscience A S, Herlev, DK 2730, Denmark
    BMC Cardiovasc Disord 10:19. 2010
    ..The aim of the current study was to investigate whether human macrophage foam cells degrade the extracellular matrix (ECM) of atherosclerotic plaques by cathepsin K mediated processes...
  3. ncbi request reprint Effects of tibolone and conventional hormone replacement therapies on arterial and hepatic cholesterol accumulation and on circulating endothelin-1, vascular cell adhesion molecule-1, and E-selectin in surgically menopausal monkeys
    Thomas C Register
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Menopause 9:411-21. 2002
    ....
  4. ncbi request reprint Soy phytoestrogens do not prevent bone loss in postmenopausal monkeys
    Thomas C Register
    Section on Comparative Medicine, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27103 1040, USA
    J Clin Endocrinol Metab 88:4362-70. 2003
    ..02). These results suggest that SPE may be poor substitutes for mammalian estrogens in protecting against bone loss resulting from estrogen deficiency...
  5. ncbi request reprint Effects of soy isoflavones and conjugated equine estrogens on inflammatory markers in atherosclerotic, ovariectomized monkeys
    Thomas C Register
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1040, USA
    J Clin Endocrinol Metab 90:1734-40. 2005
    ..The sites of IF inhibitory effects on sVCAM-1 production are not known, but likely candidates include the liver and/or the cardiovascular system...
  6. ncbi request reprint Type 2 diabetes is not independently associated with spinal trabecular volumetric bone mineral density measured by QCT in the Diabetes Heart Study
    T C Register
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Bone 39:628-33. 2006
    ..05), although the differences disappeared after additional adjustment for BMI. These data suggest that areal BMD measured by DXA and trabecular volumetric BMD measured by QCT are not associated with type 2 diabetes independently from BMI...
  7. ncbi request reprint Variability of serum soluble intercellular adhesion molecule-1 measurements attributable to a common polymorphism
    Thomas C Register
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Clin Chem 50:2185-7. 2004
  8. pmc Primate models in women's health: inflammation and atherogenesis in female cynomolgus macaques (Macaca fascicularis)
    Thomas C Register
    Wake Forest University Primate Center, Department of Pathology, Section on Comparative Medicine, Winston Salem, North Carolina 27157 1040, USA
    Am J Primatol 71:766-75. 2009
    ....
  9. pmc Effects of dietary soy protein on iliac and carotid artery atherosclerosis and gene expression in male monkeys
    Sara E Walker
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    Atherosclerosis 196:106-13. 2008
    ..The negative associations of arterial ER alpha expression with atherosclerosis lend support to a mechanistic role for estrogen receptors in atherosclerosis susceptibility which merits further study...
  10. pmc Plasma lipid-dependent and -independent effects of dietary soy protein and social status on atherogenesis in premenopausal monkeys: implications for postmenopausal atherosclerosis burden
    Sara E Walker
    Wake Forest University Primate Center, Section on Comparative, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 15:950-7. 2008
    ..The objective of this study was to determine the effects of dietary soy protein isolate (SPI) and social status on atherogenesis and arterial gene expression in a premenopausal monkey model...
  11. ncbi request reprint Effects of two novel selective estrogen receptor modulators, raloxifene, tamoxifen, and ethinyl estradiol on the uterus, vagina and breast in ovariectomized cynomolgus monkeys (Macaca fascicularis)
    Paul Sikoski
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Obstet Gynecol 196:75.e1-7. 2007
    ..Assess effects of 2 novel selective estrogen receptor modulators on the reproductive system...
  12. ncbi request reprint Effects of dietary isoflavone aglycones on the reproductive tract of male and female mice
    J Mark Cline
    The Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Toxicol Pathol 32:91-9. 2004
    ..We conclude that a diet containing approximately 40 mg/kg soy isoflavone aglycones with a genistein:daidzein ratio of 2:1 or less has marked estrogenic effects on the reproductive system of male and female mice...
  13. ncbi request reprint The inhibitory effect of soy protein isolate on atherosclerosis in mice does not require the presence of LDL receptors or alteration of plasma lipoproteins
    Michael R Adams
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nutr 132:43-9. 2002
    ..The results represent direct evidence for the existence of LDL receptor- and plasma lipoprotein-independent pathways by which dietary soy protein isolate inhibits atherosclerosis...
  14. pmc Bone morphogenetic protein 7 (BMP7) gene polymorphisms are associated with inverse relationships between vascular calcification and BMD: the Diabetes Heart Study
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1053, USA
    J Bone Miner Res 24:1719-27. 2009
    ..0143). Polymorphisms in BMP7 are associated with inverse relationships between bone mineralization and VC in the coronary, carotid, and abdominal aorta in a diabetes-enriched cohort of European Americans...
