Research Topics
Genomes and GenesSpecies | Stephen PetersSummaryAffiliation: Wake Forest University School of Medicine Country: USA Publications
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Publications
Asthma and gender impact accumulation of T cell subtypesMatthew J Loza
Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Respir Res 11:103. 2010..We sought to establish whether CD3+CD28-mediated and antigen-independent accumulation of type 1 and type 2 T cells differs significantly between nonasthmatic and asthmatic populations...- Alterations in vasodilator-stimulated phosphoprotein (VASP) phosphorylation: associations with asthmatic phenotype, airway inflammation and beta2-agonist useAnnette T Hastie
Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC, USA
Respir Res 7:25. 2006.... - Part IV: Genetic variations in beta2-adrenergic receptors: long-acting and short-acting beta2-agonists and therapeutic responseStephen Peters
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Curr Med Res Opin 23:S29-36. 2007..Any patient with asthma who requires adjunctive use of a long-acting beta2-agonist in addition to an inhaled corticosteroid should be carefully monitored for possible adverse asthma outcomes... - Asthma treatment in the 21st century: what's next?Stephen P Peters
Center for Human Genomics and Department of Medicine, Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Clin Rev Allergy Immunol 27:197-205. 2004.... - Reporting and evaluating genetic association studiesStephen P Peters
Wake Forest University Health Sciences, Center for Human Genomics, Winston Salem, NC, USA
Respir Res 10:109. 2009..All of these elements are important in evaluating such studies and should be carefully considered when these studies are conceived and carried out... - Safety of inhaled corticosteroids in the treatment of persistent asthmaStephen P Peters
Wake Forest University Health Sciences, Center for Human Genomics, Winston Salem, NC 27157, USA
J Natl Med Assoc 98:851-61. 2006..This review discusses the safety of ICSs with respect to potential systemic effects of most concern to physicians and patients... - Long-term safety and asthma control with budesonide/formoterol versus budesonide pressurized metered-dose inhaler in asthma patientsStephen P Peters
Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Allergy Asthma Proc 29:499-516. 2008..Improvements in asthma control were shown with both doses of budesonide/formoterol versus budesonide... - Uncontrolled asthma: a review of the prevalence, disease burden and options for treatmentStephen P Peters
Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Respir Med 100:1139-51. 2006..Comparative trials are needed to determine the merits of different treatments and strategies for patients with inadequately controlled severe persistent asthma and to identify patients likely to benefit from new treatment options... - The impact of comorbid atopic disease on asthma: clinical expression and treatmentStephen Peters
Department of Medicine, Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases and the Center for Human Genomics, Wake Forest University School of Medicine, Winston, NC 27157 1052, USA
J Asthma 44:149-61. 2007..IgE blockade, leukotriene modulation, and B-cell depletion therapy have all exhibited success in chronic inflammation, reinforcing and expanding the beneficial role of immunomodulation of global mediators... - Tiotropium bromide step-up therapy for adults with uncontrolled asthmaStephen P Peters
Wake Forest University Health Sciences, Center for Genomics and Personalized Medicine Research, Medical Center Blvd, Winston Salem, NC 27157, USA
N Engl J Med 363:1715-26. 2010..Long-acting beta-agonist (LABA) therapy improves symptoms in patients whose asthma is poorly controlled by an inhaled glucocorticoid alone. Alternative treatments for adults with uncontrolled asthma are needed... - Hydrofluoroalkane mandate in effect January 1, 2009: Switch from chlorofluorocarbon- to hydrofluoroalkane-propelled inhalers requires active transitionStephen Peters
Section on Pulmonary and Critical Care Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
Clin Cornerstone 9:50-3. 2009..Clinicians should actively transition patients to currently available hydrofluoroalkane-propelled devices, providing concise education and instruction for using the newer devices... - Pharmacogenetics of asthmaGregory A Hawkins
Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
Methods Mol Biol 448:359-78. 2008.... - Randomized comparison of strategies for reducing treatment in mild persistent asthmaStephen P Peters
Wake Forest University, Winston Salem, NC, USA
N Engl J Med 356:2027-39. 2007.... - Safety of investigative bronchoscopy in the Severe Asthma Research ProgramWendy C Moore
Center for Human Genomics and Personalized Medicine Research, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 128:328-336.e3. 2011..We evaluated the safety aspects of this procedure in this cohort with specific focus on patients with severe asthma... - Identification of asthma phenotypes using cluster analysis in the Severe Asthma Research ProgramWendy C Moore
Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
Am J Respir Crit Care Med 181:315-23. 2010..The Severe Asthma Research Program cohort includes subjects with persistent asthma who have undergone detailed phenotypic characterization. Previous univariate methods compared features of mild, moderate, and severe asthma... - Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control studyGregory A Hawkins
Center for Human Genomics, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
Am J Respir Crit Care Med 174:1101-9. 2006.... - Long-acting beta agonists in asthma therapyRichard W Rissmiller
Wake Forest University School of Medicine, Center for Human Genomics, Medical Center Boulevard, Winston-Salem, NC 27157, USA
Curr Allergy Asthma Rep 4:91-2. 2004 - Interactive effects of steroids and beta-agonists on accumulation of type 2 T cellsMatthew J Loza
Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 121:750.e1-5.e3. 2008.... - Severe asthma: an overviewWendy C Moore
Center for Human Genomics, and Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 117:487-94; quiz 495. 2006..Treatment algorithms based on markers of airway inflammation may decrease measures of health care utilization in severe asthma... - Update in asthma 2006Wendy C Moore
Center for Human Genomics and Department of Internal Medicine, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA
Am J Respir Crit Care Med 175:649-54. 2007 - Neutrophils in asthmaAna L MacDowell
Department of Internal Medicine, Section of Pulmonary, Critical Care, Allergy, and Immunological Diseases, Wake Forest University, Medical Center Boulevard, Winston Salem, NC 27157, USA
Curr Allergy Asthma Rep 7:464-8. 2007..Increasing evidence suggest that neutrophils may be central players with an important role in the pulmonary inflammatory process present in asthma... - The irreversible component of persistent asthmaRodolfo M Pascual
Department of Internal Medicine, Section on Pulmonary, Wake Forest University School of Medicine, Center for Human Genomics, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 124:883-90; quiz 891-2. 2009..Herein, the evidence of an irreversible component of asthma, its underlying pathology, and the limitations of current asthma treatments are reviewed... - Beta-2 adrenergic agonists: focus on safety and benefits versus risksVictor E Ortega
Wake Forest University Health Sciences, Center for Genomics and Personalized Medicine Research, Medical Center Boulevard, Winston Salem, NC, United States
Curr Opin Pharmacol 10:246-53. 2010.... - Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytesAnnette T Hastie
Center for Human Genomics, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 125:1028-1036.e13. 2010..Patients with severe asthma have increased granulocytes in their sputum compared with patients with mild to moderate asthma... - The glucocorticoid receptor heterocomplex gene STIP1 is associated with improved lung function in asthmatic subjects treated with inhaled corticosteroidsGregory A Hawkins
Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 123:1376-83.e7. 2009..Corticosteroids exert their anti-inflammatory action by binding and activating the intracellular glucocorticoid receptor heterocomplex... - Characterization of the severe asthma phenotype by the National Heart, Lung, and Blood Institute's Severe Asthma Research ProgramWendy C Moore
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 119:405-13. 2007..Severe asthma causes the majority of asthma morbidity. Understanding mechanisms that contribute to the development of severe disease is important... - Airway remodeling contributes to the progressive loss of lung function in asthma: an overviewRodolfo M Pascual
Center for Human Genomics and the Department of Internal Medicine, Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 116:477-86; quiz 487. 2005..However, clinical studies to date have been disappointing, and it remains to be seen whether targeted therapies will prevent the progressive loss of lung function seen in asthma... - Pharmacogenetics of the beta 2-adrenergic receptor geneVictor E Ortega
Center for Human Genomics, Section of Pulmonary, Critical Care, Allergy, and Immunologic Diseases, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Immunol Allergy Clin North Am 27:665-84; vii. 2007..Meanwhile, the conflicting data concerning LABAs may be caused by such factors as small sample sizes of study populations and differences in experimental design... - Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regionsXingnan Li
Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 125:328-335.e11. 2010..Genome-wide association studies (GWASs) represent a powerful approach to investigate the association of DNA variants with disease susceptibility. To date, few GWASs for asthma have been reported... - Novel and emerging therapies for asthmaThomas M Leath
Department of Medicine, Section on Pulmonary, Critical Care, Allergy and Immunological Diseases, Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, NC, USA
