Research Topics
| Linda PorrinoSummaryAffiliation: Wake Forest University School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Orbital and medial prefrontal cortex and psychostimulant abuse: studies in animal modelsL J Porrino
Center for the Neurobiological Investigation of Abused Drugs, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Cereb Cortex 10:326-33. 2000....
The effects of cocaine: a shifting target over the course of addictionLinda J Porrino
Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
Prog Neuropsychopharmacol Biol Psychiatry 31:1593-600. 2007....- Metabolic mapping of the effects of cocaine during the initial phases of self-administration in the nonhuman primateLinda J Porrino
Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
J Neurosci 22:7687-94. 2002..The assessment of the effects of cocaine at a time not readily evaluated in humans provides a baseline from which the effects of chronic cocaine exposure can be investigated... - Cocaine self-administration produces a progressive involvement of limbic, association, and sensorimotor striatal domainsLinda J Porrino
Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
J Neurosci 24:3554-62. 2004.... - Chronic cocaine self-administration is associated with altered functional activity in the temporal lobes of non human primatesThomas J R Beveridge
Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157-1083, USA
Eur J Neurosci 23:3109-18. 2006.... - Effects of chronic cocaine self-administration on norepinephrine transporters in the nonhuman primate brainThomas J R Beveridge
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA
Psychopharmacology (Berl) 180:781-8. 2005.... 
Abstinence from chronic cocaine self-administration alters striatal dopamine systems in rhesus monkeysThomas J R Beveridge
Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Winston Salem, NC 27157 1083, USA
Neuropsychopharmacology 34:1162-71. 2009....- The comparative distributions of the monoamine transporters in the rodent, monkey, and human amygdalaHilary R Smith
Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drugs of Abuse, Wake Forest University Health Sciences, Winston Salem, NC 27157 1083, USA
Brain Struct Funct 213:73-91. 2008.... - Functional effects of cocaine self-administration in primate brain regions regulating cardiovascular functionThomas J R Beveridge
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Neurosci Lett 370:201-5. 2004..These alterations progress with prolonged cocaine exposure, and therefore may be involved in mediating changes in central autonomic control and the neuroadaptations reported to result from chronic drug abuse... - The expanding effects of cocaine: studies in a nonhuman primate model of cocaine self-administrationLinda J Porrino
Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Neurosci Biobehav Rev 27:813-20. 2004.... - Chronic cocaine self-administration upregulates the norepinephrine transporter and alters functional activity in the bed nucleus of the stria terminalis of the rhesus monkeyDarrel J Macey
Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina 27157, USA
J Neurosci 23:12-6. 2003..Furthermore, given the role of the BNST in cocaine withdrawal and stress-related reinstatement of self-administration, the changes reported here may provide a substrate for these phenomena... - Effects of cocaine self-administration on striatal dopamine systems in rhesus monkeys: initial and chronic exposureMichael A Nader
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Neuropsychopharmacology 27:35-46. 2002..These findings demonstrate that chronic cocaine self-administration produces neuroadaptations in dopamine systems, but that these changes do not occur in a parallel fashion... - Loss of functional specificity in the dorsal striatum of chronic cocaine usersColleen A Hanlon
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Drug Alcohol Depend 102:88-94. 2009..Given the importance of the dorsal striatum in motor control, the purpose of the present study was to investigate potential sensorimotor deficits among cocaine users and the functional basis of these deficits within the striatum... - Review. Parallel studies of cocaine-related neural and cognitive impairment in humans and monkeysThomas J R Beveridge
Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University Health Sciences, Medical Center Boulevard, Winston Salem, NC 27157 1083, USA
Philos Trans R Soc Lond B Biol Sci 363:3257-66. 2008.... - Facilitation of task performance and removal of the effects of sleep deprivation by an ampakine (CX717) in nonhuman primatesLinda J Porrino
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston-Salem, North Carolina, USA
PLoS Biol 3:e299. 2005.... - Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primatesSam A Deadwyler
Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
J Neurosci 27:14239-47. 2007..These findings provide strong evidence for the effectiveness of intranasal orexin-A in alleviating cognitive deficits produced by loss of sleep... - Patterns of functional activity associated with cocaine self-administration in the rat change over timeDarrel J Macey
Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Winston Salem, NC 27157-1083, USA
