B W Penninx

Summary

Affiliation: Wake Forest University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Physical exercise and the prevention of disability in activities of daily living in older persons with osteoarthritis
    B W Penninx
    Sticht Center on Aging, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Arch Intern Med 161:2309-16. 2001
  2. ncbi request reprint Anemia and decline in physical performance among older persons
    Brenda W J H Penninx
    Sticht Center on Aging, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Am J Med 115:104-10. 2003
  3. ncbi request reprint Exercise and depressive symptoms: a comparison of aerobic and resistance exercise effects on emotional and physical function in older persons with high and low depressive symptomatology
    Brenda W J H Penninx
    Sticht Center on Aging, Department of Internal Medicine Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Gerontol B Psychol Sci Soc Sci 57:P124-32. 2002
  4. ncbi request reprint [Effects of depression on physical health and mortality in the elderly. Longitudinal results of the LASA research]
    B W Penninx
    EMGO Instituut, Vrije Universiteit, Amsterdam
    Tijdschr Gerontol Geriatr 31:211-8. 2000
  5. ncbi request reprint Lower extremity performance in nondisabled older persons as a predictor of subsequent hospitalization
    B W Penninx
    Epidemiology, Demography, and Biometry Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    J Gerontol A Biol Sci Med Sci 55:M691-7. 2000
  6. ncbi request reprint Depression and cardiac mortality: results from a community-based longitudinal study
    B W Penninx
    Institute for Research in Extramural Medicine, Vrije University, Amsterdam, The Netherlands
    Arch Gen Psychiatry 58:221-7. 2001
  7. ncbi request reprint Effects of social support and personal coping resources on depressive symptoms: different for various chronic diseases?
    B W Penninx
    Institute for Research in Extramural Medicine, Vrije University, Amsterdam, The Netherlands
    Health Psychol 17:551-8. 1998
  8. ncbi request reprint Minor and major depression and the risk of death in older persons
    B W Penninx
    Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Arch Gen Psychiatry 56:889-95. 1999
  9. ncbi request reprint Changes in depression and physical decline in older adults: a longitudinal perspective
    B W Penninx
    Institute for Research in Extramural Medicine, Vrije Universiteit, v d Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    J Affect Disord 61:1-12. 2000
  10. ncbi request reprint Chronically depressed mood and cancer risk in older persons
    B W Penninx
    Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, MD 20892, USA
    J Natl Cancer Inst 90:1888-93. 1998

Collaborators

Detail Information

Publications75

  1. ncbi request reprint Physical exercise and the prevention of disability in activities of daily living in older persons with osteoarthritis
    B W Penninx
    Sticht Center on Aging, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, NC 27157, USA
    Arch Intern Med 161:2309-16. 2001
    ..However, proved preventive strategies for ADL disability are lacking. A sedentary lifestyle is an important cause of disability. This study examines whether an exercise program can prevent ADL disability...
  2. ncbi request reprint Anemia and decline in physical performance among older persons
    Brenda W J H Penninx
    Sticht Center on Aging, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Am J Med 115:104-10. 2003
    ..We examined whether anemia in older persons increases the risk of subsequent decline in physical function, as measured by objective performance-based tests...
  3. ncbi request reprint Exercise and depressive symptoms: a comparison of aerobic and resistance exercise effects on emotional and physical function in older persons with high and low depressive symptomatology
    Brenda W J H Penninx
    Sticht Center on Aging, Department of Internal Medicine Department of Public Health Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Gerontol B Psychol Sci Soc Sci 57:P124-32. 2002
    ..Aerobic and resistance exercise significantly reduced disability and pain and increased walking speed both, and to an equal extent, in persons with high depressive symptomatology and persons with low depressive symptomatology...
  4. ncbi request reprint [Effects of depression on physical health and mortality in the elderly. Longitudinal results of the LASA research]
    B W Penninx
    EMGO Instituut, Vrije Universiteit, Amsterdam
    Tijdschr Gerontol Geriatr 31:211-8. 2000
    ..These results show that late-life depression has strong unfavorable physical health consequences. The consequences of minor depression are comparable with those of major depression...