  15. ncbi request reprint Effects of raloxifene on bone density, biomarkers, and histomorphometric and biomechanical measures in ovariectomized cynomolgus monkeys
    Cynthia J Lees
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Menopause 9:320-8. 2002
    ..The purpose of this study was to determine the effect of raloxifene on bone density, strength, metabolism, and histomorphometric characteristics in ovariectomized cynomolgus monkeys...
  16. ncbi request reprint Bone mass and soy isoflavones in socially housed, premenopausal macaques
    Cynthia J Lees
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 040, USA
    Am J Clin Nutr 86:245-50. 2007
    ..It is not known whether premenopausal soy exposure initiated in adulthood can increase bone mass and thereby reduce fracture risk...
  17. ncbi request reprint Hormone therapy effects on social behavior and activity levels of surgically postmenopausal cynomolgus monkeys
    Carol A Shively
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    Psychoneuroendocrinology 32:981-90. 2007
    ..Further research is needed to explore social context as an important feature of behavioral response to steroid hormone regimens and to verify and extend knowledge of systemic effects of vaginal ring-delivered progestogens...
  18. pmc Calcified atherosclerotic plaque and bone mineral density in type 2 diabetes: the diabetes heart study
    J Jeffrey Carr
    Department of Radiology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Bone 42:43-52. 2008
    ..QCT determined vBMD was more strongly related to CP than aBMD by DXA. The relation between CP and BMD in diabetes is influenced by age, sex, and ethnicity, with further effect modification by hormone replacement therapy...
  19. pmc Timing of estrogen replacement influences atherosclerosis progression and plaque leukocyte populations in ApoE-/- mice
    Jennifer A Cann
    Department of Pathology, Comparative Medicine Clinical Research Center, Wake Forest University Health Sciences, Winston Salem, NC 27157, United States
    Atherosclerosis 201:43-52. 2008
    ..These results suggest that a period of estrogen deficiency followed by reintroduction alters the immunologic environment of atherosclerotic lesions as well as plaque progression...
  20. doi request reprint Transcriptional profiles of progestogen effects in the postmenopausal breast
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Breast Cancer Res Treat 114:233-42. 2009
    ....
  21. ncbi request reprint Comparative effects of tibolone and conjugated equine estrogens with and without medroxyprogesterone acetate on the reproductive tract of female cynomolgus monkeys
    J Mark Cline
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    Menopause 9:242-52. 2002
    ..To measure the effects of 2 years' treatment with tibolone on the reproductive tract of female monkeys (Macaca fascicularis) in comparison with conventional hormone replacement therapy...
  22. doi request reprint Depressive behavior and coronary artery atherogenesis in adult female cynomolgus monkeys
    Carol A Shively
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1040, USA
    Psychosom Med 70:637-45. 2008
    ..Thus, in prospective studies of depression and CHD, CAA was likely present at baseline in most subjects who experienced cardiac events. Little is known about the relationship between depression and CAA...
  23. pmc Past oral contraceptive use and current dietary soy isoflavones influence estrogen metabolism in postmenopausal monkeys (Macaca fascicularis)
    Latanya M Scott
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Epidemiol Biomarkers Prev 17:2594-602. 2008
    ..Premenopausal OCs may have long-term systemic effects on response to estrogen and its metabolism whereas postmenopausal dietary isoflavones may alter endogenous estrogen metabolism in a modest but selective manner...
  24. pmc Hepatic steatosis and subclinical cardiovascular disease in a cohort enriched for type 2 diabetes: the Diabetes Heart Study
    Ryan L McKimmie
    Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Am J Gastroenterol 103:3029-35. 2008
    ....
  25. doi request reprint Social stress, visceral obesity, and coronary artery atherosclerosis in female primates
    Carol A Shively
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Obesity (Silver Spring) 17:1513-20. 2009
    ..Further studies are needed to understand the complex and multifactorial temporal relationship among relative visceral obesity, physiological stress responses, and CAA...
  26. doi request reprint Social stress, visceral obesity, and coronary artery atherosclerosis: product of a primate adaptation
    Carol A Shively
    Wake Forest University Primate Center, Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina NC 27157 1040, USA
    Am J Primatol 71:742-51. 2009
    ..Social stress may be engaging these same physiological systems, increasing the visceral deposition of fat and its sequelae, which increase CHD risk...
  27. ncbi request reprint A diet rich in green and yellow vegetables inhibits atherosclerosis in mice
    Michael R Adams
    Bell Institute of Health and Nutrition, General Mills Company, Minneapolis, MN 55440, USA
    J Nutr 136:1886-9. 2006
    ....