Psychopharmacology (Berl) 172:384-92. 2004..These differences in the patterns of brain activity that develop with long-term cocaine self-administration may play a role in the transition to habitual drug seeking behavior... - Functional consequences of the acute administration of the cannabinoid receptor antagonist, SR141716A, in cannabinoid-naive and -tolerant animals: a quantitative 2-[14C]deoxyglucose studyCory S Freedland
Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157-1083, USA
Brain Res 962:169-79. 2003..These data suggest that the effects of SR141716A administration shift in the tolerant animal and may involve different aspects of feeding behavior than in cannabinoid-naive animals... - Dose-dependent effects of Delta9-tetrahydrocannabinol on rates of local cerebral glucose utilization in ratCory S Freedland
Center for the Neurobiological Study of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157, USA
Synapse 45:134-42. 2002..Moreover, these findings indicate that the effects of Delta(9)-THC on cerebral metabolism are dose-dependent and that there are regional differences in the metabolic response to acute cannabinoid exposure... - Time-dependent changes in receptor/G-protein coupling in rat brain following chronic monoamine transporter blockadeLinda J Porrino
Department of Physiology/Pharmacology, Wake Forest University Health Sciences, Winston-Salem, NC 27157, USA
J Pharmacol Exp Ther 313:510-7. 2005..This reduction occurred at the same time point as the decrease in D(2) receptor/G-protein coupling, suggesting a role of D(2) desensitization in producing tolerance to WF-23-mediated behavior... - Metabolic mapping of the time-dependent effects of delta 9-tetrahydrocannabinol administration in the ratChristopher T Whitlow
Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157-1083, USA
Psychopharmacology (Berl) 161:129-36. 2002..g. anxiety, stress, and reward) may remain altered for as long as 24 h after a single exposure to THC... - Loss of laterality in chronic cocaine users: an fMRI investigation of sensorimotor controlColleen A Hanlon
Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Psychiatry Res 181:15-23. 2010.... - Functional consequences of the repeated administration of Delta9-tetrahydrocannabinol in the ratChristopher T Whitlow
Center for the Neurobiological Investigation of Drug Abuse, Department of Physiology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC, 27157-1083, USA
Drug Alcohol Depend 71:169-77. 2003.... - Long-term heavy marijuana users make costly decisions on a gambling taskChristopher T Whitlow
Department of Physiology and Pharmacology, Center for the Neurobiological Investigation of Drug Abuse, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157-1083, USA
Drug Alcohol Depend 76:107-11. 2004..It is unknown, however, whether the basis for such deficits might be attributed directly to marijuana exposure or pre-existing genetic or behavioral differences... - Cortical 3 alpha-hydroxy-5 alpha-pregnan-20-one levels after acute administration of Delta 9-tetrahydrocannabinol, cocaine and morphineA Chistina Grobin
Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7160, Chapel Hill, NC 27599 7178, USA
Psychopharmacology (Berl) 179:544-50. 2005..Thus, it is possible that enhanced allopregnanolone levels are involved in the effects of abused drugs...
Research Grants
- NEURAL SUBSTRATES OF THE ACUTE EFFECTS OF ETHANOLLinda Porrino; Fiscal Year: 1992..Experiments will be conducted in outbred as well as in rat lines genetically bred for alcohol preference...
- Decision Making in Marijuana UsersLinda Porrino; Fiscal Year: 2007..Chronic marijuana use is therefore a major national public health concern. The present studies seek to identify the nature and sources of deficient decision-making by marijuana users. ..
- Early Exposure to Stimulants as a Risk Factor for Substance AbuseLinda Porrino; Fiscal Year: 2007....
- NEUROBIOLOGICAL CORRELATES OF COCAINE ABUSELinda Porrino; Fiscal Year: 2007....
- Decision Making in Marijuana UsersLinda Porrino; Fiscal Year: 2009..Chronic marijuana use is therefore a major national public health concern. The present studies seek to identify the nature and sources of deficient decision-making by marijuana users. ..
- Early Exposure to Stimulants as a Risk Factor for Substance AbuseLinda J Porrino; Fiscal Year: 2010..abstract_text> ..
- NEUROBIOLOGICAL CORRELATES OF COCAINE ABUSELinda Porrino; Fiscal Year: 2005..Identifying these changes will provide the basis for clearer evaluations of treatment strategies whether pharmacological or behavioral. ..
- NEUROBIOLOGICAL CORRELATES OF COCAINE ABUSELinda Porrino; Fiscal Year: 1999..The results of the proposed studies will provide a clearer picture of the neurobiological and behavioral basis of cocaine abuse in humans. ..
- TIME DEPENDENT EFFECTS OF ETHANOL ON CEREBRAL METABOLISMLinda Porrino; Fiscal Year: 2001..These finding swill contribute to the body of work that supports a concept of tolerance which recognizes that integrated activity among various neural circuits are responsible for the time-dependent effects of ethanol. ..
- NEURAL SUBSTRATES OF THE ACUTE EFFECTS OF ETHANOLLinda Porrino; Fiscal Year: 2002....
- REGIONAL BRAIN ACTIVATION DURING COCAINE ABSTINENCELinda Porrino; Fiscal Year: 2002..abstract_text> ..
- NEUROBIOLOGICAL CORRELATES OF COCAINE ABUSELinda J Porrino; Fiscal Year: 2010....