  5. ncbi request reprint Lower extremity performance in nondisabled older persons as a predictor of subsequent hospitalization
    B W Penninx
    Epidemiology, Demography, and Biometry Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
    J Gerontol A Biol Sci Med Sci 55:M691-7. 2000
    ..This study examines, in initially nondisabled older persons, the impact of reduced lower extremity performance on subsequent hospitalizations...
  6. ncbi request reprint Depression and cardiac mortality: results from a community-based longitudinal study
    B W Penninx
    Institute for Research in Extramural Medicine, Vrije University, Amsterdam, The Netherlands
    Arch Gen Psychiatry 58:221-7. 2001
    ..This study examined and compared the effect of depression on cardiac mortality in community-dwelling persons with and without cardiac disease...
  7. ncbi request reprint Effects of social support and personal coping resources on depressive symptoms: different for various chronic diseases?
    B W Penninx
    Institute for Research in Extramural Medicine, Vrije University, Amsterdam, The Netherlands
    Health Psychol 17:551-8. 1998
    ..Receiving instrumental support was associated with more depressive symptoms, especially in diabetes patients...
  8. ncbi request reprint Minor and major depression and the risk of death in older persons
    B W Penninx
    Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    Arch Gen Psychiatry 56:889-95. 1999
    ..This study determined the effect of both minor and major depression on mortality and examined the role of confounding and explanatory variables on this relationship...
  9. ncbi request reprint Changes in depression and physical decline in older adults: a longitudinal perspective
    B W Penninx
    Institute for Research in Extramural Medicine, Vrije Universiteit, v d Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    J Affect Disord 61:1-12. 2000
    ..The impact of chronicity and changes in depression on physical decline over time in older persons has not been elucidated...
  10. ncbi request reprint Chronically depressed mood and cancer risk in older persons
    B W Penninx
    Epidemiology, Demography, and Biometry Program, National Institute on Aging, Bethesda, MD 20892, USA
    J Natl Cancer Inst 90:1888-93. 1998
    ..We examined whether a high level of depressive symptoms, present for a long time, is associated with increased risk of cancer in the elderly...
  11. ncbi request reprint Social network, social support, and loneliness in older persons with different chronic diseases
    B W Penninx
    Vrije University, Amsterdam
    J Aging Health 11:151-68. 1999
    ..This study examines whether patterns of social network size, functional social support, and loneliness are different for older persons with different types of chronic diseases...
  12. ncbi request reprint Coimpairments as predictors of severe walking disability in older women
    T Rantanen
    Epidemiology, Demography and Biometry Program, National Institute of Aging, National Institutes of Health, Bethesda, Maryland, USA
    J Am Geriatr Soc 49:21-7. 2001
    ....
  13. ncbi request reprint Determinants of different dimensions of disease severity in asthma and COPD : pulmonary function and health-related quality of life
    H A Wijnhoven
    Institute for Research in Extramural Medicine EMGO Institute, Vrije Universiteit, Amsterdam, The Netherlands
    Chest 119:1034-42. 2001
    ..To identify determinants of pulmonary function and health-related quality of life (HRQOL) to better understand disease severity in patients with asthma and COPD...
  14. ncbi request reprint Psychological distress in victims of elder mistreatment: the effects of social support and coping
    H C Comijs
    Institute for Research in Extramural Medicine, Vrije Universiteit, Amsterdam, The Netherlands
    J Gerontol B Psychol Sci Soc Sci 54:P240-5. 1999
    ..The beneficial role of social support, locus of control, and perceived self-efficacy on the level of psychological distress could be of importance in the development of future intervention programs...
  15. ncbi request reprint Determinants of an incorrect inhalation technique in patients with asthma or COPD
    A E Hesselink
    Institute for Research in Extramural Medicine, Department of General Practice, VU Medical Centre, Amsterdam, The Netherlands
    Scand J Prim Health Care 19:255-60. 2001
    ..To determine the prevalence of an incorrect inhalation technique and to examine its determinants among primary care patients with asthma or chronic obstructive pulmonary disease (COPD)...
  16. ncbi request reprint Determinants of high and low attendance to diet and exercise interventions among overweight and obese older adults. Results from the arthritis, diet, and activity promotion trial
    Coen H van Gool
    Department of Health Care Studies, Section of Medical Sociology, Universiteit Maastricht, Maastricht, The Netherlands
    Contemp Clin Trials 27:227-37. 2006
    ..Therefore, we explored demographic, health-related, and social determinants of high and low attendance to diet and exercise sessions among overweight and obese patients with knee osteoarthritis (> or = 60 years; N = 206)...
  17. ncbi request reprint Late-life anemia is associated with increased risk of recurrent falls
    Brenda W J H Penninx
    Institute of Research in Extramural Medicine and Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    J Am Geriatr Soc 53:2106-11. 2005
    ..To examine whether anemia is associated with a higher incidence of recurrent falls...
  18. pmc Benzodiazepine use and physical disability in community-dwelling older adults
    Shelly L Gray
    School of Pharmacy, University of Washington, Seattle, Washington 98195, USA
    J Am Geriatr Soc 54:224-30. 2006
    ..To determine whether benzodiazepine use is associated with incident disability in mobility and activities of daily living (ADLs) in older individuals...
  19. ncbi request reprint Anemia in the elderly: current understanding and emerging concepts
    Richard Eisenstaedt
    Temple University School of Medicine, Philadelphia, PA 19140, USA
    Blood Rev 20:213-26. 2006
    ..Future research on anemia in the elderly should focus on the age-related physiologic changes underlying this condition and whether anemia correction can reduce anemia-associated risks, and improve QOL...
  20. ncbi request reprint Change in serum albumin and subsequent decline in functional status in older persons
    Bianca W M Schalk
    Institute for Research in Extramural Medicine EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Aging Clin Exp Res 17:297-305. 2005
    ..This study examines whether a three-year change in serum albumin concentration is associated with subsequent decline in functional status in older persons...
  21. ncbi request reprint Anemia is associated with depression in older adults: results from the InCHIANTI study
    Graziano Onder
    Geriatric Department, Catholic University of the Sacred Heart, Rome, Italy
    J Gerontol A Biol Sci Med Sci 60:1168-72. 2005
    ..The objective of this study was to examine whether depressive symptoms and anemia are associated among older adults living in the community...
  22. ncbi request reprint Is there a biomedical explanation for socioeconomic differences in incident mobility limitation?
    Annemarie Koster
    Department of Health Care Studies, Section Medical Sociology, Universiteit Maastricht, Maastricht, The Netherlands
    J Gerontol A Biol Sci Med Sci 60:1022-7. 2005
    ..This study examines the association between socioeconomic status and incident mobility limitation in well-functioning older adults, and seeks to determine whether this link could be explained by biomedical factors...
  23. ncbi request reprint Predictors of combined cognitive and physical decline
    Hal H Atkinson
    Roena Kulynych Center for Memory and Cognition Research, Sticht Center on Aging, Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Am Geriatr Soc 53:1197-202. 2005
    ..To determine the incidence and correlates of combined declines in cognitive and physical performance...
  24. ncbi request reprint Serum albumin and muscle strength: a longitudinal study in older men and women
    Bianca W M Schalk
    Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Am Geriatr Soc 53:1331-8. 2005
    ..To examine whether low serum albumin is associated with low muscle strength and future decline in muscle strength in community-dwelling older men and women...
  25. ncbi request reprint Measures of physical performance and risk for progressive and catastrophic disability: results from the Women's Health and Aging Study
    Graziano Onder
    Centro Medicina dell Invecchiamento, Università Cattolica del Sacro Cuore Policlinico A Gemelli, L go Francesco Vito 1, 00168 Roma, Italy
    J Gerontol A Biol Sci Med Sci 60:74-9. 2005
    ..The authors evaluated the ability of upper and lower extremity performance measures to predict progressive and catastrophic disability in activities of daily living (ADL), mobility, and upper extremity function...