  28. pmc Estrogen decreases atherosclerosis in part by reducing hepatic acyl-CoA:cholesterol acyltransferase 2 (ACAT2) in monkeys
    Kylie Kavanagh
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Arterioscler Thromb Vasc Biol 29:1471-7. 2009
    ..This study aimed to determine estrogen-induced changes in hepatic cholesterol metabolism, plasma lipoproteins, and the relationship of these changes to atherosclerosis extent...
  29. ncbi request reprint A comparison of tibolone and hormone replacement therapy on coronary artery and myocardial function in ovariectomized atherosclerotic monkeys
    J Koudy Williams
    The Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    Menopause 9:41-51. 2002
    ....
  30. pmc Ethnic differences in the relationship between pericardial adipose tissue and coronary artery calcified plaque: African-American-diabetes heart study
    Jasmin Divers
    Department of Public Health Sciences, Center for Diabetes Research, Section on Nephrology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1053, USA
    J Clin Endocrinol Metab 95:5382-9. 2010
    ..Because pericardial adipose tissue (PAT) is associated with CP in the neighboring coronary arteries, we explored ethnic-specific relationships between PAT and CP...
  31. ncbi request reprint The atheroprotective effect of dietary soy isoflavones in apolipoprotein E-/- mice requires the presence of estrogen receptor-alpha
    Michael R Adams
    Department of Pathology Comparative Medicine, Wake Forest University Medical Center, Winston Salem, NC 27157 1040, USA
    Arterioscler Thromb Vasc Biol 22:1859-64. 2002
    ..We sought to determine whether soy isoflavones exert atheroprotective effects through estrogen receptor-dependent processes and, if so, which estrogen receptor subtype (ie, alpha or beta) is involved...
  32. ncbi request reprint Effects of estradiol with oral or intravaginal progesterone on risk markers for breast cancer in a postmenopausal monkey model
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 14:639-47. 2007
    ..To evaluate the effects of oral estradiol given with either oral or intravaginal micronized progesterone (P4) on risk biomarkers for breast cancer in a postmenopausal monkey model...
  33. ncbi request reprint Measurement of trabecular bone mineral density in the thoracic spine using cardiac gated quantitative computed tomography
    Leon Lenchik
    Department of Radiology, Wake Forest University School of Medicine, University Health Sciences, Winston Salem, NC 27157, USA
    J Comput Assist Tomogr 28:134-9. 2004
    ..To develop a method and evaluate the performance of thoracic bone mineral density (BMD) measurement using cardiac gated quantitative computed tomography (QCT)...
  34. ncbi request reprint Adrenocortical effects of oral estrogens and soy isoflavones in female monkeys
    Charles E Wood
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    J Clin Endocrinol Metab 89:2319-25. 2004
    ..These findings suggest that long-term estrogen treatment may contribute to an androgen-deficient and hypercortisolemic state...
  35. ncbi request reprint Breast and uterine effects of soy isoflavones and conjugated equine estrogens in postmenopausal female monkeys
    Charles E Wood
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    J Clin Endocrinol Metab 89:3462-8. 2004
    ..These findings suggest that high dietary levels of soy isoflavones do not stimulate breast or uterine proliferation in postmenopausal monkeys and may contribute to an estrogen profile associated with reduced breast cancer risk...
  36. ncbi request reprint Effects of social status and moderate alcohol consumption on mammary gland and endometrium of surgically postmenopausal monkeys
    Carol A Shively
    Comparative Medicine Section, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Menopause 11:389-99. 2004
    ..To evaluate the effects of social subordination stress and chronic moderate alcohol consumption on indices of breast and endometrial cancer risk...
  37. ncbi request reprint Social stress-associated depression in adult female cynomolgus monkeys (Macaca fascicularis)
    Carol A Shively
    Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1040, USA
    Biol Psychol 69:67-84. 2005
    ..These monkeys may be a useful model of reproductive system-associated mood disorders in females...
  38. ncbi request reprint Heritability of body composition measured by DXA in the diabetes heart study
    Fang Chi Hsu
    Department of Public Health Sciences, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Obes Res 13:312-9. 2005
    ..The purpose of this study was to investigate the heritability of body composition measured by DXA in the Diabetes Heart Study (DHS)...
  39. ncbi request reprint Soy protein containing isoflavones reduces the size of atherosclerotic plaques without affecting coronary artery reactivity in adult male monkeys
    Michael R Adams
    Department of Pathology Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nutr 135:2852-6. 2005
    ....
  40. ncbi request reprint Dietary soy isoflavones inhibit estrogen effects in the postmenopausal breast
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Cancer Res 66:1241-9. 2006
    ..These findings show that in the presence of estrogen higher doses of dietary soy isoflavones may alter ER signaling and induce selective antagonistic effects in the breast...