Drug Discov Today 10:1647-55. 2005..Finally, we will discuss the recently approved anti-IgE therapy for the treatment of allergic asthma and immune modulation using CpG oligodeoxynucleotides... - Regulation of phospholipase A2 by interleulin-1 in human airway smooth muscleRudolfo M Pascual
Department of Medicine, Jefferson Medical College, and Kimmel Cancer Center, Thomas Jefferson University, Philadelphia, PA 19107, USA
Chest 123:433S-4S. 2003 - beta-Agonist enhances type 2 T-cell survival and accumulationMatthew J Loza
Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 119:235-44. 2007..beta-Adrenergic receptor ligands (beta-agonists) subserve numerous physiologic processes but also function as pathogenic or therapeutic agents in numerous diseases with inflammatory components... - Real-world Evaluation of Asthma Control and Treatment (REACT): findings from a national Web-based surveyStephen P Peters
Center for Human Genomics and Department of Internal Medicine, Section on Pulmonary, Critical Care, Allergy and Immunologic Diseases, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Allergy Clin Immunol 119:1454-61. 2007..However, the prevalence of uncontrolled asthma in the United States is not known and has not been fully characterized... - Beta-agonists modulate T-cell functions via direct actions on type 1 and type 2 cellsMatthew J Loza
Department of Internal Medicine, Center for Human Genomics, Wake Forest University School of Medicine, Medical Center Blvd, Winston-Salem, NC 27157, USA
Blood 107:2052-60. 2006..These findings identify direct effects of beta2AR activation on T-cell subtypes and suggest a complex role for GPCRs and PKA activity in modulating T-cell functions... - Regulatory features of interleukin-1beta-mediated prostaglandin E2 synthesis in airway smooth muscleRodolfo M Pascual
Department of Internal Medicine and Center for Human Genomics, Wake Forest Univ. Health Sciences Center, Center for Human Genomics, Medical Center Blvd, Winston-Salem, NC 27157, USA
Am J Physiol Lung Cell Mol Physiol 290:L501-8. 2006..mPGES induction and, possibly, cPLA2 induction appear to cooperate with COX-2 to determine IL-1beta-mediated PGE2 production in human ASM cells... - The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trialRichard J Martin
National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 119:73-80. 2007..Although guidelines recommend anti-inflammatory therapy for persistent asthma, recent studies suggest that 25% to 35% of patients with asthma may not improve lung function with inhaled corticosteroids... - Leukotriene receptor antagonists in asthma therapyStephen P Peters
Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA
J Allergy Clin Immunol 111:S62-70. 2003.... - Modulation of vasodilator-stimulated phosphoprotein in vivo in human epithelial cells by segmental allergen challenge and beta2-agonist therapyAnnette T Hastie
Thomas Jefferson University, Philadelphia, PA 19107, USA
Chest 123:377S. 2003 - Allergic rhinitis, asthma, airway biology, and chronic obstructive pulmonary disease in AJRCCM in 2004Leonardo Fabbri
Medical, Oncological, and Radiological Sciences, University of Modena, Modena, Italy
Am J Respir Crit Care Med 171:686-98. 2005 - Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trialElliot Israel
Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Lancet 364:1505-12. 2004..However, the existence of any genotype-dependent difference has not been tested in a prospective clinical trial... - Asthma exacerbations and formoterolRichard W Rissmiller
Chest 125:1590-1. 2004 - Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroidsAaron Deykin
Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
J Allergy Clin Immunol 115:720-7. 2005..Although inhaled corticosteroids (ICSs) are effective in preventing deterioration in asthma control, at least half of subjects with mild-to-moderate asthma will remain stable when these agents are discontinued... - ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohortsAugusto A Litonjua
Channing Laboratory, Pulmonary Division, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 178:688-94. 2008..However, a substantial proportion of patients with asthma do not have a favorable response to these drugs, and identifying genetic determinants of drug response may aid in tailoring treatment for individual patients... - Daily versus as-needed corticosteroids for mild persistent asthmaHomer A Boushey
University of California at San Francisco, San Francisco, USA
N Engl J Med 352:1519-28. 2005..Further studies are required to determine whether this novel approach to treatment should be recommended... - Systemic effect comparisons of six inhaled corticosteroid preparationsRichard J Martin
National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Am J Respir Crit Care Med 165:1377-83. 2002..This study represents the first step in evaluation of ICS efficacy based on equisystemic (cortisol suppression) effects of a given ICS, rather than doses judged arbitrarily to be comparable on a microgram basis... - Lung function in adults with stable but severe asthma: air trapping and incomplete reversal of obstruction with bronchodilationRonald L Sorkness
Univ of Wisconsin, 777 Highland Ave, Madison, WI 53705, USA
