Linda Porrino

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Orbital and medial prefrontal cortex and psychostimulant abuse: studies in animal models
    L J Porrino
    Center for the Neurobiological Investigation of Abused Drugs, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Cereb Cortex 10:326-33. 2000
  2. pmc The effects of cocaine: a shifting target over the course of addiction
    Linda J Porrino
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:1593-600. 2007
  3. ncbi request reprint Metabolic mapping of the effects of cocaine during the initial phases of self-administration in the nonhuman primate
    Linda J Porrino
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurosci 22:7687-94. 2002
  4. ncbi request reprint Cocaine self-administration produces a progressive involvement of limbic, association, and sensorimotor striatal domains
    Linda J Porrino
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    J Neurosci 24:3554-62. 2004
  5. ncbi request reprint Chronic cocaine self-administration is associated with altered functional activity in the temporal lobes of non human primates
    Thomas J R Beveridge
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Eur J Neurosci 23:3109-18. 2006
  6. ncbi request reprint Effects of chronic cocaine self-administration on norepinephrine transporters in the nonhuman primate brain
    Thomas J R Beveridge
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 180:781-8. 2005
  7. doi request reprint Abstinence from chronic cocaine self-administration alters striatal dopamine systems in rhesus monkeys
    Thomas J R Beveridge
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Neuropsychopharmacology 34:1162-71. 2009
  8. doi request reprint The comparative distributions of the monoamine transporters in the rodent, monkey, and human amygdala
    Hilary R Smith
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drugs of Abuse, Wake Forest University Health Sciences, Winston Salem, NC 27157 1083, USA
    Brain Struct Funct 213:73-91. 2008
  9. ncbi request reprint Functional effects of cocaine self-administration in primate brain regions regulating cardiovascular function
    Thomas J R Beveridge
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Neurosci Lett 370:201-5. 2004
  10. ncbi request reprint The expanding effects of cocaine: studies in a nonhuman primate model of cocaine self-administration
    Linda J Porrino
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Neurosci Biobehav Rev 27:813-20. 2004

Research Grants

  1. NEURAL SUBSTRATES OF THE ACUTE EFFECTS OF ETHANOL
    Linda Porrino; Fiscal Year: 1992
  2. Decision Making in Marijuana Users
    Linda Porrino; Fiscal Year: 2007
  3. Early Exposure to Stimulants as a Risk Factor for Substance Abuse
    Linda Porrino; Fiscal Year: 2007
  4. NEUROBIOLOGICAL CORRELATES OF COCAINE ABUSE
    Linda Porrino; Fiscal Year: 2007
  5. Decision Making in Marijuana Users
    Linda Porrino; Fiscal Year: 2009
  6. Early Exposure to Stimulants as a Risk Factor for Substance Abuse
    Linda J Porrino; Fiscal Year: 2010
  7. NEUROBIOLOGICAL CORRELATES OF COCAINE ABUSE
    Linda Porrino; Fiscal Year: 2005
  8. NEUROBIOLOGICAL CORRELATES OF COCAINE ABUSE
    Linda Porrino; Fiscal Year: 1999
  9. TIME DEPENDENT EFFECTS OF ETHANOL ON CEREBRAL METABOLISM
    Linda Porrino; Fiscal Year: 2001
  10. NEURAL SUBSTRATES OF THE ACUTE EFFECTS OF ETHANOL
    Linda Porrino; Fiscal Year: 2002