  41. ncbi request reprint Soy isoflavonoid effects on endogenous estrogen metabolism in postmenopausal female monkeys
    Charles E Wood
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157 1040, USA
    Carcinogenesis 28:801-8. 2007
    ..01 for all). These findings suggest that long-term exposure to soy isoflavonoids, equol in particular, may facilitate endogenous estrogen clearance and catabolism to more benign 2-hydroxylated metabolites...
  42. ncbi request reprint Effects of estradiol with micronized progesterone or medroxyprogesterone acetate on risk markers for breast cancer in postmenopausal monkeys
    Charles E Wood
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157 1040, USA
    Breast Cancer Res Treat 101:125-34. 2007
    ..These findings suggest that oral micronized progesterone has a more favorable effect on risk biomarkers for postmenopausal breast cancer than medroxyprogesterone acetate...
  43. ncbi request reprint Effects of tibolone and hormone replacement therapy on the breast of cynomolgus monkeys
    J Mark Cline
    Comparative Medicine Clinical Research Center, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Menopause 9:422-9. 2002
    ..To measure the effects of 2 years of treatment with tibolone on the breasts of cynomolgus macaques (Macaca fascicularis) in comparison with conventional hormone replacement therapy...
  44. ncbi request reprint Effects of long-term moderate alcohol consumption on agonistic and affiliative behavior of socially housed female cynomolgus monkeys (Macaca fascicularis)
    Carol A Shively
    Department of Pathology, Comparative Medicine Section, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157 1040, USA
    Psychopharmacology (Berl) 165:1-8. 2002
    ..However, little is known about the chronic effects of moderate alcohol consumption. Alcohol, even in moderate doses, has immediate and robust effects on behavior...
  45. ncbi request reprint The effects of moderate ethanol consumption on the liver of the monkey, Macaca fascicularis
    Priscilla Ivester
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1016, USA
    Alcohol Clin Exp Res 27:1831-7. 2003
    ....
  46. ncbi request reprint Health issues in postmenopausal women who drink
    Thomas C Register
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Alcohol Res Health 26:299-307. 2002
    ..The effects of alcohol consumption on these three diseases in postmenopausal women are reviewed, along with limitations in interpreting results of studies of alcohol's effects on postmenopausal women's health...
  47. pmc Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study
    Kathryn P Burdon
    Department of Biochemistry, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Mediators Inflamm 2010:170153. 2010
    ..Genes of the 5-lipoxygenase pathway are compelling candidates for atherosclerosis. We hypothesize that polymorphisms in ALOX12, ALOX15, ALOX5, and ALOX5AP genes are associated with subclinical atherosclerosis in multiple vascular beds...
  48. ncbi request reprint Association of alpha2-Heremans-Schmid glycoprotein polymorphisms with subclinical atherosclerosis
    Allison B Lehtinen
    Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    J Clin Endocrinol Metab 92:345-52. 2007
    ....
  49. ncbi request reprint Epinephrine protects cancer cells from apoptosis via activation of cAMP-dependent protein kinase and BAD phosphorylation
    Konduru S R Sastry
    Department of Cancer Biology, Section on Comparative Medicine, and Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Biol Chem 282:14094-100. 2007
    ..Antiapoptotic signaling by epinephrine could be one of the mechanisms by which stress promotes tumorigenesis and decreases the efficacy of anti-cancer therapies...
  50. ncbi request reprint Estrogen replacement therapy induces telomerase RNA expression in the macaque endometrium
    Justin D Vidal
    Virginia Maryland Regional College of Veterinary Medicine, Blacksburg, Virginia, USA
    Fertil Steril 77:601-8. 2002
    ..To evaluate the effects of hormonal therapies on the expression of telomerase RNA (TRNA) in the endometrium of ovariectomized female cynomolgus macaques (Macaca fascicularis)...
  51. ncbi request reprint Effects of tibolone on estrogen biosynthesis in the mammary tissue of postmenopausal monkeys
    Petra Stute
    Department of Obstetrics and Gynecology, University of Munster, Munster, Germany
    Menopause 13:232-40. 2006
    ..To evaluate the long-term effects of tibolone on estrone sulfate (E1S)-sulfatase activity in breast tissue in a primate model (Macaca fascicularis) in comparison with conventional hormone therapies...
  52. ncbi request reprint Increased aggressive behavior and decreased affiliative behavior in adult male monkeys after long-term consumption of diets rich in soy protein and isoflavones
    Neal G Simon
    Department of Biological Sciences, Lehigh University, Bethlehem, PA 18015, USA
    Horm Behav 45:278-84. 2004
    ..The results indicate that long-term consumption of a diet rich in soy isoflavones can have marked influences on patterns of aggressive and social behavior...