  26. ncbi request reprint Effects of exercise adherence on physical function among overweight older adults with knee osteoarthritis
    Coen H van Gool
    Universiteit Maastricht, Maastricht, The Netherlands
    Arthritis Rheum 53:24-32. 2005
    ..To determine whether high exercise adherence improved physical function among older adults with knee osteoarthritis (OA) who were overweight or obese...
  27. pmc The influence of anxiety on the progression of disability
    Gretchen A Brenes
    Department of Psychiatry and Behavioral Medicine, Wake Forest University, School of Medicine, Winston Salem, North Carolina 25157, USA
    J Am Geriatr Soc 53:34-9. 2005
    ..To determine the influence of anxiety on the progression of disability and examine possible mediators of the relationship...
  28. ncbi request reprint Abdominal obesity is an independent risk factor for chronic heart failure in older people
    Barbara J Nicklas
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Am Geriatr Soc 54:413-20. 2006
    ..To examine whether total and abdominal adiposity are risk factors for the development of chronic heart failure (CHF) in older men and women...
  29. ncbi request reprint Association of inflammatory markers with socioeconomic status
    Annemarie Koster
    Department of Health Care Studies, Section of Medical Sociology, Universiteit Maastricht, P O Box 616, 6200 MD Maastricht, The Netherlands
    J Gerontol A Biol Sci Med Sci 61:284-90. 2006
    ....
  30. ncbi request reprint Anemia in old age is associated with increased mortality and hospitalization
    Brenda W J H Penninx
    EMGO Institute Department of Psychiatry, VU University School of Medicine, Valeriusplein 9, 1075 BG Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 61:474-9. 2006
    ..To more fully understand the detrimental health effects of anemia, we examined the relationship of anemia with death and hospitalization outcomes in a large community-based sample of older persons...
  31. doi request reprint Cardiac disease, depressive symptoms, and incident stroke in an elderly population
    Lonneke Wouts
    Department of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arch Gen Psychiatry 65:596-602. 2008
    ..However, the reliability of much research is limited by the lack of documentation on the presence of preexistent cardiovascular disease and by the use of limited measures of depression or stroke...
  32. doi request reprint Depression is associated with decreased 25-hydroxyvitamin D and increased parathyroid hormone levels in older adults
    Witte J G Hoogendijk
    Research Institute Neurosciences and the Center for Neurogenomics and Cognitive Research, VU University Medical Center, Vrije Universiteit Amsterdam, A J Ernststraat 887, 1081 HL, Amsterdam, The Netherlands
    Arch Gen Psychiatry 65:508-12. 2008
    ..Depression has incidentally been related to altered levels of 25-hydroxyvitamin D [25(OH)D] and parathyroid hormone (PTH), but this relation has never been studied systematically...
  33. ncbi request reprint The metabolic syndrome is associated with circulating adipokines in older adults across a wide range of adiposity
    Tongjian You
    Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, NY 14214, USA
    J Gerontol A Biol Sci Med Sci 63:414-9. 2008
    ..The purpose of this study was to examine the relationship of metabolic syndrome to several adipokines and the role of total and visceral adiposity in influencing this relationship in older adults...
  34. doi request reprint Lifestyle factors and incident mobility limitation in obese and non-obese older adults
    Annemarie Koster
    Department of Health Care Studies, Medical Sociology Section, Universiteit Maastricht, Maastricht, The Netherlands
    Obesity (Silver Spring) 15:3122-32. 2007
    ..This study examines the association between incident mobility limitation and 4 lifestyle factors: smoking, alcohol intake, physical activity, and diet in well-functioning obese (n = 667) and non-obese (n = 2027) older adults...
  35. pmc Late-life depressive symptoms are associated with both hyperactivity and hypoactivity of the hypothalamo-pituitary-adrenal axis
    Brenda W J H Penninx
    Department of Psychiatry and EMGO Institute, VU University Medical Center, Amsterdam, The Netherlands
    Am J Geriatr Psychiatry 15:522-9. 2007
    ..The authors examined the relationship between urinary cortisol level and late-life depressive symptoms. The authors also explored whether hypo- and hypercortisolemic depressive symptoms are qualitatively different...
  36. ncbi request reprint Psychosocial risk factors and the metabolic syndrome in elderly persons: findings from the Health, Aging and Body Composition study
    Nicole Vogelzangs
    Department of Psychiatry and Institute for Research in Extramural Medicine, VU University Medical Center, Amsterdam, The Netherlands
    J Gerontol A Biol Sci Med Sci 62:563-9. 2007
    ..This study investigated the cross-sectional relationship between psychosocial risk factors and the metabolic syndrome in a community-based sample of older persons...
  37. ncbi request reprint Chronic disease and lifestyle transitions: results from the Longitudinal Aging Study Amsterdam
    Coen H van Gool
    Center for Public Health Forecasting, National Institute for Public Health and the Environment, Universiteit Maastricht Care and Public Health Research Institute, P O Box 1, NL 3720 BA, Bilthoven, The Netherlands
    J Aging Health 19:416-38. 2007
    ..This article addresses the association between course of chronic disease and lifestyle...
  38. ncbi request reprint Major depression in late life is associated with both hypo- and hypercortisolemia
    Marijke A Bremmer
    Department of Psychiatry, VU University Medical Center, Amsterdam, The Netherlands
    Biol Psychiatry 62:479-86. 2007
    ..We also examined whether this might represent different depression subtypes...
  39. pmc Scared to death: results from the Health, Aging, and Body Composition study
    Gretchen A Brenes
    Department of Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Geriatr Psychiatry 15:262-5. 2007
    ..The purpose of this study is to determine if anxiety is associated with mortality and if race moderates and depression mediates this relationship...
  40. ncbi request reprint Socioeconomic differences in incident depression in older adults: the role of psychosocial factors, physical health status, and behavioral factors
    Annemarie Koster
    Department of Health Care Studies, Section of Medical Sociology, Universiteit Maastricht, Maastricht, The Netherlands
    J Psychosom Res 61:619-27. 2006
    ....
  41. pmc Explanations of socioeconomic differences in changes in physical function in older adults: results from the Longitudinal Aging Study Amsterdam
    Annemarie Koster
    Department of Health Care Studies, Section Medical Sociology, Universiteit Maastricht, PO Box 616, 6200 MD Maastricht, The Netherlands
    BMC Public Health 6:244. 2006
    ....
  42. doi request reprint Summed score of the Patient Health Questionnaire-9 was a reliable and valid method for depression screening in chronically ill elderly patients
    Femke Lamers
    Care and Public Health Research Institute Caphri, Department of Social Medicine, Faculty of Health, Medicine and Life Sciences, Maastricht University, P O Box 616, 6200 MD Maastricht, The Netherlands
    J Clin Epidemiol 61:679-87. 2008
    ....
  43. pmc Correlates of anxiety symptoms in physically disabled older women
    Gretchen A Brenes
    Department of Psychiatry and Behavioral Medicine, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 25157, USA
    Am J Geriatr Psychiatry 13:15-22. 2005
    ..The authors describe characteristics that are associated with chronic anxiety symptoms and examine the use of anxiolytic and antidepressant medications in physically disabled women with and without symptoms of anxiety...
  44. ncbi request reprint Impact of depression on disablement in late middle aged and older persons: results from the Longitudinal Aging Study Amsterdam
    Coen H van Gool
    Department of Health Care Studies, Section Medical Sociology, Universiteit Maastricht, P O Box 616, Maastricht 6200 MD, The Netherlands
    Soc Sci Med 60:25-36. 2005
    ..Reduction of depression may help slow down the process of disablement for persons who find themselves in those stages of the model...
  45. ncbi request reprint Relation between use of angiotensin-converting enzyme inhibitors and muscle strength and physical function in older women: an observational study
    Graziano Onder
    Sticht Center on Aging, Section on Gerontology and Geriatrics, Department of Internal Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Lancet 359:926-30. 2002
    ..We aimed to see whether ACE inhibitors also prevent reduction in physical performance and in muscle strength in older women who do not have CHF...
  46. ncbi request reprint Inflammatory markers and cardiovascular disease (The Health, Aging and Body Composition [Health ABC] Study)
    Matteo Cesari
    Sticht Center on Aging, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    Am J Cardiol 92:522-8. 2003
    ..Thus, our findings suggest an important role for IL-6 and TNF-alpha in clinical as well as subclinical cardiovascular disease. In this study, CRP had a weaker association with cardiovascular disease than the cytokines...
  47. ncbi request reprint Income differentials in functional disability in old age: relative risks of onset, recovery, decline, attrition and mortality
    Marjolein I Broese van Groenou
    Department of Sociology and Social Gerontology, Faculty of Social Sciences, Vrije University, Amsterdam, The Netherlands
    Aging Clin Exp Res 15:174-83. 2003
    ..This longitudinal study aimed at comparing income differences in the course of disability, non-mortality attrition and mortality in older adults...
  48. ncbi request reprint The influence of differing social ties on decline in physical functioning among older people with and without chronic diseases: the Longitudinal Aging Study Amsterdam
    M Isabella Bisschop
    VU University Medical Center, Institue for Research in Extramural Medicine, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    Aging Clin Exp Res 15:164-73. 2003
    ..This study examines whether differing types of social ties and support differentially mitigate the negative effects of chronic diseases on decline in physical functioning...
  49. ncbi request reprint Comparing various short-form Geriatric Depression Scales leads to the GDS-5/15
    Sandra Kenney Weeks
    North Carolina Baptist Hospital, Wake Forest University, Baptist Medical Center, Winston Salem, NC, USA
    J Nurs Scholarsh 35:133-7. 2003
    ..To compare three published short GDS scales and to identify a valid and reliable short-form alternative to the 15-item Geriatric Depression Scale...
  50. ncbi request reprint Visceral adipose tissue cutoffs associated with metabolic risk factors for coronary heart disease in women
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Diabetes Care 26:1413-20. 2003
    ..This study determined whether there is a critical level of visceral adipose tissue (VAT) associated with elevated coronary heart disease (CHD) risk factors in a cohort of women >45 years of age...
  51. ncbi request reprint Prevalence and correlates of anxiety symptoms in well-functioning older adults: findings from the health aging and body composition study
    Kala M Mehta
    Division of Geriatrics, University of California at San Francisco, San Francisco, California 94121
    J Am Geriatr Soc 51:499-504. 2003
    ..To determine the prevalence and correlates of anxiety symptoms in the absence of depression, in older black and white people...
  52. ncbi request reprint Depression and adverse drug reactions among hospitalized older adults
    Graziano Onder
    Centro Medicina dell Invecchiamento, Universita Cattolica del Sacro Cuore, Policlinico A Gemelli, L go Francesco Vito 1, 00168 Rome, Italy
    Arch Intern Med 163:301-5. 2003
    ..The aim of this study was to assess whether depression may be a risk factor for adverse drug reactions (ADRs) among hospitalized older adults...
  53. ncbi request reprint Relationship between changes in depressive symptoms and unhealthy lifestyles in late middle aged and older persons: results from the Longitudinal Aging Study Amsterdam
    Coen H van Gool
    Department of Health Care Studies, Section Medical Sociology, Universiteit Maastricht, Maastricht, The Netherlands
    Age Ageing 32:81-7. 2003
    ..Primary objective: to determine if depressed mood is associated with unhealthy lifestyles in late middle aged and older people, with or without chronic somatic diseases...
  54. ncbi request reprint Change in muscle strength explains accelerated decline of physical function in older women with high interleukin-6 serum levels
    Luigi Ferrucci
    Laboratory of Clinical Epidemiology, INRCA Geriatric Department, Florence, Italy
    J Am Geriatr Soc 50:1947-54. 2002
    ..To test whether accelerated sarcopenia in older persons with high interleukin (IL)-6 serum levels plays a role in the prospective association between inflammation and disability found in many studies...
  55. ncbi request reprint The natural history of late-life depression: a 6-year prospective study in the community
    Aartjan T F Beekman
    Department of Psychiatry, Institute of Extramural Medicine, Amsterdam, The Netherlands
    Arch Gen Psychiatry 59:605-11. 2002
    ..The primary aim was to study the natural history of late-life depression, systematically comparing those who did with those who did not fulfill rigorous diagnostic criteria...
  56. ncbi request reprint Change in physical performance over time in older women: the Women's Health and Aging Study
    Graziano Onder
    Sticht Center on Aging, Section on Gerontology and Geriatrics, Department of Internal Medicine, Wake Forest University, School of Medicine, Winston Salem, North Carolina 27157, USA
    J Gerontol A Biol Sci Med Sci 57:M289-93. 2002
    ....
  57. ncbi request reprint Inflammatory markers and depressed mood in older persons: results from the Health, Aging and Body Composition study
    Brenda W J H Penninx
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Biol Psychiatry 54:566-72. 2003
    ..In old age, depressed mood is associated with high levels of inflammatory markers, suggesting that depressed mood is causing and/or caused by systemic inflammation...
  58. ncbi request reprint Inflammatory markers and onset of cardiovascular events: results from the Health ABC study
    Matteo Cesari
    Sticht Center on Aging, Wake Forest University School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Circulation 108:2317-22. 2003
    ..Inflammation plays an important role in cardiovascular disease. The aim of this study is to investigate the predictive value of several inflammatory markers on the incidence of cardiovascular events in well-functioning older persons...
  59. ncbi request reprint Sexual satisfaction and risk of disability in older women
    Graziano Onder
    Sticht Center on Aging, Section on Gerontology and Geriatrics, Department of Internal Medicine, School of Medicine, Wake Forest University, Winston Salem, N C, USA
    J Clin Psychiatry 64:1177-82. 2003
    ....
  60. ncbi request reprint Effectiveness of an education programme by a general practice assistant for asthma and COPD patients: results from a randomised controlled trial
    Arlette E Hesselink
    Institute for Research in Extramural Medicine, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    Patient Educ Couns 55:121-8. 2004
    ..However, given the importance of improvement of patients' coping and the need for more efficient care, we recommend further exploration of the possibilities of a more structured and intensive education programme...
  61. ncbi request reprint Inflammatory markers and physical function among older adults with knee osteoarthritis
    Brenda W J H Penninx
    Sticht Center on Aging, Department of Internal Medicine, Wake Forest University School of Medicine, Wake Forest University, Winston Salem, North Carolina 27157, USA
    J Rheumatol 31:2027-31. 2004
    ..To investigate whether serum concentrations of various inflammatory markers are associated with physical function and disease severity among older obese adults with knee osteoarthritis (OA)...
  62. ncbi request reprint Association of visceral adipose tissue with incident myocardial infarction in older men and women: the Health, Aging and Body Composition Study
    Barbara J Nicklas
    Section on Gerontology and Geriatric Medicine, Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Epidemiol 160:741-9. 2004
    ..79, 95% confidence interval: 1.24, 2.58 per standard-deviation increase; p < 0.01). The amount of adipose tissue stored in the intraabdominal cavity is an important, independent risk factor for MI in well-functioning, elderly women...
  63. ncbi request reprint Socioeconomic differences in cognitive decline and the role of biomedical factors
    Annemarie Koster
    Department of Health Care Studies, Section Medical Sociology, Universiteit Maastricht, Maastricht, The Netherlands
    Ann Epidemiol 15:564-71. 2005
    ..This study examines the association between socioeconomic status and cognitive decline in a community-based cohort of well-functioning older adults and seeks to determine whether this link could be explained by biomedical factors...
  64. ncbi request reprint Inflammatory markers and incident mobility limitation in the elderly
    Brenda W J H Penninx
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 52:1105-13. 2004
    ..To examine the relationship between indicators of inflammation and the incidence of mobility limitation in older persons...
  65. ncbi request reprint Anemia is associated with disability and decreased physical performance and muscle strength in the elderly
    Brenda W J H Penninx
    Sticht Center on Aging, Section on Gerontology and Geriatric Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    J Am Geriatr Soc 52:719-24. 2004
    ..To examine the association between anemia and disability, physical performance, and muscle strength in older persons...
  66. ncbi request reprint Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial
    Barbara J Nicklas
    Wake Forest University School of Medicine, Winston Salem, NC, USA
    Am J Clin Nutr 79:544-51. 2004
    ..Persistent, low-grade inflammation is an independent predictor of several chronic diseases and all-cause mortality...
  67. ncbi request reprint Hemoglobin levels and skeletal muscle: results from the InCHIANTI study
    Matteo Cesari
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 59:249-54. 2004
    ..Anemia is associated with reduced physical performance and muscle strength. The aim of the study was to explore whether anemia and hemoglobin levels are associated with differences in quantitative and qualitative measures of muscle and fat...
  68. ncbi request reprint Inflammatory markers and physical performance in older persons: the InCHIANTI study
    Matteo Cesari
    Sticht Center on Aging, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Gerontol A Biol Sci Med Sci 59:242-8. 2004
    ..The aim of this study is to evaluate the relationship between several inflammatory markers and physical performance in an older population...
  69. ncbi request reprint Benzodiazepine use and physical performance in community-dwelling older women
    Shelly L Gray
    School of Pharmacy, University of Washington, Seattle, Washington 98195, USA
    J Am Geriatr Soc 51:1563-70. 2003
    ..To determine whether benzodiazepine use in older women increased the risk of decline in physical function...
  70. ncbi request reprint Antioxidants and physical performance in elderly persons: the Invecchiare in Chianti (InCHIANTI) study
    Matteo Cesari
    Sticht Center on Aging, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    Am J Clin Nutr 79:289-94. 2004
    ..Muscle strength and physical performance in old age might be related to the oxidative damage caused by free radicals...
  71. ncbi request reprint Activities of daily living function and disability in older adults in a randomized trial of the health enhancement program
    Elizabeth A Phelan
    Department of Medicine, Division of Gerontology and Geriatric Medicine, University of Washington, 325 9th Avenue, Box 359755, Seattle, WA 98104 2499, USA
    J Gerontol A Biol Sci Med Sci 59:838-43. 2004
    ..Little is known about ways by which ADL disability can be prevented or reversed. The authors evaluated the efficacy of the Health Enhancement Program in preventing and reducing ADL disability in community-dwelling older adults...
  72. ncbi request reprint The contribution of working conditions and social support to the onset of depressive and anxiety disorders among male and female employees
    Inger Plaisier
    Department of Social Cultural Sciences, Vrije Universiteit, de Boelelaam 1081, Amsterdam 1081HV, The Netherlands
    Soc Sci Med 64:401-10. 2007
    ..Women were more likely to report low levels of decision latitude, whereas men reported higher psychological demands. Working conditions did not explain sex differences in the incidence of depressive and anxiety disorders...
  73. doi request reprint Genome-wide association of major depression: description of samples for the GAIN Major Depressive Disorder Study: NTR and NESDA biobank projects
    Dorret I Boomsma
    Netherlands Twin Register, Department of Biological Psychology, VU University Amsterdam, Amsterdam, Netherlands
    Eur J Hum Genet 16:335-42. 2008
    ..Genome-wide association results are open-access and can be viewed at the dbGAP web portal (http://www.ncbi.nlm.nih.gov). Approved users can download the genotype and phenotype data, which have been made available as of 9 October 2007...
  74. pmc Clinical effectiveness of usual care with or without antidepressant medication for primary care patients with minor or mild-major depression: a randomized equivalence trial
    Marleen L M Hermens
    Department of General Practice, Institute for Research in Extramural Medicine, VU University Medical Center, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    BMC Med 5:36. 2007
    ..We compared the effectiveness of usual primary care treatment, with or without antidepressants, in minor and mild-major depression...
  75. pmc The Four-Dimensional Symptom Questionnaire (4DSQ): a validation study of a multidimensional self-report questionnaire to assess distress, depression, anxiety and somatization
    Berend Terluin
    Department of General Practice, EMGO Institute, VU University Medical Centre, Van der Boechorststraat 7, 1081 BT Amsterdam, The Netherlands
    BMC Psychiatry 6:34. 2006
    ..The purpose of this paper is to evaluate its criterion and construct validity...