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Orbital and medial prefrontal cortex and psychostimulant abuse: studies in animal models
    L J Porrino
    Center for the Neurobiological Investigation of Abused Drugs, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Cereb Cortex 10:326-33. 2000
    ....
  2. pmc The effects of cocaine: a shifting target over the course of addiction
    Linda J Porrino
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:1593-600. 2007
    ....
  3. ncbi request reprint Metabolic mapping of the effects of cocaine during the initial phases of self-administration in the nonhuman primate
    Linda J Porrino
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Neurosci 22:7687-94. 2002
    ..The assessment of the effects of cocaine at a time not readily evaluated in humans provides a baseline from which the effects of chronic cocaine exposure can be investigated...
  4. ncbi request reprint Cocaine self-administration produces a progressive involvement of limbic, association, and sensorimotor striatal domains
    Linda J Porrino
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    J Neurosci 24:3554-62. 2004
    ....
  5. ncbi request reprint Chronic cocaine self-administration is associated with altered functional activity in the temporal lobes of non human primates
    Thomas J R Beveridge
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Eur J Neurosci 23:3109-18. 2006
    ....
  6. ncbi request reprint Effects of chronic cocaine self-administration on norepinephrine transporters in the nonhuman primate brain
    Thomas J R Beveridge
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Psychopharmacology (Berl) 180:781-8. 2005
    ..To date, no studies have made a systematic investigation of the effects of chronic cocaine on primate NET density...
  7. doi request reprint Abstinence from chronic cocaine self-administration alters striatal dopamine systems in rhesus monkeys
    Thomas J R Beveridge
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Neuropsychopharmacology 34:1162-71. 2009
    ....
  8. doi request reprint The comparative distributions of the monoamine transporters in the rodent, monkey, and human amygdala
    Hilary R Smith
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drugs of Abuse, Wake Forest University Health Sciences, Winston Salem, NC 27157 1083, USA
    Brain Struct Funct 213:73-91. 2008
    ....
  9. ncbi request reprint Functional effects of cocaine self-administration in primate brain regions regulating cardiovascular function
    Thomas J R Beveridge
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Neurosci Lett 370:201-5. 2004
    ..These alterations progress with prolonged cocaine exposure, and therefore may be involved in mediating changes in central autonomic control and the neuroadaptations reported to result from chronic drug abuse...
  10. ncbi request reprint The expanding effects of cocaine: studies in a nonhuman primate model of cocaine self-administration
    Linda J Porrino
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Neurosci Biobehav Rev 27:813-20. 2004
    ....
  11. ncbi request reprint Chronic cocaine self-administration upregulates the norepinephrine transporter and alters functional activity in the bed nucleus of the stria terminalis of the rhesus monkey
    Darrel J Macey
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    J Neurosci 23:12-6. 2003
    ..Furthermore, given the role of the BNST in cocaine withdrawal and stress-related reinstatement of self-administration, the changes reported here may provide a substrate for these phenomena...
  12. ncbi request reprint Effects of cocaine self-administration on striatal dopamine systems in rhesus monkeys: initial and chronic exposure
    Michael A Nader
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Neuropsychopharmacology 27:35-46. 2002
    ..These findings demonstrate that chronic cocaine self-administration produces neuroadaptations in dopamine systems, but that these changes do not occur in a parallel fashion...
  13. pmc Loss of functional specificity in the dorsal striatum of chronic cocaine users
    Colleen A Hanlon
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Drug Alcohol Depend 102:88-94. 2009
    ..Given the importance of the dorsal striatum in motor control, the purpose of the present study was to investigate potential sensorimotor deficits among cocaine users and the functional basis of these deficits within the striatum...
  14. pmc Review. Parallel studies of cocaine-related neural and cognitive impairment in humans and monkeys
    Thomas J R Beveridge
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Philos Trans R Soc Lond B Biol Sci 363:3257-66. 2008
    ....
  15. pmc Facilitation of task performance and removal of the effects of sleep deprivation by an ampakine (CX717) in nonhuman primates
    Linda J Porrino
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    PLoS Biol 3:e299. 2005
    ....
  16. ncbi request reprint Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates
    Sam A Deadwyler
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    J Neurosci 27:14239-47. 2007
    ..These findings provide strong evidence for the effectiveness of intranasal orexin-A in alleviating cognitive deficits produced by loss of sleep...
  17. ncbi request reprint Patterns of functional activity associated with cocaine self-administration in the rat change over time
    Darrel J Macey
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Psychopharmacology (Berl) 172:384-92. 2004
    ..Although imaging studies in human addicts have been valuable for identifying the neural substrates of the effects of abused drugs, few studies have used this approach in animal models where conditions can be carefully controlled...
  18. ncbi request reprint Functional consequences of the acute administration of the cannabinoid receptor antagonist, SR141716A, in cannabinoid-naive and -tolerant animals: a quantitative 2-[14C]deoxyglucose study
    Cory S Freedland
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1083, USA
    Brain Res 962:169-79. 2003
    ..These data suggest that the effects of SR141716A administration shift in the tolerant animal and may involve different aspects of feeding behavior than in cannabinoid-naive animals...
  19. ncbi request reprint Dose-dependent effects of Delta9-tetrahydrocannabinol on rates of local cerebral glucose utilization in rat
    Cory S Freedland
    Center for the Neurobiological Study of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Synapse 45:134-42. 2002
    ..Moreover, these findings indicate that the effects of Delta(9)-THC on cerebral metabolism are dose-dependent and that there are regional differences in the metabolic response to acute cannabinoid exposure...
  20. ncbi request reprint Time-dependent changes in receptor/G-protein coupling in rat brain following chronic monoamine transporter blockade
    KERRY A O'CONNOR
    Department of Physiology Pharmacology, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    J Pharmacol Exp Ther 313:510-7. 2005
    ..This reduction occurred at the same time point as the decrease in D(2) receptor/G-protein coupling, suggesting a role of D(2) desensitization in producing tolerance to WF-23-mediated behavior...
  21. ncbi request reprint Metabolic mapping of the time-dependent effects of delta 9-tetrahydrocannabinol administration in the rat
    Christopher T Whitlow
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
    Psychopharmacology (Berl) 161:129-36. 2002
    ..Studies have shown that effects on some behavioral endpoints can persist for as long as 24 h after exposure, but the neural substrates underlying these long-lasting effects have not yet been determined...
  22. pmc Loss of laterality in chronic cocaine users: an fMRI investigation of sensorimotor control
    Colleen A Hanlon
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Psychiatry Res 181:15-23. 2010
    ....
  23. ncbi request reprint Functional consequences of the repeated administration of Delta9-tetrahydrocannabinol in the rat
    Christopher T Whitlow
    Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC, 27157 1083, USA
    Drug Alcohol Depend 71:169-77. 2003
    ....
  24. ncbi request reprint Long-term heavy marijuana users make costly decisions on a gambling task
    Christopher T Whitlow
    Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
    Drug Alcohol Depend 76:107-11. 2004
    ..Little is known, however, about the effects of marijuana use on other cognitive domains, such as decision-making, which are thought to play an important role in addiction and drug abuse...
  25. ncbi request reprint Cortical 3 alpha-hydroxy-5 alpha-pregnan-20-one levels after acute administration of Delta 9-tetrahydrocannabinol, cocaine and morphine
    A Chistina Grobin
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599 7178, USA
    Psychopharmacology (Berl) 179:544-50. 2005
    ..Thus, it is possible that enhanced allopregnanolone levels are involved in the effects of abused drugs...