J Appl Physiol 104:394-403. 2008..We conclude that air trapping is a characteristic feature of the severe asthma population, suggesting that there is a pathological process associated with severe asthma that makes airways more vulnerable to this component... - beta-Adrenergic receptor polymorphisms and response to salmeterolMichael E Wechsler
Brigham and Women s Hospital, 75 Francis Street, Boston, MA, 02115, USA
Am J Respir Crit Care Med 173:519-26. 2006..Several studies suggest that patients with asthma who are homozygous for arginine at the 16th position of the beta2-adrenergic receptor may not benefit from short-acting beta-agonists... - Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthmaAaron Deykin
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 175:228-34. 2007..The elements of asthma control achieved by LABAs (improved lung function) and leukotriene receptor antagonists (LTRAs; protection against exacerbations) may be complementary as well... - Asthma end points and outcomes: what have we learned?Don Bukstein
Allergy and Asthma Research, Dean Medical Center, Department of Pediatrics and Family Practice, University of Wisconsin Medical School, Madison, Wisconsin, USA
J Allergy Clin Immunol 118:S1-15. 2006..The fraction of exhaled nitric oxide as a measure of inflammation is suggested as offering the best combination of disease evaluation and practical implementation for improved asthma outcomes... - Significant variability in response to inhaled corticosteroids for persistent asthmaStanley J Szefler
National Jewish Medical and Research Center, Department of Pediatrics, Denver, CO 80206, USA
J Allergy Clin Immunol 109:410-8. 2002..It is possible that higher doses of ICSs are necessary to manage more severe patients or to achieve goals of therapy not evaluated in this study, such as prevention of asthma exacerbations... - Concentration of cytokines and growth factors in BAL fluid after allergen challenge in asthmatics and their effect on alpha-smooth muscle actin and collagen III synthesis by human lung fibroblastsVikas Batra
Thomas Jefferson University, Philadelphia, PA, USA
Chest 123:398S-9S. 2003 - Heterogeneity in the pathology and treatment of asthmaStephen P Peters
Jefferson Medical College, Pulmonary Division, Philadelphia, Pennsylvania, USA
Am J Med 115:49S-54S. 2003..Understanding the causes of asthma heterogeneity and their implications for asthma treatment is a major challenge for the new millennium... - Asthmatic epithelial cell proliferation and stimulation of collagen production: human asthmatic epithelial cells stimulate collagen type III production by human lung myofibroblasts after segmental allergen challengeAnnette T Hastie
Department of Medicine, Division of Critical Care, Pulmonary, Allergic and Immunologic Diseases, and Division of Clinical Pharmacology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, Pennsylvania
Am J Respir Crit Care Med 165:266-72. 2002..Epithelial cell proliferation appears dependent upon infiltrating inflammatory cells, but stimulation of collagen type III does not... - Alterations of the arginine metabolome in asthmaAbigail Lara
Department of Pathobiology, The Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA
Am J Respir Crit Care Med 178:673-81. 2008..As the sole nitrogen donor in nitric oxide (NO) synthesis and key intermediate in the urea cycle, arginine and its metabolic pathways are integrally linked to cellular respiration, metabolism, and inflammation... - Investigative bronchoprovocation and bronchoscopy in airway diseasesWilliam W Busse
University of Wisconsin-Madison, USA
Am J Respir Crit Care Med 172:807-16. 2005..CONCLUSION: This review of investigative bronchoscopy and bronchoprovocation could serve as the basis for future guidelines for the use of these procedures in the United States... - Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthmaStephen C Lazarus
University of California, San Francisco, 505 Parnassus Avenue, M 1083, San Francisco, CA 94143 0111, USA
Am J Respir Crit Care Med 175:783-90. 2007..One-quarter to one-third of individuals with asthma smoke, which may affect response to therapy and contribute to poor asthma control... - Distinction between IL-13+ and IFN-gamma+ natural killer cells and regulation of their pool size by IL-4Matthew J Loza
Department of Microbiology and Immunology, Kimmel Cancer Center, Jefferson Medical College, 233 S. 10th Street, Philadelphia, PA 19107, USA
Eur J Immunol 32:413-23. 2002..These data define the existence and regulation of two distinct resting peripheral NK cell subsets producing type 1 and type 2 cytokines, and suggest possible roles for IL-13+ NK cells in allergy...
Research Grants
- CONTROL OF IGE MEDIATED PULMONARY INFLAMMATION IN HUMANSStephen Peters; Fiscal Year: 2001....
- THE MODULATION OF INFLAMMATORY RESPONSES IN THE LUNGStephen Peters; Fiscal Year: 1993..In addition, they will provide crucial information needed in order to develop novel strategies for the treatment of asthma using antiinflammatory agents...
- ASTHMA CLINICAL RESEARCH NETWORK (ACRN)Stephen Peters; Fiscal Year: 2007....