Research Grants32

  1. NEURAL SUBSTRATES OF THE ACUTE EFFECTS OF ETHANOL
    Linda Porrino; Fiscal Year: 1992
    ..Experiments will be conducted in outbred as well as in rat lines genetically bred for alcohol preference...
  2. Decision Making in Marijuana Users
    Linda Porrino; Fiscal Year: 2007
    ..Chronic marijuana use is therefore a major national public health concern. The present studies seek to identify the nature and sources of deficient decision-making by marijuana users. ..
  3. Early Exposure to Stimulants as a Risk Factor for Substance Abuse
    Linda Porrino; Fiscal Year: 2007
    ....
  4. NEUROBIOLOGICAL CORRELATES OF COCAINE ABUSE
    Linda Porrino; Fiscal Year: 2007
    ....
  5. Decision Making in Marijuana Users
    Linda Porrino; Fiscal Year: 2009
    ..Chronic marijuana use is therefore a major national public health concern. The present studies seek to identify the nature and sources of deficient decision-making by marijuana users. ..
  6. Early Exposure to Stimulants as a Risk Factor for Substance Abuse
    Linda J Porrino; Fiscal Year: 2010
    ..abstract_text> ..
  7. NEUROBIOLOGICAL CORRELATES OF COCAINE ABUSE
    Linda Porrino; Fiscal Year: 2005
    ..Identifying these changes will provide the basis for clearer evaluations of treatment strategies whether pharmacological or behavioral. ..
  8. NEUROBIOLOGICAL CORRELATES OF COCAINE ABUSE
    Linda Porrino; Fiscal Year: 1999
    ..The results of the proposed studies will provide a clearer picture of the neurobiological and behavioral basis of cocaine abuse in humans. ..
  9. TIME DEPENDENT EFFECTS OF ETHANOL ON CEREBRAL METABOLISM
    Linda Porrino; Fiscal Year: 2001
    ..These finding swill contribute to the body of work that supports a concept of tolerance which recognizes that integrated activity among various neural circuits are responsible for the time-dependent effects of ethanol. ..
  10. NEURAL SUBSTRATES OF THE ACUTE EFFECTS OF ETHANOL
    Linda Porrino; Fiscal Year: 2002
    ....
  11. REGIONAL BRAIN ACTIVATION DURING COCAINE ABSTINENCE
    Linda Porrino; Fiscal Year: 2002
    ..abstract_text> ..
  12. NEUROBIOLOGICAL CORRELATES OF COCAINE ABUSE
    Linda J Porrino; Fiscal Year: 2010